The presence of residual alkaline compounds in the ultrahigh-nickel layered oxide cathodes(LiNi_(x)Co_(y)Mn_(1−x−y)O_(2),x≥_(0.9))aggravates structural degradation,increases surface reactivity,and promotes slurry gel...The presence of residual alkaline compounds in the ultrahigh-nickel layered oxide cathodes(LiNi_(x)Co_(y)Mn_(1−x−y)O_(2),x≥_(0.9))aggravates structural degradation,increases surface reactivity,and promotes slurry gelation,leading to the capacity decay of batteries with these cathodes and complicating their manufacturing.Traditional approaches for addressing this issue,including direct removal,coverage,and utilization,are complex and require surface regeneration.Herein,we propose neutralizing residual alkaline compounds with 3-thiopheneboronic acid(3-TBA)to improve the performance of LiNi_(0.9)5Co_(0.04)Mn_(0.01)O_(2)(NCM)cathode material,a facile strategy that does not require any post-treatment.The suggested reaction yields a uniform and thin organic-modified layer on the surface of the NCM cathode,improving its chemical stability toward the electrolyte,as demonstrated by multiple characterization methods.The modified NCM cathode exhibited impressive cyclic and rate performances,achieving a capacity retention of 83.34%after 200 cycles at 1.0 C and a specific capacity of 162.00 mAh·g^(−1) at 10.0 C.Most importantly,the proposed approach can efficiently suppress unfavorable phase transitions,severe electrolyte degradation,and CO_(2) gas evolution,improving the application potential of ultrahigh-nickel layered oxide cathode materials.展开更多
In the present research,nutrient broth(NB)medium was identified to be able to neutralize the antibacterial activity of chitosan and its derivatives.Therefore,an improved test method independent of NB medium was propos...In the present research,nutrient broth(NB)medium was identified to be able to neutralize the antibacterial activity of chitosan and its derivatives.Therefore,an improved test method independent of NB medium was proposed to precisely quantify the antibacterial effectiveness and efficiency of chitosan.The minimum bactericidal concentration(MBC)of chitosan was 60μg m L^(-1) against S.aureus and E.coli,and 0.01%(w/v)chitosan could kill 100%of bacteria within 3 min.From another point of view,the neutralizing efficiency of NB could be tripled by adding 25 g L^(-1) of sodium chloride.Then the neutralizing mechanism of NB medium was ascribed to flocculation between chitosan and protein.Adding extra sodium chloride could significantly reduce the size of floccules,and smaller floccules would lose the ability of binding with bacteria directly,showing higher neutralizing rate on the macro scale.展开更多
Inductively coupled radio-frequency（RF） plasma neutralizer（RPN） is an insert-free device that can be employed as an electron source in electric propulsion applications.Electron-extraction characteristics of the RP...Inductively coupled radio-frequency（RF） plasma neutralizer（RPN） is an insert-free device that can be employed as an electron source in electric propulsion applications.Electron-extraction characteristics of the RPN are related to the bulk plasma parameters and the device＇s geometry.Therefore,the effects of different electron-extraction apertures and operational parameters upon the electron-extraction characteristics are investigated according to the global nonambipolar flow and sheath model.Moreover,these models can also be used to explain why the electron-extraction characteristics of the RPN strongly depend upon the formation of the anode spot.During the experimental study,two types of anode spots are observed.Each of them has unique characteristics of electron extraction.Moreover,the hysteresis of an anode spot is observed by changing the xenon volume-flow rates or the bias voltages.In addition,the rapid ignited method,gas-utilization factor,electron-extraction cost and other factors that need to be considered in the design of the RPN are also discussed.展开更多
Scanning Mobility Particle Sizer (SMPS) spectrometers are subject to several restrictions when a radioactive source is employed to bring the aerosol to a steady-state charge distribution. An alternative solution, comm...Scanning Mobility Particle Sizer (SMPS) spectrometers are subject to several restrictions when a radioactive source is employed to bring the aerosol to a steady-state charge distribution. An alternative solution, commercially available, is represented by the soft X-ray neutralizer. The present study investigates the outcome of a combination of a Grimm SMPS, which employs a 241Am radioactive source, with the soft X-ray advanced aerosol neutralizer (TSI model 3087). To date, the latter device has been interfaced only with TSI’s Electrostatic Classifiers. Particle size distribution of sodium chloride aerosol was measured with both neutralizers and it was found that the particle number concentration agreed to be within 9% for the 10 - 700 nm range. This difference mainly corresponds to the bias reported by TSI, when the X-ray device is mounted on a TSI spectrometer. It was concluded that the X-ray neutralizer could be usefully employed, as a standalone device, in combination with Grimm Electrostatic Classifiers.展开更多
Objective: To explore whether a DNA immunization approach targeting the major haemorrhage molecule of a prothrombin activator-like metalloproteinase from Echis ocellatus(E. ocellatus) venom could be conceived to inspi...Objective: To explore whether a DNA immunization approach targeting the major haemorrhage molecule of a prothrombin activator-like metalloproteinase from Echis ocellatus(E. ocellatus) venom could be conceived to inspire antibodies with more prominent specificity and equal adequacy to current conventional antivenoms systems.Methods: The isolated DNA Eo MP-6 was used as the template for PCR amplification using the Eo DC-2-specific forward and reverse primers. A PCR product of approximately700 bp was obtained and cloned into p Sec Tag-B expression vector where anti-Eo DC-2antibodies were generated and analysed for their efficacy to neutralise local haemorrhage in vitro and in vivo.Results: Our results suggest that the generated anti-Eo DC-2 showed a remarkable efficacy by(a) interfering with the interaction of the recombinant disintegrin "Eo DC-2" isolated from the E. ocellatus as well as other viper species to the a2b1-integrins on platelets;(b) complete inhibition of the catalytic site of the metalloproteinase molecules in vitro using an adaptation antibody zymography assay. Furthermore, it has a polyspecific potential and constitutively expressed significant inhibition by cross-reaction and neutralised venom-induced local haemorrhage exerted by different viper species in vivo. The potential characteristic of Eo DC-2 against one part(the non-catalytic domain) as opposed to the whole molecule to neutralise its haemorrhagic activity is of crucial importance as it represents a novel approach with greater immunological specificity and fewer hazards, if any, than conventional systems of antivenom production, by exposure large animals that usually being used for the current antivenom production to a less injurious than expression of the whole molecule containing the catalytic metalloprotease domain. Hence, we report for the first time that our preliminary results hold a promising future for antivenom development.Conclusions: Antibodies generated against the E. ocellatus venom prothrombin activatorlike metalloprotease and disintegrin-cysteine-rich domains modulated and inhibited the catalytic activity both in vitro and in vivo of venom metalloproteinase disintegrin cysteine rich molecules. Thus, generating of venom specific-toxin antibodies by DNA immunization offer a more rational treatment of snake envenoming than conventional antivenom.展开更多
Energetic neutral atoms(ENAs)are produced by the neutralization of energetic ions formed by shock-accelerated gradual solar energetic particle events(SEP).These high-energy ENAs(HENAs)can reach the Earth earlier than ...Energetic neutral atoms(ENAs)are produced by the neutralization of energetic ions formed by shock-accelerated gradual solar energetic particle events(SEP).These high-energy ENAs(HENAs)can reach the Earth earlier than the associated SEPs and thus can provide information about the SEPs at the lower corona.The HENA properties observed at Earth depend on the properties of the coronal mass ejection(CME)-driven shocks that accelerate the SEPs.Using a model of HENA production in a shock-accelerated SEP event,we semi-quantitatively investigate the energy-time spectrum of HENAs depending on the width,propagation speed,and direction of the shock,as well as the density and ion abundances of the lower corona.Compared to the baseline model parameters,the cases with a wider shock width angle or a higher coronal density would increase the HENA flux observed at the Earth,while the case with an Earthpropagating shock shows a softened HENA spectrum.The comparison of expected HENA fluxes in different cases with a flight-proven ENA instrument suggests that solar HENAs can feasibly be monitored with current technologies,which could provide a lead time of 2−3 hours for SEPs at a few MeV.We propose that monitoring of solar HENAs could provide a new method to forecast shock-driven SEP events that are capable of significant space weather impacts on the near-Earth environment.展开更多
The rate of neutralized charge by lightning（RNCL） is an important parameter indicating the intensity of lightning activity.The total charging rate（CR）,the CR of one kind of polarity（e.g.,negative） charge（CROP）...The rate of neutralized charge by lightning（RNCL） is an important parameter indicating the intensity of lightning activity.The total charging rate（CR）,the CR of one kind of polarity（e.g.,negative） charge（CROP）,and the outflow rate of charge on precipitation（ORCP） are proposed as key factors impacting RNCL,based on the principle of conservation of one kind of polarity charge in a thunderstorm.In this paper,the impacts of updraft on CR and CROP are analyzed by using a 3D cloud resolution model for a strong storm that occurred in Beijing on 6 September 2008.The results show that updraft both promotes and inhibits RNCL at the same time.（1） Updraft always has a positive influence on CR.The correlation coefficient between the updraft volume and CR can reach 0.96.Strengthening of the updraft facilitates strengthening of RNCL through this positive influence.（2） Strengthening of the updraft also promotes reinforcement of CROP.The correlation coefficient between the updraft volume and CROP is high（about0.9）,but this promotion restrains the strengthening of RNCL because the strengthening of CROP will,most of the time,inhibit the increasing of RNCL.（3） Additionally,increasing of ORCP depresses the strengthening of RNCL.In terms of magnitude,the peak of ORCP is equal to the peak of CR.Because precipitation mainly appears after the lightning activity finishes,the depression effect of ORCP on RNCL can be ignored during the active lightning period.展开更多
Neutralizing antibodies are essential tools in antiviral therapy and epidemic preparedness,capable of directlyinhibiting viral entry and limiting disease progression.However,traditional antibody discovery strategies—...Neutralizing antibodies are essential tools in antiviral therapy and epidemic preparedness,capable of directlyinhibiting viral entry and limiting disease progression.However,traditional antibody discovery strategies—suchas animal immunization or B cell isolation from infected individuals—are often hindered by biosafety concerns,lengthy development timelines,and limited adaptability during outbreaks.In the present study,we aimed toestablish a robust and rapid in vitro platform for the efficient isolation of neutralizing antibodies targetingconserved viral epitopes.We developed an epitope-guided negative screening strategy that integrates phagedisplay technology with rational antigen mutagenesis to exclude antibodies against variable regions whileenriching for those that recognize functionally constrained epitopes.When applied to the receptor-binding domainof severe acute respiratory syndrome coronavirus 2,this method enabled the identification of six neutralizingantibodies(one IgG and five nanobodies)exhibiting broad-spectrum neutralizing activity across multiple viralvariants.Notably,antibodies recognizing distinct epitopes demonstrated significant synergistic neutralizationwhen used in combination(P<0.05).This screening approach facilitates the rapid discovery of potent andmutation-resistant antibodies and holds promise for application to other emerging pathogens.Our findingsunderscore the potential of epitope-guided,in vitro platforms in expediting therapeutic antibody developmentunder conditions of high biosafety requirements.展开更多
Countries around the world have been making efforts to reduce pollutant emissions. However, the response of global black carbon(BC) aging to emission changes remains unclear. Using the Community Atmosphere Model versi...Countries around the world have been making efforts to reduce pollutant emissions. However, the response of global black carbon(BC) aging to emission changes remains unclear. Using the Community Atmosphere Model version 6 with a machine-learning-integrated four-mode version of the Modal Aerosol Module, we quantify global BC aging responses to emission reductions for 2011–2018 and for 2050 and 2100 under carbon neutrality. During 2011–18, global trends in BC aging degree(mass ratio of coatings to BC, R_(BC)) exhibited marked regional disparities, with a significant increase in China(5.4% yr^(-1)), which contrasts with minimal changes in the USA, Europe, and India. The divergence is attributed to opposing trends in secondary organic aerosol(SOA) and sulfate coatings, driven by regional changes in the emission ratios of corresponding coating precursors to BC(volatile organic compounds-VOCs/BC and SO_(2)/BC). Projections under carbon neutrality reveal that R_(BC) will increase globally by 47%(118%) in 2050(2100), with strong convergent increases expected across major source regions. The R_(BC) increase, primarily driven by enhanced SOA coatings due to sharper BC reductions relative to VOCs, will enhance the global BC mass absorption cross-section(MAC) by 11%(17%) in 2050(2100).Consequently, although the global BC burden will decline sharply by 60%(76%), the enhanced MAC partially offsets the magnitude of the decline in the BC direct radiative effect, resulting in the moderation of global BC DRE decreases to 88%(92%) of the BC burden reductions in 2050(2100). This study highlights the globally enhanced BC aging and light absorption capacity under carbon neutrality, thereby partly offsetting the impact of BC direct emission reductions on future changes in BC radiative effects globally.展开更多
Water resources health diagnosis is increasingly recognized as a critical tool.It should not only guide the preservation of water volume,quality,and ecological integrity but also assess the viability of carbon-neutral...Water resources health diagnosis is increasingly recognized as a critical tool.It should not only guide the preservation of water volume,quality,and ecological integrity but also assess the viability of carbon-neutral development pathways.But current research tends to consider water health assessment and carbon-neutrality planning as separate endeavors,which results in imprecise boundaries,disjointed metrics,and a weak linkage between diagnostic outcomes and testable management actions.This review brings together indicator systems,diagnostic systems,and environmental management systems architectures that make it possible to have integrated water-carbon governance.We define fundamental concepts and delimiting decisions followed by the examination of indicator designs across the hydrological regime,water quality,ecological integrity,service performance,resilience,and carbon-related measures,including intensity of energy/emissions,emissions caused by the watershed process of wastewater treatment,as well as the potential sink of the watershed.We compare diagnostic methods,such as composite indices and multi-criteria decision analysis,data-driven early-warning models,process-based and integrated simulations,as well as uncertainty-aware robustness models.Here,based on this synthesis,we suggest an environmental management systems(EMS)-based pathway,which connects the setting of the baseline,the diagnosis,the design of the intervention portfolio,and the measurement-reporting-verification into the closed-loop adaptive cycle.Digital enablement,comprising Internet of Things(IoT)monitoring,remote sensing,data fusion,optimization,and digital twins,is considered a viable way of scaling implementation,subject to interoperability,validation,and model governance.Among the major gaps,there are causal attribution to outcomes,cross-scale coupling of facility emissions and basin health,propagation of uncertainty in a coupled model,and credible Measurement,Reporting,and Verification(MRV)of non-CO_(2) gases and nature-based removals.The review gives a roadmap to normalize core metrics and fast-deployable systems to protect the health of the water resources and give verifiable progress towards carbon neutrality.展开更多
Driven by the global energy transition and the urgent“dual carbon”goals,regional integrated energy system(RIES)planning is undergoing a paradigm shift from carbon reduction to negative carbon emissions.This paper pr...Driven by the global energy transition and the urgent“dual carbon”goals,regional integrated energy system(RIES)planning is undergoing a paradigm shift from carbon reduction to negative carbon emissions.This paper provides a comprehensive review of the theoretical frameworks and technical pathways for RIES planning from a carbon-centric perspective.A key contribution is the proposed Carbon-Energy-Economy(CEE)triple-dimensional governance framework,which endogenizes carbon factors into planning decisions through emission constraints,trading mechanisms,and capture technologies.We first analyze the fundamental characteristics of RIES and their critical role in achieving carbon neutrality,detailing advancements in multi-energy coupling models,energy router concepts,and standardized energy hub modeling.The paper further explores multi-energy flow analysis methods,and systematically compares the applicability and limitations of various planning algorithms,with emphasis on addressing uncertainties from renewable integration.Finally,we highlight the integration of artificial intelligence with traditional optimization methods,offering new pathways for intelligent,adaptive,and low-carbon RIES planning.This review underscores the transition towards data-physical fusion models,cooperative uncertainty optimization,multi-market planning,and innovative zero/negative-carbon technological routes.展开更多
The neutral surface of a concave thin mirror is too close to the mirror surface,which makes it difficult to effectively mount the flexible structure and increases the mirror surface shape error.To address this problem...The neutral surface of a concave thin mirror is too close to the mirror surface,which makes it difficult to effectively mount the flexible structure and increases the mirror surface shape error.To address this problem,we design a flexible support structure including connectors,a support plate,and flexible structures,and construct an equivalent mirror by installing connectors and a support plate on the back of the mirror.While ensuring that the neutral surface of the equivalent mirror is moved away from the mirror surface,we optimize the support structure so that the rotary center of the flexible structure is located on the neutral surface of the equivalent mirror,avoiding the tilting moment.Following design and modeling of the structure,we analyze the static and dynamic characteristics using a finite element simulation,finding a root-mean-square(RMS)value for the surface shape error of 9.28 nm under the coupled effects of 1g gravity load,4℃ temperature rise,and 0.005 mm unevenness assembly error,with a fundamental frequency of 170.75 Hz,which all meet the design requirements.Finally,we carry out a surface shape error test of the mirror assembly,confirming it to meet the design index requirement of the mirror assembly.Simulation and test results verify the reliability and effectiveness of our proposed support structure.展开更多
Electrocatalytic nitrate reduction reaction(NO3RR)represents a sustainable and environmentally benign route for ammonia(NH3)synthesis.However,NO3RR is still limited by the competition from hydrogen evolution reaction(...Electrocatalytic nitrate reduction reaction(NO3RR)represents a sustainable and environmentally benign route for ammonia(NH3)synthesis.However,NO3RR is still limited by the competition from hydrogen evolution reaction(HER)and the high energy barrier in the hydrogenation step of nitrogen-containing intermediates.Here,we report a selective etching strategy to construct Ru M nanoalloys(M=Fe,Co,Ni,Cu)uniformly dispersed on porous nitrogen-doped carbon substrates for efficient neutral NH3electrosynthesis.Density functional theory calculations confirm that the synergic effect between Ru and transition metal M modulates the electronic structure of the alloy,significantly lowering the energy barrier for the conversion of*NO_(2)to*HNO_(2).Experimentally,the optimized Ru Fe-NC catalyst achieves 100%Faraday efficiency with a high yield rate of 0.83 mg h^(-1)mg^(-1)catat a low potential of-0.1 V vs.RHE,outperforming most reported catalysts.In situ spectroscopic analyses further demonstrate that the Ru M-NC effectively promotes the hydrogenation of nitrogen intermediates while inhibiting the formation of hydrogen radicals,thereby reducing HER competition.The Ru FeNC assembled Zn-NO_(3)^(-)battery achieved a high open-circuit voltage and an outstanding power density and capacity,which drive selective NO_(3)^(-)conversion to NH3.This work provides a powerful synergistic design strategy for efficient NH3electrosynthesis and a general framework for the development of advanced multi-component catalysts for sustainable nitrogen conversion.展开更多
Electrocatalytic CO_(2)reduction(eCO_(2)R)in acidic electrolytes is propitious to enhance CO_(2)utilization,yet suffering from low current efficiency due to the rapid kinetics of the competing hydrogen evolution react...Electrocatalytic CO_(2)reduction(eCO_(2)R)in acidic electrolytes is propitious to enhance CO_(2)utilization,yet suffering from low current efficiency due to the rapid kinetics of the competing hydrogen evolution reaction(HER),especially under high current densities.This study proposes the implementation of a singleatom NiNC cocatalyst concurrently generating CO and releasing OH^(-)to neutralize H^(+)in the electrolyte,thereby simultaneously suppressing HER and promoting C–C coupling.By homogeneously mixing the NiNC cocatalyst with Cu nanoparticles(NPs),as opposed to a stratified configuration,a high ethylene Faradaic efficiency(FE)of 57%was achieved at 600 mA cm^(-2)in acidic media,along with a remarkable single-pass CO_(2)conversion efficiency of 52.4%.While rotating disk electrode tests and operando Raman spectroscopy attest to the restricted H^(+)diffusion and elevated local pH near the catalyst surface,in situ Infrared and differential electrochemical mass spectrometries corroborate the spillover of CO from the cocatalyst to neighboring Cu NPs for enhanced C–C coupling.This work offers new insights into the design and application principles of compositional eCO_(2)R catalysts for promoting multicarbon synthesis in acidic media at high current density.展开更多
The global transition to carbon neutrality is an urgent and multifaceted challenge that requires the deployment of renewable energy technologies and negative emission solutions(NETs)to reduce greenhouse gas emissions ...The global transition to carbon neutrality is an urgent and multifaceted challenge that requires the deployment of renewable energy technologies and negative emission solutions(NETs)to reduce greenhouse gas emissions across all sectors.This is a review article that looks at the contemporary environment of renewable technologies,such as solar,wind,biomass,hydropower,and geothermal,and how they might help to decarbonize the power sector and their combination with NETs.The paper also looks at the prospects of carbon capture,utilization,and storage,afforestation and reforestation,soil carbon sequestration,ocean-based,and enhanced weathering as some of the methods of offsetting the residual emissions.The article also outlines the economic,policy,and social factors required to have these solutions scaled up,such as the need to have good policy frameworks,invest in innovation,and the need to have the people on board.Lastly,it also gives the future perspective of having a carbon-neutral global economy,and it highlights that technology must be enhanced,more cooperation between countries must be established,and a holistic,open-ended way of attaining carbon neutrality.展开更多
Global land monsoon precipitation(GLMP)is highly sensitive to changes in interhemispheric thermal contrast(ITC).Amplified interhemispheric asymmetries of GLMP due to enhanced ITC driven by high-level anthropogenic emi...Global land monsoon precipitation(GLMP)is highly sensitive to changes in interhemispheric thermal contrast(ITC).Amplified interhemispheric asymmetries of GLMP due to enhanced ITC driven by high-level anthropogenic emissions are expected to simultaneously increase the probability of regional floods and droughts,threatening ecosystems within global terrestrial monsoon regions and the freshwater supply for billions of residents in these areas.In this study,the responses of GLMP to the evolution of ITC toward the carbon neutrality goal are assessed using multimodel outputs from a new model intercomparison project(CovidMIP).The results show that the Northern Hemisphere-Southern Hemisphere(NH-SH)asymmetry of GLMP in boreal summer weakens during the 2040s,as a persistent reduction in well-mixed greenhouse gas(WMGHG)emissions leads to a downward trend in the ITC after 2040.At the same time,the reduction in WMGHG emissions dampens the Eastern Hemisphere-Western Hemisphere(EH-WH)asymmetry of GLMP by inducing La Niña-like cooling and enhancing moisture transport to Inner America.The resulting increases in land monsoon precipitation(LMP)may alleviate drought under the global warming scenario by about 19%-25%and 7%-9%in the WH and SH monsoon regions,respectively.However,a persistent reduction in aerosol emissions in Asia will dominate the increases in LMP in this region until the mid-21st century,and these increases may be approximately 23%-60%of the growth under the global warming scenario.Our results highlight the different rates of response of aerosol and WMGHG concentrations to the carbon neutrality goal,leading to various changes in LMP at global and regional scales.展开更多
Owing to the multi-degree-of-freedom characteristics and inherent fault-tolerant capacity,six-phase motors have been widely adopted in high-power applications,such as electric vehicle propulsion and aerospace systems....Owing to the multi-degree-of-freedom characteristics and inherent fault-tolerant capacity,six-phase motors have been widely adopted in high-power applications,such as electric vehicle propulsion and aerospace systems.This paper presents the fault-tolerant control strategy of symmetrical six-phase permanent magnet synchronous motor(SSPMSM)under an isolated neutral point topology and proposes a fault diagnosis scheme based on joint diagnosis of multiple variables.First,two mathematical models of SSPMSM and their relationship are established.Subsequently,the current vectors in the torque subspace and harmonic subspace of the two winding sets under fault conditions are analyzed,and the cause of post-fault torque ripple is explained as resulting from controller conflict.In addition,a multivariate fault diagnosis scheme based on voltage threshold in the x-y subspace and current trajectory characteristics in theα-βsubspace is proposed to enhance the diagnostic accuracy.Finally,the feasibility and stability of the proposed control and diagnosis methods are verified by experiments.展开更多
When performing English-to-Tamil Neural Machine Translation(NMT),end users face several challenges due to Tamil's rich morphology,free word order,and limited annotated corpora.Although available transformer-based ...When performing English-to-Tamil Neural Machine Translation(NMT),end users face several challenges due to Tamil's rich morphology,free word order,and limited annotated corpora.Although available transformer-based models offer strong baselines,they compromise syntactic awareness and the detection and man-agement of offensive content in cluttered,noisy,and informal text.In this paper,we present POSDEP-Offense-Trans,a multi-task NMT framework that combines Part-of-Speech(POS)and Dependency Parsing(DEP)methods with a robust offensive language classification module.Our architecture enriches the Transformer encoder with syntax-aware embeddings and provides syntax-guided attention mechanisms.The architecture incorporates a structure-aware contrastive loss that reinforces syntactic consistency and deploys auxiliary classification heads for POS tagging,dependency parsing,and multi-class offensive detection.The classifier for offensive words operates at both sentence and token levels and obtains guidance from syntactic features and formal finite automata rules that model offensive language structures-hate speech,profanity,sarcasm,and threats.Using this architecture,we construct a syntactically enriched,socially annotated corpus.Experimental results show improvements in translation quality,with a BLEU score of 33.5,UAS/LAS parsing accuracies of 92.4%and 90%,and a 4.5%Fl-score gain in offensive content detection compared with baseline POS+DEP+Offense models.Also,the proposed model achieved 92.3%in offensive content neutralization,as confirmed by ablation studies.This comprehensive English-Tamil NMT model that unifies syntactic modelling and ethical filtering-laying the groundwork for applications in social media moderation,hate speech mitigation,and policy-compliant multilingual content generation.展开更多
Understanding the dynamics of vegetation carbon sequestration(VCS)is essential for regional carbon neutrality strategies.This study revealed the spatiotemporal patterns of VCS and its relationship with anthropogenic c...Understanding the dynamics of vegetation carbon sequestration(VCS)is essential for regional carbon neutrality strategies.This study revealed the spatiotemporal patterns of VCS and its relationship with anthropogenic carbon emissions(ACEs)in Shandong Province,China during 2000-2020,and identified the sensitivity factors affecting VCS.The results show that:1)VCS increased consistently from 193.45 million t to 256.41 million t,with high values areas concentrated in the central,northeastern,and southeastern mountainous and hilly regions,while low values were found in water bodies and urban built-up areas.At the city level,Linyi,Yantai,Binzhou,and Jinan experienced the most significant rises-reaching up to 243000 t/yr.At the county level,Pingdu,Qixia,and Yiyuan also showed substantial growth,each exceeding 30400 t/yr.2)Digital Elevation Molde(DEM)was identified as the dominant natural factor influencing VCS distribution,while land use optimization measures,especially afforestation and farmland conversion in sloped terrain,were the primary human drivers of VCS increase.3)Urbanization and carbon neutrality were not mutually exclusive.While urban expansion locally reduced VCS,rural emigration enhanced carbon sinks in surrounding areas,partially offsetting urban losses.This compensatory mechanism supported VCS increases in nearly all cities and 90% of counties.Nevertheless,with ACEs continuing to rise and the offset ratio by VCS declining,achieving carbon neutrality requires regional strategies that integrate with accelerated energy conservation,emission reduction technologies,and energy transition.These findings provide a scientific basis for decomposing carbon neutrality targets across cities and counties in Shandong and a reference for developing localized land use policies in similar regions.展开更多
Advanced age impairs bone fracture healing;the underlying mechanism of this phenomenon remains unknown.We determined that apolipoprotein E(ApoE)increases with age and causes poor fracture healing.After deletion of hep...Advanced age impairs bone fracture healing;the underlying mechanism of this phenomenon remains unknown.We determined that apolipoprotein E(ApoE)increases with age and causes poor fracture healing.After deletion of hepatic ApoE expression(ΔApoE),24-month-oldΔApoE mice displayed a 95%reduction in circulating ApoE levels and significantly improved fracture healing.ApoE treatment of aged BMSCs inhibited osteoblast differentiation in tissue culture models;RNA-seq,Western blot,immunofluorescence,and RT-PCR analyses indicated that the Wnt/β-catenin pathway is the target of this inhibition.Indeed,we showed that ApoE had no effect on cultures with stabilizedβ-catenin levels.Next,we determined that Lrp4 serves as the osteoblast cell surface receptor to ApoE,as expression of Lrp4 is required in ApoE-based inhibition of Wnt/β-catenin signaling and osteoblast differentiation.Importantly,we validated this ApoE-Lrp4-Wnt/β-catenin molecular mechanism in human osteoblast differentiation.Finally,we identified an ApoE-neutralizing antibody(NAb)and used it to treat aged,wildtype mice 3 days after fracture surgery resulting in fracture calluses with 35%more bone deposition.Our work here identifies novel liver-to-bone cross-talk and a noninvasive,translatable therapeutic intervention for aged bone regeneration.展开更多
基金the Yunnan Fundamental Research Projects(Grant Nos.202501AT070298,202401AU070163,and 202401AT070368)the National Natural Science Foundation of China(Grant No.52162030)+5 种基金the Yunnan Major Scientific and Technological Projects(Grant No.202202AG050003)the Yunnan Engineering Research Center Innovation Ability Construction and Enhancement Projects(Grant No.2023-XMDJ-00617107)the University Service Key Industry Project of Yunnan Province(Grant No.FWCY-ZD2024005)the Yunnan Thousand Talents Program for Young Talents(Grant No.KKS2202052001)the Scientific Research Foundation of Kunming University of Science and Technology(Grant No.20220122)the Analysis and Testing Foundation of Kunming University of Science and Technology(Grant No.2023T20220122).
文摘The presence of residual alkaline compounds in the ultrahigh-nickel layered oxide cathodes(LiNi_(x)Co_(y)Mn_(1−x−y)O_(2),x≥_(0.9))aggravates structural degradation,increases surface reactivity,and promotes slurry gelation,leading to the capacity decay of batteries with these cathodes and complicating their manufacturing.Traditional approaches for addressing this issue,including direct removal,coverage,and utilization,are complex and require surface regeneration.Herein,we propose neutralizing residual alkaline compounds with 3-thiopheneboronic acid(3-TBA)to improve the performance of LiNi_(0.9)5Co_(0.04)Mn_(0.01)O_(2)(NCM)cathode material,a facile strategy that does not require any post-treatment.The suggested reaction yields a uniform and thin organic-modified layer on the surface of the NCM cathode,improving its chemical stability toward the electrolyte,as demonstrated by multiple characterization methods.The modified NCM cathode exhibited impressive cyclic and rate performances,achieving a capacity retention of 83.34%after 200 cycles at 1.0 C and a specific capacity of 162.00 mAh·g^(−1) at 10.0 C.Most importantly,the proposed approach can efficiently suppress unfavorable phase transitions,severe electrolyte degradation,and CO_(2) gas evolution,improving the application potential of ultrahigh-nickel layered oxide cathode materials.
基金financially supported by the National Natural Science Foundation of China NSFC(Nos.U1706212 and 81671828)。
文摘In the present research,nutrient broth(NB)medium was identified to be able to neutralize the antibacterial activity of chitosan and its derivatives.Therefore,an improved test method independent of NB medium was proposed to precisely quantify the antibacterial effectiveness and efficiency of chitosan.The minimum bactericidal concentration(MBC)of chitosan was 60μg m L^(-1) against S.aureus and E.coli,and 0.01%(w/v)chitosan could kill 100%of bacteria within 3 min.From another point of view,the neutralizing efficiency of NB could be tripled by adding 25 g L^(-1) of sodium chloride.Then the neutralizing mechanism of NB medium was ascribed to flocculation between chitosan and protein.Adding extra sodium chloride could significantly reduce the size of floccules,and smaller floccules would lose the ability of binding with bacteria directly,showing higher neutralizing rate on the macro scale.
基金supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDB23030100)
文摘Inductively coupled radio-frequency（RF） plasma neutralizer（RPN） is an insert-free device that can be employed as an electron source in electric propulsion applications.Electron-extraction characteristics of the RPN are related to the bulk plasma parameters and the device＇s geometry.Therefore,the effects of different electron-extraction apertures and operational parameters upon the electron-extraction characteristics are investigated according to the global nonambipolar flow and sheath model.Moreover,these models can also be used to explain why the electron-extraction characteristics of the RPN strongly depend upon the formation of the anode spot.During the experimental study,two types of anode spots are observed.Each of them has unique characteristics of electron extraction.Moreover,the hysteresis of an anode spot is observed by changing the xenon volume-flow rates or the bias voltages.In addition,the rapid ignited method,gas-utilization factor,electron-extraction cost and other factors that need to be considered in the design of the RPN are also discussed.
文摘Scanning Mobility Particle Sizer (SMPS) spectrometers are subject to several restrictions when a radioactive source is employed to bring the aerosol to a steady-state charge distribution. An alternative solution, commercially available, is represented by the soft X-ray neutralizer. The present study investigates the outcome of a combination of a Grimm SMPS, which employs a 241Am radioactive source, with the soft X-ray advanced aerosol neutralizer (TSI model 3087). To date, the latter device has been interfaced only with TSI’s Electrostatic Classifiers. Particle size distribution of sodium chloride aerosol was measured with both neutralizers and it was found that the particle number concentration agreed to be within 9% for the 10 - 700 nm range. This difference mainly corresponds to the bias reported by TSI, when the X-ray device is mounted on a TSI spectrometer. It was concluded that the X-ray neutralizer could be usefully employed, as a standalone device, in combination with Grimm Electrostatic Classifiers.
基金Supported by the Wellcome Trust,UK(RAH,Grant No.061325)the University of Science and Technology,Yementhe Gunter Trust,UK
文摘Objective: To explore whether a DNA immunization approach targeting the major haemorrhage molecule of a prothrombin activator-like metalloproteinase from Echis ocellatus(E. ocellatus) venom could be conceived to inspire antibodies with more prominent specificity and equal adequacy to current conventional antivenoms systems.Methods: The isolated DNA Eo MP-6 was used as the template for PCR amplification using the Eo DC-2-specific forward and reverse primers. A PCR product of approximately700 bp was obtained and cloned into p Sec Tag-B expression vector where anti-Eo DC-2antibodies were generated and analysed for their efficacy to neutralise local haemorrhage in vitro and in vivo.Results: Our results suggest that the generated anti-Eo DC-2 showed a remarkable efficacy by(a) interfering with the interaction of the recombinant disintegrin "Eo DC-2" isolated from the E. ocellatus as well as other viper species to the a2b1-integrins on platelets;(b) complete inhibition of the catalytic site of the metalloproteinase molecules in vitro using an adaptation antibody zymography assay. Furthermore, it has a polyspecific potential and constitutively expressed significant inhibition by cross-reaction and neutralised venom-induced local haemorrhage exerted by different viper species in vivo. The potential characteristic of Eo DC-2 against one part(the non-catalytic domain) as opposed to the whole molecule to neutralise its haemorrhagic activity is of crucial importance as it represents a novel approach with greater immunological specificity and fewer hazards, if any, than conventional systems of antivenom production, by exposure large animals that usually being used for the current antivenom production to a less injurious than expression of the whole molecule containing the catalytic metalloprotease domain. Hence, we report for the first time that our preliminary results hold a promising future for antivenom development.Conclusions: Antibodies generated against the E. ocellatus venom prothrombin activatorlike metalloprotease and disintegrin-cysteine-rich domains modulated and inhibited the catalytic activity both in vitro and in vivo of venom metalloproteinase disintegrin cysteine rich molecules. Thus, generating of venom specific-toxin antibodies by DNA immunization offer a more rational treatment of snake envenoming than conventional antivenom.
文摘Energetic neutral atoms(ENAs)are produced by the neutralization of energetic ions formed by shock-accelerated gradual solar energetic particle events(SEP).These high-energy ENAs(HENAs)can reach the Earth earlier than the associated SEPs and thus can provide information about the SEPs at the lower corona.The HENA properties observed at Earth depend on the properties of the coronal mass ejection(CME)-driven shocks that accelerate the SEPs.Using a model of HENA production in a shock-accelerated SEP event,we semi-quantitatively investigate the energy-time spectrum of HENAs depending on the width,propagation speed,and direction of the shock,as well as the density and ion abundances of the lower corona.Compared to the baseline model parameters,the cases with a wider shock width angle or a higher coronal density would increase the HENA flux observed at the Earth,while the case with an Earthpropagating shock shows a softened HENA spectrum.The comparison of expected HENA fluxes in different cases with a flight-proven ENA instrument suggests that solar HENAs can feasibly be monitored with current technologies,which could provide a lead time of 2−3 hours for SEPs at a few MeV.We propose that monitoring of solar HENAs could provide a new method to forecast shock-driven SEP events that are capable of significant space weather impacts on the near-Earth environment.
基金Supported by the National Natural Science Foundation of China(41205001)National(Key)Basic Research and Development(973)Program of China(2014CB441406)+1 种基金National Major Scientific Instruments and Equipment Development Special(61327810)Basic Research Funds of CAMS(2012Y005 and 2013Z006)
文摘The rate of neutralized charge by lightning（RNCL） is an important parameter indicating the intensity of lightning activity.The total charging rate（CR）,the CR of one kind of polarity（e.g.,negative） charge（CROP）,and the outflow rate of charge on precipitation（ORCP） are proposed as key factors impacting RNCL,based on the principle of conservation of one kind of polarity charge in a thunderstorm.In this paper,the impacts of updraft on CR and CROP are analyzed by using a 3D cloud resolution model for a strong storm that occurred in Beijing on 6 September 2008.The results show that updraft both promotes and inhibits RNCL at the same time.（1） Updraft always has a positive influence on CR.The correlation coefficient between the updraft volume and CR can reach 0.96.Strengthening of the updraft facilitates strengthening of RNCL through this positive influence.（2） Strengthening of the updraft also promotes reinforcement of CROP.The correlation coefficient between the updraft volume and CROP is high（about0.9）,but this promotion restrains the strengthening of RNCL because the strengthening of CROP will,most of the time,inhibit the increasing of RNCL.（3） Additionally,increasing of ORCP depresses the strengthening of RNCL.In terms of magnitude,the peak of ORCP is equal to the peak of CR.Because precipitation mainly appears after the lightning activity finishes,the depression effect of ORCP on RNCL can be ignored during the active lightning period.
基金supported by the Natural Science Foundation of the Jiangsu Higher Education Institutions of China(Grant No.22KJB310001 to W.G.)the Special Project of the Jiangsu Provincial Department of Science and Technology(Grant No.BE2023603 to W.G.)the Nanjing Medical University Science and Technology Development Foundation(Grant No.NMUB20210006 to W.G.).
文摘Neutralizing antibodies are essential tools in antiviral therapy and epidemic preparedness,capable of directlyinhibiting viral entry and limiting disease progression.However,traditional antibody discovery strategies—suchas animal immunization or B cell isolation from infected individuals—are often hindered by biosafety concerns,lengthy development timelines,and limited adaptability during outbreaks.In the present study,we aimed toestablish a robust and rapid in vitro platform for the efficient isolation of neutralizing antibodies targetingconserved viral epitopes.We developed an epitope-guided negative screening strategy that integrates phagedisplay technology with rational antigen mutagenesis to exclude antibodies against variable regions whileenriching for those that recognize functionally constrained epitopes.When applied to the receptor-binding domainof severe acute respiratory syndrome coronavirus 2,this method enabled the identification of six neutralizingantibodies(one IgG and five nanobodies)exhibiting broad-spectrum neutralizing activity across multiple viralvariants.Notably,antibodies recognizing distinct epitopes demonstrated significant synergistic neutralizationwhen used in combination(P<0.05).This screening approach facilitates the rapid discovery of potent andmutation-resistant antibodies and holds promise for application to other emerging pathogens.Our findingsunderscore the potential of epitope-guided,in vitro platforms in expediting therapeutic antibody developmentunder conditions of high biosafety requirements.
基金supported by the National Natural Science Foundation of China (42505149,41925023,U2342223,42105069,and 91744208)the China Postdoctoral Science Foundation (2025M770303)+1 种基金the Fundamental Research Funds for the Central Universities (14380230)the Jiangsu Funding Program for Excellent Postdoctoral Talent,and Jiangsu Collaborative Innovation Center of Climate Change。
文摘Countries around the world have been making efforts to reduce pollutant emissions. However, the response of global black carbon(BC) aging to emission changes remains unclear. Using the Community Atmosphere Model version 6 with a machine-learning-integrated four-mode version of the Modal Aerosol Module, we quantify global BC aging responses to emission reductions for 2011–2018 and for 2050 and 2100 under carbon neutrality. During 2011–18, global trends in BC aging degree(mass ratio of coatings to BC, R_(BC)) exhibited marked regional disparities, with a significant increase in China(5.4% yr^(-1)), which contrasts with minimal changes in the USA, Europe, and India. The divergence is attributed to opposing trends in secondary organic aerosol(SOA) and sulfate coatings, driven by regional changes in the emission ratios of corresponding coating precursors to BC(volatile organic compounds-VOCs/BC and SO_(2)/BC). Projections under carbon neutrality reveal that R_(BC) will increase globally by 47%(118%) in 2050(2100), with strong convergent increases expected across major source regions. The R_(BC) increase, primarily driven by enhanced SOA coatings due to sharper BC reductions relative to VOCs, will enhance the global BC mass absorption cross-section(MAC) by 11%(17%) in 2050(2100).Consequently, although the global BC burden will decline sharply by 60%(76%), the enhanced MAC partially offsets the magnitude of the decline in the BC direct radiative effect, resulting in the moderation of global BC DRE decreases to 88%(92%) of the BC burden reductions in 2050(2100). This study highlights the globally enhanced BC aging and light absorption capacity under carbon neutrality, thereby partly offsetting the impact of BC direct emission reductions on future changes in BC radiative effects globally.
文摘Water resources health diagnosis is increasingly recognized as a critical tool.It should not only guide the preservation of water volume,quality,and ecological integrity but also assess the viability of carbon-neutral development pathways.But current research tends to consider water health assessment and carbon-neutrality planning as separate endeavors,which results in imprecise boundaries,disjointed metrics,and a weak linkage between diagnostic outcomes and testable management actions.This review brings together indicator systems,diagnostic systems,and environmental management systems architectures that make it possible to have integrated water-carbon governance.We define fundamental concepts and delimiting decisions followed by the examination of indicator designs across the hydrological regime,water quality,ecological integrity,service performance,resilience,and carbon-related measures,including intensity of energy/emissions,emissions caused by the watershed process of wastewater treatment,as well as the potential sink of the watershed.We compare diagnostic methods,such as composite indices and multi-criteria decision analysis,data-driven early-warning models,process-based and integrated simulations,as well as uncertainty-aware robustness models.Here,based on this synthesis,we suggest an environmental management systems(EMS)-based pathway,which connects the setting of the baseline,the diagnosis,the design of the intervention portfolio,and the measurement-reporting-verification into the closed-loop adaptive cycle.Digital enablement,comprising Internet of Things(IoT)monitoring,remote sensing,data fusion,optimization,and digital twins,is considered a viable way of scaling implementation,subject to interoperability,validation,and model governance.Among the major gaps,there are causal attribution to outcomes,cross-scale coupling of facility emissions and basin health,propagation of uncertainty in a coupled model,and credible Measurement,Reporting,and Verification(MRV)of non-CO_(2) gases and nature-based removals.The review gives a roadmap to normalize core metrics and fast-deployable systems to protect the health of the water resources and give verifiable progress towards carbon neutrality.
基金supported by the Natural Science Foundation of China(Grants U2166211)Zhejiang Provincial Natural Science Foundation of China(Grants LY24E070006 and LMS25E070002).
文摘Driven by the global energy transition and the urgent“dual carbon”goals,regional integrated energy system(RIES)planning is undergoing a paradigm shift from carbon reduction to negative carbon emissions.This paper provides a comprehensive review of the theoretical frameworks and technical pathways for RIES planning from a carbon-centric perspective.A key contribution is the proposed Carbon-Energy-Economy(CEE)triple-dimensional governance framework,which endogenizes carbon factors into planning decisions through emission constraints,trading mechanisms,and capture technologies.We first analyze the fundamental characteristics of RIES and their critical role in achieving carbon neutrality,detailing advancements in multi-energy coupling models,energy router concepts,and standardized energy hub modeling.The paper further explores multi-energy flow analysis methods,and systematically compares the applicability and limitations of various planning algorithms,with emphasis on addressing uncertainties from renewable integration.Finally,we highlight the integration of artificial intelligence with traditional optimization methods,offering new pathways for intelligent,adaptive,and low-carbon RIES planning.This review underscores the transition towards data-physical fusion models,cooperative uncertainty optimization,multi-market planning,and innovative zero/negative-carbon technological routes.
基金supported by the National Natural Science Foundation of China(12473085).
文摘The neutral surface of a concave thin mirror is too close to the mirror surface,which makes it difficult to effectively mount the flexible structure and increases the mirror surface shape error.To address this problem,we design a flexible support structure including connectors,a support plate,and flexible structures,and construct an equivalent mirror by installing connectors and a support plate on the back of the mirror.While ensuring that the neutral surface of the equivalent mirror is moved away from the mirror surface,we optimize the support structure so that the rotary center of the flexible structure is located on the neutral surface of the equivalent mirror,avoiding the tilting moment.Following design and modeling of the structure,we analyze the static and dynamic characteristics using a finite element simulation,finding a root-mean-square(RMS)value for the surface shape error of 9.28 nm under the coupled effects of 1g gravity load,4℃ temperature rise,and 0.005 mm unevenness assembly error,with a fundamental frequency of 170.75 Hz,which all meet the design requirements.Finally,we carry out a surface shape error test of the mirror assembly,confirming it to meet the design index requirement of the mirror assembly.Simulation and test results verify the reliability and effectiveness of our proposed support structure.
基金financially supported by National Natural Science Foundation of China(22466010)Guizhou Provincial Basic Research Program(Natural Science)ZK[2023]47 and key program ZD[2025]075+6 种基金Innovation and Entrepreneurship Project for overseas Talents in Guizhou Province[2022]02Specific Natural Science Foundation of Guizhou University(X202207)the national undergraduate innovation and entrepreneurship training program(gzugc2023006gzusc2024012)SRT project of Guizhou university(2023SRT0292023SRT024)supported by Shanghai Technical Service Center of Science and Engineering Computing,Shanghai University。
文摘Electrocatalytic nitrate reduction reaction(NO3RR)represents a sustainable and environmentally benign route for ammonia(NH3)synthesis.However,NO3RR is still limited by the competition from hydrogen evolution reaction(HER)and the high energy barrier in the hydrogenation step of nitrogen-containing intermediates.Here,we report a selective etching strategy to construct Ru M nanoalloys(M=Fe,Co,Ni,Cu)uniformly dispersed on porous nitrogen-doped carbon substrates for efficient neutral NH3electrosynthesis.Density functional theory calculations confirm that the synergic effect between Ru and transition metal M modulates the electronic structure of the alloy,significantly lowering the energy barrier for the conversion of*NO_(2)to*HNO_(2).Experimentally,the optimized Ru Fe-NC catalyst achieves 100%Faraday efficiency with a high yield rate of 0.83 mg h^(-1)mg^(-1)catat a low potential of-0.1 V vs.RHE,outperforming most reported catalysts.In situ spectroscopic analyses further demonstrate that the Ru M-NC effectively promotes the hydrogenation of nitrogen intermediates while inhibiting the formation of hydrogen radicals,thereby reducing HER competition.The Ru FeNC assembled Zn-NO_(3)^(-)battery achieved a high open-circuit voltage and an outstanding power density and capacity,which drive selective NO_(3)^(-)conversion to NH3.This work provides a powerful synergistic design strategy for efficient NH3electrosynthesis and a general framework for the development of advanced multi-component catalysts for sustainable nitrogen conversion.
基金supported by the National Natural Science Foundation of China(No.22571222 and 22309125,)the Natural Science Foundation of Jiangsu Province(No.BK20220483,BK20211306,BK20220027,and BK20221239)+2 种基金the Natural Science Foundation of the Jiangsu Higher Education Institutions of China(22KJB150010)the Six Talent Peaks Project in Jiangsu Province(No.TD-XCL-006)the Priority Academic Program Development(PAPD)of Jiangsu Higher Education Institutions。
文摘Electrocatalytic CO_(2)reduction(eCO_(2)R)in acidic electrolytes is propitious to enhance CO_(2)utilization,yet suffering from low current efficiency due to the rapid kinetics of the competing hydrogen evolution reaction(HER),especially under high current densities.This study proposes the implementation of a singleatom NiNC cocatalyst concurrently generating CO and releasing OH^(-)to neutralize H^(+)in the electrolyte,thereby simultaneously suppressing HER and promoting C–C coupling.By homogeneously mixing the NiNC cocatalyst with Cu nanoparticles(NPs),as opposed to a stratified configuration,a high ethylene Faradaic efficiency(FE)of 57%was achieved at 600 mA cm^(-2)in acidic media,along with a remarkable single-pass CO_(2)conversion efficiency of 52.4%.While rotating disk electrode tests and operando Raman spectroscopy attest to the restricted H^(+)diffusion and elevated local pH near the catalyst surface,in situ Infrared and differential electrochemical mass spectrometries corroborate the spillover of CO from the cocatalyst to neighboring Cu NPs for enhanced C–C coupling.This work offers new insights into the design and application principles of compositional eCO_(2)R catalysts for promoting multicarbon synthesis in acidic media at high current density.
文摘The global transition to carbon neutrality is an urgent and multifaceted challenge that requires the deployment of renewable energy technologies and negative emission solutions(NETs)to reduce greenhouse gas emissions across all sectors.This is a review article that looks at the contemporary environment of renewable technologies,such as solar,wind,biomass,hydropower,and geothermal,and how they might help to decarbonize the power sector and their combination with NETs.The paper also looks at the prospects of carbon capture,utilization,and storage,afforestation and reforestation,soil carbon sequestration,ocean-based,and enhanced weathering as some of the methods of offsetting the residual emissions.The article also outlines the economic,policy,and social factors required to have these solutions scaled up,such as the need to have good policy frameworks,invest in innovation,and the need to have the people on board.Lastly,it also gives the future perspective of having a carbon-neutral global economy,and it highlights that technology must be enhanced,more cooperation between countries must be established,and a holistic,open-ended way of attaining carbon neutrality.
基金funded by the National Natural Science Foundation of China(Grant No.42275039)the Meteorological Joint Fund by NSF and CMA(Grant No.U2342224)+1 种基金the National Key R&D Program of China(Grant No.2022YFC3701202)the S&T Development Fund of CAMS(Grant No.2024KJ019)。
文摘Global land monsoon precipitation(GLMP)is highly sensitive to changes in interhemispheric thermal contrast(ITC).Amplified interhemispheric asymmetries of GLMP due to enhanced ITC driven by high-level anthropogenic emissions are expected to simultaneously increase the probability of regional floods and droughts,threatening ecosystems within global terrestrial monsoon regions and the freshwater supply for billions of residents in these areas.In this study,the responses of GLMP to the evolution of ITC toward the carbon neutrality goal are assessed using multimodel outputs from a new model intercomparison project(CovidMIP).The results show that the Northern Hemisphere-Southern Hemisphere(NH-SH)asymmetry of GLMP in boreal summer weakens during the 2040s,as a persistent reduction in well-mixed greenhouse gas(WMGHG)emissions leads to a downward trend in the ITC after 2040.At the same time,the reduction in WMGHG emissions dampens the Eastern Hemisphere-Western Hemisphere(EH-WH)asymmetry of GLMP by inducing La Niña-like cooling and enhancing moisture transport to Inner America.The resulting increases in land monsoon precipitation(LMP)may alleviate drought under the global warming scenario by about 19%-25%and 7%-9%in the WH and SH monsoon regions,respectively.However,a persistent reduction in aerosol emissions in Asia will dominate the increases in LMP in this region until the mid-21st century,and these increases may be approximately 23%-60%of the growth under the global warming scenario.Our results highlight the different rates of response of aerosol and WMGHG concentrations to the carbon neutrality goal,leading to various changes in LMP at global and regional scales.
基金supported in part by the National Natural Science Foundation of China under Grant 52177051in part by the Postgraduate Research and Practice Innovation Program of Jiangsu Province under Grant SJCX25_2046in part by the Key Research Project of Basic Science(Natural Science)in Jiangsu Province under Grant 24KJA470005.
文摘Owing to the multi-degree-of-freedom characteristics and inherent fault-tolerant capacity,six-phase motors have been widely adopted in high-power applications,such as electric vehicle propulsion and aerospace systems.This paper presents the fault-tolerant control strategy of symmetrical six-phase permanent magnet synchronous motor(SSPMSM)under an isolated neutral point topology and proposes a fault diagnosis scheme based on joint diagnosis of multiple variables.First,two mathematical models of SSPMSM and their relationship are established.Subsequently,the current vectors in the torque subspace and harmonic subspace of the two winding sets under fault conditions are analyzed,and the cause of post-fault torque ripple is explained as resulting from controller conflict.In addition,a multivariate fault diagnosis scheme based on voltage threshold in the x-y subspace and current trajectory characteristics in theα-βsubspace is proposed to enhance the diagnostic accuracy.Finally,the feasibility and stability of the proposed control and diagnosis methods are verified by experiments.
文摘When performing English-to-Tamil Neural Machine Translation(NMT),end users face several challenges due to Tamil's rich morphology,free word order,and limited annotated corpora.Although available transformer-based models offer strong baselines,they compromise syntactic awareness and the detection and man-agement of offensive content in cluttered,noisy,and informal text.In this paper,we present POSDEP-Offense-Trans,a multi-task NMT framework that combines Part-of-Speech(POS)and Dependency Parsing(DEP)methods with a robust offensive language classification module.Our architecture enriches the Transformer encoder with syntax-aware embeddings and provides syntax-guided attention mechanisms.The architecture incorporates a structure-aware contrastive loss that reinforces syntactic consistency and deploys auxiliary classification heads for POS tagging,dependency parsing,and multi-class offensive detection.The classifier for offensive words operates at both sentence and token levels and obtains guidance from syntactic features and formal finite automata rules that model offensive language structures-hate speech,profanity,sarcasm,and threats.Using this architecture,we construct a syntactically enriched,socially annotated corpus.Experimental results show improvements in translation quality,with a BLEU score of 33.5,UAS/LAS parsing accuracies of 92.4%and 90%,and a 4.5%Fl-score gain in offensive content detection compared with baseline POS+DEP+Offense models.Also,the proposed model achieved 92.3%in offensive content neutralization,as confirmed by ablation studies.This comprehensive English-Tamil NMT model that unifies syntactic modelling and ethical filtering-laying the groundwork for applications in social media moderation,hate speech mitigation,and policy-compliant multilingual content generation.
基金Under the auspices of the National Natural Science Foundation of China(No.42476247,42461015)the Open Research Fund of Key Laboratory of Coastal Science and Integrated Management,Ministry of Natural Resources(No.2024COSIM01)Guangxi Science and Technology Base and Talent Special Project(No.GuikeAD23026194)。
文摘Understanding the dynamics of vegetation carbon sequestration(VCS)is essential for regional carbon neutrality strategies.This study revealed the spatiotemporal patterns of VCS and its relationship with anthropogenic carbon emissions(ACEs)in Shandong Province,China during 2000-2020,and identified the sensitivity factors affecting VCS.The results show that:1)VCS increased consistently from 193.45 million t to 256.41 million t,with high values areas concentrated in the central,northeastern,and southeastern mountainous and hilly regions,while low values were found in water bodies and urban built-up areas.At the city level,Linyi,Yantai,Binzhou,and Jinan experienced the most significant rises-reaching up to 243000 t/yr.At the county level,Pingdu,Qixia,and Yiyuan also showed substantial growth,each exceeding 30400 t/yr.2)Digital Elevation Molde(DEM)was identified as the dominant natural factor influencing VCS distribution,while land use optimization measures,especially afforestation and farmland conversion in sloped terrain,were the primary human drivers of VCS increase.3)Urbanization and carbon neutrality were not mutually exclusive.While urban expansion locally reduced VCS,rural emigration enhanced carbon sinks in surrounding areas,partially offsetting urban losses.This compensatory mechanism supported VCS increases in nearly all cities and 90% of counties.Nevertheless,with ACEs continuing to rise and the offset ratio by VCS declining,achieving carbon neutrality requires regional strategies that integrate with accelerated energy conservation,emission reduction technologies,and energy transition.These findings provide a scientific basis for decomposing carbon neutrality targets across cities and counties in Shandong and a reference for developing localized land use policies in similar regions.
基金supported by a Borden Scholars awardDuke Claude D.Pepper Older Americans Independence Center Pilot Award(P30AG028716)by the NIH/NIA(R01AG081393)。
文摘Advanced age impairs bone fracture healing;the underlying mechanism of this phenomenon remains unknown.We determined that apolipoprotein E(ApoE)increases with age and causes poor fracture healing.After deletion of hepatic ApoE expression(ΔApoE),24-month-oldΔApoE mice displayed a 95%reduction in circulating ApoE levels and significantly improved fracture healing.ApoE treatment of aged BMSCs inhibited osteoblast differentiation in tissue culture models;RNA-seq,Western blot,immunofluorescence,and RT-PCR analyses indicated that the Wnt/β-catenin pathway is the target of this inhibition.Indeed,we showed that ApoE had no effect on cultures with stabilizedβ-catenin levels.Next,we determined that Lrp4 serves as the osteoblast cell surface receptor to ApoE,as expression of Lrp4 is required in ApoE-based inhibition of Wnt/β-catenin signaling and osteoblast differentiation.Importantly,we validated this ApoE-Lrp4-Wnt/β-catenin molecular mechanism in human osteoblast differentiation.Finally,we identified an ApoE-neutralizing antibody(NAb)and used it to treat aged,wildtype mice 3 days after fracture surgery resulting in fracture calluses with 35%more bone deposition.Our work here identifies novel liver-to-bone cross-talk and a noninvasive,translatable therapeutic intervention for aged bone regeneration.
