Endosomes are crucial sites for intracellular material sorting and transportation.Endosomal transport is a critical process involved in the selective uptake,processing,and intracellular transport of substances.The equ...Endosomes are crucial sites for intracellular material sorting and transportation.Endosomal transport is a critical process involved in the selective uptake,processing,and intracellular transport of substances.The equilibrium between endocytosis and circulation mediated by the endosome-centered transport pathway plays a significant role in cell homeostasis,signal transduction,and immune response.In recent years,there have been hints linking endosomal transport abnormalities to neurodegenerative diseases,including Alzheimer’s disease.Nonetheless,the related mechanisms remain unclear.Here,we provide an overview of endosomal-centered transport pathways and highlight potential physiological processes regulated by these pathways,with a particular focus on the correlation of endosomal trafficking disorders with common pathological features of neurodegenerative diseases.Additionally,we summarize potential therapeutic agents targeting endosomal trafficking for the treatment of neurodegenerative diseases.展开更多
基金supported by the National Natural Science Foundation of China(81901309)the Science and Technology Funding Project to Support the High-Quality Development of China Medical University(2023JH2/20200039)+1 种基金the Basic Scientific Research Project of Institutions of Higher Learning of Liaoning Province(LJKZ0775)the Joint Plan of Science and Technology of Liaoning Province(2023-MSLH-369)the Science and Technology Innovation Team Project of China Medical University(CXTD2022007).
文摘Endosomes are crucial sites for intracellular material sorting and transportation.Endosomal transport is a critical process involved in the selective uptake,processing,and intracellular transport of substances.The equilibrium between endocytosis and circulation mediated by the endosome-centered transport pathway plays a significant role in cell homeostasis,signal transduction,and immune response.In recent years,there have been hints linking endosomal transport abnormalities to neurodegenerative diseases,including Alzheimer’s disease.Nonetheless,the related mechanisms remain unclear.Here,we provide an overview of endosomal-centered transport pathways and highlight potential physiological processes regulated by these pathways,with a particular focus on the correlation of endosomal trafficking disorders with common pathological features of neurodegenerative diseases.Additionally,we summarize potential therapeutic agents targeting endosomal trafficking for the treatment of neurodegenerative diseases.
