Objective To investigate the effects of WenFei JiangZhuo Formula on cognitive function,serum neurofactors,and cerebral blood flow status in patients with mild-to-moderate vascular dementia(VaD),providing evidence for ...Objective To investigate the effects of WenFei JiangZhuo Formula on cognitive function,serum neurofactors,and cerebral blood flow status in patients with mild-to-moderate vascular dementia(VaD),providing evidence for clinical treatment.Methods A total of 80 patients with mild-to-moderate VaD admitted to our hospital from January 2022 to December 2023 were randomly divided into a control group(40 cases)and an observation group(40 cases)using a random number table.The control group received oral administration of butylphenidyl soft capsules,while the observation group received WenFei JiangZhuo Formula decoction as adjunct therapy.Both groups underwent continuous treatment for 12 weeks.Clinical outcomes were compared including cognitive function scores(MMSE,MoCA),serum neurofactors[brain-derived neurotrophic factor(BDNF),nerve growth factor(NGF),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)],and cerebral hemodynamics parameters[peak systolic velocity(Vs),end-diastolic velocity(Vd),mean velocity(Vm)of the middle cerebral artery(MCA)and anterior cerebral artery(ACA)].Clinical efficacy and adverse reactions were statistically analyzed.Results:After treatment,both groups showed significantly improved MMSE and MoCA scores compared to baseline levels(P<0.05),with the observation group demonstrating greater improvement than the control group(P<0.05).Serum BDNF and NGF levels increased significantly in both groups(P<0.05),while TNF-αand IL-6 levels decreased markedly(P<0.05),with the observation group showing better improvement than the control group(P<0.05).Both groups showed significant increases in MCA,ACA,Vs,Vd,and Vm compared to baseline levels(P<0.05),with the observation group outperforming the control group(P<0.05).The overall effective rate in the observation group was 87.50%,significantly higher than the control group's 67.50%(P<0.05).No statistically significant differences were observed in adverse reaction rates between the groups(P>0.05).Conclusion:WenFei JiangZhuo Formula can effectively improve cognitive function in patients with mild-to-moderate VaD.This mechanism may involve upregulating neurotrophic factors,suppressing inflammatory responses,and enhancing cerebral blood flow perfusion,with demonstrated safety profile.展开更多
BACKGROUND Speech disorders have a substantial impact on communication abilities and quality of life.Traditional treatments such as speech and psychological therapies frequently demonstrate limited effectiveness and p...BACKGROUND Speech disorders have a substantial impact on communication abilities and quality of life.Traditional treatments such as speech and psychological therapies frequently demonstrate limited effectiveness and patient compliance.Transcranial electrical stimulation(TES)has emerged as a promising non-invasive treatment to improve neurological functions.However,its effectiveness in enhancing language functions and serum neurofactor levels in individuals with speech disorders requires further investigation.AIM To investigate the impact of TES in conjunction with standard therapies on serum neurotrophic factor levels and language function in patients with speech disorders.METHODS In a controlled study spanning from March 2019 to November 2021,81 patients with speech disorders were divided into a control group(n=40)receiving standard speech stimulation and psychological intervention,and an observation group(n=41)receiving additional TES.The study assessed serum levels of ciliary neurotrophic factor(CNTF),glial cell-derived neurotrophic factor(GDNF),brainderived neurotrophic factor(BDNF),and nerve growth factor(NGF),as well as evaluations of motor function,language function,and development quotient scores.RESULTS After 3 wk of intervention,the observation group exhibited significantly higher serum levels of CNTF,GDNF,BDNF,and NGF compared to the control group.Moreover,improvements were noted in motor function,cognitive function,language skills,physical abilities,and overall development quotient scores.It is worth mentioning that the observation group also displayed superior perfor CONCLUSION This retrospective study concluded that TES combined with traditional speech and psychotherapy can effectively increase the levels of neurokines in the blood and enhance language function in patients with speech disorders.These results provide a promising avenue for integrating TES into standard treatment methods for speech disorders.展开更多
文摘Objective To investigate the effects of WenFei JiangZhuo Formula on cognitive function,serum neurofactors,and cerebral blood flow status in patients with mild-to-moderate vascular dementia(VaD),providing evidence for clinical treatment.Methods A total of 80 patients with mild-to-moderate VaD admitted to our hospital from January 2022 to December 2023 were randomly divided into a control group(40 cases)and an observation group(40 cases)using a random number table.The control group received oral administration of butylphenidyl soft capsules,while the observation group received WenFei JiangZhuo Formula decoction as adjunct therapy.Both groups underwent continuous treatment for 12 weeks.Clinical outcomes were compared including cognitive function scores(MMSE,MoCA),serum neurofactors[brain-derived neurotrophic factor(BDNF),nerve growth factor(NGF),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)],and cerebral hemodynamics parameters[peak systolic velocity(Vs),end-diastolic velocity(Vd),mean velocity(Vm)of the middle cerebral artery(MCA)and anterior cerebral artery(ACA)].Clinical efficacy and adverse reactions were statistically analyzed.Results:After treatment,both groups showed significantly improved MMSE and MoCA scores compared to baseline levels(P<0.05),with the observation group demonstrating greater improvement than the control group(P<0.05).Serum BDNF and NGF levels increased significantly in both groups(P<0.05),while TNF-αand IL-6 levels decreased markedly(P<0.05),with the observation group showing better improvement than the control group(P<0.05).Both groups showed significant increases in MCA,ACA,Vs,Vd,and Vm compared to baseline levels(P<0.05),with the observation group outperforming the control group(P<0.05).The overall effective rate in the observation group was 87.50%,significantly higher than the control group's 67.50%(P<0.05).No statistically significant differences were observed in adverse reaction rates between the groups(P>0.05).Conclusion:WenFei JiangZhuo Formula can effectively improve cognitive function in patients with mild-to-moderate VaD.This mechanism may involve upregulating neurotrophic factors,suppressing inflammatory responses,and enhancing cerebral blood flow perfusion,with demonstrated safety profile.
文摘BACKGROUND Speech disorders have a substantial impact on communication abilities and quality of life.Traditional treatments such as speech and psychological therapies frequently demonstrate limited effectiveness and patient compliance.Transcranial electrical stimulation(TES)has emerged as a promising non-invasive treatment to improve neurological functions.However,its effectiveness in enhancing language functions and serum neurofactor levels in individuals with speech disorders requires further investigation.AIM To investigate the impact of TES in conjunction with standard therapies on serum neurotrophic factor levels and language function in patients with speech disorders.METHODS In a controlled study spanning from March 2019 to November 2021,81 patients with speech disorders were divided into a control group(n=40)receiving standard speech stimulation and psychological intervention,and an observation group(n=41)receiving additional TES.The study assessed serum levels of ciliary neurotrophic factor(CNTF),glial cell-derived neurotrophic factor(GDNF),brainderived neurotrophic factor(BDNF),and nerve growth factor(NGF),as well as evaluations of motor function,language function,and development quotient scores.RESULTS After 3 wk of intervention,the observation group exhibited significantly higher serum levels of CNTF,GDNF,BDNF,and NGF compared to the control group.Moreover,improvements were noted in motor function,cognitive function,language skills,physical abilities,and overall development quotient scores.It is worth mentioning that the observation group also displayed superior perfor CONCLUSION This retrospective study concluded that TES combined with traditional speech and psychotherapy can effectively increase the levels of neurokines in the blood and enhance language function in patients with speech disorders.These results provide a promising avenue for integrating TES into standard treatment methods for speech disorders.
