Non-Abelian topological insulators are characterized by matrix-valued,non-commuting topological charges with regard to more than one energy gap.Their descriptions go beyond the conventional topological band theory,in ...Non-Abelian topological insulators are characterized by matrix-valued,non-commuting topological charges with regard to more than one energy gap.Their descriptions go beyond the conventional topological band theory,in which an additive integer like the winding or Chern number is endowed separately with each(degenerate group of)energy band(s).In this work,we reveal that Floquet(time-periodic)driving could not only enrich the topology and phase transitions of non-Abelian topological matter,but also induce bulk-edge correspondence unique to nonequilibrium setups.Using a one-dimensional,three-band model as an illustrative example,we demonstrate that Floquet driving could reshuffle the phase diagram of the non-driven system,yielding both gapped and gapless Floquet band structures with non-Abelian topological charges.Moreover,by dynamically tuning the anomalous Floquet π-quasienergy gap,non-Abelian topological transitions inaccessible to static systems could arise,leading to much more complicated relations between non-Abelian topological charges and Floquet edge states.These discoveries put forth periodic driving as a powerful scheme of engineering non-Abelian topological phases and incubating unique non-Abelian band topology beyond equilibrium.展开更多
The published article titled“Long Noncoding RNA GAS5 Suppresses Tumorigenesis by Inhibiting miR-23a Expression inNon-Small Cell Lung Cancer”has been retracted fromOncology Research,Vol.25,No.6,2017,pp.1027–1037.DOI...The published article titled“Long Noncoding RNA GAS5 Suppresses Tumorigenesis by Inhibiting miR-23a Expression inNon-Small Cell Lung Cancer”has been retracted fromOncology Research,Vol.25,No.6,2017,pp.1027–1037.DOI:10.3727/096504016X14822800040451 URL:https://www.techscience.com/or/v25n6/56885 Following the publication,concerns have been raised about a number of figures in this article.An unexpected area of similarity was identified in terms of the cellular data,where the results from differently performed experiments were intended to have been shown,although the areas immediately surrounding this area featured comparatively different distributions of cells.展开更多
1 Introduction In highway construction,flled embankments are trapezoidal,and the ground is always improved by sand wells or columns.During embankment construction,because the width and height of the embankment are cha...1 Introduction In highway construction,flled embankments are trapezoidal,and the ground is always improved by sand wells or columns.During embankment construction,because the width and height of the embankment are changing,a non-uniform load that varies with time and lateral location is applied to the underlying ground.The consolidation phenomenon under two-dimensional(2D)conditions will keep pace with the construction of the embankment.In addition,because of evaporation and rainfall,the soils are mostly unsaturated.Therefore,it is meaningful to research the consolidation properties of unsaturated ground under non-uniform loading.展开更多
Non-O1/non-O139 Vibrio cholerae(NOVC)has multiple pathogenic pathways in humans.The cause of disease in influenced by the virulence genes carried by the infecting strain and the health condition of the host.[1-2]When ...Non-O1/non-O139 Vibrio cholerae(NOVC)has multiple pathogenic pathways in humans.The cause of disease in influenced by the virulence genes carried by the infecting strain and the health condition of the host.[1-2]When seafood,food and water sources are contaminated with feces,people are prone to gastroenteritis,and direct exposure to contaminated water may cause wound infection.展开更多
This special issue of the Asian Journal of Andrology is fully dedicated to the thematic area of non-obstructive azoospermia(NOA),one of the most complex and challenging conditions in the realm of andrology,urology,and...This special issue of the Asian Journal of Andrology is fully dedicated to the thematic area of non-obstructive azoospermia(NOA),one of the most complex and challenging conditions in the realm of andrology,urology,and reproductive medicine.展开更多
Following the publication,concerns have been raised about a number of figures in this article.The western blots in this article were presented with atypical,unusually shaped and possibly anomalous protein bands in man...Following the publication,concerns have been raised about a number of figures in this article.The western blots in this article were presented with atypical,unusually shaped and possibly anomalous protein bands in many cases.展开更多
Background:No clear evidence exists regarding the relationship between the systemic immune-inflammation index(SII)and the efficacy of first-line chemotherapy combined with immunotherapy in patients with advanced non-s...Background:No clear evidence exists regarding the relationship between the systemic immune-inflammation index(SII)and the efficacy of first-line chemotherapy combined with immunotherapy in patients with advanced non-small cell lung cancer(NSCLC).This study aimed to establish the relationship between the SII and survival of patients with advanced NSCLC.Methods:This study included 123 patients with advanced NSCLC.The cutoff value of the SII was determined to be 1172 using ROC curve analysis.We evaluated the relationship between the SII and progression-free survival(PFS)and overall survival(OS)using the Cox regression model and Kaplan-Meier(KM)curve analysis.We stratified patients into multiple subgroups based on covariates such as age,sex,and smoking history.Subgroup analysis was used to evaluate the relationship between high SII,disease progression,and mortality risk.Results:Univariate analysis indicated that no significant difference existed between SII and PFS,but univariate analysis showed a significant association between SII and OS(hazard ratio[HR]=1.93,95% confidence interval[CI]=1.14-3.29,p=0.015).The fully adjusted Cox regression analysis also showed a significant correlation between the SII and OS after adjustment for covariables(HR=1.76,95%CI=1.02-3.02,p=0.041).In some subgroups,a high SII positively correlated with the risk of disease progression,and the relationship between a high SII and the risk of mortality was consistent in almost all subgroups.Conclusions:These results indicate that pretreatment SII may be an independent predictivemarker for patients with advanced NSCLC undergoing first-line chemotherapy combined with immunotherapy.However,large-scale prospective studies are required to confirm our results.展开更多
In the past year,several advancements have been achieved in the treatment of advanced non-small cell lung cancer(NSCLC),particularly in the areas of immunotherapy and targeted therapy.These achievements have provided ...In the past year,several advancements have been achieved in the treatment of advanced non-small cell lung cancer(NSCLC),particularly in the areas of immunotherapy and targeted therapy.These achievements have provided additional options for improving patient outcomes.The 2024 Chinese Society of Clinical Oncology Guidelines for NSCLC(CSCO NSCLC),a key reference for clinical oncologists in China,have incorporated current global research and adapted recommendations for applicability in real-world scenarios in China.This update covers not only patient selection,efficacy,and safety,but also considers economics,and accessibility,with an aim to provide more precise and comprehensive treatment guidance for Chinese oncologists.展开更多
Dear Editor,This letter studies the bipartite consensus tracking problem for heterogeneous multi-agent systems with actuator faults and a leader's unknown time-varying control input. To handle such a problem, the ...Dear Editor,This letter studies the bipartite consensus tracking problem for heterogeneous multi-agent systems with actuator faults and a leader's unknown time-varying control input. To handle such a problem, the continuous fault-tolerant control protocol via observer design is developed. In addition, it is strictly proved that the multi-agent system driven by the designed controllers can still achieve bipartite consensus tracking after faults occur.展开更多
We investigate electron mesoscopic transport in a three-terminal setup with coupled quantum dots and a magnetic flux.By mapping the original transport problem into a non-Hermitian Hamiltonian form,we study the interpl...We investigate electron mesoscopic transport in a three-terminal setup with coupled quantum dots and a magnetic flux.By mapping the original transport problem into a non-Hermitian Hamiltonian form,we study the interplay between the coherent couplings between quantum dots,the magnetic flux,and the dissipation due to the tunnel coupling with the reservoirs.展开更多
Topological states realized in metamaterials have provided a versatile platform for exploring topological physics and enabling novel applications,with topolectrical circuits emerging as a prominent example.However,pre...Topological states realized in metamaterials have provided a versatile platform for exploring topological physics and enabling novel applications,with topolectrical circuits emerging as a prominent example.However,previous research in this feld has primarily focused on lumped-element implementations,while non-lumped microwave circuits remain relatively underexplored.In this work,we design and investigate a one-dimensional non-lumped Su–Schriefer–Heeger topolectrical circuit composed of copper parallel-plate transmission lines and inductors,ofering compatibility with integrated microwave applications.Full-wave microwave simulations in the 0–10 GHz range show excellent agreement with theoretical predictions.The impedance spectrum of a fveunit-cell system displays periodic resonant passbands and stopbands corresponding to bulk states,while distinct high-Q(on the order of 10^(2))topological boundary resonances(TBRs)emerge within the stopbands,indicating the presence of localized edge states.Furthermore,the TBRs vanish when the system is reconfgured into the trivial phase,providing direct evidence of its topological nature.These response characteristics make the proposed resonator a promising candidate for future microwave devices and topological circuit applications.展开更多
In the article“Silencing of the long non-coding RNA LINC00265 triggers autophagy and apoptosis in lung cancer by reducing protein stability of SIN3A oncogene”(Oncology Research.2024,Vol.32,No.7,pp.1185–1195.doi:10....In the article“Silencing of the long non-coding RNA LINC00265 triggers autophagy and apoptosis in lung cancer by reducing protein stability of SIN3A oncogene”(Oncology Research.2024,Vol.32,No.7,pp.1185–1195.doi:10.32604/or.2023.030771,https://www.techscience.com/or/v32n7/57163),an inadvertent error occurred during the compilation of Fig.3H.This needed corrections to ensure the accuracy and integrity of the data presented.展开更多
In the lattice system,when the synthetic flux reaches aπphase along a closed loop under the synthetic gauge field,destructive interference occurs and gives rise to the localization phenomenon.This is known as the Aha...In the lattice system,when the synthetic flux reaches aπphase along a closed loop under the synthetic gauge field,destructive interference occurs and gives rise to the localization phenomenon.This is known as the Aharonov-Bohm(AB)caging effect.It provides a powerful tool for the study of quantum transport and dynamical effects.In the system where lattice sites possess internal structure and the underlying gauge field is non-Abelian,localization can also occur,forming the non-Abelian AB caging.Here,we propose an experimental scheme to synthesize non-Abelian gauge fields with a single trapped ion by coupling multiple internal levels and Fock states in its motion via laser fields.In contrast to the Abelian AB caging,we numerically observe that the non-Abelian AB caging occurs either when the interference matrix is nilpotent,or when the initial state is specifically set.Our experimental scheme broadens the study of localization phenomena and provides a novel tool for the study of non-Abelian physics.展开更多
BACKGROUND Cardiac resynchronization therapy(CRT)has been a major therapeutic advancement for patients with heart failure and electrical dyssynchrony.While CRT improves symptoms,reduces hospitalizations,and enhances s...BACKGROUND Cardiac resynchronization therapy(CRT)has been a major therapeutic advancement for patients with heart failure and electrical dyssynchrony.While CRT improves symptoms,reduces hospitalizations,and enhances survival,the role of implantable cardioverter-defibrillators(ICDs)alongside CRT in patients with non-ischemic cardiomyopathy(NICM)remains controversial.To evaluate and compare the outcomes of CRT with ICD(CRT-D)versus CRT with pacemaker-only(CRT-P)in individuals diagnosed with NICM,with a specific focus on the elderly.METHODS A comprehensive search of PubMed,Embase,and the Cochrane Central Register of Controlled Trials was conducted in January 2024.Studies comparing CRT-D and CRT-P in patients with NICM were included,with subgroup analyses focusing on patients aged 75 years and older.RESULTS Twelve studies,including two randomized clinical trials,with a total of 62,145 patients and 16,754 pooled death events(9,171 in CRT-D and 7,583 in CRT-P),were analyzed.CRT-D was associated with a significantly lower risk of all-cause mortality compared to CRT-P(pooled OR=0.72;95%CI:0.61-0.85;P<0.01),with significant heterogeneity(I2=83%).RCT subgroup analysis,was not statistically significant(pooled OR=0.82;95%CI:0.64-1.06;P=0.41;I2=0%).In patients older than 75 years,no significant difference in mortality risk was observed(pooled OR 0.96;95%CI:0.81-1.15;I2=39%).CONCLUSION Our meta-analysis suggests that the addition of ICD therapy to CRT in patients with NICM significantly reduces all-cause mortality.However,this benefit does not extend to cardiovascular mortality,likely due to the primary role of ICDs in preventing sudden cardiac death rather than other causes such as progressive heart failure.The survival advantage of CRT-D is most pronounced in younger patients,with those over 75 years of age deriving less benefit.This highlights the importance of careful patient selection,considering age and comorbidities,when deciding on ICD implantation in NICM patients.展开更多
Dear Editor,Traumatic optic neuropathy(TON)is a severe vision-threatening condition,with an incidence rate ranging from 0.7% to 2.5%[1].The limited regenerative capacity of the optic nerve and the challenges of nerve ...Dear Editor,Traumatic optic neuropathy(TON)is a severe vision-threatening condition,with an incidence rate ranging from 0.7% to 2.5%[1].The limited regenerative capacity of the optic nerve and the challenges of nerve transplantation result in substantial and irreversible visual loss in patients with TON.展开更多
To the editor:Non-suicidal self-injury(NSSI)is an array of directly prepense or repetitive self-harm behaviours without suicidal intent.Individuals engage in self-injurious behaviours to reduce negative mental and cog...To the editor:Non-suicidal self-injury(NSSI)is an array of directly prepense or repetitive self-harm behaviours without suicidal intent.Individuals engage in self-injurious behaviours to reduce negative mental and cognitive states or evoke positive emotions.展开更多
Background:Innovative oral targeted therapies are warranted for patients with human epidermal growth factor receptor 2(HER2)-mutant non-small-cell lung cancer(NSCLC).Zongertinib is an oral,irreversible,HER2-selective ...Background:Innovative oral targeted therapies are warranted for patients with human epidermal growth factor receptor 2(HER2)-mutant non-small-cell lung cancer(NSCLC).Zongertinib is an oral,irreversible,HER2-selective tyrosine kinase inhibitor that has been shown to have efficacy in persons with advanced or metastatic solid tumors with HER2 alterations in a phase 1 study.展开更多
The Chinese Society of Clinical Oncology Non-small Cell Lung Cancer(CSCO NSCLC)guidelines were first published in 2016,ranking among the earliest-released guidelines within the CSCO series.In 2020 the CSCO published s...The Chinese Society of Clinical Oncology Non-small Cell Lung Cancer(CSCO NSCLC)guidelines were first published in 2016,ranking among the earliest-released guidelines within the CSCO series.In 2020 the CSCO published separate guidelines for NSCLC and small cell lung cancer(SCLC)for the first time to improve clinical usability.展开更多
With the advent of the digital era,the field of communications is undergoing profound transformation.Among the most groundbreaking developments is the emergence of non-terrestrial networks(NTN),which represent not onl...With the advent of the digital era,the field of communications is undergoing profound transformation.Among the most groundbreaking developments is the emergence of non-terrestrial networks(NTN),which represent not only a technological leap forward but also a major trend shaping the future of global connectivity.As a layered heterogeneous network,NTN integrates multiple aerial platforms—including satellites,high-altitude platform systems(HAPS),and unmanned aerial systems(UAS)—to provide flexible and composable solutions aimed at achieving seamless worldwide communication coverage.展开更多
基金supported by the National Natural Science Foundation of China(Grant Nos.12275260 and 11905211)the Fundamental Research Funds for the Central Universities(Grant No.202364008)the Young Talents Project of Ocean University of China。
文摘Non-Abelian topological insulators are characterized by matrix-valued,non-commuting topological charges with regard to more than one energy gap.Their descriptions go beyond the conventional topological band theory,in which an additive integer like the winding or Chern number is endowed separately with each(degenerate group of)energy band(s).In this work,we reveal that Floquet(time-periodic)driving could not only enrich the topology and phase transitions of non-Abelian topological matter,but also induce bulk-edge correspondence unique to nonequilibrium setups.Using a one-dimensional,three-band model as an illustrative example,we demonstrate that Floquet driving could reshuffle the phase diagram of the non-driven system,yielding both gapped and gapless Floquet band structures with non-Abelian topological charges.Moreover,by dynamically tuning the anomalous Floquet π-quasienergy gap,non-Abelian topological transitions inaccessible to static systems could arise,leading to much more complicated relations between non-Abelian topological charges and Floquet edge states.These discoveries put forth periodic driving as a powerful scheme of engineering non-Abelian topological phases and incubating unique non-Abelian band topology beyond equilibrium.
文摘The published article titled“Long Noncoding RNA GAS5 Suppresses Tumorigenesis by Inhibiting miR-23a Expression inNon-Small Cell Lung Cancer”has been retracted fromOncology Research,Vol.25,No.6,2017,pp.1027–1037.DOI:10.3727/096504016X14822800040451 URL:https://www.techscience.com/or/v25n6/56885 Following the publication,concerns have been raised about a number of figures in this article.An unexpected area of similarity was identified in terms of the cellular data,where the results from differently performed experiments were intended to have been shown,although the areas immediately surrounding this area featured comparatively different distributions of cells.
基金supported by the National Nature Science Foundation of China(No.12172211)the National Key Research and Development Program of China(No.2019YFC1509800)。
文摘1 Introduction In highway construction,flled embankments are trapezoidal,and the ground is always improved by sand wells or columns.During embankment construction,because the width and height of the embankment are changing,a non-uniform load that varies with time and lateral location is applied to the underlying ground.The consolidation phenomenon under two-dimensional(2D)conditions will keep pace with the construction of the embankment.In addition,because of evaporation and rainfall,the soils are mostly unsaturated.Therefore,it is meaningful to research the consolidation properties of unsaturated ground under non-uniform loading.
基金supported by the National Natural Science Foundation(82372206)the Jiangsu Provincial Health Commission(H2023107)the project of basic and clinical research on cardiac arrest in the Emergency and Critical Care Department of the Second Affiliated Hospital of Soochow University(XKTJ-XK202408-2).
文摘Non-O1/non-O139 Vibrio cholerae(NOVC)has multiple pathogenic pathways in humans.The cause of disease in influenced by the virulence genes carried by the infecting strain and the health condition of the host.[1-2]When seafood,food and water sources are contaminated with feces,people are prone to gastroenteritis,and direct exposure to contaminated water may cause wound infection.
文摘This special issue of the Asian Journal of Andrology is fully dedicated to the thematic area of non-obstructive azoospermia(NOA),one of the most complex and challenging conditions in the realm of andrology,urology,and reproductive medicine.
文摘Following the publication,concerns have been raised about a number of figures in this article.The western blots in this article were presented with atypical,unusually shaped and possibly anomalous protein bands in many cases.
基金supported by grants from the“Joint Project on Regional High-Incidence Diseases Research of Guangxi Natural Science Foundation”under Grant No.2023JJA141341the“Guangxi Medical and Health Key Discipline Construction Project.”。
文摘Background:No clear evidence exists regarding the relationship between the systemic immune-inflammation index(SII)and the efficacy of first-line chemotherapy combined with immunotherapy in patients with advanced non-small cell lung cancer(NSCLC).This study aimed to establish the relationship between the SII and survival of patients with advanced NSCLC.Methods:This study included 123 patients with advanced NSCLC.The cutoff value of the SII was determined to be 1172 using ROC curve analysis.We evaluated the relationship between the SII and progression-free survival(PFS)and overall survival(OS)using the Cox regression model and Kaplan-Meier(KM)curve analysis.We stratified patients into multiple subgroups based on covariates such as age,sex,and smoking history.Subgroup analysis was used to evaluate the relationship between high SII,disease progression,and mortality risk.Results:Univariate analysis indicated that no significant difference existed between SII and PFS,but univariate analysis showed a significant association between SII and OS(hazard ratio[HR]=1.93,95% confidence interval[CI]=1.14-3.29,p=0.015).The fully adjusted Cox regression analysis also showed a significant correlation between the SII and OS after adjustment for covariables(HR=1.76,95%CI=1.02-3.02,p=0.041).In some subgroups,a high SII positively correlated with the risk of disease progression,and the relationship between a high SII and the risk of mortality was consistent in almost all subgroups.Conclusions:These results indicate that pretreatment SII may be an independent predictivemarker for patients with advanced NSCLC undergoing first-line chemotherapy combined with immunotherapy.However,large-scale prospective studies are required to confirm our results.
基金supported by the Shanghai Excellent Academic Leader(Grant No.21XD1423200)。
文摘In the past year,several advancements have been achieved in the treatment of advanced non-small cell lung cancer(NSCLC),particularly in the areas of immunotherapy and targeted therapy.These achievements have provided additional options for improving patient outcomes.The 2024 Chinese Society of Clinical Oncology Guidelines for NSCLC(CSCO NSCLC),a key reference for clinical oncologists in China,have incorporated current global research and adapted recommendations for applicability in real-world scenarios in China.This update covers not only patient selection,efficacy,and safety,but also considers economics,and accessibility,with an aim to provide more precise and comprehensive treatment guidance for Chinese oncologists.
基金supported by the National Natural Science Foundation of China(62325304,U22B2046,62073079,62376029)the Jiangsu Provincial Scientific Research Center of Applied Mathematics(BK20233002)the China Postdoctoral Science Foundation(2023M730255,2024T171123)
文摘Dear Editor,This letter studies the bipartite consensus tracking problem for heterogeneous multi-agent systems with actuator faults and a leader's unknown time-varying control input. To handle such a problem, the continuous fault-tolerant control protocol via observer design is developed. In addition, it is strictly proved that the multi-agent system driven by the designed controllers can still achieve bipartite consensus tracking after faults occur.
基金supported by the National Key R&D Program of China(Grant No.2022YFA1404400)the National Natural Science Foundation of China(Grant No.12125504 and 12305050)+2 种基金Zhejiang Provincial Natural Science Foundation of China(Grant No.LZ25A050001)the Hundred Talents Program of the Chinese Academy of Sciencesthe Natural Science Foundation of Jiangsu Higher Education Institutions of China(Grant No.23KJB140017)。
文摘We investigate electron mesoscopic transport in a three-terminal setup with coupled quantum dots and a magnetic flux.By mapping the original transport problem into a non-Hermitian Hamiltonian form,we study the interplay between the coherent couplings between quantum dots,the magnetic flux,and the dissipation due to the tunnel coupling with the reservoirs.
基金supported by the National Natural Science Foundation of China(Grant No.11874431)the National Key R&D Program of China(Grant No.2018YFA0306800)。
文摘Topological states realized in metamaterials have provided a versatile platform for exploring topological physics and enabling novel applications,with topolectrical circuits emerging as a prominent example.However,previous research in this feld has primarily focused on lumped-element implementations,while non-lumped microwave circuits remain relatively underexplored.In this work,we design and investigate a one-dimensional non-lumped Su–Schriefer–Heeger topolectrical circuit composed of copper parallel-plate transmission lines and inductors,ofering compatibility with integrated microwave applications.Full-wave microwave simulations in the 0–10 GHz range show excellent agreement with theoretical predictions.The impedance spectrum of a fveunit-cell system displays periodic resonant passbands and stopbands corresponding to bulk states,while distinct high-Q(on the order of 10^(2))topological boundary resonances(TBRs)emerge within the stopbands,indicating the presence of localized edge states.Furthermore,the TBRs vanish when the system is reconfgured into the trivial phase,providing direct evidence of its topological nature.These response characteristics make the proposed resonator a promising candidate for future microwave devices and topological circuit applications.
文摘In the article“Silencing of the long non-coding RNA LINC00265 triggers autophagy and apoptosis in lung cancer by reducing protein stability of SIN3A oncogene”(Oncology Research.2024,Vol.32,No.7,pp.1185–1195.doi:10.32604/or.2023.030771,https://www.techscience.com/or/v32n7/57163),an inadvertent error occurred during the compilation of Fig.3H.This needed corrections to ensure the accuracy and integrity of the data presented.
基金supported by the National Natural Science Foundation of China(Grant Nos.92165206,12275090,and 12304554)the Innovation Program for Quantum Science and Technology(Grant Nos.2021ZD0301603 and 2021ZD0302303)。
文摘In the lattice system,when the synthetic flux reaches aπphase along a closed loop under the synthetic gauge field,destructive interference occurs and gives rise to the localization phenomenon.This is known as the Aharonov-Bohm(AB)caging effect.It provides a powerful tool for the study of quantum transport and dynamical effects.In the system where lattice sites possess internal structure and the underlying gauge field is non-Abelian,localization can also occur,forming the non-Abelian AB caging.Here,we propose an experimental scheme to synthesize non-Abelian gauge fields with a single trapped ion by coupling multiple internal levels and Fock states in its motion via laser fields.In contrast to the Abelian AB caging,we numerically observe that the non-Abelian AB caging occurs either when the interference matrix is nilpotent,or when the initial state is specifically set.Our experimental scheme broadens the study of localization phenomena and provides a novel tool for the study of non-Abelian physics.
文摘BACKGROUND Cardiac resynchronization therapy(CRT)has been a major therapeutic advancement for patients with heart failure and electrical dyssynchrony.While CRT improves symptoms,reduces hospitalizations,and enhances survival,the role of implantable cardioverter-defibrillators(ICDs)alongside CRT in patients with non-ischemic cardiomyopathy(NICM)remains controversial.To evaluate and compare the outcomes of CRT with ICD(CRT-D)versus CRT with pacemaker-only(CRT-P)in individuals diagnosed with NICM,with a specific focus on the elderly.METHODS A comprehensive search of PubMed,Embase,and the Cochrane Central Register of Controlled Trials was conducted in January 2024.Studies comparing CRT-D and CRT-P in patients with NICM were included,with subgroup analyses focusing on patients aged 75 years and older.RESULTS Twelve studies,including two randomized clinical trials,with a total of 62,145 patients and 16,754 pooled death events(9,171 in CRT-D and 7,583 in CRT-P),were analyzed.CRT-D was associated with a significantly lower risk of all-cause mortality compared to CRT-P(pooled OR=0.72;95%CI:0.61-0.85;P<0.01),with significant heterogeneity(I2=83%).RCT subgroup analysis,was not statistically significant(pooled OR=0.82;95%CI:0.64-1.06;P=0.41;I2=0%).In patients older than 75 years,no significant difference in mortality risk was observed(pooled OR 0.96;95%CI:0.81-1.15;I2=39%).CONCLUSION Our meta-analysis suggests that the addition of ICD therapy to CRT in patients with NICM significantly reduces all-cause mortality.However,this benefit does not extend to cardiovascular mortality,likely due to the primary role of ICDs in preventing sudden cardiac death rather than other causes such as progressive heart failure.The survival advantage of CRT-D is most pronounced in younger patients,with those over 75 years of age deriving less benefit.This highlights the importance of careful patient selection,considering age and comorbidities,when deciding on ICD implantation in NICM patients.
基金supported by Guangzhou Key Projects of Brain Science and Brain-Like Intelligence Technology(20200730009)the National Natural Science Foundation of China(81870656)the Natural Science Foundation of Guangdong Province of China(2017A030313610 and 2023A1515012397).
文摘Dear Editor,Traumatic optic neuropathy(TON)is a severe vision-threatening condition,with an incidence rate ranging from 0.7% to 2.5%[1].The limited regenerative capacity of the optic nerve and the challenges of nerve transplantation result in substantial and irreversible visual loss in patients with TON.
基金the Innovation 2030-Major Project of Brain Science and Brain-lnspired Intelligence Technology(2021ZD0200600)Shanghai Science and Technology Committee(22YF1439100,YDZX20213100001003)National Natural Science Foundation of China(82201678).
文摘To the editor:Non-suicidal self-injury(NSSI)is an array of directly prepense or repetitive self-harm behaviours without suicidal intent.Individuals engage in self-injurious behaviours to reduce negative mental and cognitive states or evoke positive emotions.
基金Funded by Boehringer IngelheimBeamion LUNG-1 ClinicalTrials.gov number,NCT04886804.
文摘Background:Innovative oral targeted therapies are warranted for patients with human epidermal growth factor receptor 2(HER2)-mutant non-small-cell lung cancer(NSCLC).Zongertinib is an oral,irreversible,HER2-selective tyrosine kinase inhibitor that has been shown to have efficacy in persons with advanced or metastatic solid tumors with HER2 alterations in a phase 1 study.
文摘The Chinese Society of Clinical Oncology Non-small Cell Lung Cancer(CSCO NSCLC)guidelines were first published in 2016,ranking among the earliest-released guidelines within the CSCO series.In 2020 the CSCO published separate guidelines for NSCLC and small cell lung cancer(SCLC)for the first time to improve clinical usability.
文摘With the advent of the digital era,the field of communications is undergoing profound transformation.Among the most groundbreaking developments is the emergence of non-terrestrial networks(NTN),which represent not only a technological leap forward but also a major trend shaping the future of global connectivity.As a layered heterogeneous network,NTN integrates multiple aerial platforms—including satellites,high-altitude platform systems(HAPS),and unmanned aerial systems(UAS)—to provide flexible and composable solutions aimed at achieving seamless worldwide communication coverage.
