Introduction-Nuclei near and beyond the proton drip line represent a fascinating frontier in the nuclear landscape. Proton-rich nuclei exhibit intriguing phenomena, such as the Thomas-Ehrman shift and proton-halo stru...Introduction-Nuclei near and beyond the proton drip line represent a fascinating frontier in the nuclear landscape. Proton-rich nuclei exhibit intriguing phenomena, such as the Thomas-Ehrman shift and proton-halo structure. Beyond the proton dripline, nuclei become unbound, allowing protons to be emitted and giving rise to novel radioactive decay modes. Single-proton radioactivity, a process in which some nuclei with an odd number of protons(Z) decay by ejecting a proton, was discovered several decades ago and has been extensively studied [1, 2].展开更多
The Skyrme energy density functional was used to systematically analyze the ratio of repulsive kinetic to attractive potential energy( T/U) for even-even nuclei in their ground states. Notably, the nuclei with maximal...The Skyrme energy density functional was used to systematically analyze the ratio of repulsive kinetic to attractive potential energy( T/U) for even-even nuclei in their ground states. Notably, the nuclei with maximal value of T/U are generally stable for a certain isobaric chain with Z ≤ 82. However, the known magic numbers can be more clearly observed from the T/U ratio than from nuclear binding energy, particularly for the isobaric chains with semi-magic nuclei. Combining the predicted binding energies and the T/U ratios from the Skyrme Hartree-FockBogoliubov(HFB) code transformed harmoic oscilattor(HFBTHO) with the parameter set based on the Universal Nuclear Energy Density Funcitonal(UNEDF0), the possible magic numbers in super-heavy mass region were simultaneously studied. The neutron magic number N = 184 can be clearly observed from the calculated values of T/U and the extracted microscopic energies of the nuclei.展开更多
The chemical stability of simulated waste forms Zr_（1–x）Nd_xSiO_（4–x/2） was investigated using the static leach test（MCC-1） with lixiviants of three pH values（pH=4, 6.7 and 10） at three temperature points（4...The chemical stability of simulated waste forms Zr_（1–x）Nd_xSiO_（4–x/2） was investigated using the static leach test（MCC-1） with lixiviants of three pH values（pH=4, 6.7 and 10） at three temperature points（40, 90 and 150 oC） for periods ranging from 1 to 42 d, and the influence of temperature, pH, as well as their combined effects were explored in detail. The results showed that all the normalized release rate of Nd firstly decreased with leaching time and closed to equilibrium after 14 d. As the temperature increased, the normalized release rate of Nd also increased, but it was no more than 3×10^（–5） g/（m^2·d）. And, the normalized release rate of Nd reached the highest values（~5×10^（–5） g/（m^2·d）） when pH=4, whilst the normalized release rate of Nd remained the lowest value（~1×10^（–5） g/（m^2·d）） near neutral environment（pH=6.7）.展开更多
Chloroplast or mitochondrial dysfunctions are known to induce global changes at the cellular level.This occurs through the implementation of retrograde responses emanating from the organelles and influencing nuclear g...Chloroplast or mitochondrial dysfunctions are known to induce global changes at the cellular level.This occurs through the implementation of retrograde responses emanating from the organelles and influencing nuclear gene expression.Organellar instability broadly impacts cellular function and frequently leads to defects in cell cycle progression(Figure 1A).展开更多
Activities of the chloroplasts and nucleus are coordinated by retrograde signaling,which play crucial roles in plant development and environmental adaptation.However,the connection between chloroplast status and nucle...Activities of the chloroplasts and nucleus are coordinated by retrograde signaling,which play crucial roles in plant development and environmental adaptation.However,the connection between chloroplast status and nuclear genome stability is poorly understood.Chloroplast state transitions enable the plant to balance photosystem absorption capacity in an environment with changing light quality.Here,we report that abnormal chloroplast state transitions lead to instability in the nuclear genome and impaired plant growth.We observed increased DNA damage in the state transition-defective Arabidopsis thaliana mutant stn7,and demonstrated that this damage was triggered by cytokinin accumulation and activation of cytokinin signaling.We showed that cytokinin signaling promotes a competitive association between ARABIDOPSIS RESPONSE REGULATOR 10(ARR10)with PROLIFERATING CELLULAR NUCLEAR ANTIGEN 1/2(PCNA1/2),inhibiting the binding of PCNA1/2 to nuclear DNA.This affects DNA replication,leading to replicationdependent genome instability.Treatment with 2,5-dibromo-3-methyl-6-isopropylbenzoquinone that simulates the reduction of the plastoquinone pool during abnormal state transitions increased the accumulation of ARABIDOPSIS HISTIDINE-CONTAINING PHOSPHOTRANSMITTER 1,a phosphotransfer protein involved in cytokinin signaling,and promoted the interaction between ARR10 with PCNA1/2,leading to increased DNA damage.These findings highlight the function of cytokinin signaling in coordinating chloroplast function and nuclear genome integrity during plant acclimation to environmental changes.展开更多
A simple assumption for dark matter leads to magnetic-monopole-like terms to Maxwell’s Equations, a photon model with wave-particle duality, nuclear stability, a decelerating expansion of the universe, and a dark-mat...A simple assumption for dark matter leads to magnetic-monopole-like terms to Maxwell’s Equations, a photon model with wave-particle duality, nuclear stability, a decelerating expansion of the universe, and a dark-matter relativity that defines the origin of space and time.展开更多
Background:The liver is fundamental for keeping up the entire body’s homeostasis.The liver hepatocytes have been shown to undergo genomic instability with aging.The stability of the hepatocytes depends on its nuclear...Background:The liver is fundamental for keeping up the entire body’s homeostasis.The liver hepatocytes have been shown to undergo genomic instability with aging.The stability of the hepatocytes depends on its nuclear architecture.Calorie restriction has been shown to extend life-span favorably and this may be through the reorganization of the nuclear structure.Objective:To study the effect of cyclic feeding regime on the chromatin assembly anchored to the nuclear membrane scaffold of rat models hepatocytes nuclei.Method:Rats models underwent cyclic feeding regime,after which nuclei were isolated;then,we investigated the chromatin decondensation and nuclear membrane disintegration of the hepatocytes using fluorescence imaging methods.Results:In 60 seconds,protease decondensed the chromatin and disintegrated the nuclear membrane structure of controls.After the first fasting,the time increased to 145 seconds in 3-month-old rats.The first refeeding increased the time to 156 seconds with a further rise to 340 seconds following the second fasting,then dropped to 116 seconds by the second refeeding.20 months old rats showed 186 seconds increase in the time of chromatin decondensation and nuclear membrane disintegration after the first fasting,with a decrease to 140 seconds observed after first refeeding.The second fasting increased the time to 165 seconds,which then slightly decreased to 163 seconds after the second refeeding.Conclusion:These results show that intermittent fasting may have acted on chromatin histone interactions and the structural lamin networks of the nuclear membranes in bringing about nuclear stability,which is essential for normal cellular function.展开更多
文摘Introduction-Nuclei near and beyond the proton drip line represent a fascinating frontier in the nuclear landscape. Proton-rich nuclei exhibit intriguing phenomena, such as the Thomas-Ehrman shift and proton-halo structure. Beyond the proton dripline, nuclei become unbound, allowing protons to be emitted and giving rise to novel radioactive decay modes. Single-proton radioactivity, a process in which some nuclei with an odd number of protons(Z) decay by ejecting a proton, was discovered several decades ago and has been extensively studied [1, 2].
基金Supported by the National Natural Science Foundation of China (12265006, 12375129, U1867212)the Natural Science Foundation of Guangxi,China (2017GXNSFGA198001)。
文摘The Skyrme energy density functional was used to systematically analyze the ratio of repulsive kinetic to attractive potential energy( T/U) for even-even nuclei in their ground states. Notably, the nuclei with maximal value of T/U are generally stable for a certain isobaric chain with Z ≤ 82. However, the known magic numbers can be more clearly observed from the T/U ratio than from nuclear binding energy, particularly for the isobaric chains with semi-magic nuclei. Combining the predicted binding energies and the T/U ratios from the Skyrme Hartree-FockBogoliubov(HFB) code transformed harmoic oscilattor(HFBTHO) with the parameter set based on the Universal Nuclear Energy Density Funcitonal(UNEDF0), the possible magic numbers in super-heavy mass region were simultaneously studied. The neutron magic number N = 184 can be clearly observed from the calculated values of T/U and the extracted microscopic energies of the nuclei.
基金Project supported by the National Natural Science Foundation of China(41302028,41302029,21507105)Thousand Youth Talents Plan(Y42H831301)+3 种基金Key Project of Sichuan Education Department(14ZA0099,15ZB0116)Foundation of Laboratory of National Defense Key Discipline for Nuclear Waste and Environmental Safety,Southwest University of Science and Technology(15yyhk10)the Doctor Foundation in Southwest University of Science and Technology(10zx7126)Hebei Science and Technology Support Program(15211121)
文摘The chemical stability of simulated waste forms Zr_（1–x）Nd_xSiO_（4–x/2） was investigated using the static leach test（MCC-1） with lixiviants of three pH values（pH=4, 6.7 and 10） at three temperature points（40, 90 and 150 oC） for periods ranging from 1 to 42 d, and the influence of temperature, pH, as well as their combined effects were explored in detail. The results showed that all the normalized release rate of Nd firstly decreased with leaching time and closed to equilibrium after 14 d. As the temperature increased, the normalized release rate of Nd also increased, but it was no more than 3×10^（–5） g/（m^2·d）. And, the normalized release rate of Nd reached the highest values（~5×10^（–5） g/（m^2·d）） when pH=4, whilst the normalized release rate of Nd remained the lowest value（~1×10^（–5） g/（m^2·d）） near neutral environment（pH=6.7）.
基金supported by grants from the Agence Nationale de la Recherche(21-CE20-0027)the University of Strasbourg.
文摘Chloroplast or mitochondrial dysfunctions are known to induce global changes at the cellular level.This occurs through the implementation of retrograde responses emanating from the organelles and influencing nuclear gene expression.Organellar instability broadly impacts cellular function and frequently leads to defects in cell cycle progression(Figure 1A).
基金supported by the National Natural Science Foundation of China(grant no.32322007,32100192,and U22A20446).
文摘Activities of the chloroplasts and nucleus are coordinated by retrograde signaling,which play crucial roles in plant development and environmental adaptation.However,the connection between chloroplast status and nuclear genome stability is poorly understood.Chloroplast state transitions enable the plant to balance photosystem absorption capacity in an environment with changing light quality.Here,we report that abnormal chloroplast state transitions lead to instability in the nuclear genome and impaired plant growth.We observed increased DNA damage in the state transition-defective Arabidopsis thaliana mutant stn7,and demonstrated that this damage was triggered by cytokinin accumulation and activation of cytokinin signaling.We showed that cytokinin signaling promotes a competitive association between ARABIDOPSIS RESPONSE REGULATOR 10(ARR10)with PROLIFERATING CELLULAR NUCLEAR ANTIGEN 1/2(PCNA1/2),inhibiting the binding of PCNA1/2 to nuclear DNA.This affects DNA replication,leading to replicationdependent genome instability.Treatment with 2,5-dibromo-3-methyl-6-isopropylbenzoquinone that simulates the reduction of the plastoquinone pool during abnormal state transitions increased the accumulation of ARABIDOPSIS HISTIDINE-CONTAINING PHOSPHOTRANSMITTER 1,a phosphotransfer protein involved in cytokinin signaling,and promoted the interaction between ARR10 with PCNA1/2,leading to increased DNA damage.These findings highlight the function of cytokinin signaling in coordinating chloroplast function and nuclear genome integrity during plant acclimation to environmental changes.
文摘A simple assumption for dark matter leads to magnetic-monopole-like terms to Maxwell’s Equations, a photon model with wave-particle duality, nuclear stability, a decelerating expansion of the universe, and a dark-matter relativity that defines the origin of space and time.
基金funding agency in the public,commercial,or not-for-profit sectors.
文摘Background:The liver is fundamental for keeping up the entire body’s homeostasis.The liver hepatocytes have been shown to undergo genomic instability with aging.The stability of the hepatocytes depends on its nuclear architecture.Calorie restriction has been shown to extend life-span favorably and this may be through the reorganization of the nuclear structure.Objective:To study the effect of cyclic feeding regime on the chromatin assembly anchored to the nuclear membrane scaffold of rat models hepatocytes nuclei.Method:Rats models underwent cyclic feeding regime,after which nuclei were isolated;then,we investigated the chromatin decondensation and nuclear membrane disintegration of the hepatocytes using fluorescence imaging methods.Results:In 60 seconds,protease decondensed the chromatin and disintegrated the nuclear membrane structure of controls.After the first fasting,the time increased to 145 seconds in 3-month-old rats.The first refeeding increased the time to 156 seconds with a further rise to 340 seconds following the second fasting,then dropped to 116 seconds by the second refeeding.20 months old rats showed 186 seconds increase in the time of chromatin decondensation and nuclear membrane disintegration after the first fasting,with a decrease to 140 seconds observed after first refeeding.The second fasting increased the time to 165 seconds,which then slightly decreased to 163 seconds after the second refeeding.Conclusion:These results show that intermittent fasting may have acted on chromatin histone interactions and the structural lamin networks of the nuclear membranes in bringing about nuclear stability,which is essential for normal cellular function.
