目的研究O-2A祖细胞移植对大鼠脊髓损伤(SCI)后运动功能恢复的作用。方法从新生1～2 d SD大鼠大脑皮质中分离纯化O-2A祖细胞。80只SD成年大鼠,随机分为4组:A组为正常组,与其他3组同期饲养;其他3组均行T9脊髓左半侧离断手术,B组损伤处植...目的研究O-2A祖细胞移植对大鼠脊髓损伤(SCI)后运动功能恢复的作用。方法从新生1～2 d SD大鼠大脑皮质中分离纯化O-2A祖细胞。80只SD成年大鼠,随机分为4组:A组为正常组,与其他3组同期饲养;其他3组均行T9脊髓左半侧离断手术,B组损伤处植入吸附生理盐水的明胶海绵(损伤对照组);C组损伤处移植50%O-2A祖细胞和50%1型星形胶质细胞(T1A)混悬液(O-2A+T1A组);D组损伤处植入含有纯化O-2A祖细胞的细胞悬液(O-2A移植组)。移植术后3、7、14、21、28 d分别以CBS及BBB方法进行大鼠神经功能评定。结果A组大鼠后肢CBS和BBB得分分别为100和21。O-2A祖细胞移植术后3、7、14、21、28 d,B、C、D组动物后肢神经功能均有不同程度的恢复,左后肢得分均显著低于右侧,差异均有高度统计学意义(均P<0.01),D组运动功能恢复最好。结论O-2A祖细胞移植可促进大鼠脊髓损伤后神经功能的恢复。展开更多
The title compound has been synthesized by the reaction of 3,3-dimethyl-1-（1H-1,2,4-triazol-1-yl）butan-2-one oxime with 2-chlorobenzyl chloride, and then treated with 65～68% HNO3. Its crystal structure was determin...The title compound has been synthesized by the reaction of 3,3-dimethyl-1-（1H-1,2,4-triazol-1-yl）butan-2-one oxime with 2-chlorobenzyl chloride, and then treated with 65～68% HNO3. Its crystal structure was determined by single-crystal X-ray diffraction. The crystal belongs to the monoclinic system, space group P21/c with a = 14.5481（8）, b = 9.3351（5）, c = 13.1911（7） , β = 98.9450（10）°, Z = 4, V = 1769.67（17） 3, Mr = 369.81, Dc = 1.388 g/cm3, S = 1.06, μ = 0.247 mm-1, F（000） = 776, the final R = 0.0352 and wR = 0.0960 for 3069 observed reflections （I 2σ（I））. X-ray crystal structure presents the intramolecular N–H…O hydrogen bond. The packing is nearly parallel without π-π stacking interactions between two adjacent phenyl rings and stabilized by Van der Waals force. The preliminary bioassay shows that the title compound possesses fungicidal activity against Gibberella zeae at the dosage of 25 mg/L.展开更多
2,3-Dihydro-2-aryl-4（1H）-quinazolinones were prepared in good yields via condensation of o-aminobenzamide with aldehydes promoted by a catalytic amount of Sc（OTf）3 under mild conditions.
The effects of reaction temperature, partial pressure of methane, catalyst weight and gas hourly space velocity （GHSV） on methane decomposition were reported. The decomposition reaction was performed in a vertical f...The effects of reaction temperature, partial pressure of methane, catalyst weight and gas hourly space velocity （GHSV） on methane decomposition were reported. The decomposition reaction was performed in a vertical fixed-bed reactor over 8Co-2Mo/Al 2 O 3 catalyst. The experimental results show that these four process parameters studied had vital effects on carbon yield. As revealed by the electron microscopy and Raman spectroscopy analyses, the reaction temperature and GHSV governed the average diameter, the diameter distribution and the degree of graphitization of the synthesized carbon nanotubes （CNTs）. Also, an evidence is presented to show that higher temperatures and higher GHSV favored the formation of better-graphitized CNTs with larger diameters.展开更多
文摘目的研究O-2A祖细胞移植对大鼠脊髓损伤(SCI)后运动功能恢复的作用。方法从新生1～2 d SD大鼠大脑皮质中分离纯化O-2A祖细胞。80只SD成年大鼠,随机分为4组:A组为正常组,与其他3组同期饲养;其他3组均行T9脊髓左半侧离断手术,B组损伤处植入吸附生理盐水的明胶海绵(损伤对照组);C组损伤处移植50%O-2A祖细胞和50%1型星形胶质细胞(T1A)混悬液(O-2A+T1A组);D组损伤处植入含有纯化O-2A祖细胞的细胞悬液(O-2A移植组)。移植术后3、7、14、21、28 d分别以CBS及BBB方法进行大鼠神经功能评定。结果A组大鼠后肢CBS和BBB得分分别为100和21。O-2A祖细胞移植术后3、7、14、21、28 d,B、C、D组动物后肢神经功能均有不同程度的恢复,左后肢得分均显著低于右侧,差异均有高度统计学意义(均P<0.01),D组运动功能恢复最好。结论O-2A祖细胞移植可促进大鼠脊髓损伤后神经功能的恢复。
基金Supported by the Central University Basic Scientific Research Fund of Hunan University (2009)the Key Scientific and Technological Project of Changsha, Hunan Province (No. 0901077-31)
文摘The title compound has been synthesized by the reaction of 3,3-dimethyl-1-（1H-1,2,4-triazol-1-yl）butan-2-one oxime with 2-chlorobenzyl chloride, and then treated with 65～68% HNO3. Its crystal structure was determined by single-crystal X-ray diffraction. The crystal belongs to the monoclinic system, space group P21/c with a = 14.5481（8）, b = 9.3351（5）, c = 13.1911（7） , β = 98.9450（10）°, Z = 4, V = 1769.67（17） 3, Mr = 369.81, Dc = 1.388 g/cm3, S = 1.06, μ = 0.247 mm-1, F（000） = 776, the final R = 0.0352 and wR = 0.0960 for 3069 observed reflections （I 2σ（I））. X-ray crystal structure presents the intramolecular N–H…O hydrogen bond. The packing is nearly parallel without π-π stacking interactions between two adjacent phenyl rings and stabilized by Van der Waals force. The preliminary bioassay shows that the title compound possesses fungicidal activity against Gibberella zeae at the dosage of 25 mg/L.
基金We are grateful to the National Basic Research Program （No. 2003CB114402）；the National Natural Science Foundation of China （Nos. 20476098 and 20676123） ；Wenzhou University Post-graduate Innovation Foundation （No. YCX0515） for financial support.
文摘2,3-Dihydro-2-aryl-4（1H）-quinazolinones were prepared in good yields via condensation of o-aminobenzamide with aldehydes promoted by a catalytic amount of Sc（OTf）3 under mild conditions.
基金supported by the Malaysian Technology Development Corporation (MTDC) under the Commercialization of Research & Development Fund (CRDF) (Project A/C No. MBF065-USM/05)the Monash Internal Seed Grant (A/C no: E-9-09)
文摘The effects of reaction temperature, partial pressure of methane, catalyst weight and gas hourly space velocity （GHSV） on methane decomposition were reported. The decomposition reaction was performed in a vertical fixed-bed reactor over 8Co-2Mo/Al 2 O 3 catalyst. The experimental results show that these four process parameters studied had vital effects on carbon yield. As revealed by the electron microscopy and Raman spectroscopy analyses, the reaction temperature and GHSV governed the average diameter, the diameter distribution and the degree of graphitization of the synthesized carbon nanotubes （CNTs）. Also, an evidence is presented to show that higher temperatures and higher GHSV favored the formation of better-graphitized CNTs with larger diameters.
