BACKGROUND As a substitute for traditional drug therapy,digital cognitive-behavioral therapy positively impacts the regulation of brain function,which can improve insomnia.However,there is currently a paucity of studi...BACKGROUND As a substitute for traditional drug therapy,digital cognitive-behavioral therapy positively impacts the regulation of brain function,which can improve insomnia.However,there is currently a paucity of studies on digital cognitive behavioral therapy as a treatment for insomnia.AIM To assess digital cognitive behavioral therapy for insomnia regarding its positive impact on brain function.METHODS Participants were randomly assigned to either a go/no-go group or a dot-probe group.The primary outcome was quality of sleep as assessed by the actigraphy sleep monitoring bracelet,Pittsburgh sleep quality index(PSQI),insomnia severity index(ISI),and depression anxiety and stress scale(DASS-21).RESULTS Eighty patients were included in the analysis(go/no-go group:n=40;dot-probe group:n=40).We combined the total scale scores of the two groups before and after the intervention in the analysis of covariance.Our study explored whether insomnia symptoms in both groups can be improved by using digital cognitive behavioral therapy instead of trying to compare the two trials;therefore,only one P value is listed.In both groups,we found a short-term time effect on insomnia symptom severity(PSQI:P<0.001,η^(2)=0.336;ISI:P<0.001,η^(2)=0.667;DASS-depression:P<0.001,η^(2)=0.582;DASS-anxiety:P<0.001,η^(2)=0.337;DASS-stress:P<0.001,η^(2)=0.443)and some effect on sleep efficiency(but it was not significant,P=0.585,η^(2)=0.004).CONCLUSION Go/no-go task training of inhibitory function had a short-term positive effect on sleep efficiency,whereas dotprobe task training had a positive short-term effect on emotion regulation.展开更多
研究探讨内隐联想测验(Implicit Association Test,IAT)和Go/No-go联想任务测验(Go/No-go AssociationTask,GNAT)测量大学生感恩的可行性,并分析内隐感恩与外显感恩的关系。预备性研究从现代汉语字典中挑选自我词/他人词各16个,从汉语...研究探讨内隐联想测验(Implicit Association Test,IAT)和Go/No-go联想任务测验(Go/No-go AssociationTask,GNAT)测量大学生感恩的可行性,并分析内隐感恩与外显感恩的关系。预备性研究从现代汉语字典中挑选自我词/他人词各16个,从汉语成语大辞典中挑选出与感恩相关的积极词/消极词各20个,根据65位大学生的评定结果筛选出自我词/他人词各8个,积极词/消极词各8个,用于正式研究。正式研究采用IAT、GNAT感恩测量程序和青少年感恩量表(Adolescent Gratitude Scale,AGS),对155名大学生同时进行IAT、GNAT及外显感恩的测量。结果发现:(1)大学生普遍具有积极的内隐感恩,内隐感恩不存在性别、生源地和独生与否等人口统计学指标上的显著差异;(2)大学生的内隐感恩与外显感恩相关不显著,是两个不同的建构;(3)采用IAT和GNAT研究感恩是可行的。展开更多
The olfactory bulb(OB) is the first relay station in the olfactory system.In the OB,mitral/tufted cells(M/Ts),which are the main output neurons,play important roles in the processing and representation of odor informa...The olfactory bulb(OB) is the first relay station in the olfactory system.In the OB,mitral/tufted cells(M/Ts),which are the main output neurons,play important roles in the processing and representation of odor information.Recent studies focusing on the function of M/Ts at the single-cell level in awake behaving mice have demonstrated that odor-evoked firing of single M/Ts displays transient/long-term plasticity during learning.Here,we tested whether the neural activity of M/Ts and sniffing patterns are dependent on anticipation and reward in awake behaving mice.We used an odor discrimination task combined with in vivo electrophysiological recordings in awake,head-fixed mice,and found that,while learning induced plasticity of spikes and beta oscillations during odor sampling,we also found plasticity of spikes,beta oscillation,sniffing pattern,and coherence between sniffing and theta oscillations during the periods of anticipation and/or reward.These results indicate that the activity of M/Ts plays important roles not only in odor representation but also in salience-related events such as anticipation and reward.展开更多
基金Supported by the Shanghai Pujiang Program,No.2020PJC115Social Science Incubation Fund of Naval Medical University,No.2022SK027+1 种基金Scientific Research Program of Provincial Department of Education,No.Q20224105Research on the High-quality Development of Sports Talents in Hubei Province’s Universities Under the Background of Integration of Sports and Education,No.2022GA059.
文摘BACKGROUND As a substitute for traditional drug therapy,digital cognitive-behavioral therapy positively impacts the regulation of brain function,which can improve insomnia.However,there is currently a paucity of studies on digital cognitive behavioral therapy as a treatment for insomnia.AIM To assess digital cognitive behavioral therapy for insomnia regarding its positive impact on brain function.METHODS Participants were randomly assigned to either a go/no-go group or a dot-probe group.The primary outcome was quality of sleep as assessed by the actigraphy sleep monitoring bracelet,Pittsburgh sleep quality index(PSQI),insomnia severity index(ISI),and depression anxiety and stress scale(DASS-21).RESULTS Eighty patients were included in the analysis(go/no-go group:n=40;dot-probe group:n=40).We combined the total scale scores of the two groups before and after the intervention in the analysis of covariance.Our study explored whether insomnia symptoms in both groups can be improved by using digital cognitive behavioral therapy instead of trying to compare the two trials;therefore,only one P value is listed.In both groups,we found a short-term time effect on insomnia symptom severity(PSQI:P<0.001,η^(2)=0.336;ISI:P<0.001,η^(2)=0.667;DASS-depression:P<0.001,η^(2)=0.582;DASS-anxiety:P<0.001,η^(2)=0.337;DASS-stress:P<0.001,η^(2)=0.443)and some effect on sleep efficiency(but it was not significant,P=0.585,η^(2)=0.004).CONCLUSION Go/no-go task training of inhibitory function had a short-term positive effect on sleep efficiency,whereas dotprobe task training had a positive short-term effect on emotion regulation.
基金supported by the National Natural Science Foundation of China (31571082,31872771 and 31700895)the Natural Science Foundation of the Jiangsu Higher Education Institutions of China(16KJA180007)the Natural Science Foundation of Jiangsu Province (BK20170260)。
文摘The olfactory bulb(OB) is the first relay station in the olfactory system.In the OB,mitral/tufted cells(M/Ts),which are the main output neurons,play important roles in the processing and representation of odor information.Recent studies focusing on the function of M/Ts at the single-cell level in awake behaving mice have demonstrated that odor-evoked firing of single M/Ts displays transient/long-term plasticity during learning.Here,we tested whether the neural activity of M/Ts and sniffing patterns are dependent on anticipation and reward in awake behaving mice.We used an odor discrimination task combined with in vivo electrophysiological recordings in awake,head-fixed mice,and found that,while learning induced plasticity of spikes and beta oscillations during odor sampling,we also found plasticity of spikes,beta oscillation,sniffing pattern,and coherence between sniffing and theta oscillations during the periods of anticipation and/or reward.These results indicate that the activity of M/Ts plays important roles not only in odor representation but also in salience-related events such as anticipation and reward.
