Copy number variation(CNV)is a remarkable manifestation of genomic structural variations that affect human health.However,CNV detection in low coverage and low purity data is one of the challenging issues.To fill this...Copy number variation(CNV)is a remarkable manifestation of genomic structural variations that affect human health.However,CNV detection in low coverage and low purity data is one of the challenging issues.To fill this gap,a hybrid algorithm combining an improved whale optimization algorithm(IwOA)and backpropagation(BP)neural networks(hereafter called IWOABP)is developed for CNV detection.First,to enhance the precision of detection,the detectable categories for the gain and loss are respectively expanded to two types,where gain is divided into tand_gain and inte_gain,and loss is divided into hemi_loss and homo_loss.Then,IWOA is introduced to tune the weights and bias values of BP neural network,which can improve the BP neural network abilities to jump out of the local optimums.Next,to ensure the population diversity and the uniform distribution of solutions,a pooling mechanism and a migration search strategy are designed.In addition,to balance the exploitation and exploration abilities,three position update strategies based on an adaptive inertia-weight are used.Finally,to evaluate the detection performance of IwOABP,seven state-of-the-art detection methods are chosen to make detailed comparisons with the proposed algorithm.The results show that IWOABP has outstanding performance in sensitivity,precision,and Fl-score using both simulated and real data.展开更多
General neural network inverse adaptive controller has two flaws: the first is the slow convergence speed; the second is the invalidation to the non-minimum phase system. These defects limit the scope in which the neu...General neural network inverse adaptive controller has two flaws: the first is the slow convergence speed; the second is the invalidation to the non-minimum phase system. These defects limit the scope in which the neural network inverse adaptive controller is used. We employ Davidon least squares in training the multi-layer feedforward neural network used in approximating the inverse model of plant to expedite the convergence, and then through constructing the pseudo-plant, a neural network inverse adaptive controller is put forward which is still effective to the nonlinear non-minimum phase system. The simulation results show the validity of this scheme.展开更多
基金supported by the National Science Foundation of China(Nos.62473331 and 62173216)Key projects of Yunnan Province Basic Research Program(No.202401AS070036)Yunnan Key Laboratory of Modern Analytical Mathematics and Applications(No.202302AN360007).
文摘Copy number variation(CNV)is a remarkable manifestation of genomic structural variations that affect human health.However,CNV detection in low coverage and low purity data is one of the challenging issues.To fill this gap,a hybrid algorithm combining an improved whale optimization algorithm(IwOA)and backpropagation(BP)neural networks(hereafter called IWOABP)is developed for CNV detection.First,to enhance the precision of detection,the detectable categories for the gain and loss are respectively expanded to two types,where gain is divided into tand_gain and inte_gain,and loss is divided into hemi_loss and homo_loss.Then,IWOA is introduced to tune the weights and bias values of BP neural network,which can improve the BP neural network abilities to jump out of the local optimums.Next,to ensure the population diversity and the uniform distribution of solutions,a pooling mechanism and a migration search strategy are designed.In addition,to balance the exploitation and exploration abilities,three position update strategies based on an adaptive inertia-weight are used.Finally,to evaluate the detection performance of IwOABP,seven state-of-the-art detection methods are chosen to make detailed comparisons with the proposed algorithm.The results show that IWOABP has outstanding performance in sensitivity,precision,and Fl-score using both simulated and real data.
基金Tianjin Natural Science Foundation !983602011National 863/CIMS Research Foundation !863-511-945-010
文摘General neural network inverse adaptive controller has two flaws: the first is the slow convergence speed; the second is the invalidation to the non-minimum phase system. These defects limit the scope in which the neural network inverse adaptive controller is used. We employ Davidon least squares in training the multi-layer feedforward neural network used in approximating the inverse model of plant to expedite the convergence, and then through constructing the pseudo-plant, a neural network inverse adaptive controller is put forward which is still effective to the nonlinear non-minimum phase system. The simulation results show the validity of this scheme.
