The core point of"Wuwei(non-action)"in the Dao De Jing is not passive inaction,but the concrete manifestation of"Dao",and the core point is to conform to the essential laws of things,reduce excessi...The core point of"Wuwei(non-action)"in the Dao De Jing is not passive inaction,but the concrete manifestation of"Dao",and the core point is to conform to the essential laws of things,reduce excessive subjective intervention,and stimulate the subject's self-potential.After being interpreted through the lens of modernity,this philosophy can be deeply integrated into the field of contemporary Chinese educational management,providing key theoretical support and practical pathways to address current challenges such as"over-administration"and the"weakening of teacher and student subjectivity".As a typical example of the application of the Wuwei(non-action)principle,library management—through"autonomous services that follow the natural patterns of readers'needs","flexible spatial management that minimizes redundant interventions",and"empowermentbased governance that stimulates librarians'potential"—has demonstrated the practical feasibility of the Wuwei(non-action)philosophy.Transferring its core logic to modern education management can promote the transformation of the management model from"control"to"empowerment",and help education return to the essence of"promoting the all-round development of people".展开更多
为解决实振型分解反应谱法采用强迫解耦处理调谐质量阻尼器(tuned mass damper,TMD)减震结构具有非比例的阻尼矩阵及计算精度较差的问题,引入复模态理论,利用复振型在状态空间中的正交性和叠加性,并基于复完全平方组合(complex complete...为解决实振型分解反应谱法采用强迫解耦处理调谐质量阻尼器(tuned mass damper,TMD)减震结构具有非比例的阻尼矩阵及计算精度较差的问题,引入复模态理论,利用复振型在状态空间中的正交性和叠加性,并基于复完全平方组合(complex complete quadratic combination,CCQC)法和反应谱,提出一套适用于剪切型TMD减震结构的复振型分解反应谱方法。为匹配抗震规范,基于复振型的复共轭特性以及参数矩阵与状态方程系数矩阵间的关系,推导出实数形式的标准地震作用表达。通过数值分析比较实振型和复振型2种反应谱法的误差发现,实振型误差大于10%,复振型误差在5%以内。研究表明:复振型方法考虑了非比例阻尼和振型速度的影响,比实振型方法具有更高的计算精度和稳定性。匹配规范形式的标准地震作用表达式,可使用设计反应谱,形式简单易用。展开更多
目的该研究旨在探究桑叶中的有效成分对非酒精性脂肪肝的保护作用、作用机制及效果验证。方法通过中药系统药理学数据库与分析平台(Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform,TCMSP)、Swiss A...目的该研究旨在探究桑叶中的有效成分对非酒精性脂肪肝的保护作用、作用机制及效果验证。方法通过中药系统药理学数据库与分析平台(Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform,TCMSP)、Swiss ADME及Swiss Target Prediction数据库获取桑叶成分及靶点。通过Gene Cards、在线人类孟德尔遗传(Online Mendelian Inheritance in Man,OMIM)和药物靶标数据库(Therapeutic Target Database,TTD)数据库获取非酒精性脂肪肝靶基因,通过String数据库构建蛋白质相互作用关系网络。利用Metastases数据库执行基因本体(Gene Ontology,GO)功能富集和京都基因与基因组百科全书(Kyoto Encyclopedia of Genes and Genomes,KEGG)通路富集分析。利用Cytoscape 3.10.1软件构建桑叶保护非酒精性脂肪肝的“药效成分-靶点-途径”互作网络,并筛选出桑叶有效成分和关键靶点,并通过Auto Dock Tools软件进行分子对接。基于网络药理学和分子对接结果,采用体外细胞实验初步验证预测结果。结果网络药理学结果共获得16个桑叶活性成分和376个靶点,非酒精性脂肪肝靶点2315个。蛋白互作网络拓扑分析结果表明ESR1、AKT1等为桑叶抗非酒精性脂肪肝的关键靶点。GO和KEGG富集分析显示,桑叶抗非酒精性脂肪肝作用涉及1584个条目和176个通路。分子对接结果提示山柰酚是桑叶抗非酒精性脂肪肝的关键有效成分之一。通过体外细胞试验结果验证,山柰酚能有效降低油酸诱导的非酒精性脂肪肝细胞中甘油三酯含量,减少细胞脂滴的形成,从而发挥保护肝脏作用。结论该研究通过网络药理学、分子对接技术和细胞实验的结果可以分析并推断中药桑叶可通过多成分、多靶点的方式对非酒精性脂肪肝起到预防作用。其中山柰酚作为关键有效成分之一,可为进一步利用桑叶开发保护非酒精性脂肪肝相关药物提供依据及参考。展开更多
文摘The core point of"Wuwei(non-action)"in the Dao De Jing is not passive inaction,but the concrete manifestation of"Dao",and the core point is to conform to the essential laws of things,reduce excessive subjective intervention,and stimulate the subject's self-potential.After being interpreted through the lens of modernity,this philosophy can be deeply integrated into the field of contemporary Chinese educational management,providing key theoretical support and practical pathways to address current challenges such as"over-administration"and the"weakening of teacher and student subjectivity".As a typical example of the application of the Wuwei(non-action)principle,library management—through"autonomous services that follow the natural patterns of readers'needs","flexible spatial management that minimizes redundant interventions",and"empowermentbased governance that stimulates librarians'potential"—has demonstrated the practical feasibility of the Wuwei(non-action)philosophy.Transferring its core logic to modern education management can promote the transformation of the management model from"control"to"empowerment",and help education return to the essence of"promoting the all-round development of people".
文摘目的该研究旨在探究桑叶中的有效成分对非酒精性脂肪肝的保护作用、作用机制及效果验证。方法通过中药系统药理学数据库与分析平台(Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform,TCMSP)、Swiss ADME及Swiss Target Prediction数据库获取桑叶成分及靶点。通过Gene Cards、在线人类孟德尔遗传(Online Mendelian Inheritance in Man,OMIM)和药物靶标数据库(Therapeutic Target Database,TTD)数据库获取非酒精性脂肪肝靶基因,通过String数据库构建蛋白质相互作用关系网络。利用Metastases数据库执行基因本体(Gene Ontology,GO)功能富集和京都基因与基因组百科全书(Kyoto Encyclopedia of Genes and Genomes,KEGG)通路富集分析。利用Cytoscape 3.10.1软件构建桑叶保护非酒精性脂肪肝的“药效成分-靶点-途径”互作网络,并筛选出桑叶有效成分和关键靶点,并通过Auto Dock Tools软件进行分子对接。基于网络药理学和分子对接结果,采用体外细胞实验初步验证预测结果。结果网络药理学结果共获得16个桑叶活性成分和376个靶点,非酒精性脂肪肝靶点2315个。蛋白互作网络拓扑分析结果表明ESR1、AKT1等为桑叶抗非酒精性脂肪肝的关键靶点。GO和KEGG富集分析显示,桑叶抗非酒精性脂肪肝作用涉及1584个条目和176个通路。分子对接结果提示山柰酚是桑叶抗非酒精性脂肪肝的关键有效成分之一。通过体外细胞试验结果验证,山柰酚能有效降低油酸诱导的非酒精性脂肪肝细胞中甘油三酯含量,减少细胞脂滴的形成,从而发挥保护肝脏作用。结论该研究通过网络药理学、分子对接技术和细胞实验的结果可以分析并推断中药桑叶可通过多成分、多靶点的方式对非酒精性脂肪肝起到预防作用。其中山柰酚作为关键有效成分之一,可为进一步利用桑叶开发保护非酒精性脂肪肝相关药物提供依据及参考。
