Nery do Vale诊所原空间氛围冷峻严肃,带有医疗空间常见的压迫感。一条没什么自然光的封闭走廊连接着拥挤的房间,布局草率,虽试图满足多种功能需求,却未设独立的诊室或公用茶水间。然而,设计师却发现这里蕴含着与户外、自然相连的巨大...Nery do Vale诊所原空间氛围冷峻严肃,带有医疗空间常见的压迫感。一条没什么自然光的封闭走廊连接着拥挤的房间,布局草率,虽试图满足多种功能需求,却未设独立的诊室或公用茶水间。然而,设计师却发现这里蕴含着与户外、自然相连的巨大潜力。因此,设计旨在营造一个宁静而温馨的环境,以缓解牙科诊疗给人带来的紧张感,在技术与感性,功能与关怀之间寻求平衡。展开更多
A novel environmentally benign biphasic system composed of propylene carbonate(PC) and aqueous solution of p-toluenesulfonic acid(p-TsOH aq) was designed for the efficient valorization of lignocellulosic bamboo residu...A novel environmentally benign biphasic system composed of propylene carbonate(PC) and aqueous solution of p-toluenesulfonic acid(p-TsOH aq) was designed for the efficient valorization of lignocellulosic bamboo residues, resulting in more than 95.5% of hemicellulose and 97.2% of lignin digested under mild conditions of 130°C for 1 h. Meanwhile, 91.9% of cellulose was retained with loose structure, followed by 95.8% enzyme hydrolysis yield and 347.9 mg g-1of glucose yield. Notably, the synergistic effect between PC and p-TsOH on efficiency and selectivity was proposed by a control group experiment and subsequently verified, which is believed to be responsible for the simultaneous degradation and separation of lignin and hemicelluloses into oligomeric phenols and pentose, also facilitating subsequent valorization.Furthermore, the novel PC/p-TsOH aq biphasic system demonstrated excellent retrievability and adaptability to different feedstocks, offering a promising green strategy for the efficient valorization of lignocellulosic biomass in industrial biorefineries.展开更多
The transplantation of polylactic glycolic acid conduits combining bone marrow mesenchymal stem cells and extracellular matrix gel for the repair of sciatic nerve injury is effective in some respects, but few data com...The transplantation of polylactic glycolic acid conduits combining bone marrow mesenchymal stem cells and extracellular matrix gel for the repair of sciatic nerve injury is effective in some respects, but few data comparing the biomechanical factors related to the sciatic nerve are available. In the present study, rabbit models of 10-mm sciatic nerve defects were prepared. The rabbit models were repaired with autologous nerve, a polylactic glycolic acid conduit ＋ bone marrow mesenchymal stem cells, or a polylactic glycolic acid conduit ＋ bone marrow mesenchymal stem cells ＋ extracellular matrix gel. After 24 weeks, mechanical testing was performed to determine the stress relaxation and creep parameters. Following sciatic nerve injury, the magnitudes of the stress decrease and strain increase at 7,200 seconds were largest in the polylactic glycolic acid conduit ＋ bone marrow mesenchymal stem cells ＋ extracellular matrix gel group, followed by the polylactic glycolic acid conduit ＋ bone marrow mesenchymal stem cells group, and then the autologous nerve group. Hematoxylin-eosin staining demonstrated that compared with the polylactic glycolic acid conduit ＋ bone marrow mesenchymal stem cells group and the autologous nerve group, a more complete sciatic nerve regeneration was found, including good myelination, regularly arranged nerve fibers, and a completely degraded and resorbed conduit, in the polylactic glycolic acid conduit ＋ bone marrow mesenchymal stem cells ＋ extracellular matrix gel group. These results indicate that bridging 10-mm conduit ＋ bone marrow mesenchymal stem sciatic nerve defects with a polylactic glycolic acid cells ＋ extracellular matrix gel construct increases the stress relaxation under a constant strain, reducing anastomotic tension. Large elongations under a constant physiological load can limit the anastomotic opening and shift, which is beneficial for the regeneration and functional reconstruction of sciatic nerve. Better regeneration was found with the polylactic glycolic acid conduit ＋ bone marrow mesenchymal stem cells ＋ extracellular matrix gel grafts than with the polylactic glycolic acid conduit ＋ bone marrow mesenchymal stem cells grafts and the autologous nerve grafts.展开更多
目的探讨急性A型主动脉夹层(acute type A aortic dissection,ATAAD)合并Neri C型冠状动脉(冠脉)受累细化分型的外科治疗策略。方法回顾性分析我院2020年11月~2024年2月21例ATAAD合并Neri C型冠脉受累的病例资料。夹层累及冠脉,发病时间...目的探讨急性A型主动脉夹层(acute type A aortic dissection,ATAAD)合并Neri C型冠状动脉(冠脉)受累细化分型的外科治疗策略。方法回顾性分析我院2020年11月~2024年2月21例ATAAD合并Neri C型冠脉受累的病例资料。夹层累及冠脉,发病时间<1周,行全主动脉弓替换、降主动脉支架象鼻人工血管置入、升主动脉置换及冠脉处理。细化分型及冠脉处理方法:C1型(冠脉开口局部损伤破裂,与假腔部分连接,冠脉开口内外膜无分离)7例以人工材料“铜钱样”修复;C2型(冠脉开口严重损伤撕脱,与假腔完全连接,冠脉近段累及轻微,内外膜局部分离,未形成套袖)3例以8 mm人工血管置换;C3型(冠脉开口严重损伤撕脱,与假腔完全连接,冠脉近段累及严重,内外膜完全分离,且形成套袖)11例以大隐静脉旁路移植。结果院内死亡2例(均为C3型),均心脏复跳困难,体外膜氧合(extracorporeal membrane oxygenation,ECMO)辅助循环,分别于术后当天、第2天死亡。19例出院患者出院前复查主动脉及冠脉CTA,无冠脉开口狭窄和桥血管狭窄。术后6、12、18个月复查主动脉及冠脉CTA。19例随访6~36个月,平均21个月,无冠脉开口狭窄和桥血管狭窄病例。纽约心脏协会(NYHA)心功能分级Ⅰ级15例,Ⅱ级4例。结论ATAAD合并Neri C型冠脉受累的细化分型对外科实施精准治疗具有指导性意义。展开更多
作为建筑师、设计师、发明者,Neri Oxman是MIT Media Lab炙手可热的学术明星。她将其开创的“Material Ecology”(材料生态学)形容为“形式从物质的角度形成,自然地挣脱其困境”。简单来说,材料生态学是将计算、制造和材料本身视为设计...作为建筑师、设计师、发明者,Neri Oxman是MIT Media Lab炙手可热的学术明星。她将其开创的“Material Ecology”(材料生态学)形容为“形式从物质的角度形成,自然地挣脱其困境”。简单来说,材料生态学是将计算、制造和材料本身视为设计不可分割的部分,利用合成生物学和数字算法来生产源于自然语境的产品和建筑。展开更多
During the NERIES Project, an accelerometric database containing European digital information was developed. Besides event and station metadata, ground motion parameters, computed in a homogeneous manner, were assemb...During the NERIES Project, an accelerometric database containing European digital information was developed. Besides event and station metadata, ground motion parameters, computed in a homogeneous manner, were assembled： PGA, PGV, AI, TD, CAV, H1 and PSV（f,5%） （19,961 components, 2629 events, 547 stations）. Merging small and moderate magnitude events produced a unique database capable of providing important information such as： （i） Correlations between several ground motion parameters follow analogous trends as in previous worldwide datasets, with slight corrections. （ii） Although PGA attenuations with distance show great uncertainties, four recent GMPEs recommended for Europe fit quite well the central 50% data interval for the distance range 10 〈 R 〈 200 kin; outside these distances, they do not fit. （iii） Soil amplification ratios indicate that weak motion （low magnitudes and larger distances） shows larger amplification than strong motion （short distances and large magnitudes） as represented in UBC97 for the USA, but not in EC8 for Europe. （iv） Average spectral shapes are smaller than in the EC8. （v） Differences in amplification factors for PGA, PGV and HI for EC8 soil classes B and C, and differences in spectral shapes for these soil classes, indicate that EC8, Type 2 S-coefficient should be frequency dependent, as in UBC97.展开更多
文摘Nery do Vale诊所原空间氛围冷峻严肃,带有医疗空间常见的压迫感。一条没什么自然光的封闭走廊连接着拥挤的房间,布局草率,虽试图满足多种功能需求,却未设独立的诊室或公用茶水间。然而,设计师却发现这里蕴含着与户外、自然相连的巨大潜力。因此,设计旨在营造一个宁静而温馨的环境,以缓解牙科诊疗给人带来的紧张感,在技术与感性,功能与关怀之间寻求平衡。
基金the Fundamental Research Foundation of CAF(CAFYBB2022QB001)National Nature Science Foundation of China(32222058)for financial support.
文摘A novel environmentally benign biphasic system composed of propylene carbonate(PC) and aqueous solution of p-toluenesulfonic acid(p-TsOH aq) was designed for the efficient valorization of lignocellulosic bamboo residues, resulting in more than 95.5% of hemicellulose and 97.2% of lignin digested under mild conditions of 130°C for 1 h. Meanwhile, 91.9% of cellulose was retained with loose structure, followed by 95.8% enzyme hydrolysis yield and 347.9 mg g-1of glucose yield. Notably, the synergistic effect between PC and p-TsOH on efficiency and selectivity was proposed by a control group experiment and subsequently verified, which is believed to be responsible for the simultaneous degradation and separation of lignin and hemicelluloses into oligomeric phenols and pentose, also facilitating subsequent valorization.Furthermore, the novel PC/p-TsOH aq biphasic system demonstrated excellent retrievability and adaptability to different feedstocks, offering a promising green strategy for the efficient valorization of lignocellulosic biomass in industrial biorefineries.
基金supported by the Science and Technology Development Program of Jilin Province in China,No.20110492
文摘The transplantation of polylactic glycolic acid conduits combining bone marrow mesenchymal stem cells and extracellular matrix gel for the repair of sciatic nerve injury is effective in some respects, but few data comparing the biomechanical factors related to the sciatic nerve are available. In the present study, rabbit models of 10-mm sciatic nerve defects were prepared. The rabbit models were repaired with autologous nerve, a polylactic glycolic acid conduit ＋ bone marrow mesenchymal stem cells, or a polylactic glycolic acid conduit ＋ bone marrow mesenchymal stem cells ＋ extracellular matrix gel. After 24 weeks, mechanical testing was performed to determine the stress relaxation and creep parameters. Following sciatic nerve injury, the magnitudes of the stress decrease and strain increase at 7,200 seconds were largest in the polylactic glycolic acid conduit ＋ bone marrow mesenchymal stem cells ＋ extracellular matrix gel group, followed by the polylactic glycolic acid conduit ＋ bone marrow mesenchymal stem cells group, and then the autologous nerve group. Hematoxylin-eosin staining demonstrated that compared with the polylactic glycolic acid conduit ＋ bone marrow mesenchymal stem cells group and the autologous nerve group, a more complete sciatic nerve regeneration was found, including good myelination, regularly arranged nerve fibers, and a completely degraded and resorbed conduit, in the polylactic glycolic acid conduit ＋ bone marrow mesenchymal stem cells ＋ extracellular matrix gel group. These results indicate that bridging 10-mm conduit ＋ bone marrow mesenchymal stem sciatic nerve defects with a polylactic glycolic acid cells ＋ extracellular matrix gel construct increases the stress relaxation under a constant strain, reducing anastomotic tension. Large elongations under a constant physiological load can limit the anastomotic opening and shift, which is beneficial for the regeneration and functional reconstruction of sciatic nerve. Better regeneration was found with the polylactic glycolic acid conduit ＋ bone marrow mesenchymal stem cells ＋ extracellular matrix gel grafts than with the polylactic glycolic acid conduit ＋ bone marrow mesenchymal stem cells grafts and the autologous nerve grafts.
文摘作为建筑师、设计师、发明者,Neri Oxman是MIT Media Lab炙手可热的学术明星。她将其开创的“Material Ecology”(材料生态学)形容为“形式从物质的角度形成,自然地挣脱其困境”。简单来说,材料生态学是将计算、制造和材料本身视为设计不可分割的部分,利用合成生物学和数字算法来生产源于自然语境的产品和建筑。
文摘During the NERIES Project, an accelerometric database containing European digital information was developed. Besides event and station metadata, ground motion parameters, computed in a homogeneous manner, were assembled： PGA, PGV, AI, TD, CAV, H1 and PSV（f,5%） （19,961 components, 2629 events, 547 stations）. Merging small and moderate magnitude events produced a unique database capable of providing important information such as： （i） Correlations between several ground motion parameters follow analogous trends as in previous worldwide datasets, with slight corrections. （ii） Although PGA attenuations with distance show great uncertainties, four recent GMPEs recommended for Europe fit quite well the central 50% data interval for the distance range 10 〈 R 〈 200 kin; outside these distances, they do not fit. （iii） Soil amplification ratios indicate that weak motion （low magnitudes and larger distances） shows larger amplification than strong motion （short distances and large magnitudes） as represented in UBC97 for the USA, but not in EC8 for Europe. （iv） Average spectral shapes are smaller than in the EC8. （v） Differences in amplification factors for PGA, PGV and HI for EC8 soil classes B and C, and differences in spectral shapes for these soil classes, indicate that EC8, Type 2 S-coefficient should be frequency dependent, as in UBC97.
