In this paper, a test system was developed in which a CCD camera was used as a sensor together with an IBM-AT-compatible computer with an Intel 80486 processor to measure the impurities and neps on a piece of cotton g...In this paper, a test system was developed in which a CCD camera was used as a sensor together with an IBM-AT-compatible computer with an Intel 80486 processor to measure the impurities and neps on a piece of cotton gray goods, and a method was proposed by which the differences of degree of gray between samples and interference caused by surface unevenness, creasing and the like within a test sample can be removed effectively. The whole test system is reliable, accurate and causing fewer subjective errors.展开更多
Defect free yarn is a great demand for spinner, knitter, and weaver and also other textile personnel because numerous end products from knit apparels to woven fabrics, from towels to sheets and from carpets to industr...Defect free yarn is a great demand for spinner, knitter, and weaver and also other textile personnel because numerous end products from knit apparels to woven fabrics, from towels to sheets and from carpets to industrial fabrics characteristics significantly depend on the physical properties of yarn. The qualities of rotor yarn are really directed by spinning parameters. The aim of this study is to observe the effect of spinning parameters such as rotor diameter and speed on thick, thin places and neps of yarn in rotor spinning process. 0.11 sliver hank of 100% cotton was used to produce 12 Ne yarn. 65% virgin cotton and 35% wastage cotton were mixed together. The positive impact of spinning parameters on yarn properties were accessed by thick places, thin places and neps. Results indicate that the yarn qualities were improved with increasing of rotor speed and rotor diameter. The rotor diameter was settled to 43 mm while rotor speed fluctuated from 35,000 to 45,000 rpm and rotor speed was fixed to 35,000 rpm while rotor diameter across contrasts from 43 mm to 66 mm.展开更多
为深入了解秦岭山地生态碳汇的时空变化特征及其影响因素,以2000—2023年净初级生产力(NPP)数据为基础,结合土壤异养呼吸模型估算秦岭山地植被的净生态系统生产力(NEP),采用Theil-Sen Median斜率估计、Mann-Kendall(M-K)显著性检验及地...为深入了解秦岭山地生态碳汇的时空变化特征及其影响因素,以2000—2023年净初级生产力(NPP)数据为基础,结合土壤异养呼吸模型估算秦岭山地植被的净生态系统生产力(NEP),采用Theil-Sen Median斜率估计、Mann-Kendall(M-K)显著性检验及地理探测器等方法,分析秦岭山地植被NEP的时空演变特征及其驱动因子。结果表明:2000—2023年,秦岭山地植被NEP整体呈波动上升趋势,年均增幅为5.0 g C/(m^(2)·a),表明区域植被固碳能力持续增强;在空间分布上,秦岭山地的年均NEP呈西高东低的特征,76.5%区域的NEP保持稳定或呈增加趋势。地理探测器分析显示,植被归一化指数(NDVI)对秦岭山地植被NEP的空间分异解释力最强,年均降水量、坡度、年平均气温及坡向的解释力也较强,NDVI与降水的交互作用对NEP的影响非常显著。综上,在未来提升秦岭山地固碳能力时,需重点关注多因子的协同作用,以实现更高效的固碳效果。展开更多
Vegetation in terrestrial ecosystems as a carbon sink is a crucial factor in mitigating global warming and reaching carbon neutrality targets,although the drivers of net ecosystem productivity(NEP)under combined human...Vegetation in terrestrial ecosystems as a carbon sink is a crucial factor in mitigating global warming and reaching carbon neutrality targets,although the drivers of net ecosystem productivity(NEP)under combined human and environmental pressures remain poorly understood.In this study,we analyzed the spatiotemporal evolution of NEP in the Horqin Sandy Land,China from 2000 to 2020,and observed the variation in NEP across different land use types.We further identified and quantified the effects of human activities,topographical features,climatic conditions,and soil properties on NEP through the application of structural equation modeling(SEM)and boosted regression trees(BRT).The results showed that the multi-year average NEP ranged from–137.79 to 461.96 g C/m^(2) in the Horqin Sandy Land,with 88.21%of the area showing a significant increasing trend.Among different land use types,forestland exhibited the highest NEP values,followed by cropland,grassland,impervious land,and unused land.The NEP in carbon sink areas was primarily regulated by potential evapotranspiration(negatively correlated)and precipitation(positively correlated).Slope was identified as the most significant positive determinant in carbon source areas.Forestland exhibited climate–topography interactions driving NEP,whereas cropland and grassland relied on temperature;unused land and impervious land were susceptible to land use/cover change and human footprint.This study has significant implications for maintaining the carbon sink function and promoting ecological engineering programs that aim to enhance the capacity of terrestrial carbon sinks in the semi-arid agro-pastoral ecotone.展开更多
甘肃省草地是我国碳收支研究的关键区域,其净生态系统生产力(NEP)是衡量碳源/汇功能的核心。然而复杂的地形和气候条件导致该地区NEP估算存在较大不确定性。本研究基于集成生物圈模型(IBIS),模拟了1980—2022年甘肃省草地NEP的时空格局...甘肃省草地是我国碳收支研究的关键区域,其净生态系统生产力(NEP)是衡量碳源/汇功能的核心。然而复杂的地形和气候条件导致该地区NEP估算存在较大不确定性。本研究基于集成生物圈模型(IBIS),模拟了1980—2022年甘肃省草地NEP的时空格局,并结合观测数据验证了模型精度。结果表明,IBIS模型能够较好地模拟该区域草地NEP动态(R^(2)=0.70,P<0.0001)。1980—2022年,甘肃省草地年均NEP为194.5 g m^(-2)·a^(-1)C,呈轻微上升趋势。年均NEP空间格局总体呈现东南高西北低,从东南向西北逐渐递减的趋势。南部草地大部分地区为碳汇区,北部部分干旱草原为碳源区,其NEP分布格局主要由降雨主导。本研究为甘肃省草地碳汇功能评估提供了科学依据,对实现区域“碳中和”目标具有重要参考价值。展开更多
净生态系统生产力(NEP)是评价区域生态系统碳源碳汇的重要指标,厘清其时空分异格局及驱动机制对京津冀生态系统精准保护与修复至关重要.基于MODIS遥感数据估算了净生态系统生产力(NEP),采用Sen趋势+MK检验、Hurst指数和重心迁移等方法...净生态系统生产力(NEP)是评价区域生态系统碳源碳汇的重要指标,厘清其时空分异格局及驱动机制对京津冀生态系统精准保护与修复至关重要.基于MODIS遥感数据估算了净生态系统生产力(NEP),采用Sen趋势+MK检验、Hurst指数和重心迁移等方法探究了京津冀2002~2020年固碳效益时空格局和演替规律,利用偏相关、复相关及残差分析定量解析了人类活动和气候变化驱动固碳效益时空分异的相对贡献.结果表明:①京津冀近20 a NEP呈逐年上升趋势,增长速率(以C计)为3.066 4g·(m^(2)·a)^(-1),空间上表现为西北高东南低;碳汇能力强的地区主要集中在张家口市和承德市周边,碳源效应强烈的区域分布在天津和邯郸等地;超过80%的区域碳汇能力呈上升趋势,其中极显著上升、显著上升区域占比分别为47.45%和8.29%,尤其是张-承地区,但未来增长趋势在逐步减缓;碳源重心在逐渐向东南部平原迁移,碳汇重心则由东北向西南迁移.②超过50%区域的NEP与年平均气温和年累计降水呈现正相关关系,但显著性均不强,复相关结果进一步证明了存在气象因素之外的其他条件在主导NEP的变化.③研究区域内NEP退化区与改善区占比分别为12.41%、87.59%,残差分析表明人类主导的固碳效益提升区占总改善区的94.88%,而退化区中气候主导的固碳效益降低区占62.84%,说明京津冀地区人类活动在影响生态系统固碳效益方面以正向促进为主.研究结论对精准识别京津冀生态系统保护与修复未来工作重心有指导意义.展开更多
农田生态系统是陆地生态系统的重要组成部分,其碳源汇过程对气候变化的响应非常敏感。然而,当前气候变化及其碳氮耦合作用对农田生态系统碳源汇过程的影响贡献与驱动机制尚不明晰。基于总初级生产力(GPP)、净初级生产力(NPP)和净生态系...农田生态系统是陆地生态系统的重要组成部分,其碳源汇过程对气候变化的响应非常敏感。然而,当前气候变化及其碳氮耦合作用对农田生态系统碳源汇过程的影响贡献与驱动机制尚不明晰。基于总初级生产力(GPP)、净初级生产力(NPP)和净生态系统生产力(NEP)三种碳汇指标,以及系统总呼吸(Rs)、自养呼吸(Ra)和异养呼吸(Rh)三种碳源指标构建6种情景,揭示了中国农田生态系统碳源汇时空演变趋势特征,并基于Lindeman-Merenda-Gold(LMG)模型定量评估了气候变化及其碳氮耦合作用对中国农田生态系统碳源汇变化影响贡献。研究结果表明:(1)2000-2020年中国农田生态系统碳汇与碳源均表现为波动增长趋势,其中GPP、NPP和NEP平均增长率分别为4.27、1.65与0.15 g C m^(-2) a^(-1),Rs、Ra和Rh平均增长率分别为4.12、2.62与1.50 g C m^(-2) a^(-1),由于较高的呼吸作用,中国农田生态系统总体表现为弱碳汇;(2)2000-2020年中国农田生态系统除Rs/GPP以0.12%的速率小幅增长外,NEP/NPP、NEP/GPP及NEP/Rs均呈减少趋势,变化速率分别为-0.28%、-0.39%和-0.46%,呼吸主导作用逐渐加强导致碳汇主导作用减弱;(3)CO_(2)施肥和氮沉降对中国农田生态系统净碳汇增长的贡献为28.98%,主控了25.30%的农田碳汇区域。然而,CO_(2)施肥和氮沉降也导致了中国农田生态系统碳源增强,二者相对贡献率为32.41%,主控了26.75%的农田碳源区域。(4)GPP弱主导机制驱动了中国农田生态系统NEP的增长,GPP是碳汇区(KNEP>0)碳汇增长的主要驱动因子,主控了77.14%的农田碳汇区域。相反,Rs强主导机制导致了中国农田生态系统NEP下降,Rh是碳源区(KNEP<0)碳源增强的主要驱动因子,主控了46.98%的农田碳源区域。研究结果可为巩固提升农田生态系统碳汇,促进碳中和目标实现提供科学依据。展开更多
Objective Schizophrenia is a complex neuropsychiatric disorder characterized by cognitive,affective,and behavioral abnormalities.Existing treatments have yielded limited effects on improving cognitive function.Recent ...Objective Schizophrenia is a complex neuropsychiatric disorder characterized by cognitive,affective,and behavioral abnormalities.Existing treatments have yielded limited effects on improving cognitive function.Recent studies have identified the abnormal differentiation of hippocampal neural stem cells(NSCs),neuronal loss,and dysregulated proliferation of astrocytes as significant pathological mechanisms contributing to the symptoms of schizophrenia.Impaired hippocampal neurogenesis may lead to emotional and cognitive deficits and biases in learning and memory,indicating that NSC differentiation is critical.NEP1-40,a Nogo-A receptor inhibitor,has shown promise for nerve protection and repair promotion.However,the effects of NEP1-40 on stem cell differentiation,the reduction in neuronal apoptosis,and the amelioration of schizophrenia-like behaviors have not been adequately investigated.This study examined the influence of NEP1-40 on NSC differentiation,hippocampal neuronal apoptosis,and proliferation in adolescent mice,along with its potential to enhance cognitive and behavioral outcomes in MK-801-induced schizophrenia mouse models.Methods In in vivo experiments,a schizophrenia mouse model was successfully established.Subsequently,behavioral tests were conducted,followed by Western blotting(WB)and immunofluorescence(IF)analyses.In in vitro settings,NSCs were cultured and transfected.Flow cytometry,along with WB and IF assays,was employed to evaluate the effects of NEP1-40.Results Schizophrenia-like behaviors in mice were significantly improved with the overexpression of NEP1-40.Compared with the model group,the NEP1-40 treatment group presented increased expression of a neuronal marker(Tuj1),reduced expression of an astroglial marker(GFAP),and decreased hippocampal neuronal apoptosis.NSC differentiation was assessed by quantifying the number of BrdU-positive cells coexpressing Tuj1 and GFAP in the hippocampal dentate gyrus.NEP1-40 treatment led to an increase in BrdU/Tuj1-positive cells and a reduction in BrdU/GFAP-positive cells.In cellular studies,NEP1-40 overexpression similarly increased the number of Tuj1-positive cells,reduced the number of GFAP-positive cells,decreased the degree of neuronal apoptosis,and promoted neuronal proliferation.Conclusion These findings demonstrated the neurogenic effects of NEP1-40 on NSCs and their potential to mitigate schizophrenia-like behaviors in vivo.展开更多
文摘In this paper, a test system was developed in which a CCD camera was used as a sensor together with an IBM-AT-compatible computer with an Intel 80486 processor to measure the impurities and neps on a piece of cotton gray goods, and a method was proposed by which the differences of degree of gray between samples and interference caused by surface unevenness, creasing and the like within a test sample can be removed effectively. The whole test system is reliable, accurate and causing fewer subjective errors.
文摘Defect free yarn is a great demand for spinner, knitter, and weaver and also other textile personnel because numerous end products from knit apparels to woven fabrics, from towels to sheets and from carpets to industrial fabrics characteristics significantly depend on the physical properties of yarn. The qualities of rotor yarn are really directed by spinning parameters. The aim of this study is to observe the effect of spinning parameters such as rotor diameter and speed on thick, thin places and neps of yarn in rotor spinning process. 0.11 sliver hank of 100% cotton was used to produce 12 Ne yarn. 65% virgin cotton and 35% wastage cotton were mixed together. The positive impact of spinning parameters on yarn properties were accessed by thick places, thin places and neps. Results indicate that the yarn qualities were improved with increasing of rotor speed and rotor diameter. The rotor diameter was settled to 43 mm while rotor speed fluctuated from 35,000 to 45,000 rpm and rotor speed was fixed to 35,000 rpm while rotor diameter across contrasts from 43 mm to 66 mm.
文摘为深入了解秦岭山地生态碳汇的时空变化特征及其影响因素,以2000—2023年净初级生产力(NPP)数据为基础,结合土壤异养呼吸模型估算秦岭山地植被的净生态系统生产力(NEP),采用Theil-Sen Median斜率估计、Mann-Kendall(M-K)显著性检验及地理探测器等方法,分析秦岭山地植被NEP的时空演变特征及其驱动因子。结果表明:2000—2023年,秦岭山地植被NEP整体呈波动上升趋势,年均增幅为5.0 g C/(m^(2)·a),表明区域植被固碳能力持续增强;在空间分布上,秦岭山地的年均NEP呈西高东低的特征,76.5%区域的NEP保持稳定或呈增加趋势。地理探测器分析显示,植被归一化指数(NDVI)对秦岭山地植被NEP的空间分异解释力最强,年均降水量、坡度、年平均气温及坡向的解释力也较强,NDVI与降水的交互作用对NEP的影响非常显著。综上,在未来提升秦岭山地固碳能力时,需重点关注多因子的协同作用,以实现更高效的固碳效果。
基金funded by the National Major Science and Technology Program for Water Pollution Control and Treatment(2017ZX07101-002)the Discipline Construction Program of ZHANG Huayong,Distinguished Professor of School of Life Sciences,Shandong University(61200082363001).
文摘Vegetation in terrestrial ecosystems as a carbon sink is a crucial factor in mitigating global warming and reaching carbon neutrality targets,although the drivers of net ecosystem productivity(NEP)under combined human and environmental pressures remain poorly understood.In this study,we analyzed the spatiotemporal evolution of NEP in the Horqin Sandy Land,China from 2000 to 2020,and observed the variation in NEP across different land use types.We further identified and quantified the effects of human activities,topographical features,climatic conditions,and soil properties on NEP through the application of structural equation modeling(SEM)and boosted regression trees(BRT).The results showed that the multi-year average NEP ranged from–137.79 to 461.96 g C/m^(2) in the Horqin Sandy Land,with 88.21%of the area showing a significant increasing trend.Among different land use types,forestland exhibited the highest NEP values,followed by cropland,grassland,impervious land,and unused land.The NEP in carbon sink areas was primarily regulated by potential evapotranspiration(negatively correlated)and precipitation(positively correlated).Slope was identified as the most significant positive determinant in carbon source areas.Forestland exhibited climate–topography interactions driving NEP,whereas cropland and grassland relied on temperature;unused land and impervious land were susceptible to land use/cover change and human footprint.This study has significant implications for maintaining the carbon sink function and promoting ecological engineering programs that aim to enhance the capacity of terrestrial carbon sinks in the semi-arid agro-pastoral ecotone.
文摘甘肃省草地是我国碳收支研究的关键区域,其净生态系统生产力(NEP)是衡量碳源/汇功能的核心。然而复杂的地形和气候条件导致该地区NEP估算存在较大不确定性。本研究基于集成生物圈模型(IBIS),模拟了1980—2022年甘肃省草地NEP的时空格局,并结合观测数据验证了模型精度。结果表明,IBIS模型能够较好地模拟该区域草地NEP动态(R^(2)=0.70,P<0.0001)。1980—2022年,甘肃省草地年均NEP为194.5 g m^(-2)·a^(-1)C,呈轻微上升趋势。年均NEP空间格局总体呈现东南高西北低,从东南向西北逐渐递减的趋势。南部草地大部分地区为碳汇区,北部部分干旱草原为碳源区,其NEP分布格局主要由降雨主导。本研究为甘肃省草地碳汇功能评估提供了科学依据,对实现区域“碳中和”目标具有重要参考价值。
文摘净生态系统生产力(NEP)是评价区域生态系统碳源碳汇的重要指标,厘清其时空分异格局及驱动机制对京津冀生态系统精准保护与修复至关重要.基于MODIS遥感数据估算了净生态系统生产力(NEP),采用Sen趋势+MK检验、Hurst指数和重心迁移等方法探究了京津冀2002~2020年固碳效益时空格局和演替规律,利用偏相关、复相关及残差分析定量解析了人类活动和气候变化驱动固碳效益时空分异的相对贡献.结果表明:①京津冀近20 a NEP呈逐年上升趋势,增长速率(以C计)为3.066 4g·(m^(2)·a)^(-1),空间上表现为西北高东南低;碳汇能力强的地区主要集中在张家口市和承德市周边,碳源效应强烈的区域分布在天津和邯郸等地;超过80%的区域碳汇能力呈上升趋势,其中极显著上升、显著上升区域占比分别为47.45%和8.29%,尤其是张-承地区,但未来增长趋势在逐步减缓;碳源重心在逐渐向东南部平原迁移,碳汇重心则由东北向西南迁移.②超过50%区域的NEP与年平均气温和年累计降水呈现正相关关系,但显著性均不强,复相关结果进一步证明了存在气象因素之外的其他条件在主导NEP的变化.③研究区域内NEP退化区与改善区占比分别为12.41%、87.59%,残差分析表明人类主导的固碳效益提升区占总改善区的94.88%,而退化区中气候主导的固碳效益降低区占62.84%,说明京津冀地区人类活动在影响生态系统固碳效益方面以正向促进为主.研究结论对精准识别京津冀生态系统保护与修复未来工作重心有指导意义.
文摘农田生态系统是陆地生态系统的重要组成部分,其碳源汇过程对气候变化的响应非常敏感。然而,当前气候变化及其碳氮耦合作用对农田生态系统碳源汇过程的影响贡献与驱动机制尚不明晰。基于总初级生产力(GPP)、净初级生产力(NPP)和净生态系统生产力(NEP)三种碳汇指标,以及系统总呼吸(Rs)、自养呼吸(Ra)和异养呼吸(Rh)三种碳源指标构建6种情景,揭示了中国农田生态系统碳源汇时空演变趋势特征,并基于Lindeman-Merenda-Gold(LMG)模型定量评估了气候变化及其碳氮耦合作用对中国农田生态系统碳源汇变化影响贡献。研究结果表明:(1)2000-2020年中国农田生态系统碳汇与碳源均表现为波动增长趋势,其中GPP、NPP和NEP平均增长率分别为4.27、1.65与0.15 g C m^(-2) a^(-1),Rs、Ra和Rh平均增长率分别为4.12、2.62与1.50 g C m^(-2) a^(-1),由于较高的呼吸作用,中国农田生态系统总体表现为弱碳汇;(2)2000-2020年中国农田生态系统除Rs/GPP以0.12%的速率小幅增长外,NEP/NPP、NEP/GPP及NEP/Rs均呈减少趋势,变化速率分别为-0.28%、-0.39%和-0.46%,呼吸主导作用逐渐加强导致碳汇主导作用减弱;(3)CO_(2)施肥和氮沉降对中国农田生态系统净碳汇增长的贡献为28.98%,主控了25.30%的农田碳汇区域。然而,CO_(2)施肥和氮沉降也导致了中国农田生态系统碳源增强,二者相对贡献率为32.41%,主控了26.75%的农田碳源区域。(4)GPP弱主导机制驱动了中国农田生态系统NEP的增长,GPP是碳汇区(KNEP>0)碳汇增长的主要驱动因子,主控了77.14%的农田碳汇区域。相反,Rs强主导机制导致了中国农田生态系统NEP下降,Rh是碳源区(KNEP<0)碳源增强的主要驱动因子,主控了46.98%的农田碳源区域。研究结果可为巩固提升农田生态系统碳汇,促进碳中和目标实现提供科学依据。
文摘旨在探索山东省及其子区域植被净生态系统生产力(Net Ecosystem Productivity,NEP)的时空变化特征及其驱动因素,评估气温(TEM)、降水(PRE)和饱和蒸汽压差(VPD)等因素对植被NEP的影响。基于2000-2020年间的植被净初级生产力(Net Primary Productivity,NPP),采用土壤呼吸地统计(Geostatistical Model of Soil Respiration,GSMSR)模型、植被NEP估算模型和地理探测器工具,通过趋势分析、相关分析和差异分析等研究方法,开展深入研究。结果表明,1)山东省植被NEP在2000-2020年间整体呈上升趋势,空间分布特征表现为从东北向西南递减,沿海地区高于内陆地区。全省植被NEP的年平均值为87.0 g·m^(-2)·a^(-1)(以C计),且超过1/3的地区由碳源区域转变为碳汇区域。2)山东省大部分地区植被NEP与气温、降水呈正相关,与饱和蒸汽压差呈负相关,不同因子间的交互作用普遍对植被NEP的影响大于单一因子的影响。3)山东省4个子区域(鲁西、鲁东、鲁北、鲁中南)植被NEP的变化趋势存在明显的空间分异,鲁中南地区植被NEP增加最为显著,其次是鲁西和鲁东地区,而鲁北地区的增幅相对较小。该研究为深入理解区域生态系统的碳循环动态以及制定相应的生态保护策略提供了科学依据。
基金funded by Ningxia Natural Science Foundation(No.2022AAC03154).
文摘Objective Schizophrenia is a complex neuropsychiatric disorder characterized by cognitive,affective,and behavioral abnormalities.Existing treatments have yielded limited effects on improving cognitive function.Recent studies have identified the abnormal differentiation of hippocampal neural stem cells(NSCs),neuronal loss,and dysregulated proliferation of astrocytes as significant pathological mechanisms contributing to the symptoms of schizophrenia.Impaired hippocampal neurogenesis may lead to emotional and cognitive deficits and biases in learning and memory,indicating that NSC differentiation is critical.NEP1-40,a Nogo-A receptor inhibitor,has shown promise for nerve protection and repair promotion.However,the effects of NEP1-40 on stem cell differentiation,the reduction in neuronal apoptosis,and the amelioration of schizophrenia-like behaviors have not been adequately investigated.This study examined the influence of NEP1-40 on NSC differentiation,hippocampal neuronal apoptosis,and proliferation in adolescent mice,along with its potential to enhance cognitive and behavioral outcomes in MK-801-induced schizophrenia mouse models.Methods In in vivo experiments,a schizophrenia mouse model was successfully established.Subsequently,behavioral tests were conducted,followed by Western blotting(WB)and immunofluorescence(IF)analyses.In in vitro settings,NSCs were cultured and transfected.Flow cytometry,along with WB and IF assays,was employed to evaluate the effects of NEP1-40.Results Schizophrenia-like behaviors in mice were significantly improved with the overexpression of NEP1-40.Compared with the model group,the NEP1-40 treatment group presented increased expression of a neuronal marker(Tuj1),reduced expression of an astroglial marker(GFAP),and decreased hippocampal neuronal apoptosis.NSC differentiation was assessed by quantifying the number of BrdU-positive cells coexpressing Tuj1 and GFAP in the hippocampal dentate gyrus.NEP1-40 treatment led to an increase in BrdU/Tuj1-positive cells and a reduction in BrdU/GFAP-positive cells.In cellular studies,NEP1-40 overexpression similarly increased the number of Tuj1-positive cells,reduced the number of GFAP-positive cells,decreased the degree of neuronal apoptosis,and promoted neuronal proliferation.Conclusion These findings demonstrated the neurogenic effects of NEP1-40 on NSCs and their potential to mitigate schizophrenia-like behaviors in vivo.