The primary objective of this study was to investigate the influence of high and low inclusions of nonbound amino acid(NBAA)in standard and reduced-crude protein(CP),wheat-based diets on growth performance in broiler ...The primary objective of this study was to investigate the influence of high and low inclusions of nonbound amino acid(NBAA)in standard and reduced-crude protein(CP),wheat-based diets on growth performance in broiler chickens.Dietary treatments were formulated to either 210 or 180 g/kg CP.The210 g/kg CP diets contained either 12.1 or 21.1 g/kg NBAA and 180 g/kg CP diets contained either 44.0 or55.5 g/kg NBAA.The formulations also generated different dietary starch:protein ratios which impacted on starch-protein digestive dynamics.Each of the four dietary treatments were offered to 7 replicates of15 birds housed in floor pens from 14 to 35 days post-hatch or a total of 420 male Ross 308 chickens.Growth performance,relative abdominal fat-pad weights,breast muscle and leg shank yields were determined.Ileal starch and protein(N)digestibility coefficients,disappearance rates and starch:protein disappearance rate ratios were defined.Apparent ileal digestibility coefficients and disappearance rates of 16 amino acids were determined at 35 days post-hatch and free concentrations of 20 amino acids in systemic plasma were determined at 34 days post-hatch.The transition from 210 to 180 g/kg CP diets depressed weight gain by 11.3%(1742 versus 1964 g/bird)and FCR by 10.4%(1.606 versus 1.455),although both parameters were subject to treatment interactions.The treatment interaction(P<0.001)observed for FCR was because high NBAA inclusions significantly improved FCR by 4.17%(1.424 versus1.486)in birds offered 210 g/kg CP diets,but significantly depressed FCR by 3.36%(1.632 versus 1.579)in180 g/kg CP diets.A quadratic relationship(r=0.860;P<0.001)between dietary NBAA inclusions and FCR was detected,which indicated that when NBAA inclusions exceed 18.5 g/kg efficiency of feed conversion deteriorated.However,a multiple linear regression(r=0.913;P<0.001)was detected for FCR where both NBAA inclusions and analysed dietary starch:protein ratios were significantly(P<0.001)related to FCR.This relationship indicates that growth performance of broiler chickens offered wheatbased diets is strongly influenced by dietary NBAA inclusions coupled with dietary starch:protein ratios and consideration is given to the possible underlying mechanisms.展开更多
随着柔性直流电网的发展,其边界结构将发生改变,从“有边界电网”转变为“无边界电网”。如果在配置保护时,能够在原理上尽量适用于两种边界结构,则可以大大降低电网结构变化时保护验证的繁复性、提升保护应用的经济性。为提升线路行波...随着柔性直流电网的发展,其边界结构将发生改变,从“有边界电网”转变为“无边界电网”。如果在配置保护时,能够在原理上尽量适用于两种边界结构,则可以大大降低电网结构变化时保护验证的繁复性、提升保护应用的经济性。为提升线路行波保护对不同边界结构的适用性,该文提出一种新型的行波保护方案。该保护方案主要通过非故障极电流首行波积分(first current integration of non-fault pole,FCINP)实现。基于FCINP在不同边界结构电网下的距离特性和边界特性,可有效地提升保护在有边界电网和无边界电网下的故障识别性能,从而提升保护适用性。所提保护在基于PSCAD/EMTDC直流电网仿真模型中进行了性能验证。展开更多
目的探究白蛋白结合型紫杉醇联合铂类化疗方案对晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)的疗效及毒性。方法选取2021年1月至2023年1月广元市中心医院收治的100例晚期NSCLC患者作为研究对象,按照随机数字表法分为对照组与...目的探究白蛋白结合型紫杉醇联合铂类化疗方案对晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)的疗效及毒性。方法选取2021年1月至2023年1月广元市中心医院收治的100例晚期NSCLC患者作为研究对象,按照随机数字表法分为对照组与研究组,每组50例。对照组应用紫杉醇联合顺铂治疗,研究组应用白蛋白结合型紫杉醇联合顺铂治疗。比较两组临床疗效、肿瘤标志物[癌胚抗原(carcinoembryonic antigen,CEA)、高迁移率族蛋白B1(high mobility group protein B1,HMGB1)、糖类抗原125(carbohydrate antigen 125,CA125)]、免疫功能指标(CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))、生命质量[欧洲癌症研究治疗组织癌症患者生命质量测定量表(European Organization for Research and Treatment of Cancer quality of life questionnaire core 30,EORTC QLQ-C30)]及毒副作用发生情况。结果治疗后,两组均无完全缓解病例,研究组治疗总有效率为44.00%,高于对照组的26.00%,但整体疗效比较差异无统计学意义;治疗后,两组CEA、HMGB1、CA125水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);治疗后,两组CD4^(+)水平及CD4^(+)/CD8^(+)均低于治疗前,CD8^(+)水平均高于治疗前,差异有统计学意义(P<0.05),但组间比较差异无统计学意义;治疗后,两组疲劳、恶心呕吐、疼痛评分均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);治疗期间两组无5级病例,研究组毒副作用低于对照组,差异有统计学意义(P<0.05)。结论白蛋白结合型紫杉醇联合铂类化疗方案治疗晚期NSCLC患者疗效显著,可有效降低其血清中肿瘤标志物水平,增强患者机体免疫功能,降低毒副作用,提升患者生命质量。展开更多
基金AgriFutures Chicken-meat for funding the project “Optimising amino acid profiles and energy in reducedprotein diets”(PRJ010520)the financial support provided by Australian Government Research Training Program Scholarship (RTP) received by PhD student Mr Shemil Macelline
文摘The primary objective of this study was to investigate the influence of high and low inclusions of nonbound amino acid(NBAA)in standard and reduced-crude protein(CP),wheat-based diets on growth performance in broiler chickens.Dietary treatments were formulated to either 210 or 180 g/kg CP.The210 g/kg CP diets contained either 12.1 or 21.1 g/kg NBAA and 180 g/kg CP diets contained either 44.0 or55.5 g/kg NBAA.The formulations also generated different dietary starch:protein ratios which impacted on starch-protein digestive dynamics.Each of the four dietary treatments were offered to 7 replicates of15 birds housed in floor pens from 14 to 35 days post-hatch or a total of 420 male Ross 308 chickens.Growth performance,relative abdominal fat-pad weights,breast muscle and leg shank yields were determined.Ileal starch and protein(N)digestibility coefficients,disappearance rates and starch:protein disappearance rate ratios were defined.Apparent ileal digestibility coefficients and disappearance rates of 16 amino acids were determined at 35 days post-hatch and free concentrations of 20 amino acids in systemic plasma were determined at 34 days post-hatch.The transition from 210 to 180 g/kg CP diets depressed weight gain by 11.3%(1742 versus 1964 g/bird)and FCR by 10.4%(1.606 versus 1.455),although both parameters were subject to treatment interactions.The treatment interaction(P<0.001)observed for FCR was because high NBAA inclusions significantly improved FCR by 4.17%(1.424 versus1.486)in birds offered 210 g/kg CP diets,but significantly depressed FCR by 3.36%(1.632 versus 1.579)in180 g/kg CP diets.A quadratic relationship(r=0.860;P<0.001)between dietary NBAA inclusions and FCR was detected,which indicated that when NBAA inclusions exceed 18.5 g/kg efficiency of feed conversion deteriorated.However,a multiple linear regression(r=0.913;P<0.001)was detected for FCR where both NBAA inclusions and analysed dietary starch:protein ratios were significantly(P<0.001)related to FCR.This relationship indicates that growth performance of broiler chickens offered wheatbased diets is strongly influenced by dietary NBAA inclusions coupled with dietary starch:protein ratios and consideration is given to the possible underlying mechanisms.
文摘随着柔性直流电网的发展,其边界结构将发生改变,从“有边界电网”转变为“无边界电网”。如果在配置保护时,能够在原理上尽量适用于两种边界结构,则可以大大降低电网结构变化时保护验证的繁复性、提升保护应用的经济性。为提升线路行波保护对不同边界结构的适用性,该文提出一种新型的行波保护方案。该保护方案主要通过非故障极电流首行波积分(first current integration of non-fault pole,FCINP)实现。基于FCINP在不同边界结构电网下的距离特性和边界特性,可有效地提升保护在有边界电网和无边界电网下的故障识别性能,从而提升保护适用性。所提保护在基于PSCAD/EMTDC直流电网仿真模型中进行了性能验证。
文摘目的探究白蛋白结合型紫杉醇联合铂类化疗方案对晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)的疗效及毒性。方法选取2021年1月至2023年1月广元市中心医院收治的100例晚期NSCLC患者作为研究对象,按照随机数字表法分为对照组与研究组,每组50例。对照组应用紫杉醇联合顺铂治疗,研究组应用白蛋白结合型紫杉醇联合顺铂治疗。比较两组临床疗效、肿瘤标志物[癌胚抗原(carcinoembryonic antigen,CEA)、高迁移率族蛋白B1(high mobility group protein B1,HMGB1)、糖类抗原125(carbohydrate antigen 125,CA125)]、免疫功能指标(CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))、生命质量[欧洲癌症研究治疗组织癌症患者生命质量测定量表(European Organization for Research and Treatment of Cancer quality of life questionnaire core 30,EORTC QLQ-C30)]及毒副作用发生情况。结果治疗后,两组均无完全缓解病例,研究组治疗总有效率为44.00%,高于对照组的26.00%,但整体疗效比较差异无统计学意义;治疗后,两组CEA、HMGB1、CA125水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);治疗后,两组CD4^(+)水平及CD4^(+)/CD8^(+)均低于治疗前,CD8^(+)水平均高于治疗前,差异有统计学意义(P<0.05),但组间比较差异无统计学意义;治疗后,两组疲劳、恶心呕吐、疼痛评分均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);治疗期间两组无5级病例,研究组毒副作用低于对照组,差异有统计学意义(P<0.05)。结论白蛋白结合型紫杉醇联合铂类化疗方案治疗晚期NSCLC患者疗效显著,可有效降低其血清中肿瘤标志物水平,增强患者机体免疫功能,降低毒副作用,提升患者生命质量。
