Salinity stress is amajor constraint on agricultural productivity,particularly in arid and semi-arid regions.This study evaluated the potential of Ascophyllum nodosum extract(ANE)in mitigating salinity-induced stress ...Salinity stress is amajor constraint on agricultural productivity,particularly in arid and semi-arid regions.This study evaluated the potential of Ascophyllum nodosum extract(ANE)in mitigating salinity-induced stress and enhancing the growth and physiological performance of Portulaca oleracea L.under NaCl concentrations of 0,50,70,and 100 mM for 50 days.A two-way ANOVA assessed the effects of NaCl concentration,ANE treatment,and their interaction.The results showed that ANE significantly increased plant height at 50 mMNaCl(p=0.0011)but had no effect at higher salinity levels(p>0.05).Shoot dry weight was significantly influenced by the interaction of NaCl and ANE(p=0.0064),with ANE increasing biomass at 0 mM but decreasing it at 100 mM NaCl.However,ANE did not significantly affect root dry weight(p>0.05).Physiological responses indicated a significant increase in proline content at 50mMNaCl(p=0.0011),supporting improved osmotic adjustment.Total soluble protein was significantly enhanced at all salinity levels except 100 mM NaCl(p<0.01).Regarding ionic regulation,ANE had no significant effect on leaf sap pH(p>0.05)but increased electrical conductivity(EC)at 70 and 100 mM NaCl(p<0.01),suggesting a role in ion homeostasis under high salinity.Photosynthetic pigments responded positively to ANE,with significant increases in chlorophyll“a”(p<0.0001)and carotenoid content(p<0.0001),while chlorophyll“b”remained unchanged(p>0.05).These findings highlight ANE’s potential as a sustainable biostimulant for improving salinity tolerance,particularly at moderate NaCl levels.Future research should focus on molecular mechanisms and long-term field applications to optimize ANE’s role in enhancing soil and crop productivity under salinity stress.展开更多
Background:Dietary supplementation with a fucoidan-rich Ascophyllum nodosum extract(ANE),possessing an in vitro anti-Salmonella Typhimurium activity could be a promising on-farm strategy to control Salmonella infectio...Background:Dietary supplementation with a fucoidan-rich Ascophyllum nodosum extract(ANE),possessing an in vitro anti-Salmonella Typhimurium activity could be a promising on-farm strategy to control Salmonella infection in pigs.The objectives of this study were to:1)evaluate the anti-S.Typhimurium activity of ANE(containing 46.6%fucoidan,18.6%laminarin,10.7%mannitol,4.6%alginate)in vitro,and;2)compare the effects of dietary supplementation with ANE and Zinc oxide(ZnO)on growth performance,Salmonella shedding and selected gut parameters in naturally infected pigs.This was established post-weaning(newly weaned pig experiment)and following regrouping of post-weaned pigs and experimental re-infection with S.Typhimurium(challenge experiment).Results:In the in vitro assay,increasing ANE concentrations led to a linear reduction in S.Typhimurium counts(P<0.05).In the newly weaned pig experiment(12 replicates/treatment),high ANE supplementation increased gain to feed ratio,similar to ZnO supplementation,and reduced faecal Salmonella counts on d 21 compared to the low ANE and control groups(P<0.05).The challenge experiment included thirty-six pigs from the previous experiment that remained on their original dietary treatments(control and high ANE groups with the latter being renamed to ANE group)apart from the ZnO group which transitioned onto a control diet on d 21(ZnO-residual group).These dietary treatments had no effect on performance,faecal scores,Salmonella shedding or colonic and caecal Salmonella counts(P>0.05).ANE supplementation decreased the Enterobacteriaceae counts compared to the control.Enterobacteriaceae counts were also reduced in the ZnO-residual group compared to the control(P<0.05).ANE supplementation decreased the expression of interleukin 22 and transforming growth factor beta 1 in the ileum compared to the control(P<0.05).Conclusions:ANE supplementation was associated with some beneficial changes in the composition of the colonic microbiota,Salmonella shedding,and the expression of inflammatory genes associated with persistent Salmonella infection.展开更多
A new steroid named as Zhonghualiaoine I (1) was isolated from Polygonum nodosum Pers (Chinese name 揨honghualiao? Berberidaceae). Its structure was deduced on the basis of its spectral data.
Oceans and seas form a large body of water that contains a natural biodiversity.For humans,represents a resource,which makes this a point of interest,from researches to improve the economy.Seaweeds produce many compou...Oceans and seas form a large body of water that contains a natural biodiversity.For humans,represents a resource,which makes this a point of interest,from researches to improve the economy.Seaweeds produce many compounds and secondary metabolites that can be used in different fi elds of industry such as food,agricultural,pharmaceutical and health.Even though seaweeds are ancestral resources,recently it was notorious a global interest in knowing more about its potentials,where biotechnology plays an important role in research.Studies showed that seaweed has many bioactive compounds benefi cial to plant development,giving them a great potential as an agricultural fertilizer.Adding seaweeds to the soil provides organic matter,minerals,trace elements,growth plant regulator,metabolites,vitamins,and amino acids and it can work as a soil conditioner.In Portugal,the use of seaweeds for agriculture is important since long time ago.In the past,populations that lived near coastal zone depended on the seaweeds as a family subsistence but,throughout the years,synthetic fertilizers replaced seaweeds.Our work aimed to assess the potential of the extracts obtained from Ascophyllum nodosum and from Sargassum muticum as an agricultural fertilizer.This evaluation was carried out with rice plants(Oryza sativa)and lettuce(Lactuca sativa),in germination bioassays,the culture of rice and lettuce plants in pots,and culture of lettuce plants in hydroponics.For that,seaweed liquid extracts were used in different concentrations in different bioassays.Results show that extracts obtained from two seaweeds,A.nodosum and S.muticum,can be promissory plant biofertilizer at a concentration of 25% and had a positive effect on seed germination,plant development,and production.展开更多
A 31-year-old woman was referred with a painful mass in the left breast that was initially treated with antibiotics. Three weeks later, the mass had increased and polyarthritis and erythema nodosum had developed in bo...A 31-year-old woman was referred with a painful mass in the left breast that was initially treated with antibiotics. Three weeks later, the mass had increased and polyarthritis and erythema nodosum had developed in both legs. A core needle biopsy led to a diagnosis of granulomatous mastitis with arthritis and erythema nodosum. Low-dose prednisolone (10 mg) rapidly improved the arthritis and the erythema nodosum. Granulomatous mastitis is a very rare, chronic inflammatory disease and only nine patients with granulomatous mastitis with erythema nodosum have been described. We reviewed the literature to determine the clinicopathological features and treatment of granulomatous mastitis. Appropriate diagnosis and steroid therapy should result in excellent outcomes.展开更多
Objective:To determine the clinical features predicting erythema nodosum leprosum(ENL) in a non endemic leprosy area.Methods:Twenty newly diagnosed patients with MBL attending the skin clinic,Sarawak General Hospital ...Objective:To determine the clinical features predicting erythema nodosum leprosum(ENL) in a non endemic leprosy area.Methods:Twenty newly diagnosed patients with MBL attending the skin clinic,Sarawak General Hospital from 1992 to 2007 were analyzed.They were divided into 2 groups,one with ENL and one without. Analysis of the presenting clinical features was done to determine the risk factors for ENL.Chi square and student t test was used for statistical analysis.Level of significance was set at 0.05.Results:ENL was present in 40%patients,all with lepromatous leprosy(LL).Clinical features that were seen more frequently in patients developing ENL include earlobe thickening(100%cf.25%,P =0.00),loss of the lateral third of the eyebrows(75%cf.16.7%,P=0.02) and mean bacteriology index(BI)(5.1 cf.2.9,P=0.03) and mean morphological index(MI)(17.8 cf.7.0,P =0.02).Number of thickened nerves(mean 2.5 cf. 1.4,P = 0.12),number of skin lesions(mean 19.4 cf.10.9,P = 0.15) and duration of illness(mean 15. 3 cf.12.8 months,P =0.68) did not predict ENL development.Conclusion:Finding LL patients with thickened earlobes,loss of lateral third of the eyebrow,high BI and MI should alert treating clinician to the possibility of ENL in a non endemic leprosy area.展开更多
Restenosis is a common complication following coronary angioplasty.The traditional use of seaweeds for health benefits has increasingly been explored,however few studies exist reporting its protective effects on the d...Restenosis is a common complication following coronary angioplasty.The traditional use of seaweeds for health benefits has increasingly been explored,however few studies exist reporting its protective effects on the development of restenosis and gut dysbiosis.The aim of this study was to investigate the potential of seaweed extracts(SE) of Ascophyllum nodosum and Fucus vesiculosus in inhibiting intimal hyperplasia in a rat model of restenosis and its underlying mechanisms in macrophages and vascular smooth muscle cells(vSMCs).16S rRNA sequencing was done to investigate the regulatory effect of SE on the gut microbiome of injured rats.As indicated by the results,SE significantly inhibited the progression of intimal hyperplasia in vivo,attenuated inflammation in macrophages and could inhibit the proliferation,dedifferentiation and migration of vSMCs.It was observed through immunoblotting assays that treatment with SE significantly upregulated PTEN expression in macrophages and inhibited the upregulation of PI3K and AKT expression in vSMCs.Meanwhile,according to the 16S rRNA gene sequencing analysis,supplementation with SE modulated gut microbiota composition in injured rats.In conclusion,SE could ameliorate intimal hyperplasia by inhibiting inflammation and vSMCs proliferation through the regulation of the PTEN/PI3K/AKT pathway and modulating the gut microbiome.展开更多
Epstein-Barr virus (EBV) is one of the eight known human herpesviruses, which is widespread in nature and infects most of the world population. In infants and young children, primary infection is usually asymptomatic ...Epstein-Barr virus (EBV) is one of the eight known human herpesviruses, which is widespread in nature and infects most of the world population. In infants and young children, primary infection is usually asymptomatic or produces an acute illness that is often not recognized as being due to EBV. It has a well-established oncogenic potential, and has been implicated in the pathogenesis of various autoimmune diseases. Here is reported the case of a 32-months old boy, who presented with a history of two days of low-grade fever, pain in both legs, swollen ankles and inability to walk. On physical examination, the child appeared moderately ill, without fever. On both shins were observed nodules 2 - 3 cm in diameter, red to bluish in color, firm and poorly demarcated. Clinically, a diagnosis of Erythema nodosus was performed. Laboratory examinations revealed increased inflammatory parameters. After a full workup, EBV was established as the causative agent. Erythema nodosum is the most common form of panniculitis in children;however, it is relatively uncommon in the pediatric population. It is a self-limited disease, and most of infectious origin in children. Although uncommon, EBV infection is a potential cause of pediatric erythema nodosum.展开更多
While erythema nodosum is a nodular, erythematous eruption predominantly affecting the extensor aspects of the legs, breast abscesses are the result of relatively common bacterial infections, and only 2 studies have r...While erythema nodosum is a nodular, erythematous eruption predominantly affecting the extensor aspects of the legs, breast abscesses are the result of relatively common bacterial infections, and only 2 studies have reported an association between erythema nodosum and breast abscesses. Here, we report the case of a patient with repeated erythema nodosum associated with subareolar abscesses. The patient was a 34-year-old woman with painful erythematous nodules on her right shin, accompanied by an indurated lesion on her right breast 4 days before the onset of the nodules. Therefore, the patient underwent circumareolar incision, and consequently the painful erythematous nodules disappeared. However, after 39 days, the patient developed another tender, painful lesion in her right breast and painful erythematous nodules on her right shin. After another circumareolar incision, the painful erythematous nodules disappeared again. Therefore, we suggested a significant association between erythema nodosum and breast abscess in this patient. The most common underlying causative organism in breast abscess is Staphylococcus aureus;however, erythema nodosum has rarely been proven to be associated with staphylococcal infections. Therefore, the relationship between S. aureus and erythema nodosum is rather controversial. However, the resistance to the usual treatment methods and prolonged clinical course in our case suggest that the pathogenesis of erythema nodosum associated with breast abscesses might be different from that of the common form of erythema nodosum.展开更多
Erythema nodosum (EN) is a delayed hypersensitivity response that may be triggered by a range of conditions, including infections and vaccines. Rare cases of EN caused by COVID-19 were recently reported but none due t...Erythema nodosum (EN) is a delayed hypersensitivity response that may be triggered by a range of conditions, including infections and vaccines. Rare cases of EN caused by COVID-19 were recently reported but none due to COVID-19 vaccines were documented. We report here a case of EN occurring after COVID-19 vaccination. Patient presented with painful nodular lesions of all 4 limbs, evolving for one month. These lesions appeared 48 h after the second dose of COVID-19 vaccination. The patient reported no recent infectious episodes. The physical examination found numerous, erythematous dermohypodermatitis knots with no palpable adenopathy. Some were regressive according to biligenesis shades. Biology and radiology findings eliminated other common causes of this dermatosis. The skin biopsy was done and suggested EN. The final diagnosis was post COVID-19 vaccine EN. Patient received a symptomatic treatment and had a slight improvement of the lesions 10 days after diagnosis. Physicians should be aware of the side effects of the vaccine including skin manifestations, especially since more people are bound to be vaccinated.展开更多
Objective:This study was performed to compare the efficacy and safety of methotrexate(MTX)plus prednisolone versus prednisolone monotherapy in patients with erythema nodosum leprosum(ENL).Methods:This comparative clin...Objective:This study was performed to compare the efficacy and safety of methotrexate(MTX)plus prednisolone versus prednisolone monotherapy in patients with erythema nodosum leprosum(ENL).Methods:This comparative clinical study was performed in the Chittagong Medical College Hospital,Bangladesh from June 2018 to December 2019.Nineteen patients were selected according to inclusion criteria and randomly allocated to either the MTX plus prednisolone group(Group A,n=10)or the prednisolone monotherapy group(Group B,n=9).All patients were followed up until the end of the 6-month duration of therapy to observe the clinical outcomes and adverse effects.Results:All patients in both groups showed significant improvement(P=0.005 and P=0.008 in Group A and B,respectively).However,prednisolone-related adverse events were more frequent in Group B.Conclusion:The present study has demonstrated that a combination of prednisolone and MTX is a safer and more effective treatment than steroid monotherapy in ENL patients including the healing of nodules.However,this combination therapy did not appear to have a significant steroid-sparing effect,possibly because of the small sample size and short study period.Therefore,a well-designed multicenter randomized controlled trial is recommended for validation of MTX with prednisolone for the management of ENL.展开更多
文摘Salinity stress is amajor constraint on agricultural productivity,particularly in arid and semi-arid regions.This study evaluated the potential of Ascophyllum nodosum extract(ANE)in mitigating salinity-induced stress and enhancing the growth and physiological performance of Portulaca oleracea L.under NaCl concentrations of 0,50,70,and 100 mM for 50 days.A two-way ANOVA assessed the effects of NaCl concentration,ANE treatment,and their interaction.The results showed that ANE significantly increased plant height at 50 mMNaCl(p=0.0011)but had no effect at higher salinity levels(p>0.05).Shoot dry weight was significantly influenced by the interaction of NaCl and ANE(p=0.0064),with ANE increasing biomass at 0 mM but decreasing it at 100 mM NaCl.However,ANE did not significantly affect root dry weight(p>0.05).Physiological responses indicated a significant increase in proline content at 50mMNaCl(p=0.0011),supporting improved osmotic adjustment.Total soluble protein was significantly enhanced at all salinity levels except 100 mM NaCl(p<0.01).Regarding ionic regulation,ANE had no significant effect on leaf sap pH(p>0.05)but increased electrical conductivity(EC)at 70 and 100 mM NaCl(p<0.01),suggesting a role in ion homeostasis under high salinity.Photosynthetic pigments responded positively to ANE,with significant increases in chlorophyll“a”(p<0.0001)and carotenoid content(p<0.0001),while chlorophyll“b”remained unchanged(p>0.05).These findings highlight ANE’s potential as a sustainable biostimulant for improving salinity tolerance,particularly at moderate NaCl levels.Future research should focus on molecular mechanisms and long-term field applications to optimize ANE’s role in enhancing soil and crop productivity under salinity stress.
基金supported by the Science Foundation Ireland(SFI)[grant number:14/IA/2548].
文摘Background:Dietary supplementation with a fucoidan-rich Ascophyllum nodosum extract(ANE),possessing an in vitro anti-Salmonella Typhimurium activity could be a promising on-farm strategy to control Salmonella infection in pigs.The objectives of this study were to:1)evaluate the anti-S.Typhimurium activity of ANE(containing 46.6%fucoidan,18.6%laminarin,10.7%mannitol,4.6%alginate)in vitro,and;2)compare the effects of dietary supplementation with ANE and Zinc oxide(ZnO)on growth performance,Salmonella shedding and selected gut parameters in naturally infected pigs.This was established post-weaning(newly weaned pig experiment)and following regrouping of post-weaned pigs and experimental re-infection with S.Typhimurium(challenge experiment).Results:In the in vitro assay,increasing ANE concentrations led to a linear reduction in S.Typhimurium counts(P<0.05).In the newly weaned pig experiment(12 replicates/treatment),high ANE supplementation increased gain to feed ratio,similar to ZnO supplementation,and reduced faecal Salmonella counts on d 21 compared to the low ANE and control groups(P<0.05).The challenge experiment included thirty-six pigs from the previous experiment that remained on their original dietary treatments(control and high ANE groups with the latter being renamed to ANE group)apart from the ZnO group which transitioned onto a control diet on d 21(ZnO-residual group).These dietary treatments had no effect on performance,faecal scores,Salmonella shedding or colonic and caecal Salmonella counts(P>0.05).ANE supplementation decreased the Enterobacteriaceae counts compared to the control.Enterobacteriaceae counts were also reduced in the ZnO-residual group compared to the control(P<0.05).ANE supplementation decreased the expression of interleukin 22 and transforming growth factor beta 1 in the ileum compared to the control(P<0.05).Conclusions:ANE supplementation was associated with some beneficial changes in the composition of the colonic microbiota,Salmonella shedding,and the expression of inflammatory genes associated with persistent Salmonella infection.
基金supported by the Northwest Normal University-Bring Forth new Idea Project of Science and Technology P. R. China
文摘A new steroid named as Zhonghualiaoine I (1) was isolated from Polygonum nodosum Pers (Chinese name 揨honghualiao? Berberidaceae). Its structure was deduced on the basis of its spectral data.
基金the support of Fundacao para a Ciência e Tecnologia(FCT),through the strategic project UID/MAR/04292/2019 granted to MAREthe support from the European Union through EASME Blue Labs project AMALIA-Algaeto-MArket Lab IdeAs(EASME/EMFF/2016/1.2.1.4/03/SI2.750419)+2 种基金funding from European Structural&Investment Funds through the COMPETE ProgrammeNational Funds through FCT-Fundacao para a Ciência e a Tecnologia under the Programme grant SAICTPAC/0019/2015Co-financed by the European Regional Development Fund through the Interreg Atlantic Area Programme,under the project NASPA
文摘Oceans and seas form a large body of water that contains a natural biodiversity.For humans,represents a resource,which makes this a point of interest,from researches to improve the economy.Seaweeds produce many compounds and secondary metabolites that can be used in different fi elds of industry such as food,agricultural,pharmaceutical and health.Even though seaweeds are ancestral resources,recently it was notorious a global interest in knowing more about its potentials,where biotechnology plays an important role in research.Studies showed that seaweed has many bioactive compounds benefi cial to plant development,giving them a great potential as an agricultural fertilizer.Adding seaweeds to the soil provides organic matter,minerals,trace elements,growth plant regulator,metabolites,vitamins,and amino acids and it can work as a soil conditioner.In Portugal,the use of seaweeds for agriculture is important since long time ago.In the past,populations that lived near coastal zone depended on the seaweeds as a family subsistence but,throughout the years,synthetic fertilizers replaced seaweeds.Our work aimed to assess the potential of the extracts obtained from Ascophyllum nodosum and from Sargassum muticum as an agricultural fertilizer.This evaluation was carried out with rice plants(Oryza sativa)and lettuce(Lactuca sativa),in germination bioassays,the culture of rice and lettuce plants in pots,and culture of lettuce plants in hydroponics.For that,seaweed liquid extracts were used in different concentrations in different bioassays.Results show that extracts obtained from two seaweeds,A.nodosum and S.muticum,can be promissory plant biofertilizer at a concentration of 25% and had a positive effect on seed germination,plant development,and production.
文摘A 31-year-old woman was referred with a painful mass in the left breast that was initially treated with antibiotics. Three weeks later, the mass had increased and polyarthritis and erythema nodosum had developed in both legs. A core needle biopsy led to a diagnosis of granulomatous mastitis with arthritis and erythema nodosum. Low-dose prednisolone (10 mg) rapidly improved the arthritis and the erythema nodosum. Granulomatous mastitis is a very rare, chronic inflammatory disease and only nine patients with granulomatous mastitis with erythema nodosum have been described. We reviewed the literature to determine the clinicopathological features and treatment of granulomatous mastitis. Appropriate diagnosis and steroid therapy should result in excellent outcomes.
文摘Objective:To determine the clinical features predicting erythema nodosum leprosum(ENL) in a non endemic leprosy area.Methods:Twenty newly diagnosed patients with MBL attending the skin clinic,Sarawak General Hospital from 1992 to 2007 were analyzed.They were divided into 2 groups,one with ENL and one without. Analysis of the presenting clinical features was done to determine the risk factors for ENL.Chi square and student t test was used for statistical analysis.Level of significance was set at 0.05.Results:ENL was present in 40%patients,all with lepromatous leprosy(LL).Clinical features that were seen more frequently in patients developing ENL include earlobe thickening(100%cf.25%,P =0.00),loss of the lateral third of the eyebrows(75%cf.16.7%,P=0.02) and mean bacteriology index(BI)(5.1 cf.2.9,P=0.03) and mean morphological index(MI)(17.8 cf.7.0,P =0.02).Number of thickened nerves(mean 2.5 cf. 1.4,P = 0.12),number of skin lesions(mean 19.4 cf.10.9,P = 0.15) and duration of illness(mean 15. 3 cf.12.8 months,P =0.68) did not predict ENL development.Conclusion:Finding LL patients with thickened earlobes,loss of lateral third of the eyebrow,high BI and MI should alert treating clinician to the possibility of ENL in a non endemic leprosy area.
基金supported by the research grants from the Ministry of Science and Technology of Taiwan (MOST108-2320B-038-040-MY3 and MOST 111-2320-B-038-049)the National Science and Technology Council (NSTC111-2320-B-038-049)。
文摘Restenosis is a common complication following coronary angioplasty.The traditional use of seaweeds for health benefits has increasingly been explored,however few studies exist reporting its protective effects on the development of restenosis and gut dysbiosis.The aim of this study was to investigate the potential of seaweed extracts(SE) of Ascophyllum nodosum and Fucus vesiculosus in inhibiting intimal hyperplasia in a rat model of restenosis and its underlying mechanisms in macrophages and vascular smooth muscle cells(vSMCs).16S rRNA sequencing was done to investigate the regulatory effect of SE on the gut microbiome of injured rats.As indicated by the results,SE significantly inhibited the progression of intimal hyperplasia in vivo,attenuated inflammation in macrophages and could inhibit the proliferation,dedifferentiation and migration of vSMCs.It was observed through immunoblotting assays that treatment with SE significantly upregulated PTEN expression in macrophages and inhibited the upregulation of PI3K and AKT expression in vSMCs.Meanwhile,according to the 16S rRNA gene sequencing analysis,supplementation with SE modulated gut microbiota composition in injured rats.In conclusion,SE could ameliorate intimal hyperplasia by inhibiting inflammation and vSMCs proliferation through the regulation of the PTEN/PI3K/AKT pathway and modulating the gut microbiome.
文摘Epstein-Barr virus (EBV) is one of the eight known human herpesviruses, which is widespread in nature and infects most of the world population. In infants and young children, primary infection is usually asymptomatic or produces an acute illness that is often not recognized as being due to EBV. It has a well-established oncogenic potential, and has been implicated in the pathogenesis of various autoimmune diseases. Here is reported the case of a 32-months old boy, who presented with a history of two days of low-grade fever, pain in both legs, swollen ankles and inability to walk. On physical examination, the child appeared moderately ill, without fever. On both shins were observed nodules 2 - 3 cm in diameter, red to bluish in color, firm and poorly demarcated. Clinically, a diagnosis of Erythema nodosus was performed. Laboratory examinations revealed increased inflammatory parameters. After a full workup, EBV was established as the causative agent. Erythema nodosum is the most common form of panniculitis in children;however, it is relatively uncommon in the pediatric population. It is a self-limited disease, and most of infectious origin in children. Although uncommon, EBV infection is a potential cause of pediatric erythema nodosum.
文摘While erythema nodosum is a nodular, erythematous eruption predominantly affecting the extensor aspects of the legs, breast abscesses are the result of relatively common bacterial infections, and only 2 studies have reported an association between erythema nodosum and breast abscesses. Here, we report the case of a patient with repeated erythema nodosum associated with subareolar abscesses. The patient was a 34-year-old woman with painful erythematous nodules on her right shin, accompanied by an indurated lesion on her right breast 4 days before the onset of the nodules. Therefore, the patient underwent circumareolar incision, and consequently the painful erythematous nodules disappeared. However, after 39 days, the patient developed another tender, painful lesion in her right breast and painful erythematous nodules on her right shin. After another circumareolar incision, the painful erythematous nodules disappeared again. Therefore, we suggested a significant association between erythema nodosum and breast abscess in this patient. The most common underlying causative organism in breast abscess is Staphylococcus aureus;however, erythema nodosum has rarely been proven to be associated with staphylococcal infections. Therefore, the relationship between S. aureus and erythema nodosum is rather controversial. However, the resistance to the usual treatment methods and prolonged clinical course in our case suggest that the pathogenesis of erythema nodosum associated with breast abscesses might be different from that of the common form of erythema nodosum.
文摘Erythema nodosum (EN) is a delayed hypersensitivity response that may be triggered by a range of conditions, including infections and vaccines. Rare cases of EN caused by COVID-19 were recently reported but none due to COVID-19 vaccines were documented. We report here a case of EN occurring after COVID-19 vaccination. Patient presented with painful nodular lesions of all 4 limbs, evolving for one month. These lesions appeared 48 h after the second dose of COVID-19 vaccination. The patient reported no recent infectious episodes. The physical examination found numerous, erythematous dermohypodermatitis knots with no palpable adenopathy. Some were regressive according to biligenesis shades. Biology and radiology findings eliminated other common causes of this dermatosis. The skin biopsy was done and suggested EN. The final diagnosis was post COVID-19 vaccine EN. Patient received a symptomatic treatment and had a slight improvement of the lesions 10 days after diagnosis. Physicians should be aware of the side effects of the vaccine including skin manifestations, especially since more people are bound to be vaccinated.
基金The authors thankfully acknowledge the assistance of Mr. Sultan Md Elias Uddin. Program Manager, Leprosy control project, Chittagong.
文摘Objective:This study was performed to compare the efficacy and safety of methotrexate(MTX)plus prednisolone versus prednisolone monotherapy in patients with erythema nodosum leprosum(ENL).Methods:This comparative clinical study was performed in the Chittagong Medical College Hospital,Bangladesh from June 2018 to December 2019.Nineteen patients were selected according to inclusion criteria and randomly allocated to either the MTX plus prednisolone group(Group A,n=10)or the prednisolone monotherapy group(Group B,n=9).All patients were followed up until the end of the 6-month duration of therapy to observe the clinical outcomes and adverse effects.Results:All patients in both groups showed significant improvement(P=0.005 and P=0.008 in Group A and B,respectively).However,prednisolone-related adverse events were more frequent in Group B.Conclusion:The present study has demonstrated that a combination of prednisolone and MTX is a safer and more effective treatment than steroid monotherapy in ENL patients including the healing of nodules.However,this combination therapy did not appear to have a significant steroid-sparing effect,possibly because of the small sample size and short study period.Therefore,a well-designed multicenter randomized controlled trial is recommended for validation of MTX with prednisolone for the management of ENL.
