In two-scale topology optimization,enhancing the connectivity between adjacent microstructures is crucial for achieving the collaborative optimization of micro-scale performance and macro-scale manufacturability.This ...In two-scale topology optimization,enhancing the connectivity between adjacent microstructures is crucial for achieving the collaborative optimization of micro-scale performance and macro-scale manufacturability.This paper proposes a two-scale concurrent topology optimization strategy aimed at improving the interface connection strength.This method employs a parametric approach to explicitly divide the micro-design domain into a“boundary connection region”and a“free design domain”at the initial stage of optimization.The boundary connection region is used to generate a connection layer that enhances the interface strength,while the free design domain is not constrained by this layer,thus fully exploiting the design potential of the material layout.During the optimization process,the solid isotropic material with penalization(SIMP)method is first used to optimize the material distribution in the free design domain,and filtering and projection techniques are employed to alleviate numerical instability and obtain a clear topological structure.Subsequently,the effective performance of the microstructure is calculated through homogenization and transferred to the macro-scale for global response analysis.Throughout the iterative process,the geometry of the connection layer remains unchanged,and only the free design domain is optimized,thereby achieving a balance between high performance and good manufacturability.The effectiveness of the proposed method is verified through numerical examples.展开更多
Background Fusion genes play a crucial role in the pathogenesis of acute myeloid leukemia(AML).This study investigated the utility of targeted next-generation sequencing(NGS)of RNA for detecting rare and unknown fusio...Background Fusion genes play a crucial role in the pathogenesis of acute myeloid leukemia(AML).This study investigated the utility of targeted next-generation sequencing(NGS)of RNA for detecting rare and unknown fusion genes in patients with AML.Methods A total of 85 adult AML samples previously identified as fusion gene-negative by multiplex nested reverse transcription-polymerase chain reaction(RT-PCR)were subjected to NGS analysis.Results Fusion genes were detected in 21 of 72(29.2%)patients.Among the 26 primary refractory patients,11(42.3%)exhibited fusion genes,whereas among the 18 relapsed patients,fusion genes were identified in five(27.8%).Notably,lysine methyltransferase 2A(KMT2A)and nucleoporin 98(NUP98)rearrangements were enriched in refractory/relapsed patients.Additionally,recurrent fusion transcripts involving eukaryotic translation initiation factor 4A1(EIF4A1)were identified.The identification of additional fusion genes resulted in an approximate 20.8%(11/53)reclassification of medium-risk karyotypes to the high-risk category,thereby enhancing diagnostic accuracy.Conclusions Targeted NGS may complement conventional methods for identifying novel fusions in refractory/relapsed AML;however,its prognostic value requires validation in prospective controlled trials.展开更多
To achieve efficient connection and integrity in prefabricated frame structures,a novel beam-column connection between prefabricated steel-reinforced concrete(SRC)columns and cast-in-situ reinforced concrete(RC)beams ...To achieve efficient connection and integrity in prefabricated frame structures,a novel beam-column connection between prefabricated steel-reinforced concrete(SRC)columns and cast-in-situ reinforced concrete(RC)beams is proposed.Four connection specimens with varying thicknesses of connecting cover plates were designed and fabricated.Low-cycle reversed loading tests were conducted to obtain mechanical performance data,allowing for analysis of behavioral patterns,including load-displacement hysteresis curves,skeleton curves,load-carrying capacity,deformation performance,energy dissipation capacity,and stiffness degradation.Test results indicate that properly designed prefabricated connections exhibit mechanical properties comparable to those of cast-in-situ concrete connections.The hysteresis curves of the prefabricated connections are well-shaped,with nearly no reduction in load-carrying capacity and deformation performance,demonstrating excellent seismic behavior.The findings provide a theoretical basis and reference for the design of prefabricated concrete frame structures.展开更多
Next-GenerationNetworks(NGNs)demand high resilience,dynamic adaptability,and efficient resource utilization to enable ubiquitous connectivity.In this context,the Space-Air-Ground Integrated Network(SAGIN)architecture ...Next-GenerationNetworks(NGNs)demand high resilience,dynamic adaptability,and efficient resource utilization to enable ubiquitous connectivity.In this context,the Space-Air-Ground Integrated Network(SAGIN)architecture is uniquely positioned to meet these requirements.However,conventional NGN routing algorithms often fail to account for SAGIN’s intrinsic characteristics,such as its heterogeneous structure,dynamic topology,and constrained resources,leading to suboptimal performance under disruptions such as node failures or cyberattacks.To meet these demands for SAGIN,this study proposes a resilience-oriented routing optimization framework featuring dynamic weighting and multi-objective evaluation.Methodologically,we define three core routing performance metrics,quantified through a four-dimensionalmodel,encompassing robustness Rd,resilience Rr,adaptability Ra,and resource utilization efficiency Ru,and integrate them into a comprehensive evaluation metric.In simulated SAGIN environments,the proposed Multi-Indicator Weighted Resilience Evaluation Algorithm(MIW-REA)demonstrates significant improvements in resilience enhancement,recovery acceleration,and resource optimization.It maintains 82.3%service availability even with a 30%node failure rate,reduces Distributed Denial of Service(DDoS)attack recovery time by 43%,decreases bandwidth waste by 23.4%,and lowers energy consumption by 18.9%.By addressing challenges unique to the SAGIN network,this research provides a flexible real-time solution for NGN routing optimization that balances resilience,efficiency,and adaptability,advancing the field.展开更多
This study proposes a new post-tensioned precast bridge column(PT-PBC)with a socket connection.Compared to conventional PBCs connected by PT tendons,the combination of the PT tendons with the socket connection can avo...This study proposes a new post-tensioned precast bridge column(PT-PBC)with a socket connection.Compared to conventional PBCs connected by PT tendons,the combination of the PT tendons with the socket connection can avoid tensioning the PT tendons on site,which further accelerates construction speed while improving construction quality and safety.In addition,compared to conventional PBCs with a socket connection,a rocking interface can avoid the formation of a plastic hinge in a column,which greatly alleviates seismic damage to that area.One specimen for quasi-static testing is used to validate the feasibility of this connection type.Subsequently,finite element models(FEM)are established to systematically predict the responses of the proposed columns under lateral cyclic loading.The accuracy of the FEM is verified through quasistatic testing.Next,the influences of the key design parameters of the PT-PBC,including the area ratio and prestress level of the PT tendons,the area ratio of energy dissipation(ED)steel rebars,and the total axial compression ratio on the seismic performances of PT-PBC are systematically investigated.The use of shape memory alloy(SMA)rods as energy dissipation devices and their performances also are investigated.The results show that increasing the area ratio and prestress level of PT tendons has an overall positive impact on the self-centering capacity of the column.The prestress level of PT tendons should be kept between 35%and 55%,depending on different conditions.The total compression axial ratio of the columns should be maintained between 0.3 and 0.4.Both ED steel rebars and SMA rods can boost the column’s energy dissipation capacity,while SMA rods can reduce residual deformation due to their inherent mechanical properties.展开更多
Background:Social connection is widely recognized as a protective determinant of health,yet its direct and indirect effects on mental health remain underexplored.This study examines the relationship between social con...Background:Social connection is widely recognized as a protective determinant of health,yet its direct and indirect effects on mental health remain underexplored.This study examines the relationship between social connection and mental health,focusing on the mediating role of quality of life(QoL)and the moderating effect of regional differences.Methods:We analyzed data from the 2019 Korean Community Health Survey,comprising 229,099 adults.Mental health was assessed through validated measures of depressive symptoms and psychological well-being.Social connection was measured using indicators of interpersonal ties and community participation,and QoL was assessed via self-reported health-related satisfaction across major life domains.Analytical procedures included mediation modeling and subgroup analyses by region,with significance levels set at p<0.05.Results:The results indicate that social connections are significantly associated with lower stress levels and reduced depressive symptoms,with QoL playing a critical mediating role.Notably,the indirect effect of social connection on mental health via QoL is stronger in rural areas compared to urban regions,highlighting the importance of social cohesion and community support in mental well-being.Among 203,567 adults,greater social participation was associated with lower subjective stress(total effect=−0.052,p<0.001)and fewer depressive symptoms(PHQ-9 total effect=−0.308,p<0.001).QoL significantly mediated these associations,with the strongest indirect pathways observed through usual activities(19.2%for stress;27.6%for depression)and mobility(24.4%for depression).Regional analysis showed stronger mediation in rural areas(up to 26.8%for stress and 32.6%for depression)than in urban areas(8–16%and 14.9–23%).Direct effects remained significant,indicating partial mediation.These findings highlight that social participation enhances mental health directly and indirectly through QoL,particularly in rural contexts.Conclusions:Social connection contributes to better mental health both directly and indirectly through improved QoL,with stronger effects observed in rural communities.These findings highlight the importance of fostering social cohesion and enhancing life quality as strategies for improving population mental health.Policy interventions should adopt context-sensitive approaches that account for regional differences in social resources and service availability.展开更多
Aiming at the problem of potential information noise introduced during the generation of ghost feature maps in GhostNet,this paper proposes a novel lightweight neural network model called ResghostNet.This model constr...Aiming at the problem of potential information noise introduced during the generation of ghost feature maps in GhostNet,this paper proposes a novel lightweight neural network model called ResghostNet.This model constructs the Resghost Module by combining residual connections and Adaptive-SE Blocks,which enhances the quality of generated feature maps through direct propagation of original input information and selection of important channels before cheap operations.Specifically,ResghostNet introduces residual connections on the basis of the Ghost Module to optimize the information flow,and designs a weight self-attention mechanism combined with SE blocks to enhance feature expression capabilities in cheap operations.Experimental results on the ImageNet dataset show that,compared to GhostNet,ResghostNet achieves higher accuracy while reducing the number of parameters by 52%.Although the computational complexity increases,by optimizing the usage strategy of GPU cachememory,themodel’s inference speed becomes faster.The ResghostNet is optimized in terms of classification accuracy and the number of model parameters,and shows great potential in edge computing devices.展开更多
The Wilczek–Zee connection(WZC)is a key concept in the study of topology of quantum systems.Here,we introduce the double Wilczek–Zee connection(DWZC)which naturally appears in the pure-state quantum geometric tensor...The Wilczek–Zee connection(WZC)is a key concept in the study of topology of quantum systems.Here,we introduce the double Wilczek–Zee connection(DWZC)which naturally appears in the pure-state quantum geometric tensor(QGT),another important concept in the field of quantum geometry.The DWZC is Hermitian with respect to the two integer indices,just like the original Hermitian WZC.Based on the symmetric logarithmic derivative operator,we propose a mixed-state quantum geometric tensor.Using the symmetric properties of the DWZC,we find that the real part of the QGT is connected to the real part of the DWZC and the square of eigenvalue differences of the density matrix,whereas the imaginary part can be given in terms of the imaginary part of the DWZC and the cube of the eigenvalue differences.For density matrices with full rank or no full rank,the QGT can be given in terms of real and imaginary parts of the DWZC.展开更多
Prefabricated buildings have developed rapidly due to their advantages in energy efficiency,environmental protection,and high construction efficiency,which have greatly promoted the advancements of connection technolo...Prefabricated buildings have developed rapidly due to their advantages in energy efficiency,environmental protection,and high construction efficiency,which have greatly promoted the advancements of connection technology and the mechanical properties of prefabricated hollow panels.This study proposes a new optimization scheme for prefabricated wall structures using transversely arranged prefabricated hollow plates and develops a new joint connection.First,the constitutive relations are experimentally validated to establish an accurate finite element analysis model;Then the equal-size specimens are compared with the control specimens without node connections;Finally,the effects of axial compression ratio,aspect ratio,and channel steel plate thickness on the seismic performance of the wall are discussed.The experimental results demonstrate that this joint connection can significantly enhance the mechanical performance of walls.The influence of the axial compression ratio and the aspect ratio on the seismic performance of walls is significant,necessitating strict compliance with code specifications.Excessive thickness of the steel plate may negatively impact the structural bearing capacity,providing a technical reference for further investigation.展开更多
Yunhe County in Lishui City,southwestern Zhejiang Province,doesn’t have any Disney castles.Instead,it has built bridges to the world with wood.Known as“China’s town of wooden toys,”accounting for about 40 percent ...Yunhe County in Lishui City,southwestern Zhejiang Province,doesn’t have any Disney castles.Instead,it has built bridges to the world with wood.Known as“China’s town of wooden toys,”accounting for about 40 percent of the global wooden toy market,Yunhe’s story began with a small factory established in 1970.Today,it has grown into a distinctive industrial cluster with an annual output value exceeding 8 billion yuan($1.15 billion),exporting products to 82 countries and regions.展开更多
For the ultra HVDC(UHVDC)with the hierarchical connection mode at the inverter side,considering the change of the Thevenin equivalent parameters(TEP)of post-fault AC grid,a coordinated control strategy to the subseque...For the ultra HVDC(UHVDC)with the hierarchical connection mode at the inverter side,considering the change of the Thevenin equivalent parameters(TEP)of post-fault AC grid,a coordinated control strategy to the subsequent commutation failure(SCF)at both layers is newly proposed.The originality of this work is manifested in three aspects.1)The mechanism of the SCF at the fault layer is newly found by deriving the analytical expression of the extinction angle with the TEP,and that at the non-fault layer is newly found by the voltage-time area theory with the DC current coupling.2)An estimation model for the TEPs of two AC grids at the inverter side is proposed with the post-fault quantities.To address the random noise and inaccurate measurement data,an adaptive robust least squares method based on the median principle is proposed to solve the TEP model.3)A coordinated control strategy with the estimated TEP is proposed to compensate for the extinction angle at the fault layer and limit the DC current at the non-fault layer,thus suppressing the SCF.The simulation results verify the suppression effect of the proposed control on the SCF under different fault conditions.展开更多
Founded in September 2020,the International SparkLink Alliance(iSLA)now has approximately 1,200 members in diverse sectors including terminals,homes,vehicles,manufacturing,transportation,finance and healthcare.The iSL...Founded in September 2020,the International SparkLink Alliance(iSLA)now has approximately 1,200 members in diverse sectors including terminals,homes,vehicles,manufacturing,transportation,finance and healthcare.The iSLA has established a technical standards system for wireless short-range communication covering full-stack standards such as the end-to-end protocol system.展开更多
The security of the seed industry is crucial for ensuring national food security.Currently,developed countries in Europe and America,along with international seed industry giants,have entered the Breeding 4.0 era.This...The security of the seed industry is crucial for ensuring national food security.Currently,developed countries in Europe and America,along with international seed industry giants,have entered the Breeding 4.0 era.This era integrates biotechnology,artificial intelligence(AI),and big data information technology.In contrast,China is still in a transition period between stages 2.0 and 3.0,which primarily relies on conventional selection and molecular breeding.In the context of increasingly complex international situations,accurately identifying core issues in China's seed industry innovation and seizing the frontier of international seed technology are strategically important.These efforts are essential for ensuring food security and revitalizing the seed industry.This paper systematically analyzes the characteristics of crop breeding data from artificial selection to intelligent design breeding.It explores the applications and development trends of AI and big data in modern crop breeding from several key perspectives.These include highthroughput phenotype acquisition and analysis,multiomics big data database and management system construction,AI-based multiomics integrated analysis,and the development of intelligent breeding software tools based on biological big data and AI technology.Based on an in-depth analysis of the current status and challenges of China's seed industry technology development,we propose strategic goals and key tasks for China's new generation of AI and big data-driven intelligent design breeding.These suggestions aim to accelerate the development of an intelligent-driven crop breeding engineering system that features large-scale gene mining,efficient gene manipulation,engineered variety design,and systematized biobreeding.This study provides a theoretical basis and practical guidance for the development of China's seed industry technology.展开更多
Objective and Background Early and accurate diagnosis of spinal infections,including spinal tuberculosis,is pivotal for effective treatment but remains challenging.This study aims to assess the diagnostic yield of met...Objective and Background Early and accurate diagnosis of spinal infections,including spinal tuberculosis,is pivotal for effective treatment but remains challenging.This study aims to assess the diagnostic yield of metagenomic next-generation sequencing(mNGS)compared with that of conventional microbiological tests(CMTs)in identifying pathogens associated with spinal pathologies,with a special focus on infections leading to surgical interventions.Methods We enrolled 85 patients who underwent spinal surgery,comprising 63 patients with clinically diagnosed spinal infections,including patients with spinal tuberculosis,and 22 patients with noninfectious spinal conditions.The procedures involved irrigation and debridement for persistent wound drainage,with subsequent DNA extraction from plasma and joint fluid for mNGS and CMT analysis.Results Significantly increased C-reactive protein(CRP)levels were observed in patients with infections.The mNGS approach showed greater diagnostic sensitivity(92.06%)for detecting pathogens,including Mycobacterium tuberculosis,than did CMTs(36.51%).Despite its low specificity,mNGS had considerable negative predictive value(70.59%),underscoring its utility in ruling out infections.Conclusions The mNGS offers superior sensitivity over CMTs in the diagnosis of a variety of spinal infections,notably spinal tuberculosis.This study highlights the potential of mNGS in enhancing the diagnosis of complex spinal infections,thereby informing targeted treatment strategies.展开更多
With the acceleration of urbanization,prefabricated bridges have become a significant choice for transportation infrastructure construction due to their environmental friendliness,efficiency,and reliable quality.Howev...With the acceleration of urbanization,prefabricated bridges have become a significant choice for transportation infrastructure construction due to their environmental friendliness,efficiency,and reliable quality.However,existing connection technologies still face shortcomings in construction efficiency,seismic performance,and cost control.This paper summarizes the process characteristics of commonly used connection technologies such as socket connections,grouted sleeve connections and corrugated pipe connections,and analyzes their seismic capacity and mechanical performance.In response to existing issues,two new technologies—separated steel connection and multi-chamber steel tube concrete connection—are proposed,and their comprehensive performance and economic efficiency are analyzed.The new connection technologies outperform traditional methods in construction efficiency,economic efficiency,and structural stability,with more reasonable force distribution,clearer load transfer paths,and significantly reduced overall costs.Existing technologies,such as socket connections,perform well in seismic performance but are complex to construct;grouted sleeve connections are mature in technology,but the quality of grouting is difficult to inspect.The separated steel connection and multi-chamber steel tube concrete connection technologies offer significant advantages.With the increasing demands for energy conservation and emission reduction,coupled with the rising labor costs,prefabricated bridge piers are undoubtedly poised to become one of the preferred technologies for bridge construction in China in the future.Therefore,in light of the current research landscape,this paper concludes by offering a forward-looking perspective on the development directions of connection methods for prefabricated bridge piers and identifying key areas for future research.展开更多
BACKGROUND Pepsinogen(PG)and the PG I/II ratio(PGR)are critical indicators for diagnosing Helicobacter pylori infection and chronic atrophic gastritis,and assessing gastric cancer risk.Existing reference intervals(RIs...BACKGROUND Pepsinogen(PG)and the PG I/II ratio(PGR)are critical indicators for diagnosing Helicobacter pylori infection and chronic atrophic gastritis,and assessing gastric cancer risk.Existing reference intervals(RIs)often overlook age,sex,and demographic variations.Partitioned RIs,while considering these factors,fail to capture the gradual age-related physiological changes.Next-generation RIs offer a solution to this limitation.AIM To investigate age-and sex-specific dynamics of PG and establish next-generation RIs for adults and the elderly in northern China.METHODS After screening,708 healthy individuals were included in this observational study.Serum PG was measured using chemiluminescence immunoassay.Age-and sex-related effects on PG were analyzed with a two-way analysis of variance.RI partitioning was determined by the standard deviation ratio(SDR).Traditional RIs were established using a non-parametric approach.Generalized Additive Models for Location,Scale,and Shape(GAMLSS)modeled age-related trends and continuous reference percentiles for PG I and PG II.Reference limit flagging rates for both RI types were compared.RESULTS PG I and PG II levels were influenced by age(P<0.001)and sex(P<0.001),while PGR remained stable.Age-specific RIs were required for PG I(SDR=0.366)and PG II(SDR=0.424).Partitioned RIs were established for PG I and PG II,with a single RI for PGR.GAMLSS modeling revealed distinct age-dependent trajectories:PG I increased from a median of 39.75μg/L at age 20 years to 49.75μg/L at age 60 years,a 25.16%increase,after which it plateaued through age 80 years.In contrast,PG II showed a continuous rise throughout the age range,with the median value increasing from 5.07μg/L at age 20 years to 8.36μg/L at age 80 years,corresponding to a 64.89%increase.Continuous reference percentiles intuitively reflected these trends and were detailed in this study.Next-generation RIs demonstrated superior accuracy compared to partitioned RIs when applied to specific age subgroups.CONCLUSION This study elucidates the age-and sex-specific dynamics of PG and,to our knowledge,is the first to establish next-generation RIs for PG,supporting more individualized interpretation in laboratory medicine.展开更多
BACKGROUND Leuconostoc garlicum is commonly found in fermented foods and very few infected patients have been reported,who typically present symptoms such as fever and fatigue.Conventional clinical examinations often ...BACKGROUND Leuconostoc garlicum is commonly found in fermented foods and very few infected patients have been reported,who typically present symptoms such as fever and fatigue.Conventional clinical examinations often struggle to identify this bacterium,and routine anti-infective treatments are generally ineffective.Both diagnostic challenges and therapeutic limitations pose significant difficulties for clinicians.CASE SUMMARY We report a patient ultimately diagnosed with Leuconostoc garlicum infection.The primary manifestations included persistent fever,cough and fatigue.These symptoms lasted for 2 months.He received anti-infective treatment at a community hospital,but this was ineffective.After inquiring about the patient's medical history and conducting a physical examination,the patient underwent laboratory tests.Complete blood count tests revealed that the patient had a high proportion of neutrophils,C-reactive protein level was 235.9 mg/L,erythrocyte sedimentation rate was 67 mm/h,respiratory pathogen testing was negative,and he was then thought to have an infectious disease.However,conventional anti-infective treatments were ineffective.After excluding infectious neurological diseases,urologic diseases and digestive problems,we ultimately focused our attention on the lungs.A lung computed tomography scan indicated pulmonary inflammation.Bronchoalveolar lavage fluid for next-generation sequencing suggested lung infection with Leuconostoc garlicum.The patient's symptoms gradually improved following treatment with piperacillin tazobactam and linezolid.During the follow-up period,the patient's temperature remained normal.CONCLUSION For patients with suspected bacterial infection and experiencing fever,conventional anti-infective treatment can be ineffective in controlling their symptoms,and an infection due to rare bacteria or drug-resistant bacteria should be considered.Next-generation sequencing enables rapid and precise identification of infection-related pathogens in febrile patients.展开更多
基金supported by the Science and Technology Research Project of Henan Province(242102241055)the Industry-University-Research Collaborative Innovation Base on Automobile Lightweight of“Science and Technology Innovation in Central Plains”(2024KCZY315)the Opening Fund of State Key Laboratory of Structural Analysis,Optimization and CAE Software for Industrial Equipment(GZ2024A03-ZZU).
文摘In two-scale topology optimization,enhancing the connectivity between adjacent microstructures is crucial for achieving the collaborative optimization of micro-scale performance and macro-scale manufacturability.This paper proposes a two-scale concurrent topology optimization strategy aimed at improving the interface connection strength.This method employs a parametric approach to explicitly divide the micro-design domain into a“boundary connection region”and a“free design domain”at the initial stage of optimization.The boundary connection region is used to generate a connection layer that enhances the interface strength,while the free design domain is not constrained by this layer,thus fully exploiting the design potential of the material layout.During the optimization process,the solid isotropic material with penalization(SIMP)method is first used to optimize the material distribution in the free design domain,and filtering and projection techniques are employed to alleviate numerical instability and obtain a clear topological structure.Subsequently,the effective performance of the microstructure is calculated through homogenization and transferred to the macro-scale for global response analysis.Throughout the iterative process,the geometry of the connection layer remains unchanged,and only the free design domain is optimized,thereby achieving a balance between high performance and good manufacturability.The effectiveness of the proposed method is verified through numerical examples.
基金supported by the National Natural Science Foundation of China(No.82100164,82302692)the Capital Medical University Research Cultivation Fund(No.PYZ22099)the Guangdong Provincial Medical Science and Technology Research Fund Project(No.A2024190).
文摘Background Fusion genes play a crucial role in the pathogenesis of acute myeloid leukemia(AML).This study investigated the utility of targeted next-generation sequencing(NGS)of RNA for detecting rare and unknown fusion genes in patients with AML.Methods A total of 85 adult AML samples previously identified as fusion gene-negative by multiplex nested reverse transcription-polymerase chain reaction(RT-PCR)were subjected to NGS analysis.Results Fusion genes were detected in 21 of 72(29.2%)patients.Among the 26 primary refractory patients,11(42.3%)exhibited fusion genes,whereas among the 18 relapsed patients,fusion genes were identified in five(27.8%).Notably,lysine methyltransferase 2A(KMT2A)and nucleoporin 98(NUP98)rearrangements were enriched in refractory/relapsed patients.Additionally,recurrent fusion transcripts involving eukaryotic translation initiation factor 4A1(EIF4A1)were identified.The identification of additional fusion genes resulted in an approximate 20.8%(11/53)reclassification of medium-risk karyotypes to the high-risk category,thereby enhancing diagnostic accuracy.Conclusions Targeted NGS may complement conventional methods for identifying novel fusions in refractory/relapsed AML;however,its prognostic value requires validation in prospective controlled trials.
基金supported by High-level Talents Program of Hainan Basic and Applied Basic Research Program of China(520RC543)Crosswise Tasks of Enterprise Entrusted(JG-ZH-A-202411-003).
文摘To achieve efficient connection and integrity in prefabricated frame structures,a novel beam-column connection between prefabricated steel-reinforced concrete(SRC)columns and cast-in-situ reinforced concrete(RC)beams is proposed.Four connection specimens with varying thicknesses of connecting cover plates were designed and fabricated.Low-cycle reversed loading tests were conducted to obtain mechanical performance data,allowing for analysis of behavioral patterns,including load-displacement hysteresis curves,skeleton curves,load-carrying capacity,deformation performance,energy dissipation capacity,and stiffness degradation.Test results indicate that properly designed prefabricated connections exhibit mechanical properties comparable to those of cast-in-situ concrete connections.The hysteresis curves of the prefabricated connections are well-shaped,with nearly no reduction in load-carrying capacity and deformation performance,demonstrating excellent seismic behavior.The findings provide a theoretical basis and reference for the design of prefabricated concrete frame structures.
基金supported by the Beijing Natural Science Foundation under Grant 9242003partially supported by the Natural Science Foundation of Chongqing,China under Grant CSTB2023NSCQ-MSX0391+3 种基金partially supported by the National Natural Science Foundation of China under Grant 62471493partially supported by the Natural Science Foundation of Shandong Province under Grants ZR2023LZH017,ZR2024MF066supported by the Key Laboratory of Public Opinion Governance and Computational Communication under Grant YQKFYB202501The Research Project on the Development of Social Sciences in Hebei Province in 2024(No.202403150).
文摘Next-GenerationNetworks(NGNs)demand high resilience,dynamic adaptability,and efficient resource utilization to enable ubiquitous connectivity.In this context,the Space-Air-Ground Integrated Network(SAGIN)architecture is uniquely positioned to meet these requirements.However,conventional NGN routing algorithms often fail to account for SAGIN’s intrinsic characteristics,such as its heterogeneous structure,dynamic topology,and constrained resources,leading to suboptimal performance under disruptions such as node failures or cyberattacks.To meet these demands for SAGIN,this study proposes a resilience-oriented routing optimization framework featuring dynamic weighting and multi-objective evaluation.Methodologically,we define three core routing performance metrics,quantified through a four-dimensionalmodel,encompassing robustness Rd,resilience Rr,adaptability Ra,and resource utilization efficiency Ru,and integrate them into a comprehensive evaluation metric.In simulated SAGIN environments,the proposed Multi-Indicator Weighted Resilience Evaluation Algorithm(MIW-REA)demonstrates significant improvements in resilience enhancement,recovery acceleration,and resource optimization.It maintains 82.3%service availability even with a 30%node failure rate,reduces Distributed Denial of Service(DDoS)attack recovery time by 43%,decreases bandwidth waste by 23.4%,and lowers energy consumption by 18.9%.By addressing challenges unique to the SAGIN network,this research provides a flexible real-time solution for NGN routing optimization that balances resilience,efficiency,and adaptability,advancing the field.
基金Natural Science Foundation of China under Grant No.52178449,the Beijing Natural Science Foundation under Grant No.8234060the Innovation Center of Beijing Association for Science and Technology。
文摘This study proposes a new post-tensioned precast bridge column(PT-PBC)with a socket connection.Compared to conventional PBCs connected by PT tendons,the combination of the PT tendons with the socket connection can avoid tensioning the PT tendons on site,which further accelerates construction speed while improving construction quality and safety.In addition,compared to conventional PBCs with a socket connection,a rocking interface can avoid the formation of a plastic hinge in a column,which greatly alleviates seismic damage to that area.One specimen for quasi-static testing is used to validate the feasibility of this connection type.Subsequently,finite element models(FEM)are established to systematically predict the responses of the proposed columns under lateral cyclic loading.The accuracy of the FEM is verified through quasistatic testing.Next,the influences of the key design parameters of the PT-PBC,including the area ratio and prestress level of the PT tendons,the area ratio of energy dissipation(ED)steel rebars,and the total axial compression ratio on the seismic performances of PT-PBC are systematically investigated.The use of shape memory alloy(SMA)rods as energy dissipation devices and their performances also are investigated.The results show that increasing the area ratio and prestress level of PT tendons has an overall positive impact on the self-centering capacity of the column.The prestress level of PT tendons should be kept between 35%and 55%,depending on different conditions.The total compression axial ratio of the columns should be maintained between 0.3 and 0.4.Both ED steel rebars and SMA rods can boost the column’s energy dissipation capacity,while SMA rods can reduce residual deformation due to their inherent mechanical properties.
基金supported by the“Regional Innovation System&Education(RISE)”through the Seoul RISE Center,funded by the Ministry of Education(MOE)and the Seoul Metropolitan Government.(2025-RISE-01-005-07).
文摘Background:Social connection is widely recognized as a protective determinant of health,yet its direct and indirect effects on mental health remain underexplored.This study examines the relationship between social connection and mental health,focusing on the mediating role of quality of life(QoL)and the moderating effect of regional differences.Methods:We analyzed data from the 2019 Korean Community Health Survey,comprising 229,099 adults.Mental health was assessed through validated measures of depressive symptoms and psychological well-being.Social connection was measured using indicators of interpersonal ties and community participation,and QoL was assessed via self-reported health-related satisfaction across major life domains.Analytical procedures included mediation modeling and subgroup analyses by region,with significance levels set at p<0.05.Results:The results indicate that social connections are significantly associated with lower stress levels and reduced depressive symptoms,with QoL playing a critical mediating role.Notably,the indirect effect of social connection on mental health via QoL is stronger in rural areas compared to urban regions,highlighting the importance of social cohesion and community support in mental well-being.Among 203,567 adults,greater social participation was associated with lower subjective stress(total effect=−0.052,p<0.001)and fewer depressive symptoms(PHQ-9 total effect=−0.308,p<0.001).QoL significantly mediated these associations,with the strongest indirect pathways observed through usual activities(19.2%for stress;27.6%for depression)and mobility(24.4%for depression).Regional analysis showed stronger mediation in rural areas(up to 26.8%for stress and 32.6%for depression)than in urban areas(8–16%and 14.9–23%).Direct effects remained significant,indicating partial mediation.These findings highlight that social participation enhances mental health directly and indirectly through QoL,particularly in rural contexts.Conclusions:Social connection contributes to better mental health both directly and indirectly through improved QoL,with stronger effects observed in rural communities.These findings highlight the importance of fostering social cohesion and enhancing life quality as strategies for improving population mental health.Policy interventions should adopt context-sensitive approaches that account for regional differences in social resources and service availability.
基金funded by Science and Technology Innovation Project grant No.ZZKY20222304.
文摘Aiming at the problem of potential information noise introduced during the generation of ghost feature maps in GhostNet,this paper proposes a novel lightweight neural network model called ResghostNet.This model constructs the Resghost Module by combining residual connections and Adaptive-SE Blocks,which enhances the quality of generated feature maps through direct propagation of original input information and selection of important channels before cheap operations.Specifically,ResghostNet introduces residual connections on the basis of the Ghost Module to optimize the information flow,and designs a weight self-attention mechanism combined with SE blocks to enhance feature expression capabilities in cheap operations.Experimental results on the ImageNet dataset show that,compared to GhostNet,ResghostNet achieves higher accuracy while reducing the number of parameters by 52%.Although the computational complexity increases,by optimizing the usage strategy of GPU cachememory,themodel’s inference speed becomes faster.The ResghostNet is optimized in terms of classification accuracy and the number of model parameters,and shows great potential in edge computing devices.
基金Project supported by Quantum Science and Technology–National Science and Technology Major Project(Grant No.2024ZD0301000)the National Natural Science Foundation of China(Grant No.12305031)+1 种基金the Hangzhou Joint Fund of the Natural Science Foundation of Zhejiang Province,China(Grant No.LHZSD24A050001)the Science Foundation of Zhejiang Sci-Tech University(Grant Nos.23062088Y and 23062153-Y)。
文摘The Wilczek–Zee connection(WZC)is a key concept in the study of topology of quantum systems.Here,we introduce the double Wilczek–Zee connection(DWZC)which naturally appears in the pure-state quantum geometric tensor(QGT),another important concept in the field of quantum geometry.The DWZC is Hermitian with respect to the two integer indices,just like the original Hermitian WZC.Based on the symmetric logarithmic derivative operator,we propose a mixed-state quantum geometric tensor.Using the symmetric properties of the DWZC,we find that the real part of the QGT is connected to the real part of the DWZC and the square of eigenvalue differences of the density matrix,whereas the imaginary part can be given in terms of the imaginary part of the DWZC and the cube of the eigenvalue differences.For density matrices with full rank or no full rank,the QGT can be given in terms of real and imaginary parts of the DWZC.
基金supported by Key Scientific Research Projects of Colleges and Universities in Henan Province(24A560002)Science and Technology Tackling Project of Henan Provincial Department of Education(252102320296).
文摘Prefabricated buildings have developed rapidly due to their advantages in energy efficiency,environmental protection,and high construction efficiency,which have greatly promoted the advancements of connection technology and the mechanical properties of prefabricated hollow panels.This study proposes a new optimization scheme for prefabricated wall structures using transversely arranged prefabricated hollow plates and develops a new joint connection.First,the constitutive relations are experimentally validated to establish an accurate finite element analysis model;Then the equal-size specimens are compared with the control specimens without node connections;Finally,the effects of axial compression ratio,aspect ratio,and channel steel plate thickness on the seismic performance of the wall are discussed.The experimental results demonstrate that this joint connection can significantly enhance the mechanical performance of walls.The influence of the axial compression ratio and the aspect ratio on the seismic performance of walls is significant,necessitating strict compliance with code specifications.Excessive thickness of the steel plate may negatively impact the structural bearing capacity,providing a technical reference for further investigation.
文摘Yunhe County in Lishui City,southwestern Zhejiang Province,doesn’t have any Disney castles.Instead,it has built bridges to the world with wood.Known as“China’s town of wooden toys,”accounting for about 40 percent of the global wooden toy market,Yunhe’s story began with a small factory established in 1970.Today,it has grown into a distinctive industrial cluster with an annual output value exceeding 8 billion yuan($1.15 billion),exporting products to 82 countries and regions.
基金supported in part by the National Natural Science Foundation of China under Grant 51877061.
文摘For the ultra HVDC(UHVDC)with the hierarchical connection mode at the inverter side,considering the change of the Thevenin equivalent parameters(TEP)of post-fault AC grid,a coordinated control strategy to the subsequent commutation failure(SCF)at both layers is newly proposed.The originality of this work is manifested in three aspects.1)The mechanism of the SCF at the fault layer is newly found by deriving the analytical expression of the extinction angle with the TEP,and that at the non-fault layer is newly found by the voltage-time area theory with the DC current coupling.2)An estimation model for the TEPs of two AC grids at the inverter side is proposed with the post-fault quantities.To address the random noise and inaccurate measurement data,an adaptive robust least squares method based on the median principle is proposed to solve the TEP model.3)A coordinated control strategy with the estimated TEP is proposed to compensate for the extinction angle at the fault layer and limit the DC current at the non-fault layer,thus suppressing the SCF.The simulation results verify the suppression effect of the proposed control on the SCF under different fault conditions.
文摘Founded in September 2020,the International SparkLink Alliance(iSLA)now has approximately 1,200 members in diverse sectors including terminals,homes,vehicles,manufacturing,transportation,finance and healthcare.The iSLA has established a technical standards system for wireless short-range communication covering full-stack standards such as the end-to-end protocol system.
基金partially supported by the Construction of Collaborative Innovation Center of Beijing Academy of Agricultural and Forestry Sciences(KJCX20240406)the Beijing Natural Science Foundation(JQ24037)+1 种基金the National Natural Science Foundation of China(32330075)the Earmarked Fund for China Agriculture Research System(CARS-02 and CARS-54)。
文摘The security of the seed industry is crucial for ensuring national food security.Currently,developed countries in Europe and America,along with international seed industry giants,have entered the Breeding 4.0 era.This era integrates biotechnology,artificial intelligence(AI),and big data information technology.In contrast,China is still in a transition period between stages 2.0 and 3.0,which primarily relies on conventional selection and molecular breeding.In the context of increasingly complex international situations,accurately identifying core issues in China's seed industry innovation and seizing the frontier of international seed technology are strategically important.These efforts are essential for ensuring food security and revitalizing the seed industry.This paper systematically analyzes the characteristics of crop breeding data from artificial selection to intelligent design breeding.It explores the applications and development trends of AI and big data in modern crop breeding from several key perspectives.These include highthroughput phenotype acquisition and analysis,multiomics big data database and management system construction,AI-based multiomics integrated analysis,and the development of intelligent breeding software tools based on biological big data and AI technology.Based on an in-depth analysis of the current status and challenges of China's seed industry technology development,we propose strategic goals and key tasks for China's new generation of AI and big data-driven intelligent design breeding.These suggestions aim to accelerate the development of an intelligent-driven crop breeding engineering system that features large-scale gene mining,efficient gene manipulation,engineered variety design,and systematized biobreeding.This study provides a theoretical basis and practical guidance for the development of China's seed industry technology.
基金supported by the Hubei Provincial Natural Science Foundation of China(No.2023AFB646)Knowledge Innovation Program of Wuhan(No.2023020201010155)Educational Research Program of Huazhong University of Science and Technology(No.2022135).
文摘Objective and Background Early and accurate diagnosis of spinal infections,including spinal tuberculosis,is pivotal for effective treatment but remains challenging.This study aims to assess the diagnostic yield of metagenomic next-generation sequencing(mNGS)compared with that of conventional microbiological tests(CMTs)in identifying pathogens associated with spinal pathologies,with a special focus on infections leading to surgical interventions.Methods We enrolled 85 patients who underwent spinal surgery,comprising 63 patients with clinically diagnosed spinal infections,including patients with spinal tuberculosis,and 22 patients with noninfectious spinal conditions.The procedures involved irrigation and debridement for persistent wound drainage,with subsequent DNA extraction from plasma and joint fluid for mNGS and CMT analysis.Results Significantly increased C-reactive protein(CRP)levels were observed in patients with infections.The mNGS approach showed greater diagnostic sensitivity(92.06%)for detecting pathogens,including Mycobacterium tuberculosis,than did CMTs(36.51%).Despite its low specificity,mNGS had considerable negative predictive value(70.59%),underscoring its utility in ruling out infections.Conclusions The mNGS offers superior sensitivity over CMTs in the diagnosis of a variety of spinal infections,notably spinal tuberculosis.This study highlights the potential of mNGS in enhancing the diagnosis of complex spinal infections,thereby informing targeted treatment strategies.
基金supported by Prevention the Fundamental Research Funds for the Central Universities“Study on the general joint of prefabricated high-pier columns”(ZY20230218)Science and Technology Innovation Program for Postgraduate students in IDP subsidized by Fundamental Research Funds for the Central Universities“Research on seismic performance of prefabricated bridge piers with embedded separated steel connections”(ZY20250316).
文摘With the acceleration of urbanization,prefabricated bridges have become a significant choice for transportation infrastructure construction due to their environmental friendliness,efficiency,and reliable quality.However,existing connection technologies still face shortcomings in construction efficiency,seismic performance,and cost control.This paper summarizes the process characteristics of commonly used connection technologies such as socket connections,grouted sleeve connections and corrugated pipe connections,and analyzes their seismic capacity and mechanical performance.In response to existing issues,two new technologies—separated steel connection and multi-chamber steel tube concrete connection—are proposed,and their comprehensive performance and economic efficiency are analyzed.The new connection technologies outperform traditional methods in construction efficiency,economic efficiency,and structural stability,with more reasonable force distribution,clearer load transfer paths,and significantly reduced overall costs.Existing technologies,such as socket connections,perform well in seismic performance but are complex to construct;grouted sleeve connections are mature in technology,but the quality of grouting is difficult to inspect.The separated steel connection and multi-chamber steel tube concrete connection technologies offer significant advantages.With the increasing demands for energy conservation and emission reduction,coupled with the rising labor costs,prefabricated bridge piers are undoubtedly poised to become one of the preferred technologies for bridge construction in China in the future.Therefore,in light of the current research landscape,this paper concludes by offering a forward-looking perspective on the development directions of connection methods for prefabricated bridge piers and identifying key areas for future research.
文摘BACKGROUND Pepsinogen(PG)and the PG I/II ratio(PGR)are critical indicators for diagnosing Helicobacter pylori infection and chronic atrophic gastritis,and assessing gastric cancer risk.Existing reference intervals(RIs)often overlook age,sex,and demographic variations.Partitioned RIs,while considering these factors,fail to capture the gradual age-related physiological changes.Next-generation RIs offer a solution to this limitation.AIM To investigate age-and sex-specific dynamics of PG and establish next-generation RIs for adults and the elderly in northern China.METHODS After screening,708 healthy individuals were included in this observational study.Serum PG was measured using chemiluminescence immunoassay.Age-and sex-related effects on PG were analyzed with a two-way analysis of variance.RI partitioning was determined by the standard deviation ratio(SDR).Traditional RIs were established using a non-parametric approach.Generalized Additive Models for Location,Scale,and Shape(GAMLSS)modeled age-related trends and continuous reference percentiles for PG I and PG II.Reference limit flagging rates for both RI types were compared.RESULTS PG I and PG II levels were influenced by age(P<0.001)and sex(P<0.001),while PGR remained stable.Age-specific RIs were required for PG I(SDR=0.366)and PG II(SDR=0.424).Partitioned RIs were established for PG I and PG II,with a single RI for PGR.GAMLSS modeling revealed distinct age-dependent trajectories:PG I increased from a median of 39.75μg/L at age 20 years to 49.75μg/L at age 60 years,a 25.16%increase,after which it plateaued through age 80 years.In contrast,PG II showed a continuous rise throughout the age range,with the median value increasing from 5.07μg/L at age 20 years to 8.36μg/L at age 80 years,corresponding to a 64.89%increase.Continuous reference percentiles intuitively reflected these trends and were detailed in this study.Next-generation RIs demonstrated superior accuracy compared to partitioned RIs when applied to specific age subgroups.CONCLUSION This study elucidates the age-and sex-specific dynamics of PG and,to our knowledge,is the first to establish next-generation RIs for PG,supporting more individualized interpretation in laboratory medicine.
文摘BACKGROUND Leuconostoc garlicum is commonly found in fermented foods and very few infected patients have been reported,who typically present symptoms such as fever and fatigue.Conventional clinical examinations often struggle to identify this bacterium,and routine anti-infective treatments are generally ineffective.Both diagnostic challenges and therapeutic limitations pose significant difficulties for clinicians.CASE SUMMARY We report a patient ultimately diagnosed with Leuconostoc garlicum infection.The primary manifestations included persistent fever,cough and fatigue.These symptoms lasted for 2 months.He received anti-infective treatment at a community hospital,but this was ineffective.After inquiring about the patient's medical history and conducting a physical examination,the patient underwent laboratory tests.Complete blood count tests revealed that the patient had a high proportion of neutrophils,C-reactive protein level was 235.9 mg/L,erythrocyte sedimentation rate was 67 mm/h,respiratory pathogen testing was negative,and he was then thought to have an infectious disease.However,conventional anti-infective treatments were ineffective.After excluding infectious neurological diseases,urologic diseases and digestive problems,we ultimately focused our attention on the lungs.A lung computed tomography scan indicated pulmonary inflammation.Bronchoalveolar lavage fluid for next-generation sequencing suggested lung infection with Leuconostoc garlicum.The patient's symptoms gradually improved following treatment with piperacillin tazobactam and linezolid.During the follow-up period,the patient's temperature remained normal.CONCLUSION For patients with suspected bacterial infection and experiencing fever,conventional anti-infective treatment can be ineffective in controlling their symptoms,and an infection due to rare bacteria or drug-resistant bacteria should be considered.Next-generation sequencing enables rapid and precise identification of infection-related pathogens in febrile patients.
