基于某电厂350 MW燃煤机组的历史运行数据,开展了脱硝系统入口NOx浓度预测模型的研究。研究采用Python语言实现,基于机组负荷、给煤量、烟气含氧量、燃尽风门开度等输入变量,构建脱硝系统入口NOx浓度预测模型。本文选用在线更新的最小...基于某电厂350 MW燃煤机组的历史运行数据,开展了脱硝系统入口NOx浓度预测模型的研究。研究采用Python语言实现,基于机组负荷、给煤量、烟气含氧量、燃尽风门开度等输入变量,构建脱硝系统入口NOx浓度预测模型。本文选用在线更新的最小二乘支持向量回归(Least Squares Support Vector Regression, LSSVR)和分块时序混合器(Patch-based Time Series Mixer, PatchTSMixer)两种算法进行建模对比。结果表明,在RMSE、MAE和决定系数R2等评价指标下,LSSVR模型在预测精度上优于PatchTSMixer模型,LSSVR模型具有更快的训练速度、较好的泛化性能和更强的非线性拟合能力。展开更多
Parkinson's disease is primarily caused by the loss of dopaminergic neurons in the substantia nigra compacta.Ferroptosis,a novel form of regulated cell death characterized by iron accumulation and lipid peroxidati...Parkinson's disease is primarily caused by the loss of dopaminergic neurons in the substantia nigra compacta.Ferroptosis,a novel form of regulated cell death characterized by iron accumulation and lipid peroxidation,plays a vital role in the death of dopaminergic neurons.However,the molecular mechanisms underlying ferroptosis in dopaminergic neurons have not yet been completely elucidated.NADPH oxidase 4 is related to oxidative stress,however,whether it regulates dopaminergic neuronal ferroptosis remains unknown.The aim of this study was to determine whether NADPH oxidase 4 is involved in dopaminergic neuronal ferroptosis,and if so,by what mechanism.We found that the transcriptional regulator activating transcription factor 3 increased NADPH oxidase 4 expression in dopaminergic neurons and astrocytes in an 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced Parkinson's disease model.NADPH oxidase 4 inhibition improved the behavioral impairments observed in the Parkinson's disease model animals and reduced the death of dopaminergic neurons.Moreover,NADPH oxidase 4 inhibition reduced lipid peroxidation and iron accumulation in the substantia nigra of the Parkinson's disease model animals.Mechanistically,we found that NADPH oxidase 4 interacted with activated protein kinase Cαto prevent ferroptosis of dopaminergic neurons.Furthermore,by lowering the astrocytic lipocalin-2 expression,NADPH oxidase 4 inhibition reduced 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced neuroinflammation.These findings demonstrate that NADPH oxidase 4 promotes ferroptosis of dopaminergic neurons and neuroinflammation,which contribute to dopaminergic neuron death,suggesting that NADPH oxidase 4 is a possible therapeutic target for Parkinson's disease.展开更多
文摘基于某电厂350 MW燃煤机组的历史运行数据,开展了脱硝系统入口NOx浓度预测模型的研究。研究采用Python语言实现,基于机组负荷、给煤量、烟气含氧量、燃尽风门开度等输入变量,构建脱硝系统入口NOx浓度预测模型。本文选用在线更新的最小二乘支持向量回归(Least Squares Support Vector Regression, LSSVR)和分块时序混合器(Patch-based Time Series Mixer, PatchTSMixer)两种算法进行建模对比。结果表明,在RMSE、MAE和决定系数R2等评价指标下,LSSVR模型在预测精度上优于PatchTSMixer模型,LSSVR模型具有更快的训练速度、较好的泛化性能和更强的非线性拟合能力。
基金supported by the National Natural Science Foundation of China,Nos.82271444(to JP),82271268(to BZ),and 82001346(to YL)the National Key Research and Development Program of China,No.2022YFE0210100(to BZ)。
文摘Parkinson's disease is primarily caused by the loss of dopaminergic neurons in the substantia nigra compacta.Ferroptosis,a novel form of regulated cell death characterized by iron accumulation and lipid peroxidation,plays a vital role in the death of dopaminergic neurons.However,the molecular mechanisms underlying ferroptosis in dopaminergic neurons have not yet been completely elucidated.NADPH oxidase 4 is related to oxidative stress,however,whether it regulates dopaminergic neuronal ferroptosis remains unknown.The aim of this study was to determine whether NADPH oxidase 4 is involved in dopaminergic neuronal ferroptosis,and if so,by what mechanism.We found that the transcriptional regulator activating transcription factor 3 increased NADPH oxidase 4 expression in dopaminergic neurons and astrocytes in an 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced Parkinson's disease model.NADPH oxidase 4 inhibition improved the behavioral impairments observed in the Parkinson's disease model animals and reduced the death of dopaminergic neurons.Moreover,NADPH oxidase 4 inhibition reduced lipid peroxidation and iron accumulation in the substantia nigra of the Parkinson's disease model animals.Mechanistically,we found that NADPH oxidase 4 interacted with activated protein kinase Cαto prevent ferroptosis of dopaminergic neurons.Furthermore,by lowering the astrocytic lipocalin-2 expression,NADPH oxidase 4 inhibition reduced 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced neuroinflammation.These findings demonstrate that NADPH oxidase 4 promotes ferroptosis of dopaminergic neurons and neuroinflammation,which contribute to dopaminergic neuron death,suggesting that NADPH oxidase 4 is a possible therapeutic target for Parkinson's disease.
