BACKGROUND The coronavirus disease 2019 pandemic has had an ongoing impact on the public’s mental health that requires long-term attention.Exploring the relationship between mental health indicators would aid in iden...BACKGROUND The coronavirus disease 2019 pandemic has had an ongoing impact on the public’s mental health that requires long-term attention.Exploring the relationship between mental health indicators would aid in identifying solutions to improve public mental health.AIM To investigate the prevalence of anxiety,depression,and insomnia and explore the relationship among neuroticism,cognitive failures,and mental health.METHODS A cross-sectional survey was conducted in December 2023 using an online platform to recruit adult participants.The neuroticism,subjective cognitive function,and mental health of the participants were assessed using the neuroticism subscale of the Chinese Big Five Personality Inventory Brief Version,cognitive failures questionnaire,generalized anxiety disorder-7,patient health questionnaire-9,and insomnia severity index.Pearson's correlation analysis,independent samples t-tests,one-way analysis of variance,and structural equation model were used to examine the relationship between mental health indicators.RESULTS A total of 1011 valid questionnaires were collected,of which 343 were completed by male(33.93%)respondents and 668 were completed by female(66.07%)respondents.The rates of anxiety,depression,and insomnia were 41.3%,44.6%,and 36.3%,respectively,most cases of which were mild.Among the mental health indicators,there were significant differences by age and between those with siblings and those who were only children.Neuroticism and cognitive failures were significantly positively correlated with mental health indicators.Further moderated mediation analysis showed that cognitive failures mediated the relationship between insomnia and anxiety and between insomnia and depression,with neuroticism moderating the first half of this pathway and the effect being greater in the low-neuroticism group.CONCLUSION Cognitive failures and neuroticism play important roles in mental health.Therefore,enhancing subjective cognitive function and regulating emotional stability may contribute to the improvement of mental health.展开更多
Background Ongoing debates question the harm of internet use with the evolving technology,as many individuals transition from regular to problematic internet use(PIU).The habenula(Hb),located between the thalamus and ...Background Ongoing debates question the harm of internet use with the evolving technology,as many individuals transition from regular to problematic internet use(PIU).The habenula(Hb),located between the thalamus and the third ventricle,is implicated in various psychiatric disorders.In addition,personality features have been suggested to play a role in the pathophysiology of PIU.Aims This study aimed to investigate Hb volumetry in individuals with subclinical PIU and the mediating effect of personality traits on this relationship.Methods 110 healthy adults in this cross-sectional study underwent structural magnetic resonance imaging.Hb segmentation was performed using a deep learning technique.The Internet Addiction Test(IAT)and the NEO Five-Factor Inventory were used to assess the PIU level and personality,respectively.Partial Spearman's correlation analyses were performed to explore the reiationships between Hb volumetry,IAT and NEO.Multiple regression analysis was applied to identify personality traits that predict IAT scores.The significant trait was then treated as a mediator between Hb volume and IAT correlation in mediation analysis with a bootstrap value of 5000.Results Relative Hb volume was negatively correlated with IAT scores(partial rho=-0.142,p=0.009).The IAT score was positively correlated with neuroticism(partial rho=0.430,p<0.001)and negatively correlated with extraversion,agreeableness and conscientiousness(partial rho=-0.213,p<0.001;partial rho=-0.279,p<0.001;and partial rho=-0.327,p<0.001).There was a significant indirect effect of Hb volume on this model(β=-0.061,p=0.048,boot 95%confidence interval:-0.149 to-0.001).Conclusions This study uncovered a crucial link between reduced Hb volume and heightened PIU.Our findings highlight neuroticism as a key risk factor for developing PIU.Moreover,neuroticism was shown to mediate the relationship between Hb volume and PIU tendency,offering valuable insight into the complexities of this interaction.展开更多
Introduction: Allostatic load (AL) index proposes indicators for the functioning of the main potentially stress-affected systems. Sex differences in stress response and stress-related diseases susceptibility have been...Introduction: Allostatic load (AL) index proposes indicators for the functioning of the main potentially stress-affected systems. Sex differences in stress response and stress-related diseases susceptibility have been described for the general population. In this observational study we describe the effects of sex and age on AL variables, in a cohort of patients with general anxiety disorders and neuroticism treated with alprazolam during 12 weeks, before and after treatment. Methods: Patients with general (DSM IV) anxiety disorders with >6 in Hamilton scale, AL (>1 Crimmins and Seeman AL modified criteria) and neuroticism >18 (NEO-FFI inventory), were included. All patients completed psychiatric assessment, AL index determination before (−1 week) and after 12 weeks of treatment with alprazolam (0.25 - 1 mg/t.i.d). Allostatic load parameters comprised cardiovascular, metabolic and inflammatory variables. Univariate analysis (two-way ANOVA), Student’s t-test (related variables) and Pearson correlations were determined. Results: Fifty-four patients, 35 females (48.6 ± 11.7 years) and 19 males (44.2 ± 12.8 years) with general anxiety disorder were included;28 patients with Conclusions: In this preliminary analysis we described sex and age differences in psychiatry aspects and AL indexes in patients with general anxiety disorders in the short-term treatment with alprazolam. These considerations remark the need of pondering sex and age differences during the use of drugs for protracted periods.展开更多
Mindfulness, conceptualized as a dispositional trait that differs across individuals, may potentially influence disordered eating behaviors. Previous research has independently identified insecure attachment style and...Mindfulness, conceptualized as a dispositional trait that differs across individuals, may potentially influence disordered eating behaviors. Previous research has independently identified insecure attachment style and neurotic personality traits as correlates of disordered eating behavior. Thus this current study will investigate whether neurotic personality traits, insecure attachment style and mindfulness predict disordered eating behavior controlling for gender differences. Participants (N = 126) completed the Adult Attachment Scale [1], the Three Factor Eating Questionnaire – Revised 18 [2], The Cognitive and Affective Mindfulness Scale – Revised [3] and the International Personality Item Pool [4]. The results of this cross-sectional study indicated that neurotic personality traits, insecure attachment style and mindfulness were related to disordered eating behaviors. The variance in disordered eating behaviors that was accounted for by neurotic personality traits and insecure attachment style was significantly reduced with the introduction of mindfulness. The results provides preliminary support for the inclusion of mindfulness training in disordered eating behavior interventions for individuals exhibiting an insecure attachment style and neurotic personality traits. Limitations and implications for further research are discussed.展开更多
Neurotic angioedema may be secondary to ACE (Angiotensin-converting enzyme) inhibitor. From a case of neurotic angioedema in a hypertensive man under ACE (Angiotensin-converting enzyme) inhibitor, we expose the clinic...Neurotic angioedema may be secondary to ACE (Angiotensin-converting enzyme) inhibitor. From a case of neurotic angioedema in a hypertensive man under ACE (Angiotensin-converting enzyme) inhibitor, we expose the clinical characteristics typical of the edema and its evolution. A 73-year-old man has consulted for edema of the face and redness of the palmar surface of the hand not pruriginous for 2 days. He has already had conventional anti-edematous treatments but no changes. In the absence of a technical platform, no paraclinical examination was carried out. The cessation of ACE inhibitor and the administration of tranexamic acid were made immediately. Signs regressed within 24 hours. Neurotic angioedema is a diagnostic problem in countries where biological examination is still limited and if practitioners are unaware of the possibility of its occurrence during IEC treatment. While the patient’s prognosis depends on the precocity of management.展开更多
Objective:To investigate the diversity of experiences of sadness emotion and physiological responses among female college students with high neuroticism (HN) and low neuroticism (LN) during the late luteal phase (LLP)...Objective:To investigate the diversity of experiences of sadness emotion and physiological responses among female college students with high neuroticism (HN) and low neuroticism (LN) during the late luteal phase (LLP) and early follicular phase (EFP).Methods:Forty-two participants were classified as the HN group and 41 as the LN group based on their neuroticism score (Eysenck Personality Questionnaire Short Scale for Chinese).Participants watched sadness-inducing experimental films during the LLP and EFP.Results:The HN group showed similar sadness intensities in both phases.The LN group showed higher sadness intensity in the LLP than the EFP.The LN group's sadness scale assessments were lower than the HN group in both phases.The blood volume pulse in the HN group fell in both the LLP and EFP (both P <.001).The root mean square standard deviation of NN intervals rose in the EFP in the HN group before and after watching experimental films (P =.027),but fell in the LN group (P >.05).Between-group comparisons showed heart rate was significantly lower in the HN group than the LN group during EFP (P =.009),but there were no statistically significant differences in subjective experience and physiological data during LLP.The HN group had stronger sadness feelings and greater sadness arousal than the LN group during EFP.There were significant associations between menstrual cycle-related changes in sadness ratings and changes in physiological outcomes.Conclusion:Women with HN have less fluctuation in sadness than those with LN during the menstrual cycle,but experience strong sadness feelings in the LLP.Women with HN show stronger physiological responses in the EFP than those with LN,and have the highest responses in the LLP.展开更多
Background:Neuroticism has been associated with numerous health outcomes.However,most research has focused on a single specific disorder and has produced controversial results,particularly regarding mortality risk.Her...Background:Neuroticism has been associated with numerous health outcomes.However,most research has focused on a single specific disorder and has produced controversial results,particularly regarding mortality risk.Here,we aimed to examine the association of neuroticism with morbidity and mortality and to elucidate how neuroticism affects trajectories from a healthy state,to one or more neuroticism-related disorders,and subsequent mortality risk.Methods:We included 483,916 participants from the UK Biobank at baseline(2006-2010).Neuroticism was measured using the Eysenck Personality Questionnaire.Three clusters were constructed,including worry,depressed affect,and sensitivity to environmental stress and adversity(SESA).Cox proportional hazards regression and multistate models were used.Linear regression was used to examine the association between neuroticism and immune parameters and neuroimaging measures.Results:High neuroticism was associated with 37 non-overlapping diseases,including increased risk of infectious,cardiometabolic,neuropsychiatric,digestive,and respiratory diseases,and decreased risk of cancer.After adjustment for sociodemographic variables,physical measures,healthy behaviors,and baseline diagnoses,moderate-to-high neuroticism was associated with a decreased risk of all-cause mortality.In multistate models,high neuroticism was associated with an increased risk of transitions from a healthy state to a first neuroticism-related disease(hazard ratio[HR][95%confidence interval(CI)]=1.09[1.05-1.13],P<0.001)and subsequent transitions to multimorbidity(1.08[1.02-1.14],P=0.005),but was associated with a decreased risk of transitions from multimorbidity to death(0.90[0.84-0.97],P for trend=0.006).The leading neuroticism cluster showing a detrimental role in the health-illness transition was depressed affect,which correlated with higher amygdala volume and lower insula volume.The protective effect of neuroticism against mortality was mainly contributed by the SESA cluster,which,unlike the other two clusters,did not affect the balance between innate and adaptive immunity.Conclusion:This study provides new insights into the differential role of neuroticism in health outcomes and into new perspectives for establishing mortality prevention programs for patients with multimorbidity.展开更多
Insomnia,anxiety,and depression have emerged as significant public mental health concerns,particularly during the coronavirus disease 2019(COVID-19)pandemic.Early recognition and intervention,addressing COVID-19's...Insomnia,anxiety,and depression have emerged as significant public mental health concerns,particularly during the coronavirus disease 2019(COVID-19)pandemic.Early recognition and intervention,addressing COVID-19's health effects before diverse symptoms appear,will expedite recovery and significantly enhance public mental health.Li et al conducted a cross-sectional online survey to assess neuroticism,cognitive function,insomnia,and emotional disorders in adult participants,examining how these factors correlate with mental health.The study revealed that a substantial number of participants reported experiencing varying degrees of anxiety,depression,and insomnia,most of which were classified as mild.Neuroticism was found closely associated with cognitive failure and poor mental health.Furthermore,moderated mediation analysis indicated that cognitive failure mediated the relationship between insomnia and anxiety and depression,whereas neuroticism moderated the pathway.These findings suggest that improving the subjective cognitive function and emotional stability can significantly improve mental health.However,this study has several limitations,including a limited sample size,cross-sectional design,and a focus on behavioral-level data.Future research should broaden its scope to include multiple hospitals at various levels to enhance the representativeness of the study population,adopt longitudinal designs,and integrate advanced technologies such as neuroimaging to explore the neural mechanisms underlying these conditions.展开更多
Insomnia,anxiety,and depression have become critical mental health issues exacerbated by the coronavirus disease 2019 pandemic,highlighting the importance of understanding their interrelationships.This article evaluat...Insomnia,anxiety,and depression have become critical mental health issues exacerbated by the coronavirus disease 2019 pandemic,highlighting the importance of understanding their interrelationships.This article evaluates the study by Li et al,which investigates the links between insomnia,anxiety,and depression while examining the mediating role of cognitive failures and the moderating effect of neuroticism.The study employed a cross-sectional design with 1011 participants,using validated scales to measure insomnia severity,neuroticism,cognitive failures,and mental health indicators.Li et al found that approximately 40%of participants exhibited symptoms of anxiety,depression,and insomnia,with most cases being mild.The results demonstrated that cognitive failures play a mediating role in the relationship between insomnia and both anxiety and depression.Furthermore,neuroticism moderated the relationship between insomnia and cognitive failures,with a stronger effect observed in individuals with lower levels of neuroticism.These findings underscore the importance of considering personality traits and cognitive processes in understanding mental health outcomes.This study emphasizes the critical need for interventions aimed at reducing cognitive failures and enhancing emotional stability to mitigate the impact of insomnia on mental health.Strategies to improve sleep quality,boost cognitive resilience,and regulate emotional responses could significantly enhance individuals’mental well-being.Moreover,integrating personality assessments into mental health services could facilitate more effective and personalized interventions.This article provides an original perspective on the effects of the coronavirus disease 2019 pandemic on global mental health.The content of the article addresses the complex relationships between sleep disorders,cognitive function losses,and neuroticism in light of data compiled from existing literature and current research.In addition,how these relationships have deepened during the pandemic and the effectiveness of proposed treatment methods for these phenomena are discussed in comparison with previous studies.The arguments in the article offer new perspectives and suggestions aimed at filling gaps in the literature,and make an important contribution to both clinical practice and public health policies.Li et al’s study provides a comprehensive framework for understanding the connections between insom-nia,cognitive failures,and neuroticism,as well as their influence on anxiety and depression.The findings offer valuable implications for public health strategies,emphasizing the necessity of holistic approaches to address post-pandemic mental health challenges.展开更多
基金Supported by National Natural Science Foundation of China,No.82271546 and No.82301744The Shanxi Province Science and Technology Innovation Think Tank Construction Research Project,No.KXKT202317+1 种基金Fundamental Research Program of Shanxi Province,No.202303021222346 and No.202103021223224The Research Foundation of The First Hospital of Shanxi Medical University,No.YQ2208.
文摘BACKGROUND The coronavirus disease 2019 pandemic has had an ongoing impact on the public’s mental health that requires long-term attention.Exploring the relationship between mental health indicators would aid in identifying solutions to improve public mental health.AIM To investigate the prevalence of anxiety,depression,and insomnia and explore the relationship among neuroticism,cognitive failures,and mental health.METHODS A cross-sectional survey was conducted in December 2023 using an online platform to recruit adult participants.The neuroticism,subjective cognitive function,and mental health of the participants were assessed using the neuroticism subscale of the Chinese Big Five Personality Inventory Brief Version,cognitive failures questionnaire,generalized anxiety disorder-7,patient health questionnaire-9,and insomnia severity index.Pearson's correlation analysis,independent samples t-tests,one-way analysis of variance,and structural equation model were used to examine the relationship between mental health indicators.RESULTS A total of 1011 valid questionnaires were collected,of which 343 were completed by male(33.93%)respondents and 668 were completed by female(66.07%)respondents.The rates of anxiety,depression,and insomnia were 41.3%,44.6%,and 36.3%,respectively,most cases of which were mild.Among the mental health indicators,there were significant differences by age and between those with siblings and those who were only children.Neuroticism and cognitive failures were significantly positively correlated with mental health indicators.Further moderated mediation analysis showed that cognitive failures mediated the relationship between insomnia and anxiety and between insomnia and depression,with neuroticism moderating the first half of this pathway and the effect being greater in the low-neuroticism group.CONCLUSION Cognitive failures and neuroticism play important roles in mental health.Therefore,enhancing subjective cognitive function and regulating emotional stability may contribute to the improvement of mental health.
基金funded by a Grant-in-Aid for Scientific Research(B)(Japan Society for The Promotion of Science,21H02849)Grant-in-Aid for Scientific Research(C)(Japan Society for The Promotion of Science,23K07013)+2 种基金Grant-in-Aid for Transformative Research Areas(A)(Japan Society for The Promotion of Science,JP21H05173)Grant-in-Aid by the Smoking Research FoundationGrant-in-Aid by the Telecommunications Advancement Foundation.
文摘Background Ongoing debates question the harm of internet use with the evolving technology,as many individuals transition from regular to problematic internet use(PIU).The habenula(Hb),located between the thalamus and the third ventricle,is implicated in various psychiatric disorders.In addition,personality features have been suggested to play a role in the pathophysiology of PIU.Aims This study aimed to investigate Hb volumetry in individuals with subclinical PIU and the mediating effect of personality traits on this relationship.Methods 110 healthy adults in this cross-sectional study underwent structural magnetic resonance imaging.Hb segmentation was performed using a deep learning technique.The Internet Addiction Test(IAT)and the NEO Five-Factor Inventory were used to assess the PIU level and personality,respectively.Partial Spearman's correlation analyses were performed to explore the reiationships between Hb volumetry,IAT and NEO.Multiple regression analysis was applied to identify personality traits that predict IAT scores.The significant trait was then treated as a mediator between Hb volume and IAT correlation in mediation analysis with a bootstrap value of 5000.Results Relative Hb volume was negatively correlated with IAT scores(partial rho=-0.142,p=0.009).The IAT score was positively correlated with neuroticism(partial rho=0.430,p<0.001)and negatively correlated with extraversion,agreeableness and conscientiousness(partial rho=-0.213,p<0.001;partial rho=-0.279,p<0.001;and partial rho=-0.327,p<0.001).There was a significant indirect effect of Hb volume on this model(β=-0.061,p=0.048,boot 95%confidence interval:-0.149 to-0.001).Conclusions This study uncovered a crucial link between reduced Hb volume and heightened PIU.Our findings highlight neuroticism as a key risk factor for developing PIU.Moreover,neuroticism was shown to mediate the relationship between Hb volume and PIU tendency,offering valuable insight into the complexities of this interaction.
文摘Introduction: Allostatic load (AL) index proposes indicators for the functioning of the main potentially stress-affected systems. Sex differences in stress response and stress-related diseases susceptibility have been described for the general population. In this observational study we describe the effects of sex and age on AL variables, in a cohort of patients with general anxiety disorders and neuroticism treated with alprazolam during 12 weeks, before and after treatment. Methods: Patients with general (DSM IV) anxiety disorders with >6 in Hamilton scale, AL (>1 Crimmins and Seeman AL modified criteria) and neuroticism >18 (NEO-FFI inventory), were included. All patients completed psychiatric assessment, AL index determination before (−1 week) and after 12 weeks of treatment with alprazolam (0.25 - 1 mg/t.i.d). Allostatic load parameters comprised cardiovascular, metabolic and inflammatory variables. Univariate analysis (two-way ANOVA), Student’s t-test (related variables) and Pearson correlations were determined. Results: Fifty-four patients, 35 females (48.6 ± 11.7 years) and 19 males (44.2 ± 12.8 years) with general anxiety disorder were included;28 patients with Conclusions: In this preliminary analysis we described sex and age differences in psychiatry aspects and AL indexes in patients with general anxiety disorders in the short-term treatment with alprazolam. These considerations remark the need of pondering sex and age differences during the use of drugs for protracted periods.
文摘Mindfulness, conceptualized as a dispositional trait that differs across individuals, may potentially influence disordered eating behaviors. Previous research has independently identified insecure attachment style and neurotic personality traits as correlates of disordered eating behavior. Thus this current study will investigate whether neurotic personality traits, insecure attachment style and mindfulness predict disordered eating behavior controlling for gender differences. Participants (N = 126) completed the Adult Attachment Scale [1], the Three Factor Eating Questionnaire – Revised 18 [2], The Cognitive and Affective Mindfulness Scale – Revised [3] and the International Personality Item Pool [4]. The results of this cross-sectional study indicated that neurotic personality traits, insecure attachment style and mindfulness were related to disordered eating behaviors. The variance in disordered eating behaviors that was accounted for by neurotic personality traits and insecure attachment style was significantly reduced with the introduction of mindfulness. The results provides preliminary support for the inclusion of mindfulness training in disordered eating behavior interventions for individuals exhibiting an insecure attachment style and neurotic personality traits. Limitations and implications for further research are discussed.
文摘Neurotic angioedema may be secondary to ACE (Angiotensin-converting enzyme) inhibitor. From a case of neurotic angioedema in a hypertensive man under ACE (Angiotensin-converting enzyme) inhibitor, we expose the clinical characteristics typical of the edema and its evolution. A 73-year-old man has consulted for edema of the face and redness of the palmar surface of the hand not pruriginous for 2 days. He has already had conventional anti-edematous treatments but no changes. In the absence of a technical platform, no paraclinical examination was carried out. The cessation of ACE inhibitor and the administration of tranexamic acid were made immediately. Signs regressed within 24 hours. Neurotic angioedema is a diagnostic problem in countries where biological examination is still limited and if practitioners are unaware of the possibility of its occurrence during IEC treatment. While the patient’s prognosis depends on the precocity of management.
基金This study was supported by the National Natural Science Foundation of China(81373771)the National Key Basic Research Development Program(973 Program:2011CB505101).
文摘Objective:To investigate the diversity of experiences of sadness emotion and physiological responses among female college students with high neuroticism (HN) and low neuroticism (LN) during the late luteal phase (LLP) and early follicular phase (EFP).Methods:Forty-two participants were classified as the HN group and 41 as the LN group based on their neuroticism score (Eysenck Personality Questionnaire Short Scale for Chinese).Participants watched sadness-inducing experimental films during the LLP and EFP.Results:The HN group showed similar sadness intensities in both phases.The LN group showed higher sadness intensity in the LLP than the EFP.The LN group's sadness scale assessments were lower than the HN group in both phases.The blood volume pulse in the HN group fell in both the LLP and EFP (both P <.001).The root mean square standard deviation of NN intervals rose in the EFP in the HN group before and after watching experimental films (P =.027),but fell in the LN group (P >.05).Between-group comparisons showed heart rate was significantly lower in the HN group than the LN group during EFP (P =.009),but there were no statistically significant differences in subjective experience and physiological data during LLP.The HN group had stronger sadness feelings and greater sadness arousal than the LN group during EFP.There were significant associations between menstrual cycle-related changes in sadness ratings and changes in physiological outcomes.Conclusion:Women with HN have less fluctuation in sadness than those with LN during the menstrual cycle,but experience strong sadness feelings in the LLP.Women with HN show stronger physiological responses in the EFP than those with LN,and have the highest responses in the LLP.
基金This study was supported by grants from the Science and Technology Innovation 2030 Major Projects(No.2022ZD0211600)the National Natural Science Foundation of China(Nos.82071201 and 82071997)+5 种基金Shanghai Municipal Science and Technology Major Project(No.2018SHZDZX01)Research Start-up Fund of Huashan Hospital(No.2022QD002)Excellence 2025 Talent Cultivation Program at Fudan University(No.3030277001)Shanghai Talent Development Funding for The Project(No.2019074)the Shanghai Rising-Star Program(No.21QA1408700)ZHANGJIANG LAB,Tianqiao and Chrissy Chen Institute,and the State Key Laboratory of Neurobiology and Frontiers Center for Brain Science of Ministry of Education,Fudan University.
文摘Background:Neuroticism has been associated with numerous health outcomes.However,most research has focused on a single specific disorder and has produced controversial results,particularly regarding mortality risk.Here,we aimed to examine the association of neuroticism with morbidity and mortality and to elucidate how neuroticism affects trajectories from a healthy state,to one or more neuroticism-related disorders,and subsequent mortality risk.Methods:We included 483,916 participants from the UK Biobank at baseline(2006-2010).Neuroticism was measured using the Eysenck Personality Questionnaire.Three clusters were constructed,including worry,depressed affect,and sensitivity to environmental stress and adversity(SESA).Cox proportional hazards regression and multistate models were used.Linear regression was used to examine the association between neuroticism and immune parameters and neuroimaging measures.Results:High neuroticism was associated with 37 non-overlapping diseases,including increased risk of infectious,cardiometabolic,neuropsychiatric,digestive,and respiratory diseases,and decreased risk of cancer.After adjustment for sociodemographic variables,physical measures,healthy behaviors,and baseline diagnoses,moderate-to-high neuroticism was associated with a decreased risk of all-cause mortality.In multistate models,high neuroticism was associated with an increased risk of transitions from a healthy state to a first neuroticism-related disease(hazard ratio[HR][95%confidence interval(CI)]=1.09[1.05-1.13],P<0.001)and subsequent transitions to multimorbidity(1.08[1.02-1.14],P=0.005),but was associated with a decreased risk of transitions from multimorbidity to death(0.90[0.84-0.97],P for trend=0.006).The leading neuroticism cluster showing a detrimental role in the health-illness transition was depressed affect,which correlated with higher amygdala volume and lower insula volume.The protective effect of neuroticism against mortality was mainly contributed by the SESA cluster,which,unlike the other two clusters,did not affect the balance between innate and adaptive immunity.Conclusion:This study provides new insights into the differential role of neuroticism in health outcomes and into new perspectives for establishing mortality prevention programs for patients with multimorbidity.
文摘Insomnia,anxiety,and depression have emerged as significant public mental health concerns,particularly during the coronavirus disease 2019(COVID-19)pandemic.Early recognition and intervention,addressing COVID-19's health effects before diverse symptoms appear,will expedite recovery and significantly enhance public mental health.Li et al conducted a cross-sectional online survey to assess neuroticism,cognitive function,insomnia,and emotional disorders in adult participants,examining how these factors correlate with mental health.The study revealed that a substantial number of participants reported experiencing varying degrees of anxiety,depression,and insomnia,most of which were classified as mild.Neuroticism was found closely associated with cognitive failure and poor mental health.Furthermore,moderated mediation analysis indicated that cognitive failure mediated the relationship between insomnia and anxiety and depression,whereas neuroticism moderated the pathway.These findings suggest that improving the subjective cognitive function and emotional stability can significantly improve mental health.However,this study has several limitations,including a limited sample size,cross-sectional design,and a focus on behavioral-level data.Future research should broaden its scope to include multiple hospitals at various levels to enhance the representativeness of the study population,adopt longitudinal designs,and integrate advanced technologies such as neuroimaging to explore the neural mechanisms underlying these conditions.
文摘Insomnia,anxiety,and depression have become critical mental health issues exacerbated by the coronavirus disease 2019 pandemic,highlighting the importance of understanding their interrelationships.This article evaluates the study by Li et al,which investigates the links between insomnia,anxiety,and depression while examining the mediating role of cognitive failures and the moderating effect of neuroticism.The study employed a cross-sectional design with 1011 participants,using validated scales to measure insomnia severity,neuroticism,cognitive failures,and mental health indicators.Li et al found that approximately 40%of participants exhibited symptoms of anxiety,depression,and insomnia,with most cases being mild.The results demonstrated that cognitive failures play a mediating role in the relationship between insomnia and both anxiety and depression.Furthermore,neuroticism moderated the relationship between insomnia and cognitive failures,with a stronger effect observed in individuals with lower levels of neuroticism.These findings underscore the importance of considering personality traits and cognitive processes in understanding mental health outcomes.This study emphasizes the critical need for interventions aimed at reducing cognitive failures and enhancing emotional stability to mitigate the impact of insomnia on mental health.Strategies to improve sleep quality,boost cognitive resilience,and regulate emotional responses could significantly enhance individuals’mental well-being.Moreover,integrating personality assessments into mental health services could facilitate more effective and personalized interventions.This article provides an original perspective on the effects of the coronavirus disease 2019 pandemic on global mental health.The content of the article addresses the complex relationships between sleep disorders,cognitive function losses,and neuroticism in light of data compiled from existing literature and current research.In addition,how these relationships have deepened during the pandemic and the effectiveness of proposed treatment methods for these phenomena are discussed in comparison with previous studies.The arguments in the article offer new perspectives and suggestions aimed at filling gaps in the literature,and make an important contribution to both clinical practice and public health policies.Li et al’s study provides a comprehensive framework for understanding the connections between insom-nia,cognitive failures,and neuroticism,as well as their influence on anxiety and depression.The findings offer valuable implications for public health strategies,emphasizing the necessity of holistic approaches to address post-pandemic mental health challenges.
