Non-suicidal self-injury(NSSI)is a prevalent and concerning issue in adolescent mental health,often intertwined with depressive symptoms.Despite extensive research on NSSI,a comprehensive understanding of its multifac...Non-suicidal self-injury(NSSI)is a prevalent and concerning issue in adolescent mental health,often intertwined with depressive symptoms.Despite extensive research on NSSI,a comprehensive understanding of its multifaceted nature and the intricate interplay of risk and resilience factors remains crucial.This Letter to the Editor examines a novel study by Yang et al,which utilized latent profile analysis and network analysis to delineate distinct NSSI subtypes within a Chinese adolescent population and investigate the underlying dynamics of associated factors.The study identifies three distinct NSSI subtypes:NSSI with depression,NSSI without depression,and neither,underscoring bullying as a prominent risk factor.Concurrently,the findings emphasized the pivotal role of emotional regulation and family support as protective factors.The focus of this article is to contextualize these findings within the broader framework of adolescent mental health and to highlight their implications for developing targeted interventions.These insights not only advance our understanding of adolescent NSSI but also provide a foundation for the development of targeted interventions that address the identified risk and protective factors.By focusing on these critical areas,mental health professionals can implement more effective strategies to mitigate NSSI behaviors and cultivate resilience in this vulnerable population.展开更多
BACKGROUND Depression,non-suicidal self-injury(NSSI),and suicide attempts(SA)often co-occur during adolescence and are associated with long-term adverse health outcomes.Unfortunately,neural mechanisms underlying self-...BACKGROUND Depression,non-suicidal self-injury(NSSI),and suicide attempts(SA)often co-occur during adolescence and are associated with long-term adverse health outcomes.Unfortunately,neural mechanisms underlying self-injury and SA are poorly understood in depressed adolescents but likely relate to the structural abnormalities in brain regions.AIM To investigate structural network communication within large-scale brain networks in adolescents with depression.METHODS We constructed five distinct network communication models to evaluate structural network efficiency at the whole-brain level in adolescents with depression.Diffusion magnetic resonance imaging data were acquired from 32 healthy controls and 85 depressed adolescents,including 17 depressed adolescents without SA or NSSI(major depressive disorder group),27 depressed adolescents with NSSI but no SA(NSSI group),and 41 depressed adolescents with SA and NSSI(NSSI+SA group).RESULTS Significant differences in structural network communication were observed across the four groups,involving spatially widespread brain regions,particularly encompassing cortico-cortical connections(e.g.,dorsal posterior cingulate gyrus and the right ventral posterior cingulate gyrus;connections based on precentral gyrus)and cortico-subcortical circuits(e.g.,the nucleus accumbens-frontal circuit).In addition,we examined whether compromised communication efficiency was linked to clinical symptoms in the depressed adolescents.We observed significant correlations between network communication efficiencies and clinical scale scores derived from depressed adolescents with NSSI and SA.CONCLUSION This study provides evidence of structural network communication differences in depressed adolescents with NSSI and SA,highlighting impaired neuroanatomical communication efficiency as a potential contributor to their symptoms.These findings offer new insights into the pathophysiological mechanisms underlying the comorbidity of NSSI and SA in adolescent depression.展开更多
BACKGROUND Increasing evidence has shown an increased risk of non-suicidal self-injury(NSSI)in left-behind children and adolescents(LBCAs).However,a systematic summary of studies comparing the risk of NSSI between LBC...BACKGROUND Increasing evidence has shown an increased risk of non-suicidal self-injury(NSSI)in left-behind children and adolescents(LBCAs).However,a systematic summary of studies comparing the risk of NSSI between LBCAs and non-LBCAs in China is lacking.AIM To investigate the risk of NSSI among LBCAs in China.METHODS We performed a systematic search of Embase,PubMed,and Web of Science from initiation to October 25,2024,for all relevant studies of NSSI and LBCAs.The effect sizes were reported as odds ratios(ORs)with 95%confidence intervals(CI).Sensitivity analyses were conducted to further confirm the stability of the findings.RESULTS A total of 10 studies with 165276 children and adolescents were included in this study.LBCAs had significantly higher rates of NSSI compared with non-LBCAs(OR=1.33,95%CI:1.19-1.49),with high heterogeneity observed(I^(2)=77%,P<0.001).Further sensitivity analyses were consistent with the primary analysis(OR=1.29,95%CI:1.21-1.39,I^(2)=0%).CONCLUSION LBCAs are found to be at an increased risk of NSSI compared with children and adolescents of non-migrants.More attention and intervention are urgently needed for LBCAs,especially those living in developing countries.展开更多
Objectives:To explore the approaches for reducing non-suicidal self-injury(NSSI)behaviors in Chinese adolescents,the present study investigated the association between parent-child conflict and NSSI in adolescents,whi...Objectives:To explore the approaches for reducing non-suicidal self-injury(NSSI)behaviors in Chinese adolescents,the present study investigated the association between parent-child conflict and NSSI in adolescents,while also examining the mediating role of depression and the moderating role of rumination thinking.Methods:A cluster sampling method was employed to select 1227 Chinese adolescents aged 12 to 18 as participants,who completed measures including the Parent-Child conflict,Depression,Rumination Thinking,and Non-Suicidal Self-Injury questionnaires.The present study used SPSS 26.0 to conduct the Descriptive statistics,correlation analysis,and reliability tests,and PROCESS 3.3 to test the hypothesis model.Results:(1)There is a positive correlation between parent-child conflict and NSSI in adolescents;(2)Depression mediates the relationship between parent-child conflict and NSSI in adolescents;(3)Rumination thinking acts as a moderator in the association between parent-child conflict and depression.This study finds the indirect effect of depression on NSSI behaviors among Chinese adolescents.Furthermore,the study also finds protective factors by examining the role of reducing individual rumination thinking in mitigating negative emotions following adverse experiences.In conclusion,this research provides a pathway and foundation for enhancing interventions targeting NSSI behaviors among Chinese adolescents.Conclusion:The relationship between parent-child conflict and NSSI in adolescents is positively correlated.Depression acts as a mediator in the association between parent-child conflict and NSSI in adolescents.The effect of parent-child conflict on NSSI is positively moderated by rumination thinking.Specifically,low-level rumination thinking may mitigate the negative impact of parent-child conflict on depression.展开更多
Objective:Non-suicidal self-injury(NSSI)is a mental health problem that often occurs in adolescents in Indonesia.Even though NSSI does not have the intention of suicide,some cases result in death.This research aimed t...Objective:Non-suicidal self-injury(NSSI)is a mental health problem that often occurs in adolescents in Indonesia.Even though NSSI does not have the intention of suicide,some cases result in death.This research aimed to identify the predisposition and precipitation factors associated with the dynamics of NSSI behaviors among adolescents.Methods:This research is an explanatory research design with a cross-sectional study.Out of 4000 students,904 students from State High School and Vocational School in Central Java Province were selected as respondents using non-probability sampling and a purposive sampling approach.This research was carried out using Google Forms from September to November 2023.The instrument used was the Self-Harm Inventory(SHI).Data analysis in this study used the chi-squared test.Results:The results of this study indicate that the most significant predisposition factors of NSSI behaviors experienced by respondents in this study are introverted personality and the environment that supports NSSI behaviors.In contrast,the precipitation factors are bullying and deep disappointment.Otherwise,based on the data analysis,the maladaptive coping mechanism(P-value=0.029)has become a predisposition factor related to the dynamics of NSSI behaviors.In contrast,bullying(P-value=0.000)and deep disappointment(P-value=0.000)still become precipitation factors related to the dynamics of NSSI behaviors.Conclusions:The results of this study can be evidence-based for stakeholders to provide interventions,especially for the vulnerable population affected by NSSI behaviors.展开更多
BACKGROUND Adolescence is a period marked by physiological and psychological imbalances,which pose an increased risk for adolescents with major depressive disorder(MDD)to commit non-suicidal self-injury(NSSI).AIM To i...BACKGROUND Adolescence is a period marked by physiological and psychological imbalances,which pose an increased risk for adolescents with major depressive disorder(MDD)to commit non-suicidal self-injury(NSSI).AIM To investigate the moderating role of social support utilization in depression and NSSI among adolescents with MDD.METHODS This cross-sectional study enrolled 314 adolescents with MDD(258 with NSSI,56 without)from a Chinese tertiary psychiatric hospital(2021-2023).Participants completed validated scales,including the self-esteem scale,the Barratt impulsiveness scale,the self-rating depression scale,and the teenager social support rating scale.Logistic regression and hierarchical regression analyses were used to examine predictors of NSSI and the moderating effect of social support utilization.RESULTS Results showed that the NSSI group had higher depression levels,lower selfesteem,and greater impulsivity.While overall social support was higher in the NSSI group,social support utilization significantly moderated the depression-NSSI relationship.Specifically,higher utilization levels weakened the association between depression and NSSI(β=-0.001,P<0.05).CONCLUSION These findings suggest that effective utilization of social support,rather than its mere presence,is crucial in reducing NSSI risk among depressed adolescents.展开更多
BACKGROUND Non-suicidal self-injury(NSSI)is common among adolescents and frequently cooccurs with depression.Understanding the distinct patterns of NSSI behaviors,along with their associated risk and protective factor...BACKGROUND Non-suicidal self-injury(NSSI)is common among adolescents and frequently cooccurs with depression.Understanding the distinct patterns of NSSI behaviors,along with their associated risk and protective factors,is crucial for developing effective interventions.AIM To classify NSSI behaviors and examine interactions between risk and resilience factors in Chinese adolescents.METHODS A cross-sectional study involving 3967 Chinese students(51.7%female,mean age 13.58±2.24 years)who completed questionnaires on parenting styles,bullying,childhood maltreatment,depression,resilience,and NSSI.Latent profile analysis(LPA)was used to identify NSSI subtypes,and network analysis explored interactions between risk and resilience factors.RESULTS Three NSSI subtypes were identified:NSSI with depression(18.8%),NSSI without depression(12.3%),and neither(68.9%).Bullying was the central risk factor across subtypes,while emotional control and family support were key protective factors.Statistical analyses showed significant differences between groups(P<0.001).CONCLUSION This study identified three NSSI subtypes among Chinese adolescents.Bullying emerged as a central risk factor,while emotional control and family support were key protective factors.Targeting these areas may help reduce NSSI behaviors in this population.展开更多
Background:Adolescents frequently engage in Non-Suicidal Self-Injury(NSSI),with recent trends indicating an increase in this behavior.At the same time,Chinese adolescents have a higher incidence of NSSI than Western a...Background:Adolescents frequently engage in Non-Suicidal Self-Injury(NSSI),with recent trends indicating an increase in this behavior.At the same time,Chinese adolescents have a higher incidence of NSSI than Western adolescents.Therefore,it is necessary to explore the relationship between interparental conflict and NSSI among adolescents within the context of Chinese families.Methods:The research sample comprised 755 senior high school students(46.62%male;age M=16.82,SD=0.94 years)who completed the Interparental Conflict Child Perception Scale(CPIC),Adolescent Self-Injury Behavior Questionnaire(ASHS),Toronto Alexithymia Scale-20(TAS-20),and Scale of Adolescent Resilience(RSCA).Results:Findings suggest that interparental conflict is a significant positive predictor of NSSI(r=0.22,p<0.01).Alexithymia mediates the relation between interparental conflict and NSSI(effect size=0.09,95%CI[0.05,0.13]).Additionally,resilience moderates both the direct relation(β=−0.08,p<0.05)and the latter half of the mediating pathway(β=−0.08,p<0.05)in the moderated mediation model.Conclusion:This study indicates that interparental conflict have an impact on adolescents’NSSI in Chinese families,and alexithymia and resilience play important roles in the relationship.These findings offer valuable guidance for the prevention and intervention efforts targeting NSSI among adolescents in China and in similar family contexts.展开更多
Fathers play an important role in children’s development throughout their lives,and Father-Love Absence(FLA)leads to more behavioral problems,including Non-Suicidal Self-Injury(NSSI).However,there has been no researc...Fathers play an important role in children’s development throughout their lives,and Father-Love Absence(FLA)leads to more behavioral problems,including Non-Suicidal Self-Injury(NSSI).However,there has been no research on the relationship between FLA and NSSI and its influencing mechanism.This study is based on Nock’s integrated theoretical model of NSSI,aiming to explore the influence of FLA on NSSI and further investigate the mechanism of Subjective Vitality(SV)and Forgiveness(FORG).This study recruited 1795 adolescents in central China to complete four scales,including Father-Love Absence Scale(FLAS),The Subjective Vitality Scale(SVS),The Tendency to Forgive Scale(TTF),and Non-Suicidal Self-Injury Scale.FLA can directly affect NSSI,and indirectly affect NSSI through three paths of“FLA→SV→NSSI,FLA→FORG→NSSI,FLA→SV→FORG→NSSI”.These results not only enrich our understanding of the relationship between FLA and NSSI and its internal mechanism but also provide theoretical and practical support for the reduction of NSSI in family education.展开更多
Objective Non-suicidal self-injury(NSSI)has a higher prevalence in adolescents with depressive disorders than in community adolescents.This study examined the differences in NSSI behaviors between adolescents with uni...Objective Non-suicidal self-injury(NSSI)has a higher prevalence in adolescents with depressive disorders than in community adolescents.This study examined the differences in NSSI behaviors between adolescents with unipolar depression(UD)and those with bipolar depression(BD).Methods Adolescents with UD or BD were recruited from 20 general or psychiatric hospitals across China.The methods,frequency,and function of NSSI were assessed by Functional Assessment of Self-Mutilation.The Beck Suicide Ideation Scale was used to evaluate adolescents’suicidal ideation,and the 10-item Kessler Psychological Distress Scale to estimate the anxiety and depression symptoms.Results The UD group had higher levels of depression(19.16 vs.17.37,F=15.23,P<0.001)and anxiety symptoms(17.73 vs.16.70,F=5.00,P=0.026)than the BD group.Adolescents with BD had a longer course of NSSI than those with UD(2.00 vs.1.00 year,Z=−3.39,P=0.001).There were no statistical differences in the frequency and the number of methods of NSSI between the UD and BD groups.Depression(r=0.408,P<0.01)and anxiety(r=0.391,P<0.01)were significantly and positively related to NSSI frequency.Conclusion Adolescents with BD had a longer course of NSSI than those with UD.More importantly,NSSI frequency were positively and strongly correlated with depression and anxiety symptoms,indicating the importance of adequate treatment of depression and anxiety in preventing and intervening adolescents’NSSI behaviors.展开更多
In recent years,non-suicidal self-injury(NSSI)behavior has emerged in a large number of adoles-cent depression.NSSI associated with adolescent depres-sion may be an addictive behavior,which has many sim-ilar neurobiol...In recent years,non-suicidal self-injury(NSSI)behavior has emerged in a large number of adoles-cent depression.NSSI associated with adolescent depres-sion may be an addictive behavior,which has many sim-ilar neurobiological mechanisms to substance addiction.Brain-derived neurotrophic factor(BDNF)and precursor of BDNF(proBDNF)play an important role in addiction behavior,and they may be related to endogenous opioid receptors.The location and distribution of opioidμre-ceptors in the brain are related to reward,motivation and emotion regulated by behavioral addiction.The purpose of this paper is to review the general situation,mechanism and relationship between the characteristics of NSSI be-havior addiction and brain-derived nutritional factors in adolescents with depression.展开更多
Background Non-suicidal self-injury (NSSI) behaviour is very common among adolescents. Its prevalence and behavioural characteristics may vary according to regional and cultural differences. Investigation of NSSI loca...Background Non-suicidal self-injury (NSSI) behaviour is very common among adolescents. Its prevalence and behavioural characteristics may vary according to regional and cultural differences. Investigation of NSSI locations and diagnosis of adolescents with NSSI are relatively lacking in China. Aims The study objective was to determine the prevalence and features of NSSI among middle school students in Shanghai. Methods The participants were from grade 6 to 8 selected from three junior schools in Jing’an District. Consenting students completed the Ottawa Self-Injury Inventory to determine the prevalence and characteristics of NSSI. Those who indicated NSSI within the past month were administered the Mini-International Neuropsychiatric Interview for Children and Adolescents to assess for emotional disorders. Result The result shows 510 participants (21.7%;mean age 13.51 (0.97) years old;56.7% female) reported at least one instance of NSSI during the previous 12 months. NSSI was significantly more common in girls than boys (24.9% vs 18.5%;χ^2=14.03, p=0.00). Commonly reported reasons for NSSI were for internal and external emotion regulation (87.9%, 82.3%) and social influence (57.8%). Anxiety disorders were the most common (28.9%) disorder associated with NSSI. Conclusion The rate of NSSI of middle school students in Shanghai inner bound is similar to those reported in North American and European youth. It is essential that school mental health professionals are aware of how to manage NSSI within the school setting.展开更多
Antidepressants are the main drugs used to treat depression,but they have not been shown to be effective in the treatment of child and adolescent depression.However,many adolescent depression treatment guidelines stil...Antidepressants are the main drugs used to treat depression,but they have not been shown to be effective in the treatment of child and adolescent depression.However,many adolescent depression treatment guidelines still recommend the use of antidepressants,especially specific serotonin re-uptake inhibitors.Previous studies have suggested that antidepressants have little therapeutic effect but many side effects,such as switching to mania,suicide,and non-suicidal self injury(NSSI),in the treatment of child and adolescent depression.In the process of developing guidelines,drug recommendations should not only focus on impro-ving symptoms,but they should also consider potential side effects.This review discusses the serious side effects of antidepressants,including switching to mania,suicide,and NSSI.展开更多
Genetic differences in non-human primates and the context where they were reared are important in the determination of their behaviors. Some studies suggest that Self-Injurious Behavior results from stress or anxiety,...Genetic differences in non-human primates and the context where they were reared are important in the determination of their behaviors. Some studies suggest that Self-Injurious Behavior results from stress or anxiety, but some macaques appear to be more vulnerable to acquiring Self-Injurious Behavior. Vulnerability and risk for socially reared macaques of developing Self-Injurious Behavior increased when they experienced early adverse events and suffered from consequent stress. Stressful events can cause alterations in the neuroendocrine and neuropeptide systems associated with the regulation of stress and anxiety. Dysregulation in these systems contributes to the occurrence of anxious episodes that lead to self-harm. This could be used by those animals to counteract the effects of anxiety, causing euphoria by releasing endogenous opioids. In developing an integrative approach of Self-Injurious Behavior, we propose the diathesis-stress model to illustrate how the environment and genetics are influenced as well, taking rhesus monkeys as an example. Rhesus macaques and humans have essentially the same gene 5-HTT as well as functional polymorphism. The allelic variation in the region promoting the serotonin transporter gene (5-HTT) was associated with significant differences in the number of depressive symptoms and contributions to social reward and punishment. Growing up without the mother and the rearing environment are important risk factors for developing abnormal behaviors. The main idea is that monkeys who carry short 5-HTT allele and are reared with their peers (without their mother) suffer from展开更多
BACKGROUND Non-suicidal self-injury(NSSI)in adolescents is a strong predictor of suicide and a significant mental health problem worldwide.Previous studies have identified various risk factors for NSSI.However,studies...BACKGROUND Non-suicidal self-injury(NSSI)in adolescents is a strong predictor of suicide and a significant mental health problem worldwide.Previous studies have identified various risk factors for NSSI.However,studies have not explored the association between inflammatory factors and NSSI in adolescents.AIM To investigate inflammatory marker changes post-antidepressant treatment and their association with suicide risk in NSSI adolescents.METHODS The study enrolled 68 adolescents with NSSI behaviors.The participants were divided into high and low suicide risk groups(n=38 and n=30,respectively)based on their scores on the Suicide Risk Factors Assessment Scale.Symptom severity was assessed at baseline and after six weeks of treatment.Blood samples were obtained to monitor for inflammatory factors.RESULTS The high suicide risk group exhibited higher levels of interferon(IFN)-αand interleukin(IL)-10 than the low suicide risk group.Scores on the Hamilton Anxiety Rating Scale,Hamilton Depression Rating Scale,and Insomnia Severity Index decreased significantly post-treatment.Tumor necrosis factor-α,IL-10,IL-6,IL-1,and IL-12 levels decreased,whereas IFN-γ,IL-4,and IFN-αlevels increased.IL-10 levels were correlated with the severity of suicide risk factors.CONCLUSION Adolescents with NSSI exhibit distinct inflammatory markers based on suicide risk,which change following treatment.Moreover,IL-10 levels are associated with suicide risk.These biomarkers may help assess suicide risk in clinical settings.展开更多
The field of psychology and health care are often viewed as very different. One of the main differences between these two fields is the application of prediction. When it comes to physical health, the health care and ...The field of psychology and health care are often viewed as very different. One of the main differences between these two fields is the application of prediction. When it comes to physical health, the health care and the medical field can predict outcomes of an individual’s health based on things like diet, exercise, and genetic makeup. Psychology is a little bit different;psychologists are great at predicting behavioral changes in patients, but the prediction of an individual’s mental health is not up to par with the prediction of physical health in the medical field for several factors. The scope of this study is to highlight how artificial intelligence has been applied to the field of psychology. In particular, how machine learning and deep learning technologies have been used to predict developmental risks of mental health disorders and risk of suicidal/self-injurious behaviors, as well as how artificial intelligence can be used to detect levels of depression.展开更多
Cutting or self inflicted epidermal damage (derma-abuse) describes a number of blood- letting behaviours among adolescents. Unlike suicidal behaviour, it is associated with low lethality and the absence of suicidal at...Cutting or self inflicted epidermal damage (derma-abuse) describes a number of blood- letting behaviours among adolescents. Unlike suicidal behaviour, it is associated with low lethality and the absence of suicidal attempts. The purpose of this study is two-fold: Firstly, to present and discuss vignettes of four young adolescents and secondly, to study the dynamics and characteristics of six derma-abusers who have attended Dual Group Therapy (DGT) concurrently with their parents for a six month period. Our findings suggest that patients involved in derma-abuse are generally non-suicidal but engage in comfort cutting for the psychological release of pain, tension reduction and anger management. There is a preponderance of females (80%) with an over-representation of mixed origin and borderline cultural states. In this small group, males amounted to 20% and were more bizarre, gruesome and brutal in their self-abuse. Of the total sample, 10% were of African origin, 60% were of Indian descent and 30% were of mixed ancestry. Psy- chodynamic factors explored in Dual Group Therapy (DGT) are the emphasis on non-suicidal intent, association with tension reduction, reclaiming power and mastery over self and others, life and death instincts, the significance of bloodletting in a socio-cultural context, trans- generational conflicts, dysfunctional family dynamics frequently with parental separation and sexual abuse and early sexual induction.展开更多
The Food and Drug Administration(FDA) has approved two mechanismbased treatments for tuberous sclero-sis complex(TSC)-everolimus and vigabatrin. However, these treatments have not been systematically studied in indivi...The Food and Drug Administration(FDA) has approved two mechanismbased treatments for tuberous sclero-sis complex(TSC)-everolimus and vigabatrin. However, these treatments have not been systematically studied in individuals with TSC and severe autism. The aim of this review is to identify the clinical features of severe autism in TSC, applicable preclinical models, and potential barriers that may warrant strategic planning in the design phase of clinical trial development. A comprehensive search strategy was formed and searched across Pub Med, Embase and SCOPUS from their inception to 2/21/12, 3/16/12, and 3/12/12 respectively. After the final search date, relevant, updated articles were selected from Pub Med abstracts generated electronically and emailed daily from Pub Med. The references of selected articles were searched, and relevant articles were selected. A search of clinicaltrials.gov was completed using the search term "TSC" and "tuberous sclerosis complex". Autism has been reported in as many as 60% of individuals with TSC; however, review of the literature revealed few data to support clear classification of the severity of autism in TSC. Variability was identified in the diagnostic approach, assessment of cognition, and functional outcome among the reviewed studies and case reports. Objective outcome measures were not used in many early studies; however, diffusion tensor imaging of white matter, neurophysiologic variability in infantile spasms, and cortical tuber subcategories were examined in recent studies and may be useful for objective classification of TSC in future studies. Mechanism-based treatments for TSC are currently available. However, this literature review revealed two potential barriers to successful design and implementation of clinical trials in individuals with severe autism-an unclear definition of the population and lack of validated outcome measures. Recent studies of objective outcome measures in TSC and further study of applicable preclinical models present an opportunity to overcome these barriers.展开更多
Background:The high prevalence of nonsuicidal self-injury(NSSI)in youths demonstrates a substantial population-level burden on society.NSSI is often associated with emotional and social skill deficits.To date,several ...Background:The high prevalence of nonsuicidal self-injury(NSSI)in youths demonstrates a substantial population-level burden on society.NSSI is often associated with emotional and social skill deficits.To date,several studies have aimed to identify the underlying neural mechanism of those deficits in NSSI by using functional magnetic resonance imaging(fMRI).However,their conclusions display poor consistency.Objective:We aimed to conduct ameta-analysis using activation likelihood estimation(ALE)for fMRI data based on emotional and cognitive tasks to clarify the underlying neural processing deficits of NSSI.Methods:We searched for MRI studies of NSSI in the PubMed,Cochrane,and Embase databases.We identified significant foci for the included studies and conducted two ALE meta-analyses as follows:(i)activation for the NSSI contrast healthy control group and(ii)deactivation for the NSSI contrast healthy controls.Considering the diverse sex composition of study participants and possible bias from one large sample study,we conducted sensitivity analyses for the meta-analysis.Results:Nine studies comprising 359 participants were included,and the results demonstrated substantial activation in NSSI patients compared with healthy controls in two clusters located in the right medial frontal gyrus extending to the rostral anterior cingulate and the left inferior frontal gyrus extending to the insula.Conclusions:The results suggest that individuals with NSSI show brain activity alterations that underpin their core symptoms,including poor emotional regulation and reward processing deficits.Our findings provide new insights into the neuralmechanism of NSSI,whichmay serve as functional biomarkers for developing effective diagnosis and therapeutic interventions for these patients.展开更多
基金Supported by the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education,No.RS-2023-00237287。
文摘Non-suicidal self-injury(NSSI)is a prevalent and concerning issue in adolescent mental health,often intertwined with depressive symptoms.Despite extensive research on NSSI,a comprehensive understanding of its multifaceted nature and the intricate interplay of risk and resilience factors remains crucial.This Letter to the Editor examines a novel study by Yang et al,which utilized latent profile analysis and network analysis to delineate distinct NSSI subtypes within a Chinese adolescent population and investigate the underlying dynamics of associated factors.The study identifies three distinct NSSI subtypes:NSSI with depression,NSSI without depression,and neither,underscoring bullying as a prominent risk factor.Concurrently,the findings emphasized the pivotal role of emotional regulation and family support as protective factors.The focus of this article is to contextualize these findings within the broader framework of adolescent mental health and to highlight their implications for developing targeted interventions.These insights not only advance our understanding of adolescent NSSI but also provide a foundation for the development of targeted interventions that address the identified risk and protective factors.By focusing on these critical areas,mental health professionals can implement more effective strategies to mitigate NSSI behaviors and cultivate resilience in this vulnerable population.
基金Supported by the National Natural Science Foundation of China,No.81871081 and No.62201265the Fundamental Research Funds for the Central Universities,No.NJ2024029-14the Talent Support Programs of Wuxi Health Commission,No.BJ2023085,No.FZXK2021012,and No.M202358.
文摘BACKGROUND Depression,non-suicidal self-injury(NSSI),and suicide attempts(SA)often co-occur during adolescence and are associated with long-term adverse health outcomes.Unfortunately,neural mechanisms underlying self-injury and SA are poorly understood in depressed adolescents but likely relate to the structural abnormalities in brain regions.AIM To investigate structural network communication within large-scale brain networks in adolescents with depression.METHODS We constructed five distinct network communication models to evaluate structural network efficiency at the whole-brain level in adolescents with depression.Diffusion magnetic resonance imaging data were acquired from 32 healthy controls and 85 depressed adolescents,including 17 depressed adolescents without SA or NSSI(major depressive disorder group),27 depressed adolescents with NSSI but no SA(NSSI group),and 41 depressed adolescents with SA and NSSI(NSSI+SA group).RESULTS Significant differences in structural network communication were observed across the four groups,involving spatially widespread brain regions,particularly encompassing cortico-cortical connections(e.g.,dorsal posterior cingulate gyrus and the right ventral posterior cingulate gyrus;connections based on precentral gyrus)and cortico-subcortical circuits(e.g.,the nucleus accumbens-frontal circuit).In addition,we examined whether compromised communication efficiency was linked to clinical symptoms in the depressed adolescents.We observed significant correlations between network communication efficiencies and clinical scale scores derived from depressed adolescents with NSSI and SA.CONCLUSION This study provides evidence of structural network communication differences in depressed adolescents with NSSI and SA,highlighting impaired neuroanatomical communication efficiency as a potential contributor to their symptoms.These findings offer new insights into the pathophysiological mechanisms underlying the comorbidity of NSSI and SA in adolescent depression.
基金Supported by the Fujian Provincial Health and Family Planning Youth Scientific Research Project,No.2022QNB029.
文摘BACKGROUND Increasing evidence has shown an increased risk of non-suicidal self-injury(NSSI)in left-behind children and adolescents(LBCAs).However,a systematic summary of studies comparing the risk of NSSI between LBCAs and non-LBCAs in China is lacking.AIM To investigate the risk of NSSI among LBCAs in China.METHODS We performed a systematic search of Embase,PubMed,and Web of Science from initiation to October 25,2024,for all relevant studies of NSSI and LBCAs.The effect sizes were reported as odds ratios(ORs)with 95%confidence intervals(CI).Sensitivity analyses were conducted to further confirm the stability of the findings.RESULTS A total of 10 studies with 165276 children and adolescents were included in this study.LBCAs had significantly higher rates of NSSI compared with non-LBCAs(OR=1.33,95%CI:1.19-1.49),with high heterogeneity observed(I^(2)=77%,P<0.001).Further sensitivity analyses were consistent with the primary analysis(OR=1.29,95%CI:1.21-1.39,I^(2)=0%).CONCLUSION LBCAs are found to be at an increased risk of NSSI compared with children and adolescents of non-migrants.More attention and intervention are urgently needed for LBCAs,especially those living in developing countries.
文摘Objectives:To explore the approaches for reducing non-suicidal self-injury(NSSI)behaviors in Chinese adolescents,the present study investigated the association between parent-child conflict and NSSI in adolescents,while also examining the mediating role of depression and the moderating role of rumination thinking.Methods:A cluster sampling method was employed to select 1227 Chinese adolescents aged 12 to 18 as participants,who completed measures including the Parent-Child conflict,Depression,Rumination Thinking,and Non-Suicidal Self-Injury questionnaires.The present study used SPSS 26.0 to conduct the Descriptive statistics,correlation analysis,and reliability tests,and PROCESS 3.3 to test the hypothesis model.Results:(1)There is a positive correlation between parent-child conflict and NSSI in adolescents;(2)Depression mediates the relationship between parent-child conflict and NSSI in adolescents;(3)Rumination thinking acts as a moderator in the association between parent-child conflict and depression.This study finds the indirect effect of depression on NSSI behaviors among Chinese adolescents.Furthermore,the study also finds protective factors by examining the role of reducing individual rumination thinking in mitigating negative emotions following adverse experiences.In conclusion,this research provides a pathway and foundation for enhancing interventions targeting NSSI behaviors among Chinese adolescents.Conclusion:The relationship between parent-child conflict and NSSI in adolescents is positively correlated.Depression acts as a mediator in the association between parent-child conflict and NSSI in adolescents.The effect of parent-child conflict on NSSI is positively moderated by rumination thinking.Specifically,low-level rumination thinking may mitigate the negative impact of parent-child conflict on depression.
文摘Objective:Non-suicidal self-injury(NSSI)is a mental health problem that often occurs in adolescents in Indonesia.Even though NSSI does not have the intention of suicide,some cases result in death.This research aimed to identify the predisposition and precipitation factors associated with the dynamics of NSSI behaviors among adolescents.Methods:This research is an explanatory research design with a cross-sectional study.Out of 4000 students,904 students from State High School and Vocational School in Central Java Province were selected as respondents using non-probability sampling and a purposive sampling approach.This research was carried out using Google Forms from September to November 2023.The instrument used was the Self-Harm Inventory(SHI).Data analysis in this study used the chi-squared test.Results:The results of this study indicate that the most significant predisposition factors of NSSI behaviors experienced by respondents in this study are introverted personality and the environment that supports NSSI behaviors.In contrast,the precipitation factors are bullying and deep disappointment.Otherwise,based on the data analysis,the maladaptive coping mechanism(P-value=0.029)has become a predisposition factor related to the dynamics of NSSI behaviors.In contrast,bullying(P-value=0.000)and deep disappointment(P-value=0.000)still become precipitation factors related to the dynamics of NSSI behaviors.Conclusions:The results of this study can be evidence-based for stakeholders to provide interventions,especially for the vulnerable population affected by NSSI behaviors.
基金Jiangsu Province Social Development Project,No.BE2022735Jiangsu Innovative and Entrepreneurial Talent Programme,No.JSSCBS20211584+1 种基金Suzhou Clinical Key Disciplines for Geriatric Psychiatry,No.SZXK202116Suzhou Science and Technology Program Projects,No.SKY2023075,No.SYWD2024037 and No.MSXM2024032.
文摘BACKGROUND Adolescence is a period marked by physiological and psychological imbalances,which pose an increased risk for adolescents with major depressive disorder(MDD)to commit non-suicidal self-injury(NSSI).AIM To investigate the moderating role of social support utilization in depression and NSSI among adolescents with MDD.METHODS This cross-sectional study enrolled 314 adolescents with MDD(258 with NSSI,56 without)from a Chinese tertiary psychiatric hospital(2021-2023).Participants completed validated scales,including the self-esteem scale,the Barratt impulsiveness scale,the self-rating depression scale,and the teenager social support rating scale.Logistic regression and hierarchical regression analyses were used to examine predictors of NSSI and the moderating effect of social support utilization.RESULTS Results showed that the NSSI group had higher depression levels,lower selfesteem,and greater impulsivity.While overall social support was higher in the NSSI group,social support utilization significantly moderated the depression-NSSI relationship.Specifically,higher utilization levels weakened the association between depression and NSSI(β=-0.001,P<0.05).CONCLUSION These findings suggest that effective utilization of social support,rather than its mere presence,is crucial in reducing NSSI risk among depressed adolescents.
基金Supported by Yunnan Province High-Level Health Technical Talents,Leading Talents,No.L-2019011.
文摘BACKGROUND Non-suicidal self-injury(NSSI)is common among adolescents and frequently cooccurs with depression.Understanding the distinct patterns of NSSI behaviors,along with their associated risk and protective factors,is crucial for developing effective interventions.AIM To classify NSSI behaviors and examine interactions between risk and resilience factors in Chinese adolescents.METHODS A cross-sectional study involving 3967 Chinese students(51.7%female,mean age 13.58±2.24 years)who completed questionnaires on parenting styles,bullying,childhood maltreatment,depression,resilience,and NSSI.Latent profile analysis(LPA)was used to identify NSSI subtypes,and network analysis explored interactions between risk and resilience factors.RESULTS Three NSSI subtypes were identified:NSSI with depression(18.8%),NSSI without depression(12.3%),and neither(68.9%).Bullying was the central risk factor across subtypes,while emotional control and family support were key protective factors.Statistical analyses showed significant differences between groups(P<0.001).CONCLUSION This study identified three NSSI subtypes among Chinese adolescents.Bullying emerged as a central risk factor,while emotional control and family support were key protective factors.Targeting these areas may help reduce NSSI behaviors in this population.
基金supported by the National Social Science Foundation of China(BHA240105).
文摘Background:Adolescents frequently engage in Non-Suicidal Self-Injury(NSSI),with recent trends indicating an increase in this behavior.At the same time,Chinese adolescents have a higher incidence of NSSI than Western adolescents.Therefore,it is necessary to explore the relationship between interparental conflict and NSSI among adolescents within the context of Chinese families.Methods:The research sample comprised 755 senior high school students(46.62%male;age M=16.82,SD=0.94 years)who completed the Interparental Conflict Child Perception Scale(CPIC),Adolescent Self-Injury Behavior Questionnaire(ASHS),Toronto Alexithymia Scale-20(TAS-20),and Scale of Adolescent Resilience(RSCA).Results:Findings suggest that interparental conflict is a significant positive predictor of NSSI(r=0.22,p<0.01).Alexithymia mediates the relation between interparental conflict and NSSI(effect size=0.09,95%CI[0.05,0.13]).Additionally,resilience moderates both the direct relation(β=−0.08,p<0.05)and the latter half of the mediating pathway(β=−0.08,p<0.05)in the moderated mediation model.Conclusion:This study indicates that interparental conflict have an impact on adolescents’NSSI in Chinese families,and alexithymia and resilience play important roles in the relationship.These findings offer valuable guidance for the prevention and intervention efforts targeting NSSI among adolescents in China and in similar family contexts.
基金supported by the National Social Science Fund of China(23BSH144).
文摘Fathers play an important role in children’s development throughout their lives,and Father-Love Absence(FLA)leads to more behavioral problems,including Non-Suicidal Self-Injury(NSSI).However,there has been no research on the relationship between FLA and NSSI and its influencing mechanism.This study is based on Nock’s integrated theoretical model of NSSI,aiming to explore the influence of FLA on NSSI and further investigate the mechanism of Subjective Vitality(SV)and Forgiveness(FORG).This study recruited 1795 adolescents in central China to complete four scales,including Father-Love Absence Scale(FLAS),The Subjective Vitality Scale(SVS),The Tendency to Forgive Scale(TTF),and Non-Suicidal Self-Injury Scale.FLA can directly affect NSSI,and indirectly affect NSSI through three paths of“FLA→SV→NSSI,FLA→FORG→NSSI,FLA→SV→FORG→NSSI”.These results not only enrich our understanding of the relationship between FLA and NSSI and its internal mechanism but also provide theoretical and practical support for the reduction of NSSI in family education.
基金supported by the Sanming Project of Medicine in Shenzhen(No.SZSM202011014)Shenzhen Fund for Guangdong Provincial High-level Clinical Key Specialties(No.SZGSP013)+1 种基金Shenzhen Key Medical Discipline Construction Fund(No.SZXK072)Shenzhen Science and Technology Research and Development Fund for Sustainable Development Project(No.KCXFZ20201221173613036).
文摘Objective Non-suicidal self-injury(NSSI)has a higher prevalence in adolescents with depressive disorders than in community adolescents.This study examined the differences in NSSI behaviors between adolescents with unipolar depression(UD)and those with bipolar depression(BD).Methods Adolescents with UD or BD were recruited from 20 general or psychiatric hospitals across China.The methods,frequency,and function of NSSI were assessed by Functional Assessment of Self-Mutilation.The Beck Suicide Ideation Scale was used to evaluate adolescents’suicidal ideation,and the 10-item Kessler Psychological Distress Scale to estimate the anxiety and depression symptoms.Results The UD group had higher levels of depression(19.16 vs.17.37,F=15.23,P<0.001)and anxiety symptoms(17.73 vs.16.70,F=5.00,P=0.026)than the BD group.Adolescents with BD had a longer course of NSSI than those with UD(2.00 vs.1.00 year,Z=−3.39,P=0.001).There were no statistical differences in the frequency and the number of methods of NSSI between the UD and BD groups.Depression(r=0.408,P<0.01)and anxiety(r=0.391,P<0.01)were significantly and positively related to NSSI frequency.Conclusion Adolescents with BD had a longer course of NSSI than those with UD.More importantly,NSSI frequency were positively and strongly correlated with depression and anxiety symptoms,indicating the importance of adequate treatment of depression and anxiety in preventing and intervening adolescents’NSSI behaviors.
基金Yunnan Province Psychiatric Hospital Project(Shengjing Scientific Research 2022-08).
文摘In recent years,non-suicidal self-injury(NSSI)behavior has emerged in a large number of adoles-cent depression.NSSI associated with adolescent depres-sion may be an addictive behavior,which has many sim-ilar neurobiological mechanisms to substance addiction.Brain-derived neurotrophic factor(BDNF)and precursor of BDNF(proBDNF)play an important role in addiction behavior,and they may be related to endogenous opioid receptors.The location and distribution of opioidμre-ceptors in the brain are related to reward,motivation and emotion regulated by behavioral addiction.The purpose of this paper is to review the general situation,mechanism and relationship between the characteristics of NSSI be-havior addiction and brain-derived nutritional factors in adolescents with depression.
文摘Background Non-suicidal self-injury (NSSI) behaviour is very common among adolescents. Its prevalence and behavioural characteristics may vary according to regional and cultural differences. Investigation of NSSI locations and diagnosis of adolescents with NSSI are relatively lacking in China. Aims The study objective was to determine the prevalence and features of NSSI among middle school students in Shanghai. Methods The participants were from grade 6 to 8 selected from three junior schools in Jing’an District. Consenting students completed the Ottawa Self-Injury Inventory to determine the prevalence and characteristics of NSSI. Those who indicated NSSI within the past month were administered the Mini-International Neuropsychiatric Interview for Children and Adolescents to assess for emotional disorders. Result The result shows 510 participants (21.7%;mean age 13.51 (0.97) years old;56.7% female) reported at least one instance of NSSI during the previous 12 months. NSSI was significantly more common in girls than boys (24.9% vs 18.5%;χ^2=14.03, p=0.00). Commonly reported reasons for NSSI were for internal and external emotion regulation (87.9%, 82.3%) and social influence (57.8%). Anxiety disorders were the most common (28.9%) disorder associated with NSSI. Conclusion The rate of NSSI of middle school students in Shanghai inner bound is similar to those reported in North American and European youth. It is essential that school mental health professionals are aware of how to manage NSSI within the school setting.
文摘Antidepressants are the main drugs used to treat depression,but they have not been shown to be effective in the treatment of child and adolescent depression.However,many adolescent depression treatment guidelines still recommend the use of antidepressants,especially specific serotonin re-uptake inhibitors.Previous studies have suggested that antidepressants have little therapeutic effect but many side effects,such as switching to mania,suicide,and non-suicidal self injury(NSSI),in the treatment of child and adolescent depression.In the process of developing guidelines,drug recommendations should not only focus on impro-ving symptoms,but they should also consider potential side effects.This review discusses the serious side effects of antidepressants,including switching to mania,suicide,and NSSI.
文摘Genetic differences in non-human primates and the context where they were reared are important in the determination of their behaviors. Some studies suggest that Self-Injurious Behavior results from stress or anxiety, but some macaques appear to be more vulnerable to acquiring Self-Injurious Behavior. Vulnerability and risk for socially reared macaques of developing Self-Injurious Behavior increased when they experienced early adverse events and suffered from consequent stress. Stressful events can cause alterations in the neuroendocrine and neuropeptide systems associated with the regulation of stress and anxiety. Dysregulation in these systems contributes to the occurrence of anxious episodes that lead to self-harm. This could be used by those animals to counteract the effects of anxiety, causing euphoria by releasing endogenous opioids. In developing an integrative approach of Self-Injurious Behavior, we propose the diathesis-stress model to illustrate how the environment and genetics are influenced as well, taking rhesus monkeys as an example. Rhesus macaques and humans have essentially the same gene 5-HTT as well as functional polymorphism. The allelic variation in the region promoting the serotonin transporter gene (5-HTT) was associated with significant differences in the number of depressive symptoms and contributions to social reward and punishment. Growing up without the mother and the rearing environment are important risk factors for developing abnormal behaviors. The main idea is that monkeys who carry short 5-HTT allele and are reared with their peers (without their mother) suffer from
基金Supported by the Natural Science Basic Research Program of Shaanxi Province,No.2022SF526 and No.2022SF509the National Natural Science Foundation of China,No.82301737.
文摘BACKGROUND Non-suicidal self-injury(NSSI)in adolescents is a strong predictor of suicide and a significant mental health problem worldwide.Previous studies have identified various risk factors for NSSI.However,studies have not explored the association between inflammatory factors and NSSI in adolescents.AIM To investigate inflammatory marker changes post-antidepressant treatment and their association with suicide risk in NSSI adolescents.METHODS The study enrolled 68 adolescents with NSSI behaviors.The participants were divided into high and low suicide risk groups(n=38 and n=30,respectively)based on their scores on the Suicide Risk Factors Assessment Scale.Symptom severity was assessed at baseline and after six weeks of treatment.Blood samples were obtained to monitor for inflammatory factors.RESULTS The high suicide risk group exhibited higher levels of interferon(IFN)-αand interleukin(IL)-10 than the low suicide risk group.Scores on the Hamilton Anxiety Rating Scale,Hamilton Depression Rating Scale,and Insomnia Severity Index decreased significantly post-treatment.Tumor necrosis factor-α,IL-10,IL-6,IL-1,and IL-12 levels decreased,whereas IFN-γ,IL-4,and IFN-αlevels increased.IL-10 levels were correlated with the severity of suicide risk factors.CONCLUSION Adolescents with NSSI exhibit distinct inflammatory markers based on suicide risk,which change following treatment.Moreover,IL-10 levels are associated with suicide risk.These biomarkers may help assess suicide risk in clinical settings.
文摘The field of psychology and health care are often viewed as very different. One of the main differences between these two fields is the application of prediction. When it comes to physical health, the health care and the medical field can predict outcomes of an individual’s health based on things like diet, exercise, and genetic makeup. Psychology is a little bit different;psychologists are great at predicting behavioral changes in patients, but the prediction of an individual’s mental health is not up to par with the prediction of physical health in the medical field for several factors. The scope of this study is to highlight how artificial intelligence has been applied to the field of psychology. In particular, how machine learning and deep learning technologies have been used to predict developmental risks of mental health disorders and risk of suicidal/self-injurious behaviors, as well as how artificial intelligence can be used to detect levels of depression.
文摘Cutting or self inflicted epidermal damage (derma-abuse) describes a number of blood- letting behaviours among adolescents. Unlike suicidal behaviour, it is associated with low lethality and the absence of suicidal attempts. The purpose of this study is two-fold: Firstly, to present and discuss vignettes of four young adolescents and secondly, to study the dynamics and characteristics of six derma-abusers who have attended Dual Group Therapy (DGT) concurrently with their parents for a six month period. Our findings suggest that patients involved in derma-abuse are generally non-suicidal but engage in comfort cutting for the psychological release of pain, tension reduction and anger management. There is a preponderance of females (80%) with an over-representation of mixed origin and borderline cultural states. In this small group, males amounted to 20% and were more bizarre, gruesome and brutal in their self-abuse. Of the total sample, 10% were of African origin, 60% were of Indian descent and 30% were of mixed ancestry. Psy- chodynamic factors explored in Dual Group Therapy (DGT) are the emphasis on non-suicidal intent, association with tension reduction, reclaiming power and mastery over self and others, life and death instincts, the significance of bloodletting in a socio-cultural context, trans- generational conflicts, dysfunctional family dynamics frequently with parental separation and sexual abuse and early sexual induction.
基金Supported by Grant 2K12NS001696-11A1(to Gipson TT)from the National Institute of Neurological Disorders and StrokeGrant 5T32HD007414-18(to Gerner G)from the National Institute of Child Health and Human Development
文摘The Food and Drug Administration(FDA) has approved two mechanismbased treatments for tuberous sclero-sis complex(TSC)-everolimus and vigabatrin. However, these treatments have not been systematically studied in individuals with TSC and severe autism. The aim of this review is to identify the clinical features of severe autism in TSC, applicable preclinical models, and potential barriers that may warrant strategic planning in the design phase of clinical trial development. A comprehensive search strategy was formed and searched across Pub Med, Embase and SCOPUS from their inception to 2/21/12, 3/16/12, and 3/12/12 respectively. After the final search date, relevant, updated articles were selected from Pub Med abstracts generated electronically and emailed daily from Pub Med. The references of selected articles were searched, and relevant articles were selected. A search of clinicaltrials.gov was completed using the search term "TSC" and "tuberous sclerosis complex". Autism has been reported in as many as 60% of individuals with TSC; however, review of the literature revealed few data to support clear classification of the severity of autism in TSC. Variability was identified in the diagnostic approach, assessment of cognition, and functional outcome among the reviewed studies and case reports. Objective outcome measures were not used in many early studies; however, diffusion tensor imaging of white matter, neurophysiologic variability in infantile spasms, and cortical tuber subcategories were examined in recent studies and may be useful for objective classification of TSC in future studies. Mechanism-based treatments for TSC are currently available. However, this literature review revealed two potential barriers to successful design and implementation of clinical trials in individuals with severe autism-an unclear definition of the population and lack of validated outcome measures. Recent studies of objective outcome measures in TSC and further study of applicable preclinical models present an opportunity to overcome these barriers.
基金supported by the Sichuan Provincial Science and Technology Support Program(Grant ID:2019YFS0218,2020YFS0587).
文摘Background:The high prevalence of nonsuicidal self-injury(NSSI)in youths demonstrates a substantial population-level burden on society.NSSI is often associated with emotional and social skill deficits.To date,several studies have aimed to identify the underlying neural mechanism of those deficits in NSSI by using functional magnetic resonance imaging(fMRI).However,their conclusions display poor consistency.Objective:We aimed to conduct ameta-analysis using activation likelihood estimation(ALE)for fMRI data based on emotional and cognitive tasks to clarify the underlying neural processing deficits of NSSI.Methods:We searched for MRI studies of NSSI in the PubMed,Cochrane,and Embase databases.We identified significant foci for the included studies and conducted two ALE meta-analyses as follows:(i)activation for the NSSI contrast healthy control group and(ii)deactivation for the NSSI contrast healthy controls.Considering the diverse sex composition of study participants and possible bias from one large sample study,we conducted sensitivity analyses for the meta-analysis.Results:Nine studies comprising 359 participants were included,and the results demonstrated substantial activation in NSSI patients compared with healthy controls in two clusters located in the right medial frontal gyrus extending to the rostral anterior cingulate and the left inferior frontal gyrus extending to the insula.Conclusions:The results suggest that individuals with NSSI show brain activity alterations that underpin their core symptoms,including poor emotional regulation and reward processing deficits.Our findings provide new insights into the neuralmechanism of NSSI,whichmay serve as functional biomarkers for developing effective diagnosis and therapeutic interventions for these patients.
