BACKGROUND The progression of non-alcoholic fatty liver disease(NAFLD)to non-alcoholic steatohepatitis(NASH)and liver fibrosis remains poorly understood,though liver sinusoidal endothelial cells(LSECs)are thought to p...BACKGROUND The progression of non-alcoholic fatty liver disease(NAFLD)to non-alcoholic steatohepatitis(NASH)and liver fibrosis remains poorly understood,though liver sinusoidal endothelial cells(LSECs)are thought to play a central role in disease pathogenesis.AIM To investigate the role of TSC22D1 in NAFLD fibrosis through its regulation of LSEC dysfunction and macrophage polarization.METHODS We analysed single-cell transcriptomic data(GSE129516)from NASH and normal INTRODUCTION Non-alcoholic fatty liver disease(NAFLD)is a global health issue associated with increasing rates of obesity and metabolic syndrome.NAFLD encompasses a spectrum of conditions,ranging from simple steatosis to more severe manifestations such as non-alcoholic steatohepatitis(NASH),fibrosis,cirrhosis,and hepatocellular carcinoma.Liver fibrosis represents a critical stage in NAFLD progression because of its strong association with impaired liver function,progression to end-stage liver disease,and increased disease-related mortality[1].The pathogenesis of NAFLD is multifactorial and involves complex interactions between genetic predispositions,insulin resistance,dietary factors,and chronic inflammation[2].Liver sinusoidal endothelial cells(LSECs),which are highly specialized endothelial cells lining the hepatic sinusoids,critically contribute to both the pathogenesis and progression of NAFLD[3,4].In NAFLD,LSECs undergo structural alterations such as reduced fenestrations,which impair hepatic microcirculation and hinder the exchange of lipids and other substances,thereby promoting lipid accumulation in hepatocytes[5].Furthermore,dysfunctional LSECs exacerbate hepatic inflammation and fibrogenesis by releasing pro-inflammatory cytokines and fibrogenic mediators,such as transforming growth factor-β(TGF-β).These factors activate hepatic stellate cells(HSCs),resulting in the pathological accumulation of extracellular matrix components[6].LSECs are also highly susceptible to oxidative stress,further aggravating hepatic injury[7,8].Importantly,LSECs influence macrophage polarization by producing chemotactic and immunomodulatory factors,thereby promoting the recruitment and activation of M1-type pro-inflammatory CONCLUSION In conclusion,this study provides a comprehensive understanding of the role of TSC22D1 in the pathogenesis of NAFLD fibrosis.We elucidated the mechanisms through which TSC22D1 drives LSEC microvascularization and EndMT,as well as its role in promoting the secretion of TWEAK,which induces macrophage polarization towards the M1 phenotype.These findings offer novel insights into the pathophysiology of NAFLD,particularly the interplay between endothelial dysfunction,inflammation,and fibrosis.Importantly,our results highlight the potential of TSC22D1 as a therapeutic target for NAFLD.Future research should focus on validating these mechanisms in human clinical cohorts and deve-loping targeted interventions,such as TSC22D1 inhibitors or modulators of the TWEAK/FN14 signalling pathway,to translate these findings into effective treatments for NAFLD progression to fibrosis.展开更多
Linear active noise control (ANC) system is promising in suppressing broadband and narrowband noise in a linear acoustic site.However,in some situations,the acoustic systems are nonlinear which make the primary noise ...Linear active noise control (ANC) system is promising in suppressing broadband and narrowband noise in a linear acoustic site.However,in some situations,the acoustic systems are nonlinear which make the primary noise being nonlinear distortion at the canceling point,and the linear ANC system maybe can not work well for these cases.This paper presents an adaptive network-based fuzzy inference system (ANFIS)-based nonlinear filter for active noise control,which is expected to be successfully applied to situations with nonlinear distortion.In the proposed adaptive control algorithm,the parameters are updated by gradient descent method.In the simulations,the secondary-path FIR model coefficients are estimated in advance by off-line system identification method,and one case for sinusoidal primary noise with nonlinear distortion is presented,which verifies the effectiveness of the proposed system in suppressing sinusoidal noise generated by rotating machines,e.g.,engines in vehicles.展开更多
To improve the slab quality, a kind of non-sinusoidal oscillation technique of mold driven by elliptic gears was developed. The waveform functions of non-sinusoidal oscillation were determined, and the calculation met...To improve the slab quality, a kind of non-sinusoidal oscillation technique of mold driven by elliptic gears was developed. The waveform functions of non-sinusoidal oscillation were determined, and the calculation method and curves of technological parameters for non-sinusoidal oscillation were given. At the case of waveform deviation factor a equal to 0.31 and oscillation amplitude h equal to ±2.7 mm, the relationship between oscillation frequency and casting speed is determined, and the technological parameters for non-sinusoidal oscillation are calculated. The testing results of industrial application indicated that this technique could not only improve the Slab surface quality, but also reduce the steel breakout.展开更多
A new non-sinusoidal oscillation waveform is constructed for controlling themold oscillation during continuous casting. Casting velocity and oscillation parameters are thenestablished for a computer model of the conti...A new non-sinusoidal oscillation waveform is constructed for controlling themold oscillation during continuous casting. Casting velocity and oscillation parameters are thenestablished for a computer model of the continuous casting process. The waveform distortioncoefficient ? of waveform function is close to the waveform distortion rate a, so s is taken for awhen the basic parameters are selected initially. The waveform function can be created for the servohydraulic system or the mechanical driving system. Industrial scale experiments show the waveformfunction is effective.展开更多
Due to the disadvantages of complexity,high maintenance and vast investment of the electro-hydraulic servo oscillator,a new mechanical device synchronously driven by double servomotors was proposed. The working princi...Due to the disadvantages of complexity,high maintenance and vast investment of the electro-hydraulic servo oscillator,a new mechanical device synchronously driven by double servomotors was proposed. The working principle of the non-sinusoidal oscillator was analyzed and the model of the oscillator was validated via simulation software.Then,taking advantage of resonance technology,the hinging force and moment were calculated. The results showed that the hinging force and driving moment reduced,which was useful in reducing the impact of the hinge and prolonging the service life of the bearing. Besides,the best initial spring pressure was 0. 9 times the mold gravity,which improved the oscillation system stability and reduced the load fluctuation and servomotor driving power.展开更多
The investments of the electro-hydraulic servo system of the mold non-sinusoidal oscillator are great, the modification ratio of the mechanical type is unable to be adjusted online, and some continuous casters suffer ...The investments of the electro-hydraulic servo system of the mold non-sinusoidal oscillator are great, the modification ratio of the mechanical type is unable to be adjusted online, and some continuous casters suffer from server resonance during the casting. A mold non-sinusoidal oscillation mechanism driven by servomotor is proposed and the prototype is produced in the lab, the investment is low and the modification ratio is can be adjusted online, and the stability problem is studied. At first the dynamics model of the servomotor non-sinusoidal oscillation is established, and the kinematics differential function is deduced. Furthermore, based on the harmonic balance method, the eigenvalues of the system are solved; the criterion of the stability of the system is put forward. In addition, the eigenvalues and harmonic with different oscillating parameters are analyzed. Analytical results show that the real parts of the eigenvalues are positive, the system will be unstable, and the resonance will occur when the positive real parts of the eigenvalues are extremum. A foundation is established for solving the running smooth problem and next application of this mechanism.展开更多
The line side winding is under the fundamental frequency AC voltage, while the valve side winding contains not only fundamental AC voltage component, but also the DC voltage component, fundamental AC voltage component...The line side winding is under the fundamental frequency AC voltage, while the valve side winding contains not only fundamental AC voltage component, but also the DC voltage component, fundamental AC voltage component, and higher harmonic voltage components when the converter transformer is at its normal operating condition, and the electric field of converter transformer is a non-sinusoidal steady one. To analyze the non-sinusoidal steady electric field containing the DC component, fundamental AC and higher harmonic components, the voltage spectrum of the valve winding in a ±500 kV converter transformer is firstly analyzed, and the non-sinusoidal periodic steady electric field is obtained by the fast discrete Fourier transform. Different resistivity of the oil and oil-immersed paper is adopted to simulate the aging of oil paper insulation at operation, and get the non-sinusoidal steady electric field.展开更多
AIM To characterize isolated non-obstructive sinusoidal dilatation(SD) by identifying associated conditions, laboratory findings, and histological patterns. METHODS Retrospectively reviewed 491 patients with SD betwee...AIM To characterize isolated non-obstructive sinusoidal dilatation(SD) by identifying associated conditions, laboratory findings, and histological patterns. METHODS Retrospectively reviewed 491 patients with SD between 1995 and 2015. Patients with obstruction at the level of the small/large hepatic veins, portal veins, or right-sided heart failure were excluded along with history of cirrhosis, hepatic malignancy, liver transplant, or absence of electrocardiogram/cardiac echocardiogram. Liver histology was reviewed for extent of SD, fibrosis, red blood cell extravasation, nodular regenerative hyperplasia, hepaticpeliosis, and hepatocellular plate atrophy(HPA). RESULTS We identified 88 patients with non-obstructive SD. Inflammatory conditions(32%) were the most common cause. The most common pattern of liver abnormalities was cholestatic(76%). Majority(78%) had localized SD to Zone Ⅲ. Medication-related SD had higher proportion of portal hypertension(53%), ascites(58%), and median AST(113 U/L) and ALT(90 U/L) levels. Nineteen patients in our study died within one-year after diagnosis of SD, majority from complications related to underlying diseases.CONCLUSION Significant proportion of SD and HPA exist without impaired hepatic venous outflow. Isolated SD on liver biopsy, in the absence of congestive hepatopathy, requires further evaluation and portal hypertension should be rule out.展开更多
Quantum key distribution(QKD)achieves information-theoretic security based on quantum mechanics principles,where single-photon detectors(SPDs)serve as critical components.This study focuses on the sinusoidal gated SPD...Quantum key distribution(QKD)achieves information-theoretic security based on quantum mechanics principles,where single-photon detectors(SPDs)serve as critical components.This study focuses on the sinusoidal gated SPDs widely used in high-speed QKD systems.We investigate the mechanisms underlying the rising-edge jitter in detection signals,identifying contributions from factors such as the temporal width of injected optical pulses,avalanche generation processes,avalanche signal extraction,and pulse discrimination.To address the issue of excessive jitter-induced bit errors,we propose a retiming scheme that utilizes coincidence signals synchronized with the sinusoidal gating signal.This approach effectively suppresses detection signal jitter and reduces the after-pulse probability of the detector.Experimental validation using a high-precision time-to-digital converter(TDC)demonstrates a significant reduction in the rising-edge jitter distribution after applying the suppression scheme.The proposed method features clear principles and straightforward engineering implementation,avoiding direct interference with the detector’s operational processes.The designed high-speed sinusoidal gated InGaAs/InP SPD operates at 1.25 GHz,achieving a remarkable reduction in after-pulse probability from 10.7%(without jitter suppression)to 0.72%,thereby enhancing the overall performance of QKD systems.展开更多
Sine Non-linear Chirp Keying(SNCK) is a kind of high-efficient modulation scheme, which provides a potential new beamforming method in communication and radar systems. It has been proved to have advantages in some par...Sine Non-linear Chirp Keying(SNCK) is a kind of high-efficient modulation scheme, which provides a potential new beamforming method in communication and radar systems. It has been proved to have advantages in some parameter estimation issues over conventional modulation schemes. In this paper, a novel transform termed as Discrete Sinusoidal Frequency Modulation transform(DSFMT) is proposed. Then, the DSFMT of SNCK signal is deduced and classified into three types, based on which, the time-bandwidth product is estimated by the proposed algorithm. Simulation results show that the noise has a signifi cant impact on the localization of the peak value and the time-bandwidth product can be estimated by using local ratio values when.展开更多
In this paper an attempt has been made to find the aperture field distribution in a rectangular waveguide for non-sinusoidal, periodic excitations using Multiple Cavity Modeling Technique. The excitation functions, co...In this paper an attempt has been made to find the aperture field distribution in a rectangular waveguide for non-sinusoidal, periodic excitations using Multiple Cavity Modeling Technique. The excitation functions, considered, are square, trapezoidal and clipped sine wave in nature. In the present analysis these time domain excitation functions have been represented in terms of a truncated Fourier series consisting of the fundamental frequency and its higher harmonics. Within the waveguide the fundamental frequency will give rise to a dominant mode excitation whereas the higher order modes will excite dominant as higher order modes. If the higher harmonics are assumed suppressed then the waveguide is subjected only to a dominant mode excitation. Results for dominant mode reflection coefficient (magnitude), VSWR and complex transmission coefficient have been computed and compared with theoretical data. The excellent agreement between them validates the analysis.展开更多
Optical non-reciprocity is a fundamental phenomenon in photonics.It is crucial for developing devices that rely on directional signal control,such as optical isolators and circulators.However,most research in this fie...Optical non-reciprocity is a fundamental phenomenon in photonics.It is crucial for developing devices that rely on directional signal control,such as optical isolators and circulators.However,most research in this field has focused on systems in equilibrium or steady states.In this work,we demonstrate a room-temperature Rydberg atomic platform where the unidirectional propagation of light acts as a switch to mediate time-crystalline-like collective oscillations through atomic synchronization.展开更多
Vitamin D deficiency(VDD)represents a significant nutritional concern among children and adolescents.The estimated prevalence of VDD in China is 46.8%in this population^([1]).VDD during childhood and adolescence has b...Vitamin D deficiency(VDD)represents a significant nutritional concern among children and adolescents.The estimated prevalence of VDD in China is 46.8%in this population^([1]).VDD during childhood and adolescence has been associated with the onset of various conditions,including acute respiratory infections,asthma,atopic dermatitis,and food allergies^([2]).Multiple factors,including age,sun exposure,adiposity,and genetics,influence vitamin D levels^([2,3]).Increasing attention has been directed toward understanding the environmental determinants that may influence vitamin D status.Given the potential of metallic pollutants to disrupt endocrine function and their ubiquity in the environment,investigating the effects of metal exposure on human vitamin D status,particularly in vulnerable populations,is imperative.展开更多
Hepatic sinusoidal obstruction syndrome (HSOS) can be caused by the intake of pyrrolizidine alkaloids (PAs). To date, PAs-induced HSOS has not been extensively studied. In view of the difference in etiology of HSOS be...Hepatic sinusoidal obstruction syndrome (HSOS) can be caused by the intake of pyrrolizidine alkaloids (PAs). To date, PAs-induced HSOS has not been extensively studied. In view of the difference in etiology of HSOS between the West and China, clinical profiles, imaging findings, treatment, and outcomes of HSOS associated with hematopoietic stem cell transplantation or oxaliplatin might be hardly extrapolated to PAs-induced HSOS. Reactive metabolites derived from PAs form pyrrole-protein adducts that result in toxic destruction of hepatic sinusoidal endothelial cells. PAs-induced HSOS typically manifests as painful hepatomegaly, ascites, and jaundice. Laboratory tests revealed abnormal liver function tests were observed in most of the patients with PAs-induced HSOS. In addition, contrast computed tomography and magnetic resonance imaging scan show that patients with PAs-induced HSOS have distinct imaging features, which reveal that radiological imaging provides an effective noninvasive method for the diagnosis of PAs-induced HSOS. Liver biopsy and histological examination showed that PAs-induced HSOS displayed distinct features in acute and chronic stages. Therapeutic strategies for PAs-induced HSOS include rigorous fluid management, anticoagulant therapy, glucocorticoids, transjugular intrahepatic portosystemic shunt, liver transplantation, etc. The aim of this review is to describe the pathogenesis, clinical profiles, diagnostic criteria, treatment, and outcomes of PAs-induced HSOS.展开更多
Sinusoidal obstruction syndrome(SOS), previously known as hepatic veno-occlusive disease, is a rare disorder in solid organ transplant patients, and is an uncommon complication after liver transplantation. Severe SOS ...Sinusoidal obstruction syndrome(SOS), previously known as hepatic veno-occlusive disease, is a rare disorder in solid organ transplant patients, and is an uncommon complication after liver transplantation. Severe SOS with hepatic failure causes considerable mortality. Tacrolimus has been reported to be an offending agent, which potentially plays a role in the pathophysiological process of SOS. SOS due to tacrolimus has been reported in lung and pancreatic transplantations, but has never been described in a liver transplant recipient. Herein, we present a case of SOS after liver transplantation, which was possibly related to tacrolimus. A 27-year-old man developed typical symptoms of SOS with painful hepatomegaly, ascites and jaundice after liver transplantation, which regressed following withdrawal of tacrolimus. By excluding other possible predisposing factors, we concluded that tacrolimus was the most likely cause of SOS.展开更多
The linear systems affected by additive external sinusoidal disturbances is studied. The problem is to damp this forced oscillation in an optimal fashion. The main result of this paper is a new design approach is prop...The linear systems affected by additive external sinusoidal disturbances is studied. The problem is to damp this forced oscillation in an optimal fashion. The main result of this paper is a new design approach is proposed of realizable feedforward and feedback optimal control law for a linear time invariant system with sinusoidal disturbances. The algorithm of solving the optimal control law is given. It is shown that the control law is easily realized and is robust with respect to errors produced by the external sinusoidal disturbances through simulation results.展开更多
The hepatic sinusoids are lined by a unique population of hepatic sinusoidal endothelial cells (HSEC), which is one of the first hepatic cell populations to come into contact with blood components. However, HSEC are n...The hepatic sinusoids are lined by a unique population of hepatic sinusoidal endothelial cells (HSEC), which is one of the first hepatic cell populations to come into contact with blood components. However, HSEC are not simply barrier cells that restrict the access of blood- borne compounds to the parenchyma. They are func- tionally specialised endothelial cells that have complex roles, including not only receptor-mediated clearance of endotoxin, bacteria and other compounds, but also the regulation of inflammation, leukocyte recruitment and host immune responses to pathogens. Thus understand- ing the differentiation and function of HSEC is critical for the elucidation of liver biology and pathophysiology. This article reviews methods for isolating and studying human hepatic endothelial cell populations using in vitro models. We also discuss the expression and functions of phe- notypic markers, such as the presence of fenestrations and expression of VAP-1, Stabilin-1, L-SIGN, which can be used to identify sinusoidal endothelium and to permit discrimination from vascular and lymphatic endothelial cells.展开更多
基金Supported by the Changzhou Science and Techology Program,No.CJ20241048Changzhou High-Level Medical Talents Training Project,No.2022CZBJ105+1 种基金Development Foundation of the Affiliated Hospital of Xuzhou Medical University,No.XYFC202304 and No.XYFM202307The Open Project of Jiangsu Provincial Key Laboratory of Laboratory Medicine,No.JSKLM-Z-2024-002.
文摘BACKGROUND The progression of non-alcoholic fatty liver disease(NAFLD)to non-alcoholic steatohepatitis(NASH)and liver fibrosis remains poorly understood,though liver sinusoidal endothelial cells(LSECs)are thought to play a central role in disease pathogenesis.AIM To investigate the role of TSC22D1 in NAFLD fibrosis through its regulation of LSEC dysfunction and macrophage polarization.METHODS We analysed single-cell transcriptomic data(GSE129516)from NASH and normal INTRODUCTION Non-alcoholic fatty liver disease(NAFLD)is a global health issue associated with increasing rates of obesity and metabolic syndrome.NAFLD encompasses a spectrum of conditions,ranging from simple steatosis to more severe manifestations such as non-alcoholic steatohepatitis(NASH),fibrosis,cirrhosis,and hepatocellular carcinoma.Liver fibrosis represents a critical stage in NAFLD progression because of its strong association with impaired liver function,progression to end-stage liver disease,and increased disease-related mortality[1].The pathogenesis of NAFLD is multifactorial and involves complex interactions between genetic predispositions,insulin resistance,dietary factors,and chronic inflammation[2].Liver sinusoidal endothelial cells(LSECs),which are highly specialized endothelial cells lining the hepatic sinusoids,critically contribute to both the pathogenesis and progression of NAFLD[3,4].In NAFLD,LSECs undergo structural alterations such as reduced fenestrations,which impair hepatic microcirculation and hinder the exchange of lipids and other substances,thereby promoting lipid accumulation in hepatocytes[5].Furthermore,dysfunctional LSECs exacerbate hepatic inflammation and fibrogenesis by releasing pro-inflammatory cytokines and fibrogenic mediators,such as transforming growth factor-β(TGF-β).These factors activate hepatic stellate cells(HSCs),resulting in the pathological accumulation of extracellular matrix components[6].LSECs are also highly susceptible to oxidative stress,further aggravating hepatic injury[7,8].Importantly,LSECs influence macrophage polarization by producing chemotactic and immunomodulatory factors,thereby promoting the recruitment and activation of M1-type pro-inflammatory CONCLUSION In conclusion,this study provides a comprehensive understanding of the role of TSC22D1 in the pathogenesis of NAFLD fibrosis.We elucidated the mechanisms through which TSC22D1 drives LSEC microvascularization and EndMT,as well as its role in promoting the secretion of TWEAK,which induces macrophage polarization towards the M1 phenotype.These findings offer novel insights into the pathophysiology of NAFLD,particularly the interplay between endothelial dysfunction,inflammation,and fibrosis.Importantly,our results highlight the potential of TSC22D1 as a therapeutic target for NAFLD.Future research should focus on validating these mechanisms in human clinical cohorts and deve-loping targeted interventions,such as TSC22D1 inhibitors or modulators of the TWEAK/FN14 signalling pathway,to translate these findings into effective treatments for NAFLD progression to fibrosis.
基金Sponsored by the National Natural Science Foundation of China (Grant No.61171183)the Natural Science Foundation of Heilongjiang Province (Grant No.F201027)
文摘Linear active noise control (ANC) system is promising in suppressing broadband and narrowband noise in a linear acoustic site.However,in some situations,the acoustic systems are nonlinear which make the primary noise being nonlinear distortion at the canceling point,and the linear ANC system maybe can not work well for these cases.This paper presents an adaptive network-based fuzzy inference system (ANFIS)-based nonlinear filter for active noise control,which is expected to be successfully applied to situations with nonlinear distortion.In the proposed adaptive control algorithm,the parameters are updated by gradient descent method.In the simulations,the secondary-path FIR model coefficients are estimated in advance by off-line system identification method,and one case for sinusoidal primary noise with nonlinear distortion is presented,which verifies the effectiveness of the proposed system in suppressing sinusoidal noise generated by rotating machines,e.g.,engines in vehicles.
基金Item Sponsored by National Natural Science Foundation of China(51275446)National Natural Science Foundation of China and Baosteel Group Co.,Ltd.(U1260203)Natural Science Foundation of Hebei Province of China(E2012203080)
文摘To improve the slab quality, a kind of non-sinusoidal oscillation technique of mold driven by elliptic gears was developed. The waveform functions of non-sinusoidal oscillation were determined, and the calculation method and curves of technological parameters for non-sinusoidal oscillation were given. At the case of waveform deviation factor a equal to 0.31 and oscillation amplitude h equal to ±2.7 mm, the relationship between oscillation frequency and casting speed is determined, and the technological parameters for non-sinusoidal oscillation are calculated. The testing results of industrial application indicated that this technique could not only improve the Slab surface quality, but also reduce the steel breakout.
文摘A new non-sinusoidal oscillation waveform is constructed for controlling themold oscillation during continuous casting. Casting velocity and oscillation parameters are thenestablished for a computer model of the continuous casting process. The waveform distortioncoefficient ? of waveform function is close to the waveform distortion rate a, so s is taken for awhen the basic parameters are selected initially. The waveform function can be created for the servohydraulic system or the mechanical driving system. Industrial scale experiments show the waveformfunction is effective.
基金financially supported by the National Natural Science Foundation of China(51275446, 61503323 )National Natural Science Foundation of China and Baosteel Group Co.,Ltd.(U1260203)Natural Science Foundation of Hebe Province of China(E2016203492)
文摘Due to the disadvantages of complexity,high maintenance and vast investment of the electro-hydraulic servo oscillator,a new mechanical device synchronously driven by double servomotors was proposed. The working principle of the non-sinusoidal oscillator was analyzed and the model of the oscillator was validated via simulation software.Then,taking advantage of resonance technology,the hinging force and moment were calculated. The results showed that the hinging force and driving moment reduced,which was useful in reducing the impact of the hinge and prolonging the service life of the bearing. Besides,the best initial spring pressure was 0. 9 times the mold gravity,which improved the oscillation system stability and reduced the load fluctuation and servomotor driving power.
基金Supported by National Natural Science Foundation of China and Baosteel Group Co.Ltd.(Grant No.U1260203)Natural Science Foundation Steel and Iron Foundation of Hebei Province,China(Grant No.F2013203291)+1 种基金Doctor Startup Foundation of Hebei University of Science and Technology,China(Grant No.QD201247)Foundation of Hebei University of Science and Technology,China(Grant No.XL201004)
文摘The investments of the electro-hydraulic servo system of the mold non-sinusoidal oscillator are great, the modification ratio of the mechanical type is unable to be adjusted online, and some continuous casters suffer from server resonance during the casting. A mold non-sinusoidal oscillation mechanism driven by servomotor is proposed and the prototype is produced in the lab, the investment is low and the modification ratio is can be adjusted online, and the stability problem is studied. At first the dynamics model of the servomotor non-sinusoidal oscillation is established, and the kinematics differential function is deduced. Furthermore, based on the harmonic balance method, the eigenvalues of the system are solved; the criterion of the stability of the system is put forward. In addition, the eigenvalues and harmonic with different oscillating parameters are analyzed. Analytical results show that the real parts of the eigenvalues are positive, the system will be unstable, and the resonance will occur when the positive real parts of the eigenvalues are extremum. A foundation is established for solving the running smooth problem and next application of this mechanism.
文摘The line side winding is under the fundamental frequency AC voltage, while the valve side winding contains not only fundamental AC voltage component, but also the DC voltage component, fundamental AC voltage component, and higher harmonic voltage components when the converter transformer is at its normal operating condition, and the electric field of converter transformer is a non-sinusoidal steady one. To analyze the non-sinusoidal steady electric field containing the DC component, fundamental AC and higher harmonic components, the voltage spectrum of the valve winding in a ±500 kV converter transformer is firstly analyzed, and the non-sinusoidal periodic steady electric field is obtained by the fast discrete Fourier transform. Different resistivity of the oil and oil-immersed paper is adopted to simulate the aging of oil paper insulation at operation, and get the non-sinusoidal steady electric field.
文摘AIM To characterize isolated non-obstructive sinusoidal dilatation(SD) by identifying associated conditions, laboratory findings, and histological patterns. METHODS Retrospectively reviewed 491 patients with SD between 1995 and 2015. Patients with obstruction at the level of the small/large hepatic veins, portal veins, or right-sided heart failure were excluded along with history of cirrhosis, hepatic malignancy, liver transplant, or absence of electrocardiogram/cardiac echocardiogram. Liver histology was reviewed for extent of SD, fibrosis, red blood cell extravasation, nodular regenerative hyperplasia, hepaticpeliosis, and hepatocellular plate atrophy(HPA). RESULTS We identified 88 patients with non-obstructive SD. Inflammatory conditions(32%) were the most common cause. The most common pattern of liver abnormalities was cholestatic(76%). Majority(78%) had localized SD to Zone Ⅲ. Medication-related SD had higher proportion of portal hypertension(53%), ascites(58%), and median AST(113 U/L) and ALT(90 U/L) levels. Nineteen patients in our study died within one-year after diagnosis of SD, majority from complications related to underlying diseases.CONCLUSION Significant proportion of SD and HPA exist without impaired hepatic venous outflow. Isolated SD on liver biopsy, in the absence of congestive hepatopathy, requires further evaluation and portal hypertension should be rule out.
基金supported by the Major Scientific and Technological Special Project of Anhui Province(202103a13010004)the Major Scientific and Technological Special Project of Hefei City(2021DX007)the Manufacturing Industry Project of Attracting Talents and Wisdom of Anhui Province(JB24179).
文摘Quantum key distribution(QKD)achieves information-theoretic security based on quantum mechanics principles,where single-photon detectors(SPDs)serve as critical components.This study focuses on the sinusoidal gated SPDs widely used in high-speed QKD systems.We investigate the mechanisms underlying the rising-edge jitter in detection signals,identifying contributions from factors such as the temporal width of injected optical pulses,avalanche generation processes,avalanche signal extraction,and pulse discrimination.To address the issue of excessive jitter-induced bit errors,we propose a retiming scheme that utilizes coincidence signals synchronized with the sinusoidal gating signal.This approach effectively suppresses detection signal jitter and reduces the after-pulse probability of the detector.Experimental validation using a high-precision time-to-digital converter(TDC)demonstrates a significant reduction in the rising-edge jitter distribution after applying the suppression scheme.The proposed method features clear principles and straightforward engineering implementation,avoiding direct interference with the detector’s operational processes.The designed high-speed sinusoidal gated InGaAs/InP SPD operates at 1.25 GHz,achieving a remarkable reduction in after-pulse probability from 10.7%(without jitter suppression)to 0.72%,thereby enhancing the overall performance of QKD systems.
基金supported by Science and Technology on Information Transmission and Dissemination in Communication Networks Laboratory(KX152600015/ITD-U15006)National Natural Science Foundation of China(No.61401196)
文摘Sine Non-linear Chirp Keying(SNCK) is a kind of high-efficient modulation scheme, which provides a potential new beamforming method in communication and radar systems. It has been proved to have advantages in some parameter estimation issues over conventional modulation schemes. In this paper, a novel transform termed as Discrete Sinusoidal Frequency Modulation transform(DSFMT) is proposed. Then, the DSFMT of SNCK signal is deduced and classified into three types, based on which, the time-bandwidth product is estimated by the proposed algorithm. Simulation results show that the noise has a signifi cant impact on the localization of the peak value and the time-bandwidth product can be estimated by using local ratio values when.
文摘In this paper an attempt has been made to find the aperture field distribution in a rectangular waveguide for non-sinusoidal, periodic excitations using Multiple Cavity Modeling Technique. The excitation functions, considered, are square, trapezoidal and clipped sine wave in nature. In the present analysis these time domain excitation functions have been represented in terms of a truncated Fourier series consisting of the fundamental frequency and its higher harmonics. Within the waveguide the fundamental frequency will give rise to a dominant mode excitation whereas the higher order modes will excite dominant as higher order modes. If the higher harmonics are assumed suppressed then the waveguide is subjected only to a dominant mode excitation. Results for dominant mode reflection coefficient (magnitude), VSWR and complex transmission coefficient have been computed and compared with theoretical data. The excellent agreement between them validates the analysis.
基金supported by the National Natural Science Foundation of China (Grant No.12274131)the Innovation Program for Quantum Science and Technology (Grant No.2024ZD0300101)。
文摘Optical non-reciprocity is a fundamental phenomenon in photonics.It is crucial for developing devices that rely on directional signal control,such as optical isolators and circulators.However,most research in this field has focused on systems in equilibrium or steady states.In this work,we demonstrate a room-temperature Rydberg atomic platform where the unidirectional propagation of light acts as a switch to mediate time-crystalline-like collective oscillations through atomic synchronization.
基金supported by grants from the National Natural Science Foundation of China(G.F.Wang,grant number 82204071)(P.Y.Su,grant numbers 81874268 and 82473655)the Research Funds of the Center for Big Data and Population Health of IHM(P.Y.Su,No.JKS2023016)Anhui Provincial Health Commission Scientific Research Project(Y.Zhou,No.AHWJ2023A30027)。
文摘Vitamin D deficiency(VDD)represents a significant nutritional concern among children and adolescents.The estimated prevalence of VDD in China is 46.8%in this population^([1]).VDD during childhood and adolescence has been associated with the onset of various conditions,including acute respiratory infections,asthma,atopic dermatitis,and food allergies^([2]).Multiple factors,including age,sun exposure,adiposity,and genetics,influence vitamin D levels^([2,3]).Increasing attention has been directed toward understanding the environmental determinants that may influence vitamin D status.Given the potential of metallic pollutants to disrupt endocrine function and their ubiquity in the environment,investigating the effects of metal exposure on human vitamin D status,particularly in vulnerable populations,is imperative.
基金Supported by National Natural Science Foundation of China,No.81570555 and No.81770582
文摘Hepatic sinusoidal obstruction syndrome (HSOS) can be caused by the intake of pyrrolizidine alkaloids (PAs). To date, PAs-induced HSOS has not been extensively studied. In view of the difference in etiology of HSOS between the West and China, clinical profiles, imaging findings, treatment, and outcomes of HSOS associated with hematopoietic stem cell transplantation or oxaliplatin might be hardly extrapolated to PAs-induced HSOS. Reactive metabolites derived from PAs form pyrrole-protein adducts that result in toxic destruction of hepatic sinusoidal endothelial cells. PAs-induced HSOS typically manifests as painful hepatomegaly, ascites, and jaundice. Laboratory tests revealed abnormal liver function tests were observed in most of the patients with PAs-induced HSOS. In addition, contrast computed tomography and magnetic resonance imaging scan show that patients with PAs-induced HSOS have distinct imaging features, which reveal that radiological imaging provides an effective noninvasive method for the diagnosis of PAs-induced HSOS. Liver biopsy and histological examination showed that PAs-induced HSOS displayed distinct features in acute and chronic stages. Therapeutic strategies for PAs-induced HSOS include rigorous fluid management, anticoagulant therapy, glucocorticoids, transjugular intrahepatic portosystemic shunt, liver transplantation, etc. The aim of this review is to describe the pathogenesis, clinical profiles, diagnostic criteria, treatment, and outcomes of PAs-induced HSOS.
基金Supported by National Natural Science Foundation of China,No.81373160
文摘Sinusoidal obstruction syndrome(SOS), previously known as hepatic veno-occlusive disease, is a rare disorder in solid organ transplant patients, and is an uncommon complication after liver transplantation. Severe SOS with hepatic failure causes considerable mortality. Tacrolimus has been reported to be an offending agent, which potentially plays a role in the pathophysiological process of SOS. SOS due to tacrolimus has been reported in lung and pancreatic transplantations, but has never been described in a liver transplant recipient. Herein, we present a case of SOS after liver transplantation, which was possibly related to tacrolimus. A 27-year-old man developed typical symptoms of SOS with painful hepatomegaly, ascites and jaundice after liver transplantation, which regressed following withdrawal of tacrolimus. By excluding other possible predisposing factors, we concluded that tacrolimus was the most likely cause of SOS.
文摘The linear systems affected by additive external sinusoidal disturbances is studied. The problem is to damp this forced oscillation in an optimal fashion. The main result of this paper is a new design approach is proposed of realizable feedforward and feedback optimal control law for a linear time invariant system with sinusoidal disturbances. The algorithm of solving the optimal control law is given. It is shown that the control law is easily realized and is robust with respect to errors produced by the external sinusoidal disturbances through simulation results.
文摘The hepatic sinusoids are lined by a unique population of hepatic sinusoidal endothelial cells (HSEC), which is one of the first hepatic cell populations to come into contact with blood components. However, HSEC are not simply barrier cells that restrict the access of blood- borne compounds to the parenchyma. They are func- tionally specialised endothelial cells that have complex roles, including not only receptor-mediated clearance of endotoxin, bacteria and other compounds, but also the regulation of inflammation, leukocyte recruitment and host immune responses to pathogens. Thus understand- ing the differentiation and function of HSEC is critical for the elucidation of liver biology and pathophysiology. This article reviews methods for isolating and studying human hepatic endothelial cell populations using in vitro models. We also discuss the expression and functions of phe- notypic markers, such as the presence of fenestrations and expression of VAP-1, Stabilin-1, L-SIGN, which can be used to identify sinusoidal endothelium and to permit discrimination from vascular and lymphatic endothelial cells.
