Objective:To compare the clinical efficacy and safety of intravitreal injection of faricimab and conbercept in the treatment of diabetic macular edema(DME).Methods:A total of 50 patients diagnosed with DME in our hosp...Objective:To compare the clinical efficacy and safety of intravitreal injection of faricimab and conbercept in the treatment of diabetic macular edema(DME).Methods:A total of 50 patients diagnosed with DME in our hospital from January 2023 to May 2025 were selected and randomly divided into an observation group and a control group,with 25 cases in each group,using a random number table method.The observation group received intravitreal injection of faricimab,while the control group received intravitreal injection of conbercept.Both groups adopted a loading phase plus maintenance phase treatment regimen.The best-corrected visual acuity(BCVA,expressed in logMAR)and central subfield thickness(CST)of the two groups were compared before treatment and at 1,3,and 6 months after treatment,and the incidence of adverse events during treatment was recorded.Results:The logMAR BCVA in the observation group was lower than that in the control group at 3 and 6 months after treatment(both p<0.05).The CST in the observation group was smaller than that in the control group at 1,3,and 6 months after treatment(all p<0.05).There was no statistically significant difference in the overall incidence of adverse events between the two groups(χ^(2)=0.189,p=0.663).Conclusion:Both intravitreal injections of faricimab and conbercept are effective in improving visual acuity and reducing macular edema in patients with DME,with good safety profiles.However,faricimab demonstrates superior efficacy in the medium to long term(3 and 6 months)compared to conbercept,making it more suitable for long-term treatment of patients with DME.展开更多
Objective:To investigate the clinical efficacy of electrophysiological therapy under different parameter modes in chronic pelvic pain syndrome(CPPS).Methods:A total of 95patients with CPPS from the Department of Urolo...Objective:To investigate the clinical efficacy of electrophysiological therapy under different parameter modes in chronic pelvic pain syndrome(CPPS).Methods:A total of 95patients with CPPS from the Department of Urology,First Affiliated Hospital of Jinan University,were selected and treated with electrophysiological therapy.They were randomly divided into three groups:the fixed-parameter AA7 treatment group,the P2+P4 treatment group,and the precision treatment group(individualized parameter treatment).Pain scores of patients in each group were compared before and after treatment,with a pain score of 0 indicating cure.The cure rate of each group was observed.Results:The average ages of the AA7 group,P2+P4 group,and precision treatment group were 34±14.17 years,35.58±12.57 years,and 35.5±11.27 years,respectively.There was no significant difference in age among the three groups(p>0.05).Before treatment,the pain scores of the AA7 group,P2+P4 group,and precision treatment group were 4.14±1.74,4.64±1.72,and 3.50±1.89,respectively,with no significant differences among the groups(p>0.05).After treatment,the pain scores were 0.71±0.99 for the AA7 group(cure rate:57%),0.49±0.79 for the P2+P4 group(cure rate:67%),and 0.50±0.77 for the precision treatment group(cure rate:64%),with no significant differences among the groups(p>0.05).The cure rates for different pain locations were as follows:83%for lower abdominal pain,74%for perineal pain,62%for dysuria,49%for testicular pain,and 75%for inguinal pain.Conclusion:The pathogenesis of CPPS is complex and diverse,with numerous treatment options and uncertain efficacy,posing significant challenges to clinical practice.This study showed that electrophysiological therapy under different parameter modes significantly reduced pain scores before and after treatment,indicating significant therapeutic effects on CPPS.All three modes demonstrated good cure rates.Individualized precision treatment and fixed-mode P2+P4 or AA7 treatment were safe and effective in CPPS treatment and are worth promoting.Fixed-mode P2+P4 and AA7,due to their easier standardization of parameters and patch modes,reduced the learning curve and had better potential for widespread application.展开更多
Chemotherapy-induced diarrhea(CID)is a major concern for cancer patients and is associated with significant morbidity and mortality.Currently,the clinical management of CID is limited.The utilization of antidiarrheal ...Chemotherapy-induced diarrhea(CID)is a major concern for cancer patients and is associated with significant morbidity and mortality.Currently,the clinical management of CID is limited.The utilization of antidiarrheal medications,such as loperamide and octreotide,is relatively limited because of their unsatisfactory efficacy and adverse effects.In recent years,traditional Chinese medicine(TCM)has attracted great interest because of its beneficial effect in treating CID,which has multitarget and low-toxicity therapeutic characteristics.TCM exhibits remarkable therapeutic potential in the prevention and treatment of CID.It can alleviate and treat CID by regulating chemical drug metabolism,improving the integrity of the intestinal barrier,stimulating proliferation while suppressing the apoptosis of intestinal epithelial cells,ameliorating oxidative stress and inflammation and regulating bile acids and aquaporins.However,large-scale,randomized,double-blind clinical trials of TCM for the treatment of CID are lacking,and most preclinical experiments have not been translated to clinical trials.Accordingly,this review highlights the clinical efficacy and molecular mechanisms of TCM against CID via PubMed,Web of Science and China National Knowledge Infrastructure and proposes that future research on TCM against CID should focus on strengthening the connection from bench to bed,which may help to comprehensively evaluate the therapeutic potential of TCM against CID.展开更多
Objective:To retrospectively evaluate the diagnostic efficacy of traditional MRI and T2 Mapping quantitative imaging technology for knee joint cartilage injury,clarify the differences in diagnostic value of the two im...Objective:To retrospectively evaluate the diagnostic efficacy of traditional MRI and T2 Mapping quantitative imaging technology for knee joint cartilage injury,clarify the differences in diagnostic value of the two imaging methods in different injury grades and different cartilage subregions,and provide evidence-based basis for the accurate diagnosis of clinical cartilage injury.Methods:Clinical and imaging data of 286 patients with knee joint lesions admitted to the Affiliated Hospital of Xiangtan Medicine and Health Vocational College from January 2020 to June 2023 were collected retrospectively.All patients underwent both traditional MRI sequences and T2 Mapping sequences.The knee joint cartilage was divided into 14 subregions.Two senior radiologists independently diagnosed the images of the two imaging technologies using a blind method and recorded the cartilage injury grades.The sensitivity,specificity,accuracy,positive predictive value,negative predictive value,and area under the receiver operating characteristic curve(AUC)of the two technologies for diagnosing cartilage injury were calculated and compared,and the differences in their diagnostic efficacy in different injury grades and different subregions were analyzed.Results:A total of 4004 cartilage subregions from 286 patients were included in the analysis,including 1836 injured subregions and 2168 normal subregions.The overall sensitivity(89.7%),accuracy(91.2%),and AUC(0.946)of T2 Mapping quantitative imaging for diagnosing cartilage injury were significantly higher than those of traditional MRI(76.3%,82.5%,and 0.852 respectively),with statistically significant differences(p<0.001);there was no significant difference in specificity between the two(93.5%vs 90.8%,p=0.062).Subgroup analysis showed that T2 Mapping had the most significant diagnostic advantage in early cartilage injury(Grade 1),with sensitivity(78.5%)33.2%higher than that of traditional MRI(45.3%)(p<0.001).Conclusion:The diagnostic efficacy of T2 Mapping quantitative imaging for knee joint cartilage injury is significantly superior to that of traditional MRI,especially in the detection of early cartilage injury and accurate evaluation of weight-bearing area injury.Data verify its clinical applicability and reliability.It can be used as an important supplementary method to traditional MRI,and is recommended for the early diagnosis,grading evaluation,and clinical follow-up of cartilage injury.展开更多
Objective:To evaluate the clinical efficacy of blood-letting cupping combined with manual lymphatic drainage in treating breast cancer-related lymphedema(BCRL)and explore its mechanism of action from both traditional ...Objective:To evaluate the clinical efficacy of blood-letting cupping combined with manual lymphatic drainage in treating breast cancer-related lymphedema(BCRL)and explore its mechanism of action from both traditional Chinese medicine and modern medical perspectives,providing a scientific basis and novel therapeutic approaches for clinical management of BCRL.Methods:Patients with BCRL admitted to the outpatient and inpatient departments of Hebei University Affiliated Hospital were enrolled.A prospective randomized controlled trial design was adopted,with eligible patients randomly assigned to a treatment group and a control group.The control group received manual lymphatic drainage alone,while the treatment group received manual lymphtic drainage combined with blood-letting cupping therapy.Posttreatment comparisons evaluated upper limb circumference reduction,edema severity grading,and upper limb functional scores.Vital signs and adverse reactions during treatment were recorded for both groups.Statistical software analyzed the data.Results:The treatment group demonstrated significantly greater reduction in upper limb circumference,improvement in edema severity,and higher upper limb function scores compared to the control group(P<0.05).Vital signs remained stable throughout treatment in both groups.No severe adverse reactions occurred in the treatment group;only isolated cases of mild skin itching were reported,which resolved after symptomatic management.Conclusion:The combination of bloodletting cupping and manual lymphatic drainage demonstrates reliable efficacy in treating BCRL,effectively alleviating edema symptoms and improving upper limb function with high safety.Its mechanism may relate to traditional Chinese medicine principles of“unblocking meridians,promoting blood circulation,and resolving stasis”and modern medical concepts of“enhancing local blood circulation,facilitating lymphatic drainage,and reducing inflammatory responses”.展开更多
Concerns about the long-term safety and efficacy of glibenclamide(GLIB),a type 2 diabetes mellitus(T2DM)treatment,have been reported[1].Recent evidence indicates the gut microbiota composition significantly affects ho...Concerns about the long-term safety and efficacy of glibenclamide(GLIB),a type 2 diabetes mellitus(T2DM)treatment,have been reported[1].Recent evidence indicates the gut microbiota composition significantly affects host glucose metabolism and drugbioavailability,increasingthe efficacy of T2DM therapy[2].In this context,probiotic-drug coadministration,an emerging adjunct approach for treating metabolic diseases,improves therapeutic outcomes and ameliorates side effects[3].展开更多
The advent of the Age of Information brings about bright prospects to Network-based Language Learning(NBLL).The thesis adopts the Engagement Theory as guided principles.The purpose is to use the novel NBLL model effec...The advent of the Age of Information brings about bright prospects to Network-based Language Learning(NBLL).The thesis adopts the Engagement Theory as guided principles.The purpose is to use the novel NBLL model effectively with the help of modern technology especially in less-developed areas.This thesis focuses on network-based experimental study.The research shows that the students under NBLL environment have cultivated the capabilities in information collection,computer operation,and information evaluation,as well as the abilities in problem solving,reasoning with criticism,and cooperating with others.展开更多
A network-based Virtual Private Network(VPN)architecture by using fundamental routing mechanism is proposed.This network is a virtual overlay network based on the relay of IP-in-IP tunneling of virtual routing modules...A network-based Virtual Private Network(VPN)architecture by using fundamental routing mechanism is proposed.This network is a virtual overlay network based on the relay of IP-in-IP tunneling of virtual routing modules.The packet format employs the encapsulation of IPSec ESP(Encapsulating Security Payload),an impact path code and an extended DS(Differentiated Services)code to support multi-path routing and QoS.Comparing with other models of VPN,this network system can be deployed in the current network with little investment,and it is easy to implement.The simulation result shows its performance is better than the traditional VPN system of black box mode.展开更多
An efficient and accurate prediction of a precise tidal level in estuaries and coastal areas is indispensable for the management and decision-making of human activity in the field wok of marine engineering. The variat...An efficient and accurate prediction of a precise tidal level in estuaries and coastal areas is indispensable for the management and decision-making of human activity in the field wok of marine engineering. The variation of the tidal level is a time-varying process. The time-varying factors including interference from the external environment that cause the change of tides are fairly complicated. Furthermore, tidal variations are affected not only by periodic movement of celestial bodies but also by time-varying interference from the external environment. Consequently, for the efficient and precise tidal level prediction, a neuro-fuzzy hybrid technology based on the combination of harmonic analysis and adaptive network-based fuzzy inference system（ANFIS）model is utilized to construct a precise tidal level prediction system, which takes both advantages of the harmonic analysis method and the ANFIS network. The proposed prediction model is composed of two modules： the astronomical tide module caused by celestial bodies’ movement and the non-astronomical tide module caused by various meteorological and other environmental factors. To generate a fuzzy inference system（FIS） structure,three approaches which include grid partition（GP）, fuzzy c-means（FCM） and sub-clustering（SC） are used in the ANFIS network constructing process. Furthermore, to obtain the optimal ANFIS based prediction model, large numbers of simulation experiments are implemented for each FIS generating approach. In this tidal prediction study, the optimal ANFIS model is used to predict the non-astronomical tide module, while the conventional harmonic analysis model is used to predict the astronomical tide module. The final prediction result is performed by combining the estimation outputs of the harmonious analysis model and the optimal ANFIS model. To demonstrate the applicability and capability of the proposed novel prediction model, measured tidal level samples of Fort Pulaski tidal station are selected as the testing database. Simulation and experimental results confirm that the proposed prediction approach can achieve precise predictions for the tidal level with high accuracy, satisfactory convergence and stability.展开更多
Semiconductor manufacturing (SM) system is one of the most complicated hybrid processes involved continuously variable dynamical systems and discrete event dynamical systems. The optimization and scheduling of semicon...Semiconductor manufacturing (SM) system is one of the most complicated hybrid processes involved continuously variable dynamical systems and discrete event dynamical systems. The optimization and scheduling of semiconductor fabrication has long been a hot research direction in automation. Bottleneck is the key factor to a SM system, which seriously influences the throughput rate, cycle time, time-delivery rate, etc. Efficient prediction for the bottleneck of a SM system provides the best support for the consequent scheduling. Because categorical data (product types, releasing strategies) and numerical data (work in process, processing time, utilization rate, buffer length, etc.) have significant effect on bottleneck, an improved adaptive network-based fuzzy inference system (ANFIS) was adopted in this study to predict bottleneck since conventional neural network-based methods accommodate only numerical inputs. In this improved ANFIS, the contribution of categorical inputs to firing strength is reflected through a transformation matrix. In order to tackle high-dimensional inputs, reduce the number of fuzzy rules and obtain high prediction accuracy, a fuzzy c-means method combining binary tree linear division method was applied to identify the initial structure of fuzzy inference system. According to the experimental results, the main-bottleneck and sub-bottleneck of SM system can be predicted accurately with the proposed method.展开更多
This paper investigates the remote tracking control problem of Network-based Agents with communication delays existing in both forward and feedback communication channels.A networked predictive tracking controller is ...This paper investigates the remote tracking control problem of Network-based Agents with communication delays existing in both forward and feedback communication channels.A networked predictive tracking controller is proposed to compensate the negative effects caused by bilateral time-delays in a wireless network.Furthermore,the problem of consecutive data loss in the feedback channel is solved using aforementioned controller,where lateral movement perturbations are introduced.Simulations and experiments are provided for several cases,which verify the realizability and effectiveness of the proposed controller.展开更多
A parallel neural network-based controller （PNNC） is presented for the motion control of underwater vehicles in this paper. It consists of a real-time part, a self-learning part and a desired-state programmer, and i...A parallel neural network-based controller （PNNC） is presented for the motion control of underwater vehicles in this paper. It consists of a real-time part, a self-learning part and a desired-state programmer, and it is different from normal adaptive neural network controller in structure. Owing to the introduction of the self-learning part, on-line learning can be performed without sample data in several sample periods, resulting in high learning speed of the controller and good control performance. The desired-state programmer is utilized to obtain better learning samples of the neural network to keep the stability of the controller. The developed controller is applied to the 4-degree of freedom control of the AUV “IUV- IV” and is successful on the simulation platform. The control performance is also compared with that of neural network controller with different structures such as normal adaptive neural network and different learning methods. Current effects and surge velocity control are also included to demonstrate the controller＇ s performance. It is shown that the PNNC has a great possibility to solve the problems in the control system design of underwater vehicles.展开更多
In order to make equipment run safely, economically and continuously, some new maintenance models were put forward to improve the equipment after-sale maintenance service, such as E-maintenance, third-party maintenanc...In order to make equipment run safely, economically and continuously, some new maintenance models were put forward to improve the equipment after-sale maintenance service, such as E-maintenance, third-party maintenance, etc. To certain extent, the models solved the problem of the distance between the manufacturer and customer and the dispersion of the maintenance technologies, however, those resources are still widely distributed and do not collaborate efficiently. In this paper, a network-based collaborative maintenance service model was proposed for after-sales equipment to solve the problem of maintenance resources integration. Concretely, equipment designers, maintainers, spare parts suppliers and maintenance experts were grouped together to establish dynamic alliance. The leader of the alliance is the manufacturer under guaranty period or equipment user exceeding the guaranty period. The process of maintenance service was divided into three stages which are fault diagnosis, maintenance decision and maintenance implementation. The sub-alliances were established to carry out maintenance work at each stage. In addition, the business process of network-based collaborative maintenance was analyzed and collaborative business system for equipment＇s after-sales collaborative maintenance service was designed. In the end, an informational economics model of network-based collaborative maintenance was established to demonstrate the effectiveness of this maintenance model.展开更多
Static secure techniques, such as firewall, hierarchy filtering, distributed disposing,layer management, autonomy agent, secure communication, were introduced in distributed intrusion detection. The self-protection ag...Static secure techniques, such as firewall, hierarchy filtering, distributed disposing,layer management, autonomy agent, secure communication, were introduced in distributed intrusion detection. The self-protection agents were designed, which have the distributed architecture,cooperate with the agents in intrusion detection in a loose-coupled manner, protect the security of intrusion detection system, and respond to the intrusion actively. A prototype self-protection agent was implemented by using the packet filter in operation system kernel. The results show that all the hosts with the part of network-based intrusion detection system and the whole intrusion detection system are invisible from the outside and network scanning, and cannot apperceive the existence of network-based intrusion detection system. The communication between every part is secure. In the low layer, the packet streams are controlled to avoid the buffer leaks exist ing in some system service process and back-door programs, so as to prevent users from misusing and vicious attack like Trojan Horse effectively.展开更多
To respond to the further development of college English reforms,many universities employed network-based selflearning classes to aid the traditional classroom teaching,especially in teaching listening,but as time wen...To respond to the further development of college English reforms,many universities employed network-based selflearning classes to aid the traditional classroom teaching,especially in teaching listening,but as time went by,some universities gradually gave them up.The paper intends to reflect on the employment of network-based self-learning listening classes,analyz ing the learning with and without its aid,and meanwhile introduce the need to re-employ it,and discuss how we can improve the network-based self-learning classes to help with students' listening.展开更多
A new method that stabilizes network-based systems with both bounded delay and packet disordering is discussed under the state feedback controller. A novel model, fully describing the dynamic characteristic of network...A new method that stabilizes network-based systems with both bounded delay and packet disordering is discussed under the state feedback controller. A novel model, fully describing the dynamic characteristic of network-based systems with packet disordering, is constructed. Different from the existing models of network-based systems, the number of delay items is time-varying in the model proposed. Further, this model is converted into a parameter-uncertain discrete-time system with time-varying delay item numbers in terms of matrix theory. Moreover, the less conservative stability condition is obtained by avoiding utilisation of Moon et al.’ inequality and bounding inequalities for quadratic functional terms. By solving a minization problem based on linear matrix inequalities, the state feedback controller is presented. A numerical example is given to illustrate the effectiveness of the proposed method.展开更多
Error codes induced by M-ary modulation and modulation selection in network-based control systems are studied.It is the first time the issue of error codes induced by M-ary modulation is addressed in control field.In ...Error codes induced by M-ary modulation and modulation selection in network-based control systems are studied.It is the first time the issue of error codes induced by M-ary modulation is addressed in control field.In network-based control systems,error codes induced by noisy channel can significantly decrease the quality of control.To solve this problem,the network-based control system with delay and noisy channel is firstly modeled as an asynchronous dynamic system(ADS).Secondly,conditions of packet with error codes(PEC)loss rate by using M-ary modulation are obtained based on dynamic output feedback scheme.Thirdly,more importantly,the selection principle of M-ary modulation is proposed according to the measured signal-to-noise ratio(SNR)and conditions of PEC loss rate.Finally,system stability is analyzed and controller is designed through Lyapunov function and linear matrix inequality(LMI)scheme,and numerical simulations are made to demonstrate the effectiveness of the proposed scheme.展开更多
Chronic atrophic gastritis(CAG)is an important stage of precancerous lesions of gastric cancer.Effective treatment and regulation of CAG are essential to prevent its progression to malignancy.Traditional Chinese medic...Chronic atrophic gastritis(CAG)is an important stage of precancerous lesions of gastric cancer.Effective treatment and regulation of CAG are essential to prevent its progression to malignancy.Traditional Chinese medicine(TCM)has shown multi-targeted efficacy in CAG treatment,with advantages in enhancing gastric mucosal barrier defense,improving microcirculation,modulating inflammatory and immune responses,and promoting lesion healing,etc.Clinical studies and meta-analyses indicate that TCM provides significant benefits,with specific Chinese herbal compounds and monomers demonstrating protective effects on the gastric mucosa through mechanisms including anti-inflammation,antioxidation,and regulation of cellular proliferation and apoptosis,etc.Finally,it is pointed out that the efficacy of TCM in the treatment of CAG requires standardized research and unified standards,and constantly clarifies and improves the evaluation criteria of each dimension of gastric mucosal barrier function.展开更多
With the swift development of network technology, research on how to integrate network technology into language learning has become a trend. This paper examines whether the application of language learning strategy(LL...With the swift development of network technology, research on how to integrate network technology into language learning has become a trend. This paper examines whether the application of language learning strategy(LLS) in the networkbased environment has incomparable superiority. Beginning with the literature review, it presents an analysis on similarities and differences between network-based language learning strategy(NBLLS) and non-NBLLS, and then expounds the characteristics,the influencing factors and teachers' role of NBLLS. Taking 25 participants in the group of non-NBLL and 34 in the NBLL group as the comparative survey study, the empirical result shows the new evidence that there is a little difference between the two groups in the use of LLS. The findings of this study have implications for the application of NBLLS.展开更多
文摘Objective:To compare the clinical efficacy and safety of intravitreal injection of faricimab and conbercept in the treatment of diabetic macular edema(DME).Methods:A total of 50 patients diagnosed with DME in our hospital from January 2023 to May 2025 were selected and randomly divided into an observation group and a control group,with 25 cases in each group,using a random number table method.The observation group received intravitreal injection of faricimab,while the control group received intravitreal injection of conbercept.Both groups adopted a loading phase plus maintenance phase treatment regimen.The best-corrected visual acuity(BCVA,expressed in logMAR)and central subfield thickness(CST)of the two groups were compared before treatment and at 1,3,and 6 months after treatment,and the incidence of adverse events during treatment was recorded.Results:The logMAR BCVA in the observation group was lower than that in the control group at 3 and 6 months after treatment(both p<0.05).The CST in the observation group was smaller than that in the control group at 1,3,and 6 months after treatment(all p<0.05).There was no statistically significant difference in the overall incidence of adverse events between the two groups(χ^(2)=0.189,p=0.663).Conclusion:Both intravitreal injections of faricimab and conbercept are effective in improving visual acuity and reducing macular edema in patients with DME,with good safety profiles.However,faricimab demonstrates superior efficacy in the medium to long term(3 and 6 months)compared to conbercept,making it more suitable for long-term treatment of patients with DME.
文摘Objective:To investigate the clinical efficacy of electrophysiological therapy under different parameter modes in chronic pelvic pain syndrome(CPPS).Methods:A total of 95patients with CPPS from the Department of Urology,First Affiliated Hospital of Jinan University,were selected and treated with electrophysiological therapy.They were randomly divided into three groups:the fixed-parameter AA7 treatment group,the P2+P4 treatment group,and the precision treatment group(individualized parameter treatment).Pain scores of patients in each group were compared before and after treatment,with a pain score of 0 indicating cure.The cure rate of each group was observed.Results:The average ages of the AA7 group,P2+P4 group,and precision treatment group were 34±14.17 years,35.58±12.57 years,and 35.5±11.27 years,respectively.There was no significant difference in age among the three groups(p>0.05).Before treatment,the pain scores of the AA7 group,P2+P4 group,and precision treatment group were 4.14±1.74,4.64±1.72,and 3.50±1.89,respectively,with no significant differences among the groups(p>0.05).After treatment,the pain scores were 0.71±0.99 for the AA7 group(cure rate:57%),0.49±0.79 for the P2+P4 group(cure rate:67%),and 0.50±0.77 for the precision treatment group(cure rate:64%),with no significant differences among the groups(p>0.05).The cure rates for different pain locations were as follows:83%for lower abdominal pain,74%for perineal pain,62%for dysuria,49%for testicular pain,and 75%for inguinal pain.Conclusion:The pathogenesis of CPPS is complex and diverse,with numerous treatment options and uncertain efficacy,posing significant challenges to clinical practice.This study showed that electrophysiological therapy under different parameter modes significantly reduced pain scores before and after treatment,indicating significant therapeutic effects on CPPS.All three modes demonstrated good cure rates.Individualized precision treatment and fixed-mode P2+P4 or AA7 treatment were safe and effective in CPPS treatment and are worth promoting.Fixed-mode P2+P4 and AA7,due to their easier standardization of parameters and patch modes,reduced the learning curve and had better potential for widespread application.
基金supported by the Innovative Team Project of Ordinary Universities in Guangdong Province(No.2022KCXTD016).
文摘Chemotherapy-induced diarrhea(CID)is a major concern for cancer patients and is associated with significant morbidity and mortality.Currently,the clinical management of CID is limited.The utilization of antidiarrheal medications,such as loperamide and octreotide,is relatively limited because of their unsatisfactory efficacy and adverse effects.In recent years,traditional Chinese medicine(TCM)has attracted great interest because of its beneficial effect in treating CID,which has multitarget and low-toxicity therapeutic characteristics.TCM exhibits remarkable therapeutic potential in the prevention and treatment of CID.It can alleviate and treat CID by regulating chemical drug metabolism,improving the integrity of the intestinal barrier,stimulating proliferation while suppressing the apoptosis of intestinal epithelial cells,ameliorating oxidative stress and inflammation and regulating bile acids and aquaporins.However,large-scale,randomized,double-blind clinical trials of TCM for the treatment of CID are lacking,and most preclinical experiments have not been translated to clinical trials.Accordingly,this review highlights the clinical efficacy and molecular mechanisms of TCM against CID via PubMed,Web of Science and China National Knowledge Infrastructure and proposes that future research on TCM against CID should focus on strengthening the connection from bench to bed,which may help to comprehensively evaluate the therapeutic potential of TCM against CID.
基金Application Research of MRI Physiological Quantitative Imaging Technology in the Diagnosis of Cartilage Injury(Project No.:RCYJ2021-04)。
文摘Objective:To retrospectively evaluate the diagnostic efficacy of traditional MRI and T2 Mapping quantitative imaging technology for knee joint cartilage injury,clarify the differences in diagnostic value of the two imaging methods in different injury grades and different cartilage subregions,and provide evidence-based basis for the accurate diagnosis of clinical cartilage injury.Methods:Clinical and imaging data of 286 patients with knee joint lesions admitted to the Affiliated Hospital of Xiangtan Medicine and Health Vocational College from January 2020 to June 2023 were collected retrospectively.All patients underwent both traditional MRI sequences and T2 Mapping sequences.The knee joint cartilage was divided into 14 subregions.Two senior radiologists independently diagnosed the images of the two imaging technologies using a blind method and recorded the cartilage injury grades.The sensitivity,specificity,accuracy,positive predictive value,negative predictive value,and area under the receiver operating characteristic curve(AUC)of the two technologies for diagnosing cartilage injury were calculated and compared,and the differences in their diagnostic efficacy in different injury grades and different subregions were analyzed.Results:A total of 4004 cartilage subregions from 286 patients were included in the analysis,including 1836 injured subregions and 2168 normal subregions.The overall sensitivity(89.7%),accuracy(91.2%),and AUC(0.946)of T2 Mapping quantitative imaging for diagnosing cartilage injury were significantly higher than those of traditional MRI(76.3%,82.5%,and 0.852 respectively),with statistically significant differences(p<0.001);there was no significant difference in specificity between the two(93.5%vs 90.8%,p=0.062).Subgroup analysis showed that T2 Mapping had the most significant diagnostic advantage in early cartilage injury(Grade 1),with sensitivity(78.5%)33.2%higher than that of traditional MRI(45.3%)(p<0.001).Conclusion:The diagnostic efficacy of T2 Mapping quantitative imaging for knee joint cartilage injury is significantly superior to that of traditional MRI,especially in the detection of early cartilage injury and accurate evaluation of weight-bearing area injury.Data verify its clinical applicability and reliability.It can be used as an important supplementary method to traditional MRI,and is recommended for the early diagnosis,grading evaluation,and clinical follow-up of cartilage injury.
文摘Objective:To evaluate the clinical efficacy of blood-letting cupping combined with manual lymphatic drainage in treating breast cancer-related lymphedema(BCRL)and explore its mechanism of action from both traditional Chinese medicine and modern medical perspectives,providing a scientific basis and novel therapeutic approaches for clinical management of BCRL.Methods:Patients with BCRL admitted to the outpatient and inpatient departments of Hebei University Affiliated Hospital were enrolled.A prospective randomized controlled trial design was adopted,with eligible patients randomly assigned to a treatment group and a control group.The control group received manual lymphatic drainage alone,while the treatment group received manual lymphtic drainage combined with blood-letting cupping therapy.Posttreatment comparisons evaluated upper limb circumference reduction,edema severity grading,and upper limb functional scores.Vital signs and adverse reactions during treatment were recorded for both groups.Statistical software analyzed the data.Results:The treatment group demonstrated significantly greater reduction in upper limb circumference,improvement in edema severity,and higher upper limb function scores compared to the control group(P<0.05).Vital signs remained stable throughout treatment in both groups.No severe adverse reactions occurred in the treatment group;only isolated cases of mild skin itching were reported,which resolved after symptomatic management.Conclusion:The combination of bloodletting cupping and manual lymphatic drainage demonstrates reliable efficacy in treating BCRL,effectively alleviating edema symptoms and improving upper limb function with high safety.Its mechanism may relate to traditional Chinese medicine principles of“unblocking meridians,promoting blood circulation,and resolving stasis”and modern medical concepts of“enhancing local blood circulation,facilitating lymphatic drainage,and reducing inflammatory responses”.
基金supported by the National Natural Science Foundation of China(32525049).
文摘Concerns about the long-term safety and efficacy of glibenclamide(GLIB),a type 2 diabetes mellitus(T2DM)treatment,have been reported[1].Recent evidence indicates the gut microbiota composition significantly affects host glucose metabolism and drugbioavailability,increasingthe efficacy of T2DM therapy[2].In this context,probiotic-drug coadministration,an emerging adjunct approach for treating metabolic diseases,improves therapeutic outcomes and ameliorates side effects[3].
文摘The advent of the Age of Information brings about bright prospects to Network-based Language Learning(NBLL).The thesis adopts the Engagement Theory as guided principles.The purpose is to use the novel NBLL model effectively with the help of modern technology especially in less-developed areas.This thesis focuses on network-based experimental study.The research shows that the students under NBLL environment have cultivated the capabilities in information collection,computer operation,and information evaluation,as well as the abilities in problem solving,reasoning with criticism,and cooperating with others.
基金Supported by the National Natural Scjence Foun-dation of China(90104029)
文摘A network-based Virtual Private Network(VPN)architecture by using fundamental routing mechanism is proposed.This network is a virtual overlay network based on the relay of IP-in-IP tunneling of virtual routing modules.The packet format employs the encapsulation of IPSec ESP(Encapsulating Security Payload),an impact path code and an extended DS(Differentiated Services)code to support multi-path routing and QoS.Comparing with other models of VPN,this network system can be deployed in the current network with little investment,and it is easy to implement.The simulation result shows its performance is better than the traditional VPN system of black box mode.
基金The National Natural Science Foundation of China under contract No.51379002the Fundamental Research Funds for the Central Universities of China under contract Nos 3132016322 and 3132016314the Applied Basic Research Project Fund of the Chinese Ministry of Transport of China under contract No.2014329225010
文摘An efficient and accurate prediction of a precise tidal level in estuaries and coastal areas is indispensable for the management and decision-making of human activity in the field wok of marine engineering. The variation of the tidal level is a time-varying process. The time-varying factors including interference from the external environment that cause the change of tides are fairly complicated. Furthermore, tidal variations are affected not only by periodic movement of celestial bodies but also by time-varying interference from the external environment. Consequently, for the efficient and precise tidal level prediction, a neuro-fuzzy hybrid technology based on the combination of harmonic analysis and adaptive network-based fuzzy inference system（ANFIS）model is utilized to construct a precise tidal level prediction system, which takes both advantages of the harmonic analysis method and the ANFIS network. The proposed prediction model is composed of two modules： the astronomical tide module caused by celestial bodies’ movement and the non-astronomical tide module caused by various meteorological and other environmental factors. To generate a fuzzy inference system（FIS） structure,three approaches which include grid partition（GP）, fuzzy c-means（FCM） and sub-clustering（SC） are used in the ANFIS network constructing process. Furthermore, to obtain the optimal ANFIS based prediction model, large numbers of simulation experiments are implemented for each FIS generating approach. In this tidal prediction study, the optimal ANFIS model is used to predict the non-astronomical tide module, while the conventional harmonic analysis model is used to predict the astronomical tide module. The final prediction result is performed by combining the estimation outputs of the harmonious analysis model and the optimal ANFIS model. To demonstrate the applicability and capability of the proposed novel prediction model, measured tidal level samples of Fort Pulaski tidal station are selected as the testing database. Simulation and experimental results confirm that the proposed prediction approach can achieve precise predictions for the tidal level with high accuracy, satisfactory convergence and stability.
基金Supported by the National Key Basic Research and Development Program of China (2009CB320602)the National Natural Science Foundation of China (60834004, 61025018)+2 种基金the Open Project Program of the State Key Lab of Industrial ControlTechnology (ICT1108)the Open Project Program of the State Key Lab of CAD & CG (A1120)the Foundation of Key Laboratory of System Control and Information Processing (SCIP2011005),Ministry of Education,China
文摘Semiconductor manufacturing (SM) system is one of the most complicated hybrid processes involved continuously variable dynamical systems and discrete event dynamical systems. The optimization and scheduling of semiconductor fabrication has long been a hot research direction in automation. Bottleneck is the key factor to a SM system, which seriously influences the throughput rate, cycle time, time-delivery rate, etc. Efficient prediction for the bottleneck of a SM system provides the best support for the consequent scheduling. Because categorical data (product types, releasing strategies) and numerical data (work in process, processing time, utilization rate, buffer length, etc.) have significant effect on bottleneck, an improved adaptive network-based fuzzy inference system (ANFIS) was adopted in this study to predict bottleneck since conventional neural network-based methods accommodate only numerical inputs. In this improved ANFIS, the contribution of categorical inputs to firing strength is reflected through a transformation matrix. In order to tackle high-dimensional inputs, reduce the number of fuzzy rules and obtain high prediction accuracy, a fuzzy c-means method combining binary tree linear division method was applied to identify the initial structure of fuzzy inference system. According to the experimental results, the main-bottleneck and sub-bottleneck of SM system can be predicted accurately with the proposed method.
基金supported in part by the National Natural Science Foundation of China(61333003,61690212)
文摘This paper investigates the remote tracking control problem of Network-based Agents with communication delays existing in both forward and feedback communication channels.A networked predictive tracking controller is proposed to compensate the negative effects caused by bilateral time-delays in a wireless network.Furthermore,the problem of consecutive data loss in the feedback channel is solved using aforementioned controller,where lateral movement perturbations are introduced.Simulations and experiments are provided for several cases,which verify the realizability and effectiveness of the proposed controller.
文摘A parallel neural network-based controller （PNNC） is presented for the motion control of underwater vehicles in this paper. It consists of a real-time part, a self-learning part and a desired-state programmer, and it is different from normal adaptive neural network controller in structure. Owing to the introduction of the self-learning part, on-line learning can be performed without sample data in several sample periods, resulting in high learning speed of the controller and good control performance. The desired-state programmer is utilized to obtain better learning samples of the neural network to keep the stability of the controller. The developed controller is applied to the 4-degree of freedom control of the AUV “IUV- IV” and is successful on the simulation platform. The control performance is also compared with that of neural network controller with different structures such as normal adaptive neural network and different learning methods. Current effects and surge velocity control are also included to demonstrate the controller＇ s performance. It is shown that the PNNC has a great possibility to solve the problems in the control system design of underwater vehicles.
基金supported by National Natural Science Foundation of China (Grant No. 70301012)National Hi-tech Research and Development Program of China (863 Program, Grant No. 2006AA04Z369-1)Innovative Talent Project of the Third Stage of "211" Project, Chongqing University, China (Grant No. S-09107)
文摘In order to make equipment run safely, economically and continuously, some new maintenance models were put forward to improve the equipment after-sale maintenance service, such as E-maintenance, third-party maintenance, etc. To certain extent, the models solved the problem of the distance between the manufacturer and customer and the dispersion of the maintenance technologies, however, those resources are still widely distributed and do not collaborate efficiently. In this paper, a network-based collaborative maintenance service model was proposed for after-sales equipment to solve the problem of maintenance resources integration. Concretely, equipment designers, maintainers, spare parts suppliers and maintenance experts were grouped together to establish dynamic alliance. The leader of the alliance is the manufacturer under guaranty period or equipment user exceeding the guaranty period. The process of maintenance service was divided into three stages which are fault diagnosis, maintenance decision and maintenance implementation. The sub-alliances were established to carry out maintenance work at each stage. In addition, the business process of network-based collaborative maintenance was analyzed and collaborative business system for equipment＇s after-sales collaborative maintenance service was designed. In the end, an informational economics model of network-based collaborative maintenance was established to demonstrate the effectiveness of this maintenance model.
文摘Static secure techniques, such as firewall, hierarchy filtering, distributed disposing,layer management, autonomy agent, secure communication, were introduced in distributed intrusion detection. The self-protection agents were designed, which have the distributed architecture,cooperate with the agents in intrusion detection in a loose-coupled manner, protect the security of intrusion detection system, and respond to the intrusion actively. A prototype self-protection agent was implemented by using the packet filter in operation system kernel. The results show that all the hosts with the part of network-based intrusion detection system and the whole intrusion detection system are invisible from the outside and network scanning, and cannot apperceive the existence of network-based intrusion detection system. The communication between every part is secure. In the low layer, the packet streams are controlled to avoid the buffer leaks exist ing in some system service process and back-door programs, so as to prevent users from misusing and vicious attack like Trojan Horse effectively.
文摘To respond to the further development of college English reforms,many universities employed network-based selflearning classes to aid the traditional classroom teaching,especially in teaching listening,but as time went by,some universities gradually gave them up.The paper intends to reflect on the employment of network-based self-learning listening classes,analyz ing the learning with and without its aid,and meanwhile introduce the need to re-employ it,and discuss how we can improve the network-based self-learning classes to help with students' listening.
基金supported by the National Natural Science Foundation of China (60874057 60725312+3 种基金 61074029)the Liaoning Provincal Foundation of Science and Technology (20082023)the Natural Science Foundation of Liaoning Province (20092083)China Postdoctoral Science Foundation Project (20100471488)
文摘A new method that stabilizes network-based systems with both bounded delay and packet disordering is discussed under the state feedback controller. A novel model, fully describing the dynamic characteristic of network-based systems with packet disordering, is constructed. Different from the existing models of network-based systems, the number of delay items is time-varying in the model proposed. Further, this model is converted into a parameter-uncertain discrete-time system with time-varying delay item numbers in terms of matrix theory. Moreover, the less conservative stability condition is obtained by avoiding utilisation of Moon et al.’ inequality and bounding inequalities for quadratic functional terms. By solving a minization problem based on linear matrix inequalities, the state feedback controller is presented. A numerical example is given to illustrate the effectiveness of the proposed method.
基金Project(61172022) supported by the National Natural Science Foundation of ChinaProject(GDW20151100010) supported by the State Administration of Foreign Experts Affairs of China
文摘Error codes induced by M-ary modulation and modulation selection in network-based control systems are studied.It is the first time the issue of error codes induced by M-ary modulation is addressed in control field.In network-based control systems,error codes induced by noisy channel can significantly decrease the quality of control.To solve this problem,the network-based control system with delay and noisy channel is firstly modeled as an asynchronous dynamic system(ADS).Secondly,conditions of packet with error codes(PEC)loss rate by using M-ary modulation are obtained based on dynamic output feedback scheme.Thirdly,more importantly,the selection principle of M-ary modulation is proposed according to the measured signal-to-noise ratio(SNR)and conditions of PEC loss rate.Finally,system stability is analyzed and controller is designed through Lyapunov function and linear matrix inequality(LMI)scheme,and numerical simulations are made to demonstrate the effectiveness of the proposed scheme.
基金Supported by the Scientific and Technological Innovation Project of China Academy of Chinese Medical Sciences,No.CI2021A00806High Level Chinese Medical Hospital Promotion Project,No.HLCMHPP2023086the Fundamental Research Funds for the Central Public Welfare Research Institutes,No.ZZ17-XRZ-041.
文摘Chronic atrophic gastritis(CAG)is an important stage of precancerous lesions of gastric cancer.Effective treatment and regulation of CAG are essential to prevent its progression to malignancy.Traditional Chinese medicine(TCM)has shown multi-targeted efficacy in CAG treatment,with advantages in enhancing gastric mucosal barrier defense,improving microcirculation,modulating inflammatory and immune responses,and promoting lesion healing,etc.Clinical studies and meta-analyses indicate that TCM provides significant benefits,with specific Chinese herbal compounds and monomers demonstrating protective effects on the gastric mucosa through mechanisms including anti-inflammation,antioxidation,and regulation of cellular proliferation and apoptosis,etc.Finally,it is pointed out that the efficacy of TCM in the treatment of CAG requires standardized research and unified standards,and constantly clarifies and improves the evaluation criteria of each dimension of gastric mucosal barrier function.
文摘With the swift development of network technology, research on how to integrate network technology into language learning has become a trend. This paper examines whether the application of language learning strategy(LLS) in the networkbased environment has incomparable superiority. Beginning with the literature review, it presents an analysis on similarities and differences between network-based language learning strategy(NBLLS) and non-NBLLS, and then expounds the characteristics,the influencing factors and teachers' role of NBLLS. Taking 25 participants in the group of non-NBLL and 34 in the NBLL group as the comparative survey study, the empirical result shows the new evidence that there is a little difference between the two groups in the use of LLS. The findings of this study have implications for the application of NBLLS.
