As the high-density nuclear equation of state(EOS) is not very well constrained, we suggest that the structural properties from the finite systems can be used to extract a more accurate constraint. By including the st...As the high-density nuclear equation of state(EOS) is not very well constrained, we suggest that the structural properties from the finite systems can be used to extract a more accurate constraint. By including the strangeness degrees of freedom, the hyperon or anti-kaon, the finite systems can then have a rather high-density core which is relevant to the nuclear EOS at high densities directly. It is found that the density dependence of the symmetry energy is sensitive to the properties of multi-K hypernuclei, while the high-density EOS of symmetric matter correlates sensitively to the properties of kaonic nuclei.展开更多
Accurate and reliable nuclear data libraries are essential for calculation and design of advanced nuclea systems. A 1200 fine group nuclear data library Hybrid Evaluated Nuclear Data Library/Fine Group(HENDL/FG with n...Accurate and reliable nuclear data libraries are essential for calculation and design of advanced nuclea systems. A 1200 fine group nuclear data library Hybrid Evaluated Nuclear Data Library/Fine Group(HENDL/FG with neutrons of up to 150 Me V has been developed to improve the accuracy of neutronics calculations and anal ysis. Corrections of Doppler, resonance self-shielding, and thermal upscatter effects were done for HENDL/FG Shielding and critical safety benchmarks were performed to test the accuracy and reliability of the library. The dis crepancy between calculated and measured nuclea parameters fell into a reasonable range.展开更多
Nuclear factor Y is a ubiquitous heterotrimeric transcription factor complex conserved across eukaryotes that binds to CCAAT boxes,one of the most common motifs found in gene promoters and enhancers.Over the last 30 y...Nuclear factor Y is a ubiquitous heterotrimeric transcription factor complex conserved across eukaryotes that binds to CCAAT boxes,one of the most common motifs found in gene promoters and enhancers.Over the last 30 years,research has revealed that the nuclear factor Y complex controls many aspects of brain development,including differentiation,axon guidance,homeostasis,disease,and most recently regeneration.However,a complete understanding of transcriptional regulatory networks,including how the nuclear factor Y complex binds to specific CCAAT boxes to perform its function remains elusive.In this review,we explore the nuclear factor Y complex’s role and mode of action during brain development,as well as how genomic technologies may expand understanding of this key regulator of gene expression.展开更多
In nuclear power engineering,the quality requirements for concrete are extremely stringent.Concrete structures must exhibit high durability to withstand the effects of nuclear radiation,chemical corrosion,and environm...In nuclear power engineering,the quality requirements for concrete are extremely stringent.Concrete structures must exhibit high durability to withstand the effects of nuclear radiation,chemical corrosion,and environmental changes.In particular,nuclear power projects impose higher design standards and safety requirements regarding concrete density.Traditional manual vibration and visual inspection methods are difficult to ensure the required level of concrete compaction.This paper presents an intelligent vibration technology for concrete in nuclear power engineering to enhance construction quality and efficiency.By integrating intelligent sensors,control systems,and data processing algorithms,the technology enables real-time monitoring and evaluation of the vibration process.Results show that intelligent vibration technology effectively ensures the density and uniformity of concrete in nuclear power engineering,thereby improving structural safety and reliability.展开更多
Compared to other energy sources,nuclear reactors offer several advantages as a spacecraft power source,including compact size,high power density,and long operating life.These qualities make nuclear power an ideal ene...Compared to other energy sources,nuclear reactors offer several advantages as a spacecraft power source,including compact size,high power density,and long operating life.These qualities make nuclear power an ideal energy source for future deep space exploration.A whole system model of the space nuclear reactor consisting of the reactor neutron kinetics,reactivity control,reactor heat transfer,heat exchanger,and thermoelectric converter was developed.In addition,an electrical power control system was designed based on the developed dynamic model.The GRS method was used to quantitatively calculate the uncertainty of coupling parameters of the neutronics,thermal-hydraulics,and control system for the space reactor.The Spearman correlation coefficient was applied in the sensitivity analysis of system input parameters to output parameters.The calculation results showed that the uncertainty of the output parameters caused by coupling parameters had the most considerable variation,with a relative standard deviation<2.01%.Effective delayed neutron fraction was most sensitive to electrical power.To obtain optimal control performance,the non-dominated sorting genetic algorithm method was employed to optimize the controller parameters based on the uncertainty quantification calculation.Two typical transient simulations were conducted to test the adaptive ability of the optimized controller in the uncertainty dynamic system,including 100%full power(FP)to 90%FP step load reduction transient and 5%FP/min linear variable load transient.The results showed that,considering the influence of system uncertainty,the optimized controller could improve the response speed and load following accuracy of electrical power control,in which the effectiveness and superiority have been verified.展开更多
The α-nucleus interaction is crucial in the description of α decay. Recently, we developed a pocket-type dynamical doublefolding potential(DDFP) that effectively incorporates both the surface-medium effect and inter...The α-nucleus interaction is crucial in the description of α decay. Recently, we developed a pocket-type dynamical doublefolding potential(DDFP) that effectively incorporates both the surface-medium effect and interior Pauli repulsion in α decay [H. Zheng et al., Phys. Rev. C 109, L011301(2024)]. This potential results in a pocket geometry within the nuclear surface region, which is consistent with the α-clustering characteristics predicted by microscopic calculations. In this study, the accuracy of the pocket-type DDFP was validated via systematic calculations of α-decay half-lives and an extended evaluation of the nuclear charge radii of the daughter nuclei. The results demonstrate good agreement with the experimental data for both quantities, thereby confirming the reliability of the DDFP model. Compared with calculations that use α-nucleus interactions derived from conventional double-folding procedures, DDFP employs fewer adjustable parameters to achieve a more accurate description of the charge radii based on the experimental α-decay energies.展开更多
Introduction-Nuclei near and beyond the proton drip line represent a fascinating frontier in the nuclear landscape. Proton-rich nuclei exhibit intriguing phenomena, such as the Thomas-Ehrman shift and proton-halo stru...Introduction-Nuclei near and beyond the proton drip line represent a fascinating frontier in the nuclear landscape. Proton-rich nuclei exhibit intriguing phenomena, such as the Thomas-Ehrman shift and proton-halo structure. Beyond the proton dripline, nuclei become unbound, allowing protons to be emitted and giving rise to novel radioactive decay modes. Single-proton radioactivity, a process in which some nuclei with an odd number of protons(Z) decay by ejecting a proton, was discovered several decades ago and has been extensively studied [1, 2].展开更多
Strokes include both ischemic stroke,which is mediated by a blockade or reduction in the blood supply to the brain,and hemorrhagic stroke,which comprises intracerebral hemorrhage and subarachnoid hemorrhage and is cha...Strokes include both ischemic stroke,which is mediated by a blockade or reduction in the blood supply to the brain,and hemorrhagic stroke,which comprises intracerebral hemorrhage and subarachnoid hemorrhage and is characterized by bleeding within the brain.Stroke is a lifethreatening cerebrovascular condition characterized by intricate pathophysiological mechanisms,including oxidative stress,inflammation,mitochondrial dysfunction,and neuronal injury.Critical transcription factors,such as nuclear factor erythroid 2-related factor 2 and nuclear factor kappa B,play central roles in the progression of stroke.Nuclear factor erythroid 2-related factor 2 is sensitive to changes in the cellular redox status and is crucial in protecting cells against oxidative damage,inflammatory responses,and cytotoxic agents.It plays a significant role in post-stroke neuroprotection and repair by influencing mitochondrial function,endoplasmic reticulum stress,and lysosomal activity and regulating metabolic pathways and cytokine expression.Conversely,nuclear factor-kappa B is closely associated with mitochondrial dysfunction,the generation of reactive oxygen species,oxidative stress exacerbation,and inflammation.Nuclear factor-kappa B contributes to neuronal injury,apoptosis,and immune responses following stroke by modulating cell adhesion molecules and inflammatory mediators.The interplay between these pathways,potentially involving crosstalk among various organelles,significantly influences stroke pathophysiology.Advancements in single-cell sequencing and spatial transcriptomics have greatly improved our understanding of stroke pathogenesis and offer new opportunities for the development of targeted,individualized,cell typespecific treatments.In this review,we discuss the mechanisms underlying the involvement of nuclear factor erythroid 2-related factor 2 and nuclear factor-kappa B in both ischemic and hemorrhagic stroke,with an emphasis on their roles in oxidative stress,inflammation,and neuroprotection.展开更多
The nuclear and Coulomb potentials between deformed nuclei with octupole deformations and arbitrary orientations are evaluated numerically. The effects of the octupole deformation on the potential between nuclei and t...The nuclear and Coulomb potentials between deformed nuclei with octupole deformations and arbitrary orientations are evaluated numerically. The effects of the octupole deformation on the potential between nuclei and the potential energy surface （PES） used in the description of the production of super-heavy nuclei （SHN） by heavy-ion fusion reactions are investigated in the di-nuclear system model. It is found that the nuclear octupole deformation significantly changes the shape of the PES, which may influence the fusion probability of the SHN. Also, PESs in the tip-belly and belly-belly cases are investigated. Finally, the quasi-fission barriers in the tip-tip and belly-belly cases are evaluated. It is found that the quasi-fission barriers of the belly-belly case are generally larger than those of the tip-tip case.展开更多
AIM To explore the relationship between the configuration changes of the nuclear matrix-intermediate filament system in cancer cell induced by retinoic acid and the malignantphenotypic reversion of cancer cells.METHOD...AIM To explore the relationship between the configuration changes of the nuclear matrix-intermediate filament system in cancer cell induced by retinoic acid and the malignantphenotypic reversion of cancer cells.METHODS The human gastric adenocarcinomacell line MGc80-3 cells were induced with 10-6mol/ L retinoic acid and subouItured at cover slipstrip and gold grids. The cells were treated byselective extraction methOd and prepared for whole mount electron microscopy observation.The samples were examined respectively withscanning and transmission electron microscope.RESULTS The nuclear matrix filaments andintermediate filaments in MGC80-3 cells wererelatively few and scattered, not welldistributed and arranged irregularly. The nuclear lamina was ununiformly thick and compact,connected to the nuclear matrix filaments and intermediate filaments relaxedly. However, thetwo kinds of filaments were abundant and welldistributed, different in slender and thick form and interweaved into a regular network in the cells induced by 10-6 mol/ L RA. The nuclear matrix filaments and intermediate filaments were connected closely by the thin and compact fiber-Iike lamina, and interlaced into a regularnetwork throughout the whole cell region.CONCLUSION The NM-IF system in MGc80-3cells had undergone a restorational changesimilar to those of normaI cells after RAinducement. This alternation is an importantmorpholOgical and functional expression to themalignant phenotypic reversion of cancer cells.展开更多
Activation of nuclear factor kappa B （NF-κB） is a hallmark of various central nervous system （CNS） pathologies. Neuron-specific inhibition of its transcriptional activator subunit RelA, also referred to as p65, p...Activation of nuclear factor kappa B （NF-κB） is a hallmark of various central nervous system （CNS） pathologies. Neuron-specific inhibition of its transcriptional activator subunit RelA, also referred to as p65, promotes neuronal survival under a range of conditions, i.e., for ischemic or excitotoxic insults. In macro- and microglial cells, post-lesional activation of NF-κB triggers a growth-permissive program which contributes to neural tissue inflammation, scar formation, and the expression of axonal growth inhibitors. Intriguingly, inhibition of such inducible NF-~B in the neuro-glial compartment, i.e., by genetic ablation of RelA or overexpression of a trans- dominant negative mutant of its upstream regulator IκBa, significantly enhances functional recovery and promotes axonal regeneration in the mature CNS. By contrast, depletion of the NF-κB subunit p50, which lacks transcriptional activator function and acts as a transcriptional repressor on its own, causes precocious neuronal loss and exacerbates axonal degeneration in the lesioned brain. Collectively, the data imply that NF-κB orchestrates a multicellular pro- gram in which κB-dependent gene expression establishes a growth-repulsive terrain within the post-lesioned brain that limits structural regeneration of neuronal circuits. Considering these subunit-specific functions, interference with the NF-κB pathway might hold clinical potentials to improve functional restoration following traumatic CNS injury.展开更多
The paper presents a computer code system 'SRDAAR- QNPP' for the real-time dose as-sessment of an accident release for Qinshan Nuclear Power Plant. It includes three parts:thereal-time data acquisition system,...The paper presents a computer code system 'SRDAAR- QNPP' for the real-time dose as-sessment of an accident release for Qinshan Nuclear Power Plant. It includes three parts:thereal-time data acquisition system, assessment computer. and the assessment operating code system. InSRDAAR-QNPP, the wind field of the surface and the lower levels are determined hourly by using amass consistent three-dimension diasnosis model with the topographic following coordinate system.A Lagrangin Puff model under changing meteorological condition is adopted for atmosphericdispersion, the correction for dry and wet depositions. physical decay and partial plume penetrationof the top inversion and the deviation of plume axis caused by complex terrain have been taken in-to account. The calculation domain areas include three square grid areas with the sideline 10 km, 40krn and 160 km and a grid interval 0.5 km, 2.0 km, 8.0 km respectively. Three exposure pathwaysare taken into account:the external exposure from immersion cloud and passing puff, the internalexposure from inhalation and the external exposure from contaminated ground. This system is ableto provide the results of concentration and dose distributions within 10 minutes after the data havebeen inputed.展开更多
AIM： To investigate the association between the configurational and compositional changes of nuclear matrix and the differentiation of carcinoma cells. METHODS： Cells cultured with or without 5 × 10^-3 mmol/L o...AIM： To investigate the association between the configurational and compositional changes of nuclear matrix and the differentiation of carcinoma cells. METHODS： Cells cultured with or without 5 × 10^-3 mmol/L of hexamethylene bisacetamide （HMBA） on Nickel grids were treated by selective extraction and prepared for whole mount observation under electron microscopy. The samples were examined under transmission electron microscope. Nuclear matrix proteins were selectively extracted and subjected to subcellular proteomics study. The protein expression patterns were analyzed by PDQuest software. Spots of differentially expressed nuclear matrix proteins were excised and subjected to in situ digestion with trypsin. The peptides were analyzed by matrix-assisted laser- desorption/ionization time of flight mass spectrometry （MALDI-TOF-MS）. Data were submitted for database searching using Mascot tool （www.matrixscience.com）. RESULTS： The nuclear matrix （NM） and intermediate filament （IF） in SMMC-7721 hepatocarcinoma cells were found relatively sparse and arranged irregularly. The nuclear lamina was non-uniform, and two kinds of filaments were not tightly connected. After induction for differentiation by HMBA, the NM-IF filaments were concentrated and distributed uniformly. The heterogeneous population of filaments, including highly branched utrathin filaments could also be seen in the regular meshwork. The connection between the two kinds of filaments and the relatively thin, condensed and sharply demarcated lamina composed of intermediate- sized filaments was relatively fastened. Meanwhile, 21 NM proteins changed remarkably during SMMC-7721 cell differentiation. Four proteins, i.e. mutant Pystl, hypothetical protein, nucleophosminl, and LBP were downregulated, whereas four other proteins, eIF6, p44 subunit, 13-tubulin, and SIN3B were upregulated with the last one, SR2/ASF found only in the differentiated SMMC-7721 cells. CONCLUSION： The induced differentiation of SMMC-7721 cells by HMBA is accompanied by the configurational changes of nuclear matrix-intermediate filament （NM-IF） system and the compositional changes of nuclear matrix protein expression. These changes may be important morphological or functional indications of the cancer cell reversion.展开更多
This paper proposes a sub-critical nuclear energy system driven by fusion neutron source, FDS, which can be used to transmute long-lived radioactive wastes and to produce fissile nuclear fuel as a way for early applic...This paper proposes a sub-critical nuclear energy system driven by fusion neutron source, FDS, which can be used to transmute long-lived radioactive wastes and to produce fissile nuclear fuel as a way for early application of fusion technology. The necessity and feasibility to develop that system in China are illustrated on the basis of prediction of the demand of energy source in the first half of the 21th century, the status of current fission energy supply and the progress in fusion technology in the world. The characteristics of fusion neutron driver and the potential for transmutation of long-lived nuclear wastes and breeding of fissile nuclear fuel in a blanket are analyzed. A scenario of development steps is proposed.展开更多
We discuss cluster phenomena in light nuclei. As examples of typical cluster structures, we first review cluster structures of 12C, 16O, and 20Ne, and then introduce some topics of cluster phenomena in light neutron-r...We discuss cluster phenomena in light nuclei. As examples of typical cluster structures, we first review cluster structures of 12C, 16O, and 20Ne, and then introduce some topics of cluster phenomena in light neutron-rich nuclei such as Be and C isotopes. A particular attention is paid on coexistence of cluster and shell-model aspects.展开更多
Scheduled maintenance and condition-based online monitoring are among the focal points of recent research to enhance nuclear plant safety.One of the most effective ways to monitor plant conditions is by implementing a...Scheduled maintenance and condition-based online monitoring are among the focal points of recent research to enhance nuclear plant safety.One of the most effective ways to monitor plant conditions is by implementing a full-scope,plant-wide fault diagnostic system.However,most of the proposed diagnostic techniques are perceived as unreliable by operators because they lack an explanation module,their implementation is complex,and their decision/inference path is unclear.Graphical formalism has been considered for fault diagnosis because of its clear decision and inference modules,and its ability to display the complex causal relationships between plant variables and reveal the propagation path used for fault localization in complex systems.However,in a graphbased approach,decision-making is slow because of rule explosion.In this paper,we present an enhanced signed directed graph that utilizes qualitative trend evaluation and a granular computing algorithm to improve the decision speed and increase the resolution of the graphical method.We integrate the attribute reduction capability of granular computing with the causal/fault propagation reasoning capability of the signed directed graph and comprehensive rules in a decision table to diagnose faults in a nuclear power plant.Qualitative trend analysis is used to solve the problems of fault diagnostic threshold selection and signed directed graph node state determination.The similarity reasoning and detection ability of the granular computing algorithm ensure a compact decision table and improve the decision result.The performance of the proposed enhanced system was evaluated on selected faults of the Chinese Fuqing 2 nuclear reactor.The proposed method offers improved diagnostic speed and efficient data processing.In addition,the result shows a considerable reduction in false positives,indicating that the method provides a reliable diagnostic system to support further intervention by operators.展开更多
The ITER Gas Injection System（GIS） plays an important role on fueling, wall conditioning and distribution for plasma operation. Besides that, to support the safety function of ITER, GIS needs to implement three nucl...The ITER Gas Injection System（GIS） plays an important role on fueling, wall conditioning and distribution for plasma operation. Besides that, to support the safety function of ITER, GIS needs to implement three nuclear safety Instrumentation and Control（I＆C） functions.In this paper, these three functions are introduced with the emphasis on their latest safety classifications. The nuclear I＆C design concept is briefly discussed at the end.展开更多
Herein,we employ the threshold energy neutron analysis(TENA)technique to introduce the world's first active interrogation system to detect special nuclear materials(SNMs),including U-235 and Pu-239.The system util...Herein,we employ the threshold energy neutron analysis(TENA)technique to introduce the world's first active interrogation system to detect special nuclear materials(SNMs),including U-235 and Pu-239.The system utilizes a DD neutron generator based on inertial electrostatic confinement(IEC)to interrogate suspicious objects.To detect secondary neutrons produced during fission reactions induced in SNMs,a tensioned metastable fluid detector(TMFD)is employed.The current status of the system's development is reported in this paper,accompanied by the results from experiments conducted to detect 10 g of highly enriched uranium(HEU).Notably,the experimental findings demonstrate a distinct difference in the count rates of measurements with and without HEU.This difference in count rates surpasses two times the standard deviation,indicating a confidence level of more than 96% for identifying the presence of HEU.The paper presents and extensively discusses the proof-of-principle experimental results,along with the system's planned trajectory.展开更多
BACKGROUND The Nuclear factor erythroid 2-related factor 2(NRF2)transcription factor has attracted much attention in the context of neurological diseases.However,none of the studies have systematically clarified this ...BACKGROUND The Nuclear factor erythroid 2-related factor 2(NRF2)transcription factor has attracted much attention in the context of neurological diseases.However,none of the studies have systematically clarified this field's research hotspots and evolution rules.AIM To investigate the research hotspots,evolution patterns,and future research trends in this field in recent years.METHODS We conducted a comprehensive literature search in the Web of Science Core Collection database using the following methods:(((((TS=(NFE2 L2))OR TS=(Nfe2 L2 protein,mouse))OR TS=(NF-E2-Related Factor 2))OR TS=(NRF2))OR TS=(NFE2L2))OR TS=(Nuclear factor erythroid2-related factor 2)AND(((((((TS=(neurological diseases))OR TS=(neurological disorder))OR TS=(brain disorder))OR TS=(brain injury))OR TS=(central nervous system disease))OR TS=(CNS disease))OR TS=(central nervous system disorder))OR TS=(CNS disorder)AND Language=English from 2010 to 2022.There are just two forms of literature available:Articles and reviews.Data were processed with the software Cite-Space(version 6.1.R6).RESULTS We analyzed 1884 articles from 200 schools in 72 countries/regions.Since 2015,the number of publications in this field has increased rapidly.China has the largest number of publications,but the articles published in the United States have better centrality and H-index.Among the top ten authors with the most published papers,five of them are from China,and the author with the most published papers is Wang Handong.The institution with the most articles was Nanjing University.To their credit,three of the top 10 most cited articles were written by Chinese scholars.The keyword co-occurrence map showed that"oxidative stress","NRF2","activation","expression"and"brain"were the five most frequently used keywords.CONCLUSION Research on the role of NRF2 in neurological diseases continues unabated.Researchers in developed countries published more influential papers,while Chinese scholars provided the largest number of articles.There have been numerous studies on the mechanism of NRF2 transcription factor in neurological diseases.NRF2 is also emerging as a potentially effective target for the treatment of neurological diseases.However,despite decades of research,our knowledge of NRF2 transcription factor in nervous system diseases is still limited.Further studies are needed in the future.展开更多
The intricate balance between reactor economics and safety necessitates the emergence of new and advanced nuclear systems and,very importantly,advanced materials,which can overcome current shortcomings and bring about...The intricate balance between reactor economics and safety necessitates the emergence of new and advanced nuclear systems and,very importantly,advanced materials,which can overcome current shortcomings and bring about more economic nuclear systems with designed-in inherent safety features.These advances will achieve greater safety and better nuclear reactor economics by reaching longer reactor lives with higher levels neutron irradiation,and by providing higher operation temperatures and resistance to more aggressive corrosive environments.This paper provides a review of the current state of research and development on innovative nuclear fuel materials design and development which have the potential of benefiting simultaneously reactor economics and safety.Our discussion focuses on three areas of research:Accident-tolerant Fuels(ATFs),Oxidation Dispersion Strengthened(ODS)steels and High Entropy Alloys(HEAs).The paper also gives a prospective description of future research activities on these materials.展开更多
基金supported by the National Natural Science Foundation of China(Nos.11275048,11775049)the China Jiangsu Provincial Natural Science Foundation(No.BK20131286)
文摘As the high-density nuclear equation of state(EOS) is not very well constrained, we suggest that the structural properties from the finite systems can be used to extract a more accurate constraint. By including the strangeness degrees of freedom, the hyperon or anti-kaon, the finite systems can then have a rather high-density core which is relevant to the nuclear EOS at high densities directly. It is found that the density dependence of the symmetry energy is sensitive to the properties of multi-K hypernuclei, while the high-density EOS of symmetric matter correlates sensitively to the properties of kaonic nuclei.
基金supported by the Natural Science Foundation of China(Nos.11405204 11305205 and 10675123)Special Program for Informatization of Chinese Academy of Sciences(No.XXH12504-1-09)the National Special Program for ITER(No.2014GB1120001)
文摘Accurate and reliable nuclear data libraries are essential for calculation and design of advanced nuclea systems. A 1200 fine group nuclear data library Hybrid Evaluated Nuclear Data Library/Fine Group(HENDL/FG with neutrons of up to 150 Me V has been developed to improve the accuracy of neutronics calculations and anal ysis. Corrections of Doppler, resonance self-shielding, and thermal upscatter effects were done for HENDL/FG Shielding and critical safety benchmarks were performed to test the accuracy and reliability of the library. The dis crepancy between calculated and measured nuclea parameters fell into a reasonable range.
基金supported by National Health and Medical Research Council GNT1105374,GNT1137645,GNT2000766 and veski Innovation Fellowship(VIF23)to RP.
文摘Nuclear factor Y is a ubiquitous heterotrimeric transcription factor complex conserved across eukaryotes that binds to CCAAT boxes,one of the most common motifs found in gene promoters and enhancers.Over the last 30 years,research has revealed that the nuclear factor Y complex controls many aspects of brain development,including differentiation,axon guidance,homeostasis,disease,and most recently regeneration.However,a complete understanding of transcriptional regulatory networks,including how the nuclear factor Y complex binds to specific CCAAT boxes to perform its function remains elusive.In this review,we explore the nuclear factor Y complex’s role and mode of action during brain development,as well as how genomic technologies may expand understanding of this key regulator of gene expression.
基金The Advanced Civil Design and Construction Technology Joint LAB of Nuclear Engineering(Project No.:KY23015).
文摘In nuclear power engineering,the quality requirements for concrete are extremely stringent.Concrete structures must exhibit high durability to withstand the effects of nuclear radiation,chemical corrosion,and environmental changes.In particular,nuclear power projects impose higher design standards and safety requirements regarding concrete density.Traditional manual vibration and visual inspection methods are difficult to ensure the required level of concrete compaction.This paper presents an intelligent vibration technology for concrete in nuclear power engineering to enhance construction quality and efficiency.By integrating intelligent sensors,control systems,and data processing algorithms,the technology enables real-time monitoring and evaluation of the vibration process.Results show that intelligent vibration technology effectively ensures the density and uniformity of concrete in nuclear power engineering,thereby improving structural safety and reliability.
基金supported by the National Natural Science Foundation of China(12305185)Natural Science Foundation of Hunan Province,China(No.2023JJ50122)+1 种基金International Cooperative Research Project of the Ministry of Education,China(No.HZKY20220355)Scientific Research Foundation of the Education Department of Hunan Province,China(No.22A0307).
文摘Compared to other energy sources,nuclear reactors offer several advantages as a spacecraft power source,including compact size,high power density,and long operating life.These qualities make nuclear power an ideal energy source for future deep space exploration.A whole system model of the space nuclear reactor consisting of the reactor neutron kinetics,reactivity control,reactor heat transfer,heat exchanger,and thermoelectric converter was developed.In addition,an electrical power control system was designed based on the developed dynamic model.The GRS method was used to quantitatively calculate the uncertainty of coupling parameters of the neutronics,thermal-hydraulics,and control system for the space reactor.The Spearman correlation coefficient was applied in the sensitivity analysis of system input parameters to output parameters.The calculation results showed that the uncertainty of the output parameters caused by coupling parameters had the most considerable variation,with a relative standard deviation<2.01%.Effective delayed neutron fraction was most sensitive to electrical power.To obtain optimal control performance,the non-dominated sorting genetic algorithm method was employed to optimize the controller parameters based on the uncertainty quantification calculation.Two typical transient simulations were conducted to test the adaptive ability of the optimized controller in the uncertainty dynamic system,including 100%full power(FP)to 90%FP step load reduction transient and 5%FP/min linear variable load transient.The results showed that,considering the influence of system uncertainty,the optimized controller could improve the response speed and load following accuracy of electrical power control,in which the effectiveness and superiority have been verified.
基金supported by the National Natural Science Foundation of China(Nos.12035011,11975167,12175151,12005139,11947123)the Guangdong Major Project of Basic and Applied Basic Research(No.2021B0301030006)the Steady Support Program for Higher Education Institutions of Shenzhen(Nos.20200810163629001,20200817005440001).
文摘The α-nucleus interaction is crucial in the description of α decay. Recently, we developed a pocket-type dynamical doublefolding potential(DDFP) that effectively incorporates both the surface-medium effect and interior Pauli repulsion in α decay [H. Zheng et al., Phys. Rev. C 109, L011301(2024)]. This potential results in a pocket geometry within the nuclear surface region, which is consistent with the α-clustering characteristics predicted by microscopic calculations. In this study, the accuracy of the pocket-type DDFP was validated via systematic calculations of α-decay half-lives and an extended evaluation of the nuclear charge radii of the daughter nuclei. The results demonstrate good agreement with the experimental data for both quantities, thereby confirming the reliability of the DDFP model. Compared with calculations that use α-nucleus interactions derived from conventional double-folding procedures, DDFP employs fewer adjustable parameters to achieve a more accurate description of the charge radii based on the experimental α-decay energies.
文摘Introduction-Nuclei near and beyond the proton drip line represent a fascinating frontier in the nuclear landscape. Proton-rich nuclei exhibit intriguing phenomena, such as the Thomas-Ehrman shift and proton-halo structure. Beyond the proton dripline, nuclei become unbound, allowing protons to be emitted and giving rise to novel radioactive decay modes. Single-proton radioactivity, a process in which some nuclei with an odd number of protons(Z) decay by ejecting a proton, was discovered several decades ago and has been extensively studied [1, 2].
基金supported by grants from the Zhejiang Provincial TCM Science and Technology Plan Project,No.2023ZL156(to YH)Ningbo Top Medical and Health Research Program,No.2022020304(to XG)+1 种基金the Natural Science Foundation of Ningbo,No.2023J019(to YH)Key Laboratory of Precision Medicine for Atherosclerotic Diseases of Zhejiang Province,No.2022E10026(to YH)。
文摘Strokes include both ischemic stroke,which is mediated by a blockade or reduction in the blood supply to the brain,and hemorrhagic stroke,which comprises intracerebral hemorrhage and subarachnoid hemorrhage and is characterized by bleeding within the brain.Stroke is a lifethreatening cerebrovascular condition characterized by intricate pathophysiological mechanisms,including oxidative stress,inflammation,mitochondrial dysfunction,and neuronal injury.Critical transcription factors,such as nuclear factor erythroid 2-related factor 2 and nuclear factor kappa B,play central roles in the progression of stroke.Nuclear factor erythroid 2-related factor 2 is sensitive to changes in the cellular redox status and is crucial in protecting cells against oxidative damage,inflammatory responses,and cytotoxic agents.It plays a significant role in post-stroke neuroprotection and repair by influencing mitochondrial function,endoplasmic reticulum stress,and lysosomal activity and regulating metabolic pathways and cytokine expression.Conversely,nuclear factor-kappa B is closely associated with mitochondrial dysfunction,the generation of reactive oxygen species,oxidative stress exacerbation,and inflammation.Nuclear factor-kappa B contributes to neuronal injury,apoptosis,and immune responses following stroke by modulating cell adhesion molecules and inflammatory mediators.The interplay between these pathways,potentially involving crosstalk among various organelles,significantly influences stroke pathophysiology.Advancements in single-cell sequencing and spatial transcriptomics have greatly improved our understanding of stroke pathogenesis and offer new opportunities for the development of targeted,individualized,cell typespecific treatments.In this review,we discuss the mechanisms underlying the involvement of nuclear factor erythroid 2-related factor 2 and nuclear factor-kappa B in both ischemic and hemorrhagic stroke,with an emphasis on their roles in oxidative stress,inflammation,and neuroprotection.
基金Supported by National Natural Science Foundation of China (10975100,11011130216,10979024,10705014)the financial support from DFG of Germany and Major State Basic Research Development Progrom of China (2007CB81500)
文摘The nuclear and Coulomb potentials between deformed nuclei with octupole deformations and arbitrary orientations are evaluated numerically. The effects of the octupole deformation on the potential between nuclei and the potential energy surface （PES） used in the description of the production of super-heavy nuclei （SHN） by heavy-ion fusion reactions are investigated in the di-nuclear system model. It is found that the nuclear octupole deformation significantly changes the shape of the PES, which may influence the fusion probability of the SHN. Also, PESs in the tip-belly and belly-belly cases are investigated. Finally, the quasi-fission barriers in the tip-tip and belly-belly cases are evaluated. It is found that the quasi-fission barriers of the belly-belly case are generally larger than those of the tip-tip case.
文摘AIM To explore the relationship between the configuration changes of the nuclear matrix-intermediate filament system in cancer cell induced by retinoic acid and the malignantphenotypic reversion of cancer cells.METHODS The human gastric adenocarcinomacell line MGc80-3 cells were induced with 10-6mol/ L retinoic acid and subouItured at cover slipstrip and gold grids. The cells were treated byselective extraction methOd and prepared for whole mount electron microscopy observation.The samples were examined respectively withscanning and transmission electron microscope.RESULTS The nuclear matrix filaments andintermediate filaments in MGC80-3 cells wererelatively few and scattered, not welldistributed and arranged irregularly. The nuclear lamina was ununiformly thick and compact,connected to the nuclear matrix filaments and intermediate filaments relaxedly. However, thetwo kinds of filaments were abundant and welldistributed, different in slender and thick form and interweaved into a regular network in the cells induced by 10-6 mol/ L RA. The nuclear matrix filaments and intermediate filaments were connected closely by the thin and compact fiber-Iike lamina, and interlaced into a regularnetwork throughout the whole cell region.CONCLUSION The NM-IF system in MGc80-3cells had undergone a restorational changesimilar to those of normaI cells after RAinducement. This alternation is an importantmorpholOgical and functional expression to themalignant phenotypic reversion of cancer cells.
基金supported by the Leibniz Association,Germany,and the VELUX Foundation,Switzerland
文摘Activation of nuclear factor kappa B （NF-κB） is a hallmark of various central nervous system （CNS） pathologies. Neuron-specific inhibition of its transcriptional activator subunit RelA, also referred to as p65, promotes neuronal survival under a range of conditions, i.e., for ischemic or excitotoxic insults. In macro- and microglial cells, post-lesional activation of NF-κB triggers a growth-permissive program which contributes to neural tissue inflammation, scar formation, and the expression of axonal growth inhibitors. Intriguingly, inhibition of such inducible NF-~B in the neuro-glial compartment, i.e., by genetic ablation of RelA or overexpression of a trans- dominant negative mutant of its upstream regulator IκBa, significantly enhances functional recovery and promotes axonal regeneration in the mature CNS. By contrast, depletion of the NF-κB subunit p50, which lacks transcriptional activator function and acts as a transcriptional repressor on its own, causes precocious neuronal loss and exacerbates axonal degeneration in the lesioned brain. Collectively, the data imply that NF-κB orchestrates a multicellular pro- gram in which κB-dependent gene expression establishes a growth-repulsive terrain within the post-lesioned brain that limits structural regeneration of neuronal circuits. Considering these subunit-specific functions, interference with the NF-κB pathway might hold clinical potentials to improve functional restoration following traumatic CNS injury.
文摘The paper presents a computer code system 'SRDAAR- QNPP' for the real-time dose as-sessment of an accident release for Qinshan Nuclear Power Plant. It includes three parts:thereal-time data acquisition system, assessment computer. and the assessment operating code system. InSRDAAR-QNPP, the wind field of the surface and the lower levels are determined hourly by using amass consistent three-dimension diasnosis model with the topographic following coordinate system.A Lagrangin Puff model under changing meteorological condition is adopted for atmosphericdispersion, the correction for dry and wet depositions. physical decay and partial plume penetrationof the top inversion and the deviation of plume axis caused by complex terrain have been taken in-to account. The calculation domain areas include three square grid areas with the sideline 10 km, 40krn and 160 km and a grid interval 0.5 km, 2.0 km, 8.0 km respectively. Three exposure pathwaysare taken into account:the external exposure from immersion cloud and passing puff, the internalexposure from inhalation and the external exposure from contaminated ground. This system is ableto provide the results of concentration and dose distributions within 10 minutes after the data havebeen inputed.
基金Supported by the National Natural Science Foundation of China, No. 30470877
文摘AIM： To investigate the association between the configurational and compositional changes of nuclear matrix and the differentiation of carcinoma cells. METHODS： Cells cultured with or without 5 × 10^-3 mmol/L of hexamethylene bisacetamide （HMBA） on Nickel grids were treated by selective extraction and prepared for whole mount observation under electron microscopy. The samples were examined under transmission electron microscope. Nuclear matrix proteins were selectively extracted and subjected to subcellular proteomics study. The protein expression patterns were analyzed by PDQuest software. Spots of differentially expressed nuclear matrix proteins were excised and subjected to in situ digestion with trypsin. The peptides were analyzed by matrix-assisted laser- desorption/ionization time of flight mass spectrometry （MALDI-TOF-MS）. Data were submitted for database searching using Mascot tool （www.matrixscience.com）. RESULTS： The nuclear matrix （NM） and intermediate filament （IF） in SMMC-7721 hepatocarcinoma cells were found relatively sparse and arranged irregularly. The nuclear lamina was non-uniform, and two kinds of filaments were not tightly connected. After induction for differentiation by HMBA, the NM-IF filaments were concentrated and distributed uniformly. The heterogeneous population of filaments, including highly branched utrathin filaments could also be seen in the regular meshwork. The connection between the two kinds of filaments and the relatively thin, condensed and sharply demarcated lamina composed of intermediate- sized filaments was relatively fastened. Meanwhile, 21 NM proteins changed remarkably during SMMC-7721 cell differentiation. Four proteins, i.e. mutant Pystl, hypothetical protein, nucleophosminl, and LBP were downregulated, whereas four other proteins, eIF6, p44 subunit, 13-tubulin, and SIN3B were upregulated with the last one, SR2/ASF found only in the differentiated SMMC-7721 cells. CONCLUSION： The induced differentiation of SMMC-7721 cells by HMBA is accompanied by the configurational changes of nuclear matrix-intermediate filament （NM-IF） system and the compositional changes of nuclear matrix protein expression. These changes may be important morphological or functional indications of the cancer cell reversion.
文摘This paper proposes a sub-critical nuclear energy system driven by fusion neutron source, FDS, which can be used to transmute long-lived radioactive wastes and to produce fissile nuclear fuel as a way for early application of fusion technology. The necessity and feasibility to develop that system in China are illustrated on the basis of prediction of the demand of energy source in the first half of the 21th century, the status of current fission energy supply and the progress in fusion technology in the world. The characteristics of fusion neutron driver and the potential for transmutation of long-lived nuclear wastes and breeding of fissile nuclear fuel in a blanket are analyzed. A scenario of development steps is proposed.
文摘We discuss cluster phenomena in light nuclei. As examples of typical cluster structures, we first review cluster structures of 12C, 16O, and 20Ne, and then introduce some topics of cluster phenomena in light neutron-rich nuclei such as Be and C isotopes. A particular attention is paid on coexistence of cluster and shell-model aspects.
基金supported by the project of State Key Laboratory of Nuclear Power Safety Monitoring Technology and Equipment(No.KA2019.418)the Foundation of Science and Technology on Reactor System Design Technology Laboratory(HT-KFKT-14-2017003)+1 种基金the technical support project for Suzhou Nuclear Power Research Institute(SNPI)(No.029-GN-B-2018-C45-P.0.99-00003)the project of the Research Institute of Nuclear Power Operation(No.RIN180149-SCCG)
文摘Scheduled maintenance and condition-based online monitoring are among the focal points of recent research to enhance nuclear plant safety.One of the most effective ways to monitor plant conditions is by implementing a full-scope,plant-wide fault diagnostic system.However,most of the proposed diagnostic techniques are perceived as unreliable by operators because they lack an explanation module,their implementation is complex,and their decision/inference path is unclear.Graphical formalism has been considered for fault diagnosis because of its clear decision and inference modules,and its ability to display the complex causal relationships between plant variables and reveal the propagation path used for fault localization in complex systems.However,in a graphbased approach,decision-making is slow because of rule explosion.In this paper,we present an enhanced signed directed graph that utilizes qualitative trend evaluation and a granular computing algorithm to improve the decision speed and increase the resolution of the graphical method.We integrate the attribute reduction capability of granular computing with the causal/fault propagation reasoning capability of the signed directed graph and comprehensive rules in a decision table to diagnose faults in a nuclear power plant.Qualitative trend analysis is used to solve the problems of fault diagnostic threshold selection and signed directed graph node state determination.The similarity reasoning and detection ability of the granular computing algorithm ensure a compact decision table and improve the decision result.The performance of the proposed enhanced system was evaluated on selected faults of the Chinese Fuqing 2 nuclear reactor.The proposed method offers improved diagnostic speed and efficient data processing.In addition,the result shows a considerable reduction in false positives,indicating that the method provides a reliable diagnostic system to support further intervention by operators.
文摘The ITER Gas Injection System（GIS） plays an important role on fueling, wall conditioning and distribution for plasma operation. Besides that, to support the safety function of ITER, GIS needs to implement three nuclear safety Instrumentation and Control（I＆C） functions.In this paper, these three functions are introduced with the emphasis on their latest safety classifications. The nuclear I＆C design concept is briefly discussed at the end.
基金supported by Special Coordination Funds for Promoting Science and Technology,sponsored by Japan’s Ministry of Education,Culture,Sports,Science and Technology(MEXT).
文摘Herein,we employ the threshold energy neutron analysis(TENA)technique to introduce the world's first active interrogation system to detect special nuclear materials(SNMs),including U-235 and Pu-239.The system utilizes a DD neutron generator based on inertial electrostatic confinement(IEC)to interrogate suspicious objects.To detect secondary neutrons produced during fission reactions induced in SNMs,a tensioned metastable fluid detector(TMFD)is employed.The current status of the system's development is reported in this paper,accompanied by the results from experiments conducted to detect 10 g of highly enriched uranium(HEU).Notably,the experimental findings demonstrate a distinct difference in the count rates of measurements with and without HEU.This difference in count rates surpasses two times the standard deviation,indicating a confidence level of more than 96% for identifying the presence of HEU.The paper presents and extensively discusses the proof-of-principle experimental results,along with the system's planned trajectory.
文摘BACKGROUND The Nuclear factor erythroid 2-related factor 2(NRF2)transcription factor has attracted much attention in the context of neurological diseases.However,none of the studies have systematically clarified this field's research hotspots and evolution rules.AIM To investigate the research hotspots,evolution patterns,and future research trends in this field in recent years.METHODS We conducted a comprehensive literature search in the Web of Science Core Collection database using the following methods:(((((TS=(NFE2 L2))OR TS=(Nfe2 L2 protein,mouse))OR TS=(NF-E2-Related Factor 2))OR TS=(NRF2))OR TS=(NFE2L2))OR TS=(Nuclear factor erythroid2-related factor 2)AND(((((((TS=(neurological diseases))OR TS=(neurological disorder))OR TS=(brain disorder))OR TS=(brain injury))OR TS=(central nervous system disease))OR TS=(CNS disease))OR TS=(central nervous system disorder))OR TS=(CNS disorder)AND Language=English from 2010 to 2022.There are just two forms of literature available:Articles and reviews.Data were processed with the software Cite-Space(version 6.1.R6).RESULTS We analyzed 1884 articles from 200 schools in 72 countries/regions.Since 2015,the number of publications in this field has increased rapidly.China has the largest number of publications,but the articles published in the United States have better centrality and H-index.Among the top ten authors with the most published papers,five of them are from China,and the author with the most published papers is Wang Handong.The institution with the most articles was Nanjing University.To their credit,three of the top 10 most cited articles were written by Chinese scholars.The keyword co-occurrence map showed that"oxidative stress","NRF2","activation","expression"and"brain"were the five most frequently used keywords.CONCLUSION Research on the role of NRF2 in neurological diseases continues unabated.Researchers in developed countries published more influential papers,while Chinese scholars provided the largest number of articles.There have been numerous studies on the mechanism of NRF2 transcription factor in neurological diseases.NRF2 is also emerging as a potentially effective target for the treatment of neurological diseases.However,despite decades of research,our knowledge of NRF2 transcription factor in nervous system diseases is still limited.Further studies are needed in the future.
文摘The intricate balance between reactor economics and safety necessitates the emergence of new and advanced nuclear systems and,very importantly,advanced materials,which can overcome current shortcomings and bring about more economic nuclear systems with designed-in inherent safety features.These advances will achieve greater safety and better nuclear reactor economics by reaching longer reactor lives with higher levels neutron irradiation,and by providing higher operation temperatures and resistance to more aggressive corrosive environments.This paper provides a review of the current state of research and development on innovative nuclear fuel materials design and development which have the potential of benefiting simultaneously reactor economics and safety.Our discussion focuses on three areas of research:Accident-tolerant Fuels(ATFs),Oxidation Dispersion Strengthened(ODS)steels and High Entropy Alloys(HEAs).The paper also gives a prospective description of future research activities on these materials.
