Plain concrete is regarded as a two-phase material comprising randomly distributed aggregates and mortar matrix. A series of three-point bending concrete beams with symmetric or asymmetric double notches are modeled u...Plain concrete is regarded as a two-phase material comprising randomly distributed aggregates and mortar matrix. A series of three-point bending concrete beams with symmetric or asymmetric double notches are modeled using the modified random aggregate generation and packing algorithm. The cohesive zone model is used as the fracture criterion and the cohesive el- ements are inserted into both the mortar matrix and the aggregate-mortar interfaces as potential micro-cracking zones. The dead and alive crack phenomena are studied experimentally and nu- merically; and the influences of notch location, aggregate distribution and gradation on fracture are numerically evaluated. Some important conclusions are given.展开更多
Ln this paper, the super-inverse iterative method is proposed to compute the accurate and complete eigen-solutions for anti-plane cracks/notches with multi-materials, arbitrary opening angles and various surface condi...Ln this paper, the super-inverse iterative method is proposed to compute the accurate and complete eigen-solutions for anti-plane cracks/notches with multi-materials, arbitrary opening angles and various surface conditions. Taking the advantage of the knowledge of the variation forms of the eigen-functions, a series of numerical techniques are proposed to simplify the computation and speed up the convergence rare of the inverse iteration. A number of numerical examples are given to demonstrate the excellent accuracy, efficiency and reliability of the proposed approach.展开更多
In this paper, an antenna with reconfigurable band notches, for cognitive radio applications, is proposed. The antenna can be operated as ultra wideband, and is reconfigurable in terms of the ability to select a notch...In this paper, an antenna with reconfigurable band notches, for cognitive radio applications, is proposed. The antenna can be operated as ultra wideband, and is reconfigurable in terms of the ability to select a notched band in the SRR resonant frequency. The reconfigurable band notches are induced using a band-stop filter based on split-ring resonators (SRRs), and are controlled using electronic switches mounted over the SRRs. For this sake, the design of the band-stop filter is proposed. A prototype of filter is fabricated and measured. The incorporation of a band-stop filter, into a wideband antenna, is then looked into. The proposed antenna is designed and simulated using Ansoft HFSS. A prototype of the antenna is fabricated and measured. A good analogy between simulated and measured results is obtained.展开更多
On April 15-30,2007,the 101st session of China Import and Export Fair has successfully concluded with a total export turnover of 36.39 billion USD, hitting a historical high with an increase of 6.8% over the last sess...On April 15-30,2007,the 101st session of China Import and Export Fair has successfully concluded with a total export turnover of 36.39 billion USD, hitting a historical high with an increase of 6.8% over the last session,and over 1,700 exhibitors from 36 countries and regions participated in the International Pavilion.展开更多
The deformation behavior in Zr36 Cu64 metallic glasses with pre-introduced indent-notches has been studied by molecular dynamics simulation at the atomic scale.The indent-notches can trigger the formation of densely-p...The deformation behavior in Zr36 Cu64 metallic glasses with pre-introduced indent-notches has been studied by molecular dynamics simulation at the atomic scale.The indent-notches can trigger the formation of densely-packed clusters composed of solid-like atoms in the indent-notch affected zone.These denselypacked clusters are highly resistant to the nucleation of shear bands.Hence,there is more tendency for the shear bands to nucleate outside the indent-notch affected zone,which enlarges the deformation region and enhances both the strengthening effect and the plastic deformation ability.For indent-notched MGs,when determining the initial yielding level,there is a competition process occurring between the densely-packed clusters leading to the shear band formation outside the indent-notch affected zone and the stress-concentration localizing deformation around the notch roots.When the indent-notch depth is small,the stress-concentration around the notch root plays a dominant role,leading to the shear bands initiating from the notch root,reminiscence of the cut-notches.As the indent-notch depth increases,there are many densely-packed clusters with high resistance to deformation in the indent-notch affected zone,leading to the shear band formation from the interface between the indent-notch affected zone and the matrix.Current research findings provide a feasible means for improving the strength and the plasticity of metallic glasses at room temperature.展开更多
Owing to the special working characteristics and operation requirements,lots of working ships have notches in different sizes and shapes in their hulls.In order to study the resistance performance of the vessel with n...Owing to the special working characteristics and operation requirements,lots of working ships have notches in different sizes and shapes in their hulls.In order to study the resistance performance of the vessel with notches,a series of model resistance tests were performed in respect to the 4 500 m 3 /h cutter suction dredger,and the tests were simulated based on the computational fluid dynamics software FLUENT.Based on analysis to the experimental data and the computational fluid dynamics(CFD) calculation results,the change of the flow field and the resistance performance caused by the notches were studied,and the reliability of the software in simulation of viscous flow around the hull was proved.It provides the basis for the future study and the design optimization of this kind of working ships.展开更多
The effects of the number and the location of notches on the formation of flux-closure states in bi-rings with fields applied in the x direction （i.e., along the short axis direction of hi-rings） and y direction （i...The effects of the number and the location of notches on the formation of flux-closure states in bi-rings with fields applied in the x direction （i.e., along the short axis direction of hi-rings） and y direction （i.e., along the long axis direction of bi-rings） are investigated using micromagnetic simulation. For the bi-rings with one notch and the bi-rings with two notches symmetric about y axis, the order of flux-closure state formation in each ring can be controlled. But the flux-closure state forms simultaneously in each ring for the bi-rings with two notches symmetric about x axis. For the bi-rings with two notches that are symmetric neither about x axis nor about y axis, only one ring can form a flux- closure state in the y-direction field and no fluxclosure state can be found in rings in the x-direction field. Therefore, logic states can be defined by controlling the order of flux-closure state formation, which can be utilized in future logic devices.展开更多
The purpose of this study is to investigate the control function and mechanisms of natural river notches. Physical and numerical experiments are analyzed in this study for two representative types of sediment events：...The purpose of this study is to investigate the control function and mechanisms of natural river notches. Physical and numerical experiments are analyzed in this study for two representative types of sediment events： high intensity and short duration Type A sediment disaster events, and low intensity and long duration Type B moderate non-disaster events. Two dimensionless parameters, sediment trapping rate and reduction rate of peak sediment transport, are defined to evaluate the sediment control function of river notches. Study results indicate that the contraction ratio of the notch has a significant influence on sediment control function, with high contraction ratios resulting in both high sediment-trapping and high reduction rates. River notches provide better sediment control during Type A events than Type B events. The sediment control mechanism of river notches is the result of multiple interactions among river flow, sediment transport, and riverbed variation. Analysis of these interactions supports the significant protection role of river notches on sediment control for disaster events.展开更多
目前针对恶性胶质瘤的治疗手段十分有限,本研究旨在通过揭示天然产物银杏叶提取物(Ginkgo biloba extract,GBE)的抗肿瘤机制,为恶性胶质瘤的治疗提供新的潜在治疗方案。研究发现,125μg/mL GBE处理A172胶质瘤细胞可显著抑制其活力(EC50=...目前针对恶性胶质瘤的治疗手段十分有限,本研究旨在通过揭示天然产物银杏叶提取物(Ginkgo biloba extract,GBE)的抗肿瘤机制,为恶性胶质瘤的治疗提供新的潜在治疗方案。研究发现,125μg/mL GBE处理A172胶质瘤细胞可显著抑制其活力(EC50=128.6μg/mL),TUNEL及瑞氏染色均观察到典型的细胞凋亡形态。机制上,GBE处理导致线粒体膜电位显著下降(JC-1法检测)并引发内质网扩张(ER-Tracker观察)。Western blot分析证实,GBE激活了线粒体自噬与内质网应激,表现为LC3-Ⅱ/Ⅰ比值升高以及葡萄糖调节蛋白78(glucose-regulated protein 78,GRP78)和C/EBP同源蛋白(C/EBP homologous protein,CHOP)表达上调。与此同时,免疫荧光与Western blot结果显示,Notch同源物1(neurogenic locus notch homolog protein 1,Notch1)/转化生长因子-β1(transforming growth factor-beta1,TGF-β1)/Smad家族成员2/3(Smad family member 2/3,Smad2/3)通路被激活,且Notch1胞内结构域(Notch1 intracellular domain,NICD)发生核转位。双荧光素酶报告实验进一步揭示,Smad2/3可直接促进LC3和CHOP的转录。关键的是,使用Notch1抑制剂(DAPT)或TGF-β1抑制剂(SB431542)进行干预,可部分逆转由GBE诱导的细胞器应激并提升细胞存活率。综上所述,GBE通过激活Notch1/TGF-β1/Smad2/3通路,破坏细胞器稳态,进而诱导A172胶质瘤细胞凋亡。本研究的目的在于系统阐明GBE通过“信号通路-细胞器”互作以发挥抗癌作用的全新分子机制,其意义不仅为GBE作为潜在的胶质瘤治疗药物提供了坚实的实验证据,更揭示了Notch1/TGF-β1/Smad2/3通路可作为未来开发抗胶质瘤新药的重要靶点。展开更多
基金Project supported by the National Basic Research Program of China(973 Program:No.2011CB013800)Hubei Provincial Natural Science Foundation of China(No.2015CFB205)
文摘Plain concrete is regarded as a two-phase material comprising randomly distributed aggregates and mortar matrix. A series of three-point bending concrete beams with symmetric or asymmetric double notches are modeled using the modified random aggregate generation and packing algorithm. The cohesive zone model is used as the fracture criterion and the cohesive el- ements are inserted into both the mortar matrix and the aggregate-mortar interfaces as potential micro-cracking zones. The dead and alive crack phenomena are studied experimentally and nu- merically; and the influences of notch location, aggregate distribution and gradation on fracture are numerically evaluated. Some important conclusions are given.
基金The project is supported by the Natural Science Foundation of China.
文摘Ln this paper, the super-inverse iterative method is proposed to compute the accurate and complete eigen-solutions for anti-plane cracks/notches with multi-materials, arbitrary opening angles and various surface conditions. Taking the advantage of the knowledge of the variation forms of the eigen-functions, a series of numerical techniques are proposed to simplify the computation and speed up the convergence rare of the inverse iteration. A number of numerical examples are given to demonstrate the excellent accuracy, efficiency and reliability of the proposed approach.
文摘In this paper, an antenna with reconfigurable band notches, for cognitive radio applications, is proposed. The antenna can be operated as ultra wideband, and is reconfigurable in terms of the ability to select a notched band in the SRR resonant frequency. The reconfigurable band notches are induced using a band-stop filter based on split-ring resonators (SRRs), and are controlled using electronic switches mounted over the SRRs. For this sake, the design of the band-stop filter is proposed. A prototype of filter is fabricated and measured. The incorporation of a band-stop filter, into a wideband antenna, is then looked into. The proposed antenna is designed and simulated using Ansoft HFSS. A prototype of the antenna is fabricated and measured. A good analogy between simulated and measured results is obtained.
文摘On April 15-30,2007,the 101st session of China Import and Export Fair has successfully concluded with a total export turnover of 36.39 billion USD, hitting a historical high with an increase of 6.8% over the last session,and over 1,700 exhibitors from 36 countries and regions participated in the International Pavilion.
基金supported by the National Natural Science Foundation of China under Grant 51801174the Program for the Top Young Talents of Higher Learning Institutions of Hebei under Grant BJ2018021+2 种基金the National Key R&D Program of China under Grant 2018YFA0703602the Hong Kong Scholars Program under Grant XJ2017049support from the National Science Foundation under grant number CMMI 17-026。
文摘The deformation behavior in Zr36 Cu64 metallic glasses with pre-introduced indent-notches has been studied by molecular dynamics simulation at the atomic scale.The indent-notches can trigger the formation of densely-packed clusters composed of solid-like atoms in the indent-notch affected zone.These denselypacked clusters are highly resistant to the nucleation of shear bands.Hence,there is more tendency for the shear bands to nucleate outside the indent-notch affected zone,which enlarges the deformation region and enhances both the strengthening effect and the plastic deformation ability.For indent-notched MGs,when determining the initial yielding level,there is a competition process occurring between the densely-packed clusters leading to the shear band formation outside the indent-notch affected zone and the stress-concentration localizing deformation around the notch roots.When the indent-notch depth is small,the stress-concentration around the notch root plays a dominant role,leading to the shear bands initiating from the notch root,reminiscence of the cut-notches.As the indent-notch depth increases,there are many densely-packed clusters with high resistance to deformation in the indent-notch affected zone,leading to the shear band formation from the interface between the indent-notch affected zone and the matrix.Current research findings provide a feasible means for improving the strength and the plasticity of metallic glasses at room temperature.
文摘Owing to the special working characteristics and operation requirements,lots of working ships have notches in different sizes and shapes in their hulls.In order to study the resistance performance of the vessel with notches,a series of model resistance tests were performed in respect to the 4 500 m 3 /h cutter suction dredger,and the tests were simulated based on the computational fluid dynamics software FLUENT.Based on analysis to the experimental data and the computational fluid dynamics(CFD) calculation results,the change of the flow field and the resistance performance caused by the notches were studied,and the reliability of the software in simulation of viscous flow around the hull was proved.It provides the basis for the future study and the design optimization of this kind of working ships.
基金Project supported by the National Natural Science Foundation of China (Grant No. 50801033)
文摘The effects of the number and the location of notches on the formation of flux-closure states in bi-rings with fields applied in the x direction （i.e., along the short axis direction of hi-rings） and y direction （i.e., along the long axis direction of bi-rings） are investigated using micromagnetic simulation. For the bi-rings with one notch and the bi-rings with two notches symmetric about y axis, the order of flux-closure state formation in each ring can be controlled. But the flux-closure state forms simultaneously in each ring for the bi-rings with two notches symmetric about x axis. For the bi-rings with two notches that are symmetric neither about x axis nor about y axis, only one ring can form a flux- closure state in the y-direction field and no fluxclosure state can be found in rings in the x-direction field. Therefore, logic states can be defined by controlling the order of flux-closure state formation, which can be utilized in future logic devices.
基金financial support were provided by the Disaster Prevention Research Center, National Cheng Kung University
文摘The purpose of this study is to investigate the control function and mechanisms of natural river notches. Physical and numerical experiments are analyzed in this study for two representative types of sediment events： high intensity and short duration Type A sediment disaster events, and low intensity and long duration Type B moderate non-disaster events. Two dimensionless parameters, sediment trapping rate and reduction rate of peak sediment transport, are defined to evaluate the sediment control function of river notches. Study results indicate that the contraction ratio of the notch has a significant influence on sediment control function, with high contraction ratios resulting in both high sediment-trapping and high reduction rates. River notches provide better sediment control during Type A events than Type B events. The sediment control mechanism of river notches is the result of multiple interactions among river flow, sediment transport, and riverbed variation. Analysis of these interactions supports the significant protection role of river notches on sediment control for disaster events.
文摘目前针对恶性胶质瘤的治疗手段十分有限,本研究旨在通过揭示天然产物银杏叶提取物(Ginkgo biloba extract,GBE)的抗肿瘤机制,为恶性胶质瘤的治疗提供新的潜在治疗方案。研究发现,125μg/mL GBE处理A172胶质瘤细胞可显著抑制其活力(EC50=128.6μg/mL),TUNEL及瑞氏染色均观察到典型的细胞凋亡形态。机制上,GBE处理导致线粒体膜电位显著下降(JC-1法检测)并引发内质网扩张(ER-Tracker观察)。Western blot分析证实,GBE激活了线粒体自噬与内质网应激,表现为LC3-Ⅱ/Ⅰ比值升高以及葡萄糖调节蛋白78(glucose-regulated protein 78,GRP78)和C/EBP同源蛋白(C/EBP homologous protein,CHOP)表达上调。与此同时,免疫荧光与Western blot结果显示,Notch同源物1(neurogenic locus notch homolog protein 1,Notch1)/转化生长因子-β1(transforming growth factor-beta1,TGF-β1)/Smad家族成员2/3(Smad family member 2/3,Smad2/3)通路被激活,且Notch1胞内结构域(Notch1 intracellular domain,NICD)发生核转位。双荧光素酶报告实验进一步揭示,Smad2/3可直接促进LC3和CHOP的转录。关键的是,使用Notch1抑制剂(DAPT)或TGF-β1抑制剂(SB431542)进行干预,可部分逆转由GBE诱导的细胞器应激并提升细胞存活率。综上所述,GBE通过激活Notch1/TGF-β1/Smad2/3通路,破坏细胞器稳态,进而诱导A172胶质瘤细胞凋亡。本研究的目的在于系统阐明GBE通过“信号通路-细胞器”互作以发挥抗癌作用的全新分子机制,其意义不仅为GBE作为潜在的胶质瘤治疗药物提供了坚实的实验证据,更揭示了Notch1/TGF-β1/Smad2/3通路可作为未来开发抗胶质瘤新药的重要靶点。
