Experimental therapies targeting immune and stromal cells,such as mast cells,cancer-associated fibroblasts,dendritic cells,and tumor endothelial cells,in the treatment of gastrointestinal solid tumors pose new and com...Experimental therapies targeting immune and stromal cells,such as mast cells,cancer-associated fibroblasts,dendritic cells,and tumor endothelial cells,in the treatment of gastrointestinal solid tumors pose new and complex surgical and medico-legal challenges.These innovative treatments require that informed consent not be limited to simple acceptance of the medical procedure,but instead reflect a true relational and cognitive process grounded in understanding,free choice,and the ability to revoke consent at any time.In particular,it is essential that the patient understands the experimental nature of the therapy,its development stage,potential benefits and risks,as well as the implications for their health and personal dignity.In the case of stromal cell-based treatments,which may exert complex immunomodulatory effects or activate angiogenic pathways that are not yet fully understood,patients must be made fully aware that they are participating in a non-standardized therapy whose outcomes,whether beneficial or harmful,cannot yet be predicted with certainty.This requires particularly careful medical communication,using simple yet scientifically accurate explanations delivered in appropriate language,along with a final verification of the patient’s actual understanding.展开更多
This paper focuses on studying the Noether symmetry and the conserved quantity with non-standard Lagrangians, namely exponential Lagrangians and power-law Lagrangians on time scales. Firstly, for each case, the Hamilt...This paper focuses on studying the Noether symmetry and the conserved quantity with non-standard Lagrangians, namely exponential Lagrangians and power-law Lagrangians on time scales. Firstly, for each case, the Hamilton prin- ciple based on the action with non-standard Lagrangians on time scales is established, with which the corresponding Euler-Lagrange equation is given. Secondly, according to the invariance of the Hamilton action under the infinitesimal transformation, the Noether theorem for the dynamical system with non-standard Lagrangians on time scales is established. The proof of the theorem consists of two steps. First, it is proved under the infinitesimal transformations of a special one-parameter group without transforming time. Second, utilizing the technique of time-re-parameterization, the Noether theorem in a general form is obtained. The Noether-type conserved quantities with non-standard Lagrangians in both clas- sical and discrete cases are given. Finally, an example in Friedmann-Robertson-Walker spacetime and an example about second order Duffing equation are given to illustrate the application of the results.展开更多
The canonical transformation and Poisson theory of dynamical systems with exponential,power-law,and logarithmic non-standard Lagrangians are studied,respectively.The criterion equations of canonical transformation are...The canonical transformation and Poisson theory of dynamical systems with exponential,power-law,and logarithmic non-standard Lagrangians are studied,respectively.The criterion equations of canonical transformation are established,and four basic forms of canonical transformations are given.The dynamic equations with non-standard Lagrangians admit Lie algebraic structure.From this,we es-tablish the Poisson theory,which makes it possible to find new conservation laws through known conserved quantities.Some examples are put forward to demonstrate the use of the theory and verify its effectiveness.展开更多
Recently,the notion of non-standard Lagrangians was discussed widely in literature in an attempt to explore the inverse variational problem of nonlinear differential equations.Different forms of non-standard Lagrangia...Recently,the notion of non-standard Lagrangians was discussed widely in literature in an attempt to explore the inverse variational problem of nonlinear differential equations.Different forms of non-standard Lagrangians were introduced in literature and have revealed nice mathematical and physical properties.One interesting form related to the inverse variational problem is the logarithmic Lagrangian,which has a number of motivating features related to the Li′enard-type and Emden nonlinear differential equations.Such types of Lagrangians lead to nonlinear dynamics based on non-standard Hamiltonians.In this communication,we show that some new dynamical properties are obtained in stellar dynamics if standard Lagrangians are replaced by Logarithmic Lagrangians and their corresponding non-standard Hamiltonians.One interesting consequence concerns the emergence of an extra pressure term,which is related to the gravitational field suggesting that gravitation may act as a pressure in a strong gravitational field.The case of the stellar halo of the Milky Way is considered.展开更多
We introduce a non-standard quantum group Xq（Bn） of type Bn which is a Hopf algebra. Then we replace the group of grouplike elements of Xq（Bn）, and obtain a weak Hopf algebra wXq（Bn）. Finally, we describe the Ex...We introduce a non-standard quantum group Xq（Bn） of type Bn which is a Hopf algebra. Then we replace the group of grouplike elements of Xq（Bn）, and obtain a weak Hopf algebra wXq（Bn）. Finally, we describe the Ext-quiver of wXq（Bn） as a coalgebra.展开更多
Based on the features of the non-standard equipment executing work, a project management and decision support system oriented to the non-standard equipment is developed, and the information model, function model as we...Based on the features of the non-standard equipment executing work, a project management and decision support system oriented to the non-standard equipment is developed, and the information model, function model as well as the structure framework of the system are also introduced in this paper.展开更多
In liver haemangiomas, the risk of complication rises with increasing size, and treatment can be obligatory. Here we present a case of a 46-year-old female who suffered from a giant haemangioma causing severe portal h...In liver haemangiomas, the risk of complication rises with increasing size, and treatment can be obligatory. Here we present a case of a 46-year-old female who suffered from a giant haemangioma causing severe portal hypertension and vena cava compression, leading to therapy refractory ascites, hyponatremia and venostasis-associated thrombosis with pulmonary embolism. The patients did not experience tumour rupture or consumptive coagulopathy. Surgical resection was impossible because of steatosis of the non-affected liver. Orthotopic liver transplantation was identified as the only treatment option. The patient's renal function remained stable even though progressive morbidity and organ allocation were improbable according to the patient's lab model for end-stage liver disease(lab MELD) score. Therefore, non-standard exception status was approved by the European organ allocation network "Eurotransplant". The patient underwent successful orthotopic liver transplantation 16 mo after admission to our centre. Our case report indicates the underrepresentation of morbidity associated with refractory ascites in the lab MELD-based transplant allocation system, and it indicates the necessity of promptly applying for non-standard exception status to enable transplantation in patients with a severe clinical condition but low lab MELD score. Our case highlights the fact that liver transplantation should be considered early in patients with non-resectable, symptomatic benign liver tumours.展开更多
It follows from the analysis of artillery fire errors that approximately two-thirds of the inaccuracy of indirect artillery fire is caused by inaccuracies in the determination of the meteo parameters included in fire ...It follows from the analysis of artillery fire errors that approximately two-thirds of the inaccuracy of indirect artillery fire is caused by inaccuracies in the determination of the meteo parameters included in fire error budget model.Trajectories calculated under non-standard conditions are considered to be perturbed.The tools utilized for the analysis of perturbed trajectories are weighting factor functions(WFFs)which are a special kind of sensitivity functions.WFFs are used for calculation of meteo ballistic elements B(ballistic wind w B,densityρB,virtual temperatureτB,pressure p B)as well.We have found that the existing theory of WFF calculation has several significant shortcomings.The aim of the article is to present a new,improved theory of generalized WFFs that eliminates the deficiencies found.Using this theory will improve methods for designing firing tables,fire control systems algorithms,and meteo message generation algorithms.展开更多
BACKGROUND Only 50% of patients with type 2 diabetes mellitus(T2DM) can control their blood glucose levels. Dapagliflozin is a selective inhibitor of sodium-glucose cotransporter 2(SGLT-2) that improves the insulin se...BACKGROUND Only 50% of patients with type 2 diabetes mellitus(T2DM) can control their blood glucose levels. Dapagliflozin is a selective inhibitor of sodium-glucose cotransporter 2(SGLT-2) that improves the insulin sensitivity of the liver and peripheral tissues. Many studies confirmed that SGLT2 inhibitors reduce blood glucose and have multiple beneficial effects such as weight loss, lipid regulation, and kidney protection. Nevertheless, the mechanisms of the renal and cardiovascular protective effects of dapagliflozin from the perspective of differentially expressed proteins in the serum of T2DM patients have not been intensively explored so far.AIM To identify differentially expressed proteins associated with dapagliflozin treatment in patients with T2DM.METHODS Twenty T2DM patients [hemoglobin A1c(HbA1c) 7.0%-10.0%] were enrolled at The Affiliated Hospital of Inner Mongolia Medical University between January 1, 2017 and December 1, 2018. They received dapagliflozin(10 mg/d) for 3 mo, and the HbA1c < 7.0% target was achieved. The changes in clinical indexes were compared before and after treatments. Label-free quantitative proteomics was used to identify differentially expressed proteins using the serum samples of five patients. The identified differentially expressed proteins were analyzed using various bioinformatics tools.RESULTS Dapagliflozin significantly improved the clinical manifestation of the patients. There were 18 downregulated proteins and one upregulated protein in the serum samples of patients after dapagliflozin administration. Bioinformatics analyses, including subcellular localization, Eu Karyotic Orthologous Groups, Gene Ontology, and Kyoto Encyclopedia of Genes and Genomes annotations, were used to profile the biological characteristics of the 19 differentially expressed proteins. Based on the literature and function enrichment analysis, two downregulated proteins, myeloperoxidase(MPO) and alpha Ⅱ B integrin(ITGA2B), and one upregulated protein, podocalyxin(PCX), were selected for enzyme linked immunosorbent assay validation. These validated differentially expressed proteins had multiple correlations with clinical indexes, including Hb Ac1 and fasting C-peptide.CONCLUSION Dapagliflozin has hypoglycemic effects and regulates the serum expressions of MPO, ITGA2B, and PCX, possibly contributing to the effects of dapagliflozin on oxidative stress, insulin resistance, and lipid metabolism.展开更多
[Objectives]This study was conducted to provide an accurate and reliable method for rapid high-throughput screening of veterinary drug preparations.[Methods]For the matrixes of veterinary drug preparations,high-perfor...[Objectives]This study was conducted to provide an accurate and reliable method for rapid high-throughput screening of veterinary drug preparations.[Methods]For the matrixes of veterinary drug preparations,high-performance liquid chromatography-high resolution quadrupole time-of-flight mass spectrometry(UPLC-QTOF/MS)was used to establish a fast screening method for 59 non-standard components in five categories of antiviral agents,aminoglycosides,quinolones,sulfonamides,and tetracyclines in veterinary drugs.The target drugs were separated by a Waters ACQUITY UPLC HSS T3 chromatographic column(50 mm×2.1 mm,1.8μm),and data were collected in the positive ion mode.Good separation of the 59 drugs was achieved within 7 min.[Results]In the concentration range of 0-100 ng/ml,each drug showed a good linear relationship,and the correlation coefficients were all greater than 0.999.The detection limits of the 59 drugs were in the range of 0.1-0.5 mg/ml,and the recovery under the addition concentration of 5 mg/ml was in the range of 85.2%-103.8%.[Conclusions]The method is fast,simple,accurate,and highly sensitive,and is suitable for high-throughput screening and qualitative identification of non-standard components in veterinary drug preparations.展开更多
The purpose of this paper is to propose a synthesis method of parametric sensitivity constrained linear quadratic (SCLQ) controller for an uncertain linear time invariant (LTI) system. System sensitivity to parameter ...The purpose of this paper is to propose a synthesis method of parametric sensitivity constrained linear quadratic (SCLQ) controller for an uncertain linear time invariant (LTI) system. System sensitivity to parameter variation is handled through an additional quadratic trajectory parametric sensitivity term in the standard LQ criterion to be minimized. The main purpose here is to find a suboptimal linear quadratic control taking explicitly into account the parametric uncertainties. The paper main contribution is threefold: 1) A descriptor system approach is used to show that the underlying singular linear-quadratic optimal control problem leads to a non-standard Riccati equation. 2) A solution to the proposed control problem is then given based on a connection to the so-called Lur'e matrix equations. 3) A synthesis method of multiple parametric SCLQ controllers is proposed to cover the whole parametric uncertainty while degrading as less as possible the intrinsic robustness properties of each local linear quadratic controller. Some examples are presented in order to illustrate the effectiveness of the approach.展开更多
The experimental investigation of unsteady complex flow fields in wind tunnels requires advanced measurement techniques. The most important of such image based measurement techniques are those for the measurement of p...The experimental investigation of unsteady complex flow fields in wind tunnels requires advanced measurement techniques. The most important of such image based measurement techniques are those for the measurement of planar flow velocity fields, planar pressure distribution, model location and deformation, model temperature and quantitative high speed flow visualization. The applications as carried out by DLR range from low speed flows to transonic flows, from high lift configurations to propellers and rotors, from wake vortex investigations in catapult facilities and water towing tanks to investigations of vortex break down phenomena on delta wings. The capability to use image based measurement techniques in transonic flows requires dedicated technical developments and experienced scientists due to the special environment of a transonic wind tunnel. In this paper an overview of the state-of-the art of the application of image based measurement techniques in transonic flows as performed by DLR＇s Institute of Aerodynamics and Flow Technology will be given.展开更多
We investigate prospects of building a future accelerator-based neutrino oscillation experiment in China,including site selection,beam optimization and tau neutrino physics aspects.CP violation,non-unitary mixing and ...We investigate prospects of building a future accelerator-based neutrino oscillation experiment in China,including site selection,beam optimization and tau neutrino physics aspects.CP violation,non-unitary mixing and non-standard neutrino interactions are discussed.We simulate neutrino beam setups based on muon and beta decay techniques and compare Chinese laboratory sites by their expected sensitivities.A case study on the Super Proton-Proton Collider and the China JinPing Laboratory is also presented.It is shown that the muon-decay-based beam setup can measure the Dirac CP phase by about 14.2°precision at 1σCL,whereas non-unitarity can be probed down to |α_(ij)|≲0.37(i≠j=1,2,3)and non-standard interactions to|ϵ_(ℓℓ′)^(m)|≲0.11(ℓ≠ℓ′=e,μ,τ)at 90% CL,respectively.展开更多
In this paper, we consider an SIR-model for which the interaction term is the square root of the susceptible and infected individuals in the form of fractional order differential equations. First the non-negative solu...In this paper, we consider an SIR-model for which the interaction term is the square root of the susceptible and infected individuals in the form of fractional order differential equations. First the non-negative solution of the model in fractional order is presented. Then the local stability analysis of the model in fractional order is discussed. Finally, the general solutions are presented and a discrete-time finite difference scheme is constructed using the nonstandard finite difference (NSFD) method. A comparative study of the classical Runge-Kutta method and ODE45 is presented in the case of integer order derivatives. The solutions obtained are presented graphically.展开更多
Binary logistic regression models are commonly used to assess the association between outcomes and covariates. Many covariates are inherently continuous, and have a variety of distributions, including those that are h...Binary logistic regression models are commonly used to assess the association between outcomes and covariates. Many covariates are inherently continuous, and have a variety of distributions, including those that are heavily skewed to the left or right. Existing theoretical formulas, criteria, and simulation programs cannot accurately estimate the sample size and power of non-standard distributions. Therefore, we have developed a simulation program that uses Monte Carlo methods to estimate the exact power of a binary logistic regression model. This power calculation can be used for distributions of any shape and covariates of any type (continuous, ordinal, and nominal), and can account for nonlinear relationships between covariates and outcomes. For illustrative purposes, this simulation program is applied to real data obtained from a study on the influence of smoking on 90-day outcomes after acute atherothrombotic stroke. Our program is applicable to all effect sizes and makes it possible to apply various statistical methods, logistic regression and related simulations such as Bayesian inference with some modifications.展开更多
We propose and analyze an epidemiological model to evaluate the effectiveness of bed nets as a prophylactic measure in malaria-endemic areas. The main purpose in this work is the modeling of the aggressiveness of anop...We propose and analyze an epidemiological model to evaluate the effectiveness of bed nets as a prophylactic measure in malaria-endemic areas. The main purpose in this work is the modeling of the aggressiveness of anopheles mosquitoes relative to the way humans use to protect themselves against bites of mosquitoes. This model is a system of several differential equations: the number of equations depends on the particular assumptions of the model. We compute the basic reproduction number, and show that if, the disease free equilibrium (DFE) is globally asymptotically stable on the non-negative orthant. If, the system admits a unique endemic equilibrium (EE) that is globally and asymptotically stable. Numerical simulations are presented corresponding to scenarios typical of malaria-endemic areas, based on data collected in the literature. Finally, we discuss the relative effectiveness of different kinds of bed nets.展开更多
Ordinary and high performance concrete （OC-C 25/30 and HPC C-50/60） made with fly ash has found numerous applications all over the world since 1970. In Kosovo, fly ash as cement substitution in concrete has not been...Ordinary and high performance concrete （OC-C 25/30 and HPC C-50/60） made with fly ash has found numerous applications all over the world since 1970. In Kosovo, fly ash as cement substitution in concrete has not been utilized yet despite the large amount that is produced annually and the positive economical-environment aspects of such technique. This hesitance is due to the laek of experience in the concrete engineering field and because of the chemical composition of Kosovo fly ash, which is classified as non-standard high calcium fly ash （KF）. In light of this fact, this study intended to develop further. So, this paper reports the consistency, workability, shrinkage, high and ordinary compressive strength of concrete containing different percentage of non-class high calcium fly ash as Portland cement substitution （first case-Kosovo fly ash KF） comparing results with F class-low caleium fly ash content （second ease-Japanese fly ash JF） which is common used as cement replacement.展开更多
Analysis of free fall and acceleration of the mass on the Earth shows that using abstract entities such as absolute space or inertial space to explain mass dynamics leads to the violation of the principle of action an...Analysis of free fall and acceleration of the mass on the Earth shows that using abstract entities such as absolute space or inertial space to explain mass dynamics leads to the violation of the principle of action and reaction. Many scientists including Newton, Mach, and Einstein recognized that inertial force has no reaction that originates on mass. Einstein calls the lack of reaction to the inertial force a serious criticism of the space-time continuum concept. Presented is the hypothesis that the inertial force develops in an interaction of two masses via the force field. The inertial force created by such a field has reaction force. The dynamic gravitational field predicted is strong enough to be detected in the laboratory. This article describes the laboratory experiment which can prove or disprove the hypothesis of the dynamic gravitational field. The inertial force, calculated using the equation for the dynamic gravitational field, agrees with the behavior of inertial force observed in the experiments on the Earth. The movement of the planets in our solar system calculated using that equation is the same as that calculated using Newton’s method. The space properties calculated by the candidate equation explain the aberration of light and the results of light propagation experiments. The dynamic gravitational field can explain the discrepancy between the observed velocity of stars in the galaxy and those predicted by Newton’s theory of gravitation without the need for the dark matter hypothesis.展开更多
Three classical compactification procedures are presented with nonstandard flavour. This is to illustrate the applicability of Nonstandard analytic tool to beginners interested in Nonstandard analytic methods. The gen...Three classical compactification procedures are presented with nonstandard flavour. This is to illustrate the applicability of Nonstandard analytic tool to beginners interested in Nonstandard analytic methods. The general procedure is as follows: A suitable equivalence relation is defined on an enlargement <sup>*</sup>X of the space X which is a completely regular space or a locally compact Hausdorff space or a locally compact Abelian group. Accordingly, every f in C(X,R) (the space of bounded continuous real valued functions on X) or Cc(X,R) (the space of continuous real valued functions on X with compact support) or the dual group <span style="white-space:nowrap;">Γ of the locally compact Abelian group G is extended to the set <img alt="" src="Edit_b9535172-924d-44f0-bab3-c49db17a3b7a.png" /> of the above mentioned equivalence classes. A compact topology on <img alt="" src="Edit_9d7962a3-b8a3-4693-b62a-078c8c4b4853.png" /> is obtained as the weak topology generated by these extensions of f. Then X is naturally imbedded densely in <img alt="" src="Edit_f7d403b2-eff3-4555-b8e7-1b106e06d2e7.png" />.展开更多
Two case studies,referring to historic Italian buildings housing city halls,provide an opportunity to investigate the design of non-standard elements aimed at protecting masonry vaults,with particular reference to the...Two case studies,referring to historic Italian buildings housing city halls,provide an opportunity to investigate the design of non-standard elements aimed at protecting masonry vaults,with particular reference to the preliminary works prior to the actual structural restoration work.There is in fact a phase in which it is a priority to secure the vault to avert possible risks to the users of that portion of the building.This phase is temporarily intermediate between the detection and aggravation of injuries and the renovation and consolidation project.Although these are provisional works,they are intended for buildings that are often public and therefore intended for a wide range of users,such as schools,offices or monumental buildings.In analyzing traditional techniques and systems used in similar cases,the possibility of developing evolutionary aspects with respect to,above all,simple shoring techniques emerged.In these areas,hybrids between a structural and architectural project,it is possible to reconcile static requirements with architectural techniques of space management,attentive to the quality of the interior and the integration of the provisional work with the reference context.展开更多
文摘Experimental therapies targeting immune and stromal cells,such as mast cells,cancer-associated fibroblasts,dendritic cells,and tumor endothelial cells,in the treatment of gastrointestinal solid tumors pose new and complex surgical and medico-legal challenges.These innovative treatments require that informed consent not be limited to simple acceptance of the medical procedure,but instead reflect a true relational and cognitive process grounded in understanding,free choice,and the ability to revoke consent at any time.In particular,it is essential that the patient understands the experimental nature of the therapy,its development stage,potential benefits and risks,as well as the implications for their health and personal dignity.In the case of stromal cell-based treatments,which may exert complex immunomodulatory effects or activate angiogenic pathways that are not yet fully understood,patients must be made fully aware that they are participating in a non-standardized therapy whose outcomes,whether beneficial or harmful,cannot yet be predicted with certainty.This requires particularly careful medical communication,using simple yet scientifically accurate explanations delivered in appropriate language,along with a final verification of the patient’s actual understanding.
基金supported by the National Natural Science Foundation of China(Grant Nos.11572212 and 11272227)the Innovation Program of Suzhou University of Science and Technology,China(Grant No.SKYCX16 012)
文摘This paper focuses on studying the Noether symmetry and the conserved quantity with non-standard Lagrangians, namely exponential Lagrangians and power-law Lagrangians on time scales. Firstly, for each case, the Hamilton prin- ciple based on the action with non-standard Lagrangians on time scales is established, with which the corresponding Euler-Lagrange equation is given. Secondly, according to the invariance of the Hamilton action under the infinitesimal transformation, the Noether theorem for the dynamical system with non-standard Lagrangians on time scales is established. The proof of the theorem consists of two steps. First, it is proved under the infinitesimal transformations of a special one-parameter group without transforming time. Second, utilizing the technique of time-re-parameterization, the Noether theorem in a general form is obtained. The Noether-type conserved quantities with non-standard Lagrangians in both clas- sical and discrete cases are given. Finally, an example in Friedmann-Robertson-Walker spacetime and an example about second order Duffing equation are given to illustrate the application of the results.
基金Supported by the National Natural Science Foundation of China(12272248,11972241)。
文摘The canonical transformation and Poisson theory of dynamical systems with exponential,power-law,and logarithmic non-standard Lagrangians are studied,respectively.The criterion equations of canonical transformation are established,and four basic forms of canonical transformations are given.The dynamic equations with non-standard Lagrangians admit Lie algebraic structure.From this,we es-tablish the Poisson theory,which makes it possible to find new conservation laws through known conserved quantities.Some examples are put forward to demonstrate the use of the theory and verify its effectiveness.
文摘Recently,the notion of non-standard Lagrangians was discussed widely in literature in an attempt to explore the inverse variational problem of nonlinear differential equations.Different forms of non-standard Lagrangians were introduced in literature and have revealed nice mathematical and physical properties.One interesting form related to the inverse variational problem is the logarithmic Lagrangian,which has a number of motivating features related to the Li′enard-type and Emden nonlinear differential equations.Such types of Lagrangians lead to nonlinear dynamics based on non-standard Hamiltonians.In this communication,we show that some new dynamical properties are obtained in stellar dynamics if standard Lagrangians are replaced by Logarithmic Lagrangians and their corresponding non-standard Hamiltonians.One interesting consequence concerns the emergence of an extra pressure term,which is related to the gravitational field suggesting that gravitation may act as a pressure in a strong gravitational field.The case of the stellar halo of the Milky Way is considered.
基金Supported by the National Natural Science Foundation of China(Grant Nos.11671024 11471186)the Natural Science Foundation of Beijing(Grant No.1162002)
文摘We introduce a non-standard quantum group Xq（Bn） of type Bn which is a Hopf algebra. Then we replace the group of grouplike elements of Xq（Bn）, and obtain a weak Hopf algebra wXq（Bn）. Finally, we describe the Ext-quiver of wXq（Bn） as a coalgebra.
文摘Based on the features of the non-standard equipment executing work, a project management and decision support system oriented to the non-standard equipment is developed, and the information model, function model as well as the structure framework of the system are also introduced in this paper.
文摘In liver haemangiomas, the risk of complication rises with increasing size, and treatment can be obligatory. Here we present a case of a 46-year-old female who suffered from a giant haemangioma causing severe portal hypertension and vena cava compression, leading to therapy refractory ascites, hyponatremia and venostasis-associated thrombosis with pulmonary embolism. The patients did not experience tumour rupture or consumptive coagulopathy. Surgical resection was impossible because of steatosis of the non-affected liver. Orthotopic liver transplantation was identified as the only treatment option. The patient's renal function remained stable even though progressive morbidity and organ allocation were improbable according to the patient's lab model for end-stage liver disease(lab MELD) score. Therefore, non-standard exception status was approved by the European organ allocation network "Eurotransplant". The patient underwent successful orthotopic liver transplantation 16 mo after admission to our centre. Our case report indicates the underrepresentation of morbidity associated with refractory ascites in the lab MELD-based transplant allocation system, and it indicates the necessity of promptly applying for non-standard exception status to enable transplantation in patients with a severe clinical condition but low lab MELD score. Our case highlights the fact that liver transplantation should be considered early in patients with non-resectable, symptomatic benign liver tumours.
基金support of financing from the Research Project for the Development of the Department of Weapons and Ammunition, Faculty of Military Technology, University of Defence, Brno, DZRO K–201
文摘It follows from the analysis of artillery fire errors that approximately two-thirds of the inaccuracy of indirect artillery fire is caused by inaccuracies in the determination of the meteo parameters included in fire error budget model.Trajectories calculated under non-standard conditions are considered to be perturbed.The tools utilized for the analysis of perturbed trajectories are weighting factor functions(WFFs)which are a special kind of sensitivity functions.WFFs are used for calculation of meteo ballistic elements B(ballistic wind w B,densityρB,virtual temperatureτB,pressure p B)as well.We have found that the existing theory of WFF calculation has several significant shortcomings.The aim of the article is to present a new,improved theory of generalized WFFs that eliminates the deficiencies found.Using this theory will improve methods for designing firing tables,fire control systems algorithms,and meteo message generation algorithms.
基金Supported by Major Scientific Research Program of The Affiliated Hospital of Inner Mongolia Medical University,No. NYFY ZD 001
文摘BACKGROUND Only 50% of patients with type 2 diabetes mellitus(T2DM) can control their blood glucose levels. Dapagliflozin is a selective inhibitor of sodium-glucose cotransporter 2(SGLT-2) that improves the insulin sensitivity of the liver and peripheral tissues. Many studies confirmed that SGLT2 inhibitors reduce blood glucose and have multiple beneficial effects such as weight loss, lipid regulation, and kidney protection. Nevertheless, the mechanisms of the renal and cardiovascular protective effects of dapagliflozin from the perspective of differentially expressed proteins in the serum of T2DM patients have not been intensively explored so far.AIM To identify differentially expressed proteins associated with dapagliflozin treatment in patients with T2DM.METHODS Twenty T2DM patients [hemoglobin A1c(HbA1c) 7.0%-10.0%] were enrolled at The Affiliated Hospital of Inner Mongolia Medical University between January 1, 2017 and December 1, 2018. They received dapagliflozin(10 mg/d) for 3 mo, and the HbA1c < 7.0% target was achieved. The changes in clinical indexes were compared before and after treatments. Label-free quantitative proteomics was used to identify differentially expressed proteins using the serum samples of five patients. The identified differentially expressed proteins were analyzed using various bioinformatics tools.RESULTS Dapagliflozin significantly improved the clinical manifestation of the patients. There were 18 downregulated proteins and one upregulated protein in the serum samples of patients after dapagliflozin administration. Bioinformatics analyses, including subcellular localization, Eu Karyotic Orthologous Groups, Gene Ontology, and Kyoto Encyclopedia of Genes and Genomes annotations, were used to profile the biological characteristics of the 19 differentially expressed proteins. Based on the literature and function enrichment analysis, two downregulated proteins, myeloperoxidase(MPO) and alpha Ⅱ B integrin(ITGA2B), and one upregulated protein, podocalyxin(PCX), were selected for enzyme linked immunosorbent assay validation. These validated differentially expressed proteins had multiple correlations with clinical indexes, including Hb Ac1 and fasting C-peptide.CONCLUSION Dapagliflozin has hypoglycemic effects and regulates the serum expressions of MPO, ITGA2B, and PCX, possibly contributing to the effects of dapagliflozin on oxidative stress, insulin resistance, and lipid metabolism.
基金Supported by Key R&D Project of Hebei Province(19227516D)Hebei Provincial Phase II Modern Agricultural Industry Technology System Innovation Team Building Project(HBCT2018120207)+2 种基金Hebei Provincial Phase II Modern Agricultural Industry Technology System Grass Industry Innovation Team Building Project(HBCT2018160403)Hebei Provincial Science and Technology Innovation Leading Talents(21130243A)The Fourth Batch of High-end Talent Project in Hebei Province。
文摘[Objectives]This study was conducted to provide an accurate and reliable method for rapid high-throughput screening of veterinary drug preparations.[Methods]For the matrixes of veterinary drug preparations,high-performance liquid chromatography-high resolution quadrupole time-of-flight mass spectrometry(UPLC-QTOF/MS)was used to establish a fast screening method for 59 non-standard components in five categories of antiviral agents,aminoglycosides,quinolones,sulfonamides,and tetracyclines in veterinary drugs.The target drugs were separated by a Waters ACQUITY UPLC HSS T3 chromatographic column(50 mm×2.1 mm,1.8μm),and data were collected in the positive ion mode.Good separation of the 59 drugs was achieved within 7 min.[Results]In the concentration range of 0-100 ng/ml,each drug showed a good linear relationship,and the correlation coefficients were all greater than 0.999.The detection limits of the 59 drugs were in the range of 0.1-0.5 mg/ml,and the recovery under the addition concentration of 5 mg/ml was in the range of 85.2%-103.8%.[Conclusions]The method is fast,simple,accurate,and highly sensitive,and is suitable for high-throughput screening and qualitative identification of non-standard components in veterinary drug preparations.
文摘The purpose of this paper is to propose a synthesis method of parametric sensitivity constrained linear quadratic (SCLQ) controller for an uncertain linear time invariant (LTI) system. System sensitivity to parameter variation is handled through an additional quadratic trajectory parametric sensitivity term in the standard LQ criterion to be minimized. The main purpose here is to find a suboptimal linear quadratic control taking explicitly into account the parametric uncertainties. The paper main contribution is threefold: 1) A descriptor system approach is used to show that the underlying singular linear-quadratic optimal control problem leads to a non-standard Riccati equation. 2) A solution to the proposed control problem is then given based on a connection to the so-called Lur'e matrix equations. 3) A synthesis method of multiple parametric SCLQ controllers is proposed to cover the whole parametric uncertainty while degrading as less as possible the intrinsic robustness properties of each local linear quadratic controller. Some examples are presented in order to illustrate the effectiveness of the approach.
文摘The experimental investigation of unsteady complex flow fields in wind tunnels requires advanced measurement techniques. The most important of such image based measurement techniques are those for the measurement of planar flow velocity fields, planar pressure distribution, model location and deformation, model temperature and quantitative high speed flow visualization. The applications as carried out by DLR range from low speed flows to transonic flows, from high lift configurations to propellers and rotors, from wake vortex investigations in catapult facilities and water towing tanks to investigations of vortex break down phenomena on delta wings. The capability to use image based measurement techniques in transonic flows requires dedicated technical developments and experienced scientists due to the special environment of a transonic wind tunnel. In this paper an overview of the state-of-the art of the application of image based measurement techniques in transonic flows as performed by DLR＇s Institute of Aerodynamics and Flow Technology will be given.
基金supported in part by National Natural Science Foundation of China under Grant No.12075326 and No.11881240247by Guangdong Basic and Applied Basic Research Foundation under Grant No.2019A1515012216+1 种基金supported by China Postdoctoral Science Foundation under Grant No.2020M672930the support from the CAS Center for Excellence in Particle Physics(CCEPP)。
文摘We investigate prospects of building a future accelerator-based neutrino oscillation experiment in China,including site selection,beam optimization and tau neutrino physics aspects.CP violation,non-unitary mixing and non-standard neutrino interactions are discussed.We simulate neutrino beam setups based on muon and beta decay techniques and compare Chinese laboratory sites by their expected sensitivities.A case study on the Super Proton-Proton Collider and the China JinPing Laboratory is also presented.It is shown that the muon-decay-based beam setup can measure the Dirac CP phase by about 14.2°precision at 1σCL,whereas non-unitarity can be probed down to |α_(ij)|≲0.37(i≠j=1,2,3)and non-standard interactions to|ϵ_(ℓℓ′)^(m)|≲0.11(ℓ≠ℓ′=e,μ,τ)at 90% CL,respectively.
文摘In this paper, we consider an SIR-model for which the interaction term is the square root of the susceptible and infected individuals in the form of fractional order differential equations. First the non-negative solution of the model in fractional order is presented. Then the local stability analysis of the model in fractional order is discussed. Finally, the general solutions are presented and a discrete-time finite difference scheme is constructed using the nonstandard finite difference (NSFD) method. A comparative study of the classical Runge-Kutta method and ODE45 is presented in the case of integer order derivatives. The solutions obtained are presented graphically.
文摘Binary logistic regression models are commonly used to assess the association between outcomes and covariates. Many covariates are inherently continuous, and have a variety of distributions, including those that are heavily skewed to the left or right. Existing theoretical formulas, criteria, and simulation programs cannot accurately estimate the sample size and power of non-standard distributions. Therefore, we have developed a simulation program that uses Monte Carlo methods to estimate the exact power of a binary logistic regression model. This power calculation can be used for distributions of any shape and covariates of any type (continuous, ordinal, and nominal), and can account for nonlinear relationships between covariates and outcomes. For illustrative purposes, this simulation program is applied to real data obtained from a study on the influence of smoking on 90-day outcomes after acute atherothrombotic stroke. Our program is applicable to all effect sizes and makes it possible to apply various statistical methods, logistic regression and related simulations such as Bayesian inference with some modifications.
文摘We propose and analyze an epidemiological model to evaluate the effectiveness of bed nets as a prophylactic measure in malaria-endemic areas. The main purpose in this work is the modeling of the aggressiveness of anopheles mosquitoes relative to the way humans use to protect themselves against bites of mosquitoes. This model is a system of several differential equations: the number of equations depends on the particular assumptions of the model. We compute the basic reproduction number, and show that if, the disease free equilibrium (DFE) is globally asymptotically stable on the non-negative orthant. If, the system admits a unique endemic equilibrium (EE) that is globally and asymptotically stable. Numerical simulations are presented corresponding to scenarios typical of malaria-endemic areas, based on data collected in the literature. Finally, we discuss the relative effectiveness of different kinds of bed nets.
文摘Ordinary and high performance concrete （OC-C 25/30 and HPC C-50/60） made with fly ash has found numerous applications all over the world since 1970. In Kosovo, fly ash as cement substitution in concrete has not been utilized yet despite the large amount that is produced annually and the positive economical-environment aspects of such technique. This hesitance is due to the laek of experience in the concrete engineering field and because of the chemical composition of Kosovo fly ash, which is classified as non-standard high calcium fly ash （KF）. In light of this fact, this study intended to develop further. So, this paper reports the consistency, workability, shrinkage, high and ordinary compressive strength of concrete containing different percentage of non-class high calcium fly ash as Portland cement substitution （first case-Kosovo fly ash KF） comparing results with F class-low caleium fly ash content （second ease-Japanese fly ash JF） which is common used as cement replacement.
文摘Analysis of free fall and acceleration of the mass on the Earth shows that using abstract entities such as absolute space or inertial space to explain mass dynamics leads to the violation of the principle of action and reaction. Many scientists including Newton, Mach, and Einstein recognized that inertial force has no reaction that originates on mass. Einstein calls the lack of reaction to the inertial force a serious criticism of the space-time continuum concept. Presented is the hypothesis that the inertial force develops in an interaction of two masses via the force field. The inertial force created by such a field has reaction force. The dynamic gravitational field predicted is strong enough to be detected in the laboratory. This article describes the laboratory experiment which can prove or disprove the hypothesis of the dynamic gravitational field. The inertial force, calculated using the equation for the dynamic gravitational field, agrees with the behavior of inertial force observed in the experiments on the Earth. The movement of the planets in our solar system calculated using that equation is the same as that calculated using Newton’s method. The space properties calculated by the candidate equation explain the aberration of light and the results of light propagation experiments. The dynamic gravitational field can explain the discrepancy between the observed velocity of stars in the galaxy and those predicted by Newton’s theory of gravitation without the need for the dark matter hypothesis.
文摘Three classical compactification procedures are presented with nonstandard flavour. This is to illustrate the applicability of Nonstandard analytic tool to beginners interested in Nonstandard analytic methods. The general procedure is as follows: A suitable equivalence relation is defined on an enlargement <sup>*</sup>X of the space X which is a completely regular space or a locally compact Hausdorff space or a locally compact Abelian group. Accordingly, every f in C(X,R) (the space of bounded continuous real valued functions on X) or Cc(X,R) (the space of continuous real valued functions on X with compact support) or the dual group <span style="white-space:nowrap;">Γ of the locally compact Abelian group G is extended to the set <img alt="" src="Edit_b9535172-924d-44f0-bab3-c49db17a3b7a.png" /> of the above mentioned equivalence classes. A compact topology on <img alt="" src="Edit_9d7962a3-b8a3-4693-b62a-078c8c4b4853.png" /> is obtained as the weak topology generated by these extensions of f. Then X is naturally imbedded densely in <img alt="" src="Edit_f7d403b2-eff3-4555-b8e7-1b106e06d2e7.png" />.
文摘Two case studies,referring to historic Italian buildings housing city halls,provide an opportunity to investigate the design of non-standard elements aimed at protecting masonry vaults,with particular reference to the preliminary works prior to the actual structural restoration work.There is in fact a phase in which it is a priority to secure the vault to avert possible risks to the users of that portion of the building.This phase is temporarily intermediate between the detection and aggravation of injuries and the renovation and consolidation project.Although these are provisional works,they are intended for buildings that are often public and therefore intended for a wide range of users,such as schools,offices or monumental buildings.In analyzing traditional techniques and systems used in similar cases,the possibility of developing evolutionary aspects with respect to,above all,simple shoring techniques emerged.In these areas,hybrids between a structural and architectural project,it is possible to reconcile static requirements with architectural techniques of space management,attentive to the quality of the interior and the integration of the provisional work with the reference context.
