An efficient and novel methodology to access phenolic glycosides has been established by using coppermediated coupling reaction of aryl boronic acids with hemiacetals.The reaction takes place normally in the presence ...An efficient and novel methodology to access phenolic glycosides has been established by using coppermediated coupling reaction of aryl boronic acids with hemiacetals.The reaction takes place normally in the presence of Cu(OAc)_2(1.0 equiv.)and pyridine(2.0 equiv.)at 40℃.This protocol distinguishes itself by wide substrate scope,operational simplicity and giving rise to a myriad of phenolic glycosides in good to excellent yields.展开更多
Anhydrous Cu(OAc)<sub>2</sub> mediated efficient protocol has been developed in the area of C-O coupling from potassium aryltrifluoroborates and aliphatic amino alcohols such as β-hydroxy, γ-hydroxy, and...Anhydrous Cu(OAc)<sub>2</sub> mediated efficient protocol has been developed in the area of C-O coupling from potassium aryltrifluoroborates and aliphatic amino alcohols such as β-hydroxy, γ-hydroxy, and δ-hydroxy amines. The scope of this transformation focuses on direct O-arylation and O-styrylation. The reaction vial loaded with reactants under argon atmosphere is microwaved at 140°C for 30 min to furnish the corresponding cross-coupling product, amino ethers, in good yields.展开更多
A computer-assisted retention prediction system (RPS) of fifteen O-ethyl O-aryl N-iso- propyl phosphoramidothioates (1) in reversed-phase HPLC was investigated. The system is based on the use of four physicochemical p...A computer-assisted retention prediction system (RPS) of fifteen O-ethyl O-aryl N-iso- propyl phosphoramidothioates (1) in reversed-phase HPLC was investigated. The system is based on the use of four physicochemical parameters (hydrophobicity , electric effect σ, field effect F and steric effect ) which is closely related to the retention mechanism in reversed-phase HPLC. The system was evaluated by comparing the measured retention data with the predicted ones. The predicted values were consistent with the measured values within a relative error of 11.5%.展开更多
基金financially supported by the National Key R&D Program of China (No. 2018YFA0507602)the National Natural Science Foundation of China (Nos. 21572012, 21772006)the State Key Laboratory of Drug Research (No. SIMM1803KF-02)
文摘An efficient and novel methodology to access phenolic glycosides has been established by using coppermediated coupling reaction of aryl boronic acids with hemiacetals.The reaction takes place normally in the presence of Cu(OAc)_2(1.0 equiv.)and pyridine(2.0 equiv.)at 40℃.This protocol distinguishes itself by wide substrate scope,operational simplicity and giving rise to a myriad of phenolic glycosides in good to excellent yields.
文摘Anhydrous Cu(OAc)<sub>2</sub> mediated efficient protocol has been developed in the area of C-O coupling from potassium aryltrifluoroborates and aliphatic amino alcohols such as β-hydroxy, γ-hydroxy, and δ-hydroxy amines. The scope of this transformation focuses on direct O-arylation and O-styrylation. The reaction vial loaded with reactants under argon atmosphere is microwaved at 140°C for 30 min to furnish the corresponding cross-coupling product, amino ethers, in good yields.
文摘A computer-assisted retention prediction system (RPS) of fifteen O-ethyl O-aryl N-iso- propyl phosphoramidothioates (1) in reversed-phase HPLC was investigated. The system is based on the use of four physicochemical parameters (hydrophobicity , electric effect σ, field effect F and steric effect ) which is closely related to the retention mechanism in reversed-phase HPLC. The system was evaluated by comparing the measured retention data with the predicted ones. The predicted values were consistent with the measured values within a relative error of 11.5%.
