Non-obese children with elevated serum insulin levels and metabolic disorders such as,hyperglycemia,hypertension,and/or hypertriglyceridemia are a subset of children in high risk of developing cardiovascular disease l...Non-obese children with elevated serum insulin levels and metabolic disorders such as,hyperglycemia,hypertension,and/or hypertriglyceridemia are a subset of children in high risk of developing cardiovascular disease later in life.Since usually the health policies for the prevention of the obesity associated disorders in children are based on the screening focused on the obese,frequently the metabolically obese normalweight(MONW) children are not identified in primary care setting.Given that characterization of the MONW children is an important public health issue,and that a large amount of resources might be unnecessarily used in the screening of metabolic risk of nonobese children; we review data regarding criteria for the early recognition of this subset of children in high risk of developing cardiovascular disease.Results of our review suggests that the presence of family history of type 2 diabetes and/or hypertension,the elevated percentage of body fat,and the high birth-weight should be taken into account as criteria of high cardiovascular risk,irrespective of obesity.展开更多
Background Not only the obese, but also the non-obese adults have the high prevalence of metabolic syndrome in the upper normal weight. The aim of this study was to assess the prevalence rates of metabolic syndrome an...Background Not only the obese, but also the non-obese adults have the high prevalence of metabolic syndrome in the upper normal weight. The aim of this study was to assess the prevalence rates of metabolic syndrome and its individual components in non-obese adult Taiwan Residents （body mass index （BMI） ≤ 26.9 kg/m^2）. Methods A cross-sectional study was conducted from January 2006 to December 2007. One thousand six hundred and fifty-nine subjects （aged 47.5±12.4 years）, 60.8% of which were men, were enrolled. The prevalence and odds ratios of metabolic syndrome, defined by the American Heart Association/National Heart, Lung and Blood Institute （2005）, were analyzed in the BMI category according to 2.0 unit increments, in individuals seeking a health examination. Results The higher the BMI categories, the more prevalent the metabolic syndrome was in women and in men （P 〈0.001）. Compared with those women with a BMI ≤20.9 kg/m^2, the odds ratios for metabolic syndrome in women were 1.3 （95% CI： 0.5-3.2） with BMI 21.0-22.9 kg/m^2, 3.0 （1.3-7.1） with BMI 23.0-24.9 kg/m^2, and 8.6 （3.6-20.8） for women with BMI 25.0-26.9 kg/m^2, after controlling for age, smoking status, alcohol consumption, betel nut chewing, blood routine, biochemical data, hepatitis B virus surface antigen and anti-hepatitis C virus. The corresponding odds ratios in men were 1.6 （0.6-4.2）, 3.7 （1.6-8.8）, and 9.9 （4.2-23.2）. Conclusions Individuals in the upper normal weight and slightly overweight BMI range have relatively high prevalence and increased risk of having metabolic syndrome. Therefore, physicians should screen metabolic syndrome in not only obese but also non-obese individuals for the prevention of cardiovascular disease.展开更多
Objective:This study aimed to examine the associations of waist circumference with hypertension and cardiometabolic dysregulation among normal-weight adults.Methods:This cross-sectional study included 8795 normal-weig...Objective:This study aimed to examine the associations of waist circumference with hypertension and cardiometabolic dysregulation among normal-weight adults.Methods:This cross-sectional study included 8795 normal-weight participants aged 20 to 79 years from the 2009–2018 US National Health and Nutrition Examination Survey.The demographic characteristics and cardiometabolic risk factors across waist circumference quartiles were summarized.We used adjusted multivariate logistic regression models,subgroup analysis,and restricted cubic spline to analyze the association between waist circumference and the prevalence of hypertension.Thereafter,we used the random forest supervised machine learning method,together with least absolute shrinkage and selection operator regression,to select hypertension-related features and created a predictive model based on regression analysis to identify hypertension in normal-weight individuals.Results:Waist circumference was positively correlated with hypertension in the non-adjusted,minimally adjusted,and fully adjusted models,with odds ratios(95%confidence interval)of 2.28(2.14–2.44),1.27(1.12–1.44),and 1.27(1.12–1.44),respectively.In the fully adjusted model,participants in the highest waist circumference quartile had a higher risk of hypertension relative to those in the lowest quartile,with an odds ratio(95%confidence interval)of 3.87(1.59–10.34).Sensitivity analysis demonstrated the robustness of the association.In the testing set,the predictive model exhibited good performance,with an area under the curve of 0.803,sensitivity of 0.72,specificity of 0.76,and negative predictive value of 0.84.Conclusions:Measuring waist circumference may improve the evaluation of the risk of hypertension and help to manage cardiometabolic risk in normal-weight individuals.展开更多
文摘Non-obese children with elevated serum insulin levels and metabolic disorders such as,hyperglycemia,hypertension,and/or hypertriglyceridemia are a subset of children in high risk of developing cardiovascular disease later in life.Since usually the health policies for the prevention of the obesity associated disorders in children are based on the screening focused on the obese,frequently the metabolically obese normalweight(MONW) children are not identified in primary care setting.Given that characterization of the MONW children is an important public health issue,and that a large amount of resources might be unnecessarily used in the screening of metabolic risk of nonobese children; we review data regarding criteria for the early recognition of this subset of children in high risk of developing cardiovascular disease.Results of our review suggests that the presence of family history of type 2 diabetes and/or hypertension,the elevated percentage of body fat,and the high birth-weight should be taken into account as criteria of high cardiovascular risk,irrespective of obesity.
文摘Background Not only the obese, but also the non-obese adults have the high prevalence of metabolic syndrome in the upper normal weight. The aim of this study was to assess the prevalence rates of metabolic syndrome and its individual components in non-obese adult Taiwan Residents （body mass index （BMI） ≤ 26.9 kg/m^2）. Methods A cross-sectional study was conducted from January 2006 to December 2007. One thousand six hundred and fifty-nine subjects （aged 47.5±12.4 years）, 60.8% of which were men, were enrolled. The prevalence and odds ratios of metabolic syndrome, defined by the American Heart Association/National Heart, Lung and Blood Institute （2005）, were analyzed in the BMI category according to 2.0 unit increments, in individuals seeking a health examination. Results The higher the BMI categories, the more prevalent the metabolic syndrome was in women and in men （P 〈0.001）. Compared with those women with a BMI ≤20.9 kg/m^2, the odds ratios for metabolic syndrome in women were 1.3 （95% CI： 0.5-3.2） with BMI 21.0-22.9 kg/m^2, 3.0 （1.3-7.1） with BMI 23.0-24.9 kg/m^2, and 8.6 （3.6-20.8） for women with BMI 25.0-26.9 kg/m^2, after controlling for age, smoking status, alcohol consumption, betel nut chewing, blood routine, biochemical data, hepatitis B virus surface antigen and anti-hepatitis C virus. The corresponding odds ratios in men were 1.6 （0.6-4.2）, 3.7 （1.6-8.8）, and 9.9 （4.2-23.2）. Conclusions Individuals in the upper normal weight and slightly overweight BMI range have relatively high prevalence and increased risk of having metabolic syndrome. Therefore, physicians should screen metabolic syndrome in not only obese but also non-obese individuals for the prevention of cardiovascular disease.
基金supported by the Postgraduate Research&Practice Innovation Program of Jiangsu Province(SJCX21_0626).
文摘Objective:This study aimed to examine the associations of waist circumference with hypertension and cardiometabolic dysregulation among normal-weight adults.Methods:This cross-sectional study included 8795 normal-weight participants aged 20 to 79 years from the 2009–2018 US National Health and Nutrition Examination Survey.The demographic characteristics and cardiometabolic risk factors across waist circumference quartiles were summarized.We used adjusted multivariate logistic regression models,subgroup analysis,and restricted cubic spline to analyze the association between waist circumference and the prevalence of hypertension.Thereafter,we used the random forest supervised machine learning method,together with least absolute shrinkage and selection operator regression,to select hypertension-related features and created a predictive model based on regression analysis to identify hypertension in normal-weight individuals.Results:Waist circumference was positively correlated with hypertension in the non-adjusted,minimally adjusted,and fully adjusted models,with odds ratios(95%confidence interval)of 2.28(2.14–2.44),1.27(1.12–1.44),and 1.27(1.12–1.44),respectively.In the fully adjusted model,participants in the highest waist circumference quartile had a higher risk of hypertension relative to those in the lowest quartile,with an odds ratio(95%confidence interval)of 3.87(1.59–10.34).Sensitivity analysis demonstrated the robustness of the association.In the testing set,the predictive model exhibited good performance,with an area under the curve of 0.803,sensitivity of 0.72,specificity of 0.76,and negative predictive value of 0.84.Conclusions:Measuring waist circumference may improve the evaluation of the risk of hypertension and help to manage cardiometabolic risk in normal-weight individuals.
