Objective： To provide the clinical evidence to evaluate the feasibility and refine the protocol for acupotomy combined with fire needle and pudendal nerve block therapy in treatment of sacral nerve dysfunction syndr...Objective： To provide the clinical evidence to evaluate the feasibility and refine the protocol for acupotomy combined with fire needle and pudendal nerve block therapy in treatment of sacral nerve dysfunction syndrome（SNDS）. Methods： Seventy-five patients with SNDS were randomized into the treatment group（acupotomy and fire needle and pudendal nerve block therapy） and the control group（pudendal nerve block therapy）. After a course of treatment, Visual Analogue Scales（VAS） of anorectal pain, defecation disorders, anal incontinence, VAS of lumbar pain or soreness, VAS of abdominal distension and pain were compared before and after the treatment. Result： Scores of defecation disorders, including defecation interval time index, defecation time index, fecal property index and defecation difficulty index, of patients with SNDS in the two groups were statistically different before and after the treatment in the same group（all P〈0.05）, but the differences of those indexes between two groups were not statistically significant（all P〈0.05） after the treatment,. Scores of anal incontinence, VAS scores of lumbar pain or soreness, VAS scores of abdominal pain and distension in the two groups were statistically different before and after the treatment（all P〈0.05）. However, after treatment, the differences between two groups were not statistically significant（all P〈0.05）. VAS scores of anorectal pain in the two groups were statistically different before and after the treatment（both P〈0.05）, and that of the treatment group was statistically lower than control group after the treatment（1.61 ± 0.95 vs. 3.04 ± 1.81, P〈0.01）, the total effective rate of the treatment group was higher than that of the control group, and the difference was statistically significant（94.74% vs. 81.08%, P〈0.01）, there was no difference in self-evaluation between the two groups（P〈0.05）. Conclusion： In treating SNDS, acupotomy combined with fire needle and pudendal nerve block therapy can more effectively alleviate anorectal pain and improve the total effective rate.展开更多
The relationship between sleep disturbance,autonomic nerve dysfunction,and blood pressure in patients with major depressive disorder(MDD)was unclear.We studied 66 patients with MDD and 66 age-matched and sex-matched c...The relationship between sleep disturbance,autonomic nerve dysfunction,and blood pressure in patients with major depressive disorder(MDD)was unclear.We studied 66 patients with MDD and 66 age-matched and sex-matched controls.Objective and subjective sleep were assessed using the poly-somnography and Pittsburgh Sleep Quality Index,respectively.Autonomic nerve function was assessed using the heart rate variability(HRV).The averaged evening and morning systolic(SBP)and diastolic blood pressure(DBP)were analyzed.In patients with MDD,each 1 h reduction in an objective sleep duration was associated with 2.56-mmHg increase in SBP(p=0.011)and 1.59-mmHg increase in DBP(p=0.043).Increase in NREM-heart rate(HR),NREM-low frequency normalized unit(LFnu),and REM-HR and decrease in NREM-standard deviation of NN intervals,NREM-root mean square of successive differences,and NREM-LFnu were associated with shorter objective sleep duration(all p≤0.043)and higher SBP and DBP(all p≤0.037).These HRV mediated the association between objective sleep duration and BP with 17–79%mediating effects.No association was observed between subjective sleep duration and BP in patients with MDD or between objective/subjective sleep duration and BP in controls.In conclusion,objective,but not subjective short sleep duration,is associated with increased blood pressure in patents with MDD,that is mediated by autonomic nerve dysfunction.展开更多
基金Youth Foundation Project of Jiangsu Natural Science Foundation of China,NO.BK20160135The twelfth batch of high-level talents training target of "Six Talent Peaks",NO.2015-WSW-070+1 种基金Third level of training target candidates of the fifth phase of the Jiangsu"333 Project":2016Ⅲ-0094Nanjing Medical Science and Technology Development Project,NO.YKK15127~~
文摘Objective： To provide the clinical evidence to evaluate the feasibility and refine the protocol for acupotomy combined with fire needle and pudendal nerve block therapy in treatment of sacral nerve dysfunction syndrome（SNDS）. Methods： Seventy-five patients with SNDS were randomized into the treatment group（acupotomy and fire needle and pudendal nerve block therapy） and the control group（pudendal nerve block therapy）. After a course of treatment, Visual Analogue Scales（VAS） of anorectal pain, defecation disorders, anal incontinence, VAS of lumbar pain or soreness, VAS of abdominal distension and pain were compared before and after the treatment. Result： Scores of defecation disorders, including defecation interval time index, defecation time index, fecal property index and defecation difficulty index, of patients with SNDS in the two groups were statistically different before and after the treatment in the same group（all P〈0.05）, but the differences of those indexes between two groups were not statistically significant（all P〈0.05） after the treatment,. Scores of anal incontinence, VAS scores of lumbar pain or soreness, VAS scores of abdominal pain and distension in the two groups were statistically different before and after the treatment（all P〈0.05）. However, after treatment, the differences between two groups were not statistically significant（all P〈0.05）. VAS scores of anorectal pain in the two groups were statistically different before and after the treatment（both P〈0.05）, and that of the treatment group was statistically lower than control group after the treatment（1.61 ± 0.95 vs. 3.04 ± 1.81, P〈0.01）, the total effective rate of the treatment group was higher than that of the control group, and the difference was statistically significant（94.74% vs. 81.08%, P〈0.01）, there was no difference in self-evaluation between the two groups（P〈0.05）. Conclusion： In treating SNDS, acupotomy combined with fire needle and pudendal nerve block therapy can more effectively alleviate anorectal pain and improve the total effective rate.
文摘The relationship between sleep disturbance,autonomic nerve dysfunction,and blood pressure in patients with major depressive disorder(MDD)was unclear.We studied 66 patients with MDD and 66 age-matched and sex-matched controls.Objective and subjective sleep were assessed using the poly-somnography and Pittsburgh Sleep Quality Index,respectively.Autonomic nerve function was assessed using the heart rate variability(HRV).The averaged evening and morning systolic(SBP)and diastolic blood pressure(DBP)were analyzed.In patients with MDD,each 1 h reduction in an objective sleep duration was associated with 2.56-mmHg increase in SBP(p=0.011)and 1.59-mmHg increase in DBP(p=0.043).Increase in NREM-heart rate(HR),NREM-low frequency normalized unit(LFnu),and REM-HR and decrease in NREM-standard deviation of NN intervals,NREM-root mean square of successive differences,and NREM-LFnu were associated with shorter objective sleep duration(all p≤0.043)and higher SBP and DBP(all p≤0.037).These HRV mediated the association between objective sleep duration and BP with 17–79%mediating effects.No association was observed between subjective sleep duration and BP in patients with MDD or between objective/subjective sleep duration and BP in controls.In conclusion,objective,but not subjective short sleep duration,is associated with increased blood pressure in patents with MDD,that is mediated by autonomic nerve dysfunction.
