Coal-based soild wastes(CBSWs)are industrial byproducts that can be harmful to the environment.The exploitation and utilization of CBsWs offer societal advantages such as resource conservation,pollution reduction,and ...Coal-based soild wastes(CBSWs)are industrial byproducts that can be harmful to the environment.The exploitation and utilization of CBsWs offer societal advantages such as resource conservation,pollution reduction,and cost-effective production.However,environmentally sustainable management remains a worldwide challenge due to the substantial production volume and limited disposal capacity of CBSWs.The physicochemical properties and utilization of CBSWs are summarized,including fly ash,coal gangue and coal gasification slag.It also presents the current global applications status of CBSWs resources and examines market supply and demand.Subsequently,the paper provides an overview of studies on ways to utilise CBSWs,highlighting the primary avenues of CBSWs resource utilization which are mainly from the fields of chemical materials,metallurgy and agriculture.Furthermore,a comparative evaluation of the various methods for CBSWs resource recovery is conducted,outlining their respective advantages and disadvantages.The future development of CBSWs recycling processes is also discussed.The review concludes that while there is a growing need for attention in CBSWs recycling,its utilization will involve a combination of both large-scale treatment and refinement processes.The paper aims to offer references and insights for the effective utilization and environmental protection of CBSWs.Future direction will focus on the collaborative utilization of CBSWs,emphasizing on the combination of large-scale and high-value utilization.In addition,there is a need to establish a comprehensive database based on on-site production practices,explore on-site solutions to reduce transportation costs,and improve physicochemical properties during the production process.展开更多
Background There is a growing focus on using various plant-derived agricultural by-products to increase the benefits of pig farming,but these feedstuffs are fibrous in nature.This study investigated the relationship b...Background There is a growing focus on using various plant-derived agricultural by-products to increase the benefits of pig farming,but these feedstuffs are fibrous in nature.This study investigated the relationship between dietary fiber physicochemical properties and feedstuff fermentation characteristics and their effects on nutrient utilization,energy metabolism,and gut microbiota in growing pigs.Methods Thirty-six growing barrows(47.2±1.5 kg)were randomly allotted to 6 dietary treatments with 2 apparent viscosity levels and 3β-glucan-to-arabinoxylan ratios.In the experiment,nutrient utilization,energy metabolism,fecal microbial community,and production and absorption of short-chain fatty acid(SCFA)of pigs were investigated.In vitro digestion and fermentation models were used to compare the fermentation characteristics of feedstuffs and ileal digesta in the pig’s hindgut.Results The production dynamics of SCFA and dry matter corrected gas production of different feedstuffs during in vitro fermentation were different and closely related to the physical properties and chemical structure of the fiber.In animal experiments,increasing the dietary apparent viscosity and theβ-glucan-to-arabinoxylan ratios both increased the apparent ileal digestibility(AID),apparent total tract digestibility(ATTD),and hindgut digestibility of fiber components while decreasing the AID and ATTD of dry matter and organic matter(P<0.05).In addition,increasing dietary apparent viscosity andβ-glucan-to-arabinoxylan ratios both increased gas exchange,heat production,and protein oxidation,and decreased energy deposition(P<0.05).The dietary apparent viscosity andβ-glucanto-arabinoxylan ratios had linear interaction effects on the digestible energy,metabolizable energy,retained energy(RE),and net energy(NE)of the diets(P<0.05).At the same time,the increase of dietary apparent viscosity andβ-glucan-to-arabinoxylan ratios both increased SCFA production and absorption(P<0.05).Increasing the dietary apparent viscosity andβ-glucan-to-arabinoxylan ratios increased the diversity and abundance of bacteria(P<0.05)and the relative abundance of beneficial bacteria.Furthermore,increasing the dietaryβ-glucan-to-arabinoxylan ratios led to a linear increase in SCFA production during the in vitro fermentation of ileal digesta(P<0.001).Finally,the prediction equations for RE and NE were established.Conclusion Dietary fiber physicochemical properties alter dietary fermentation patterns and regulate nutrient utilization,energy metabolism,and pig gut microbiota composition and metabolites.展开更多
Objective The analgesic effect of acupuncture has been widely accepted.Nevertheless,the mechanism behind its analgesic effect remains elusive,thus impeding the progress of research geared toward enhancing the analgesi...Objective The analgesic effect of acupuncture has been widely accepted.Nevertheless,the mechanism behind its analgesic effect remains elusive,thus impeding the progress of research geared toward enhancing the analgesic effect of acupuncture.This paper investigated the role of acupuncture needle surface textures on acupuncture’s analgesic effect by creating four experimental acupuncture needles with different patterns of surface augmentation.Methods Four types of acupuncture needles with different surface textures(the lined needle,circle needle,sandpaper needle,and threaded needle)were designed.Additionally,the force/torque measurement system used a robot arm and mechanical sensor to measure the force on the needle during insertion and manipulation.To perform acupuncture analgesia experiments,four experimental acupuncture needles and a normal needle were inserted into the Zusanli(ST36)acupoint of rats with inflammatory pain.By comparing the force and torque and the analgesic efficacy of the different acupuncture needles,these experiments tested the role of acupuncture needle body texture on acupuncture analgesia.Results The analgesic effects of different acupuncture needle body textures varied.Specifically,the force required to penetrate the skin with the lined needle was not greater than that for the normal needle;however,the needle with inscribed circles and the sandpaper-roughened needle both required greater force for insertion.Additionally,the torque of the lined needle reached 2×10^(-4)N·m under twisting manipulation,which was four times greater the torque of a normal needle(5×10^(-5)N·m).Furthermore,the lined needle improved pain threshold and mast cell degranulation rate compared to the normal needle.Conclusion Optimizing the texture of acupuncture needles can enhance acupuncture analgesia.The texture of our experimental acupuncture needles had a significant impact on the force needed to penetrate the skin and the torque needed to manipulate the needle;it was also linked to variable analgesic effects.This study provides a theoretical basis for enhancing the analgesic efficacy of acupuncture through the modification of needles and promoting the development of acupuncture therapy.展开更多
BACKGROUND This is a randomized study to compare the diagnostic accuracy of endoscopic ultrasound(EUS)-guided sampling of pancreatic solid lesions obtained with the 22-gauge Franseen(EUS-fine needle biopsy)vs the 22-g...BACKGROUND This is a randomized study to compare the diagnostic accuracy of endoscopic ultrasound(EUS)-guided sampling of pancreatic solid lesions obtained with the 22-gauge Franseen(EUS-fine needle biopsy)vs the 22-gauge standard needle(EUS-fine needle aspiration)without rapid onsite evaluation(ROSE),since,in most endoscopy units around the world ROSE is not routinely available.AIM To investigate the accuracy of EUS-guided sampling of pancreatic solid lesions obtained between two different needles without ROSE.METHODS Patients with a solid pancreatic were included.Patients were biopsied in a randomized order.The primary endpoint was the diagnostic sensitivity for pancreatic malignancy(PM).Secondary outcomes were adequacy of the sample,the mean tissue area,the mean tumor area,and the adverse event rate.RESULTS The final diagnosis was pancreatic adenocarcinoma in 38(76%),neuroendocrine tumor in 4(8%),chronic pancreatitis in 3(6%)patients.The sensitivity for PM with Franseen needle was 0.91[95%confidence interval(CI):0.80-0.98],vs 0.8(95%CI:0.67-0.91)(P=0.025)with standard needle.The specificity for PM did not differentiate.The accuracy of the standard needle for PM was 0.80(95%CI:0.66-0.90),and the Franseen group was 0.90(95%CI:0.78-0.97)(P=0.074).The technical success rates for the standard and Franseen needle groups were 94%(95%CI:0.83-0.99)and 100%(95%CI:0.92-1.00),respectively.The mean total tissue area in mm2(SD)was greater in the Franseen group,2.07(0.22)vs 1.16(0.17)(P<0.01).The mean tumor area in mm2(SD)was not different in Franseen group vs standard group,0.42(0.09)vs 0.47(0.09)(P=0.80).There were no adverse events.CONCLUSION The sensitivity for PM and mean total tissue area,was greater in the as compared with standard needle.The mean tumor area did not differ between the groups.展开更多
With the rapid growth of the global population and the increasing demand for healthier diets,improving the nutrient utilization efficiency of staple food crops has become a critical scientific and industrial chal-leng...With the rapid growth of the global population and the increasing demand for healthier diets,improving the nutrient utilization efficiency of staple food crops has become a critical scientific and industrial chal-lenge,prompting innovation in food processing technologies.This review introduces first the common nutritional challenges in the processing of staple food crops,followed by the comprehensive examination of research aiming to enhance the nutritional quality of staple food crop-based foods through innovative processing technologies,including microwave(MW),pulsed electric field(PEF),ultrasound,modern fer-mentation technology,and enzyme technology.Additionally,soybean processing is used as an example to underscore the importance of integrating innovative processing technologies for optimizing nutrient utilization in staple food crops.Although these innovative processing technologies have demonstrated a significant potential to improve nutrient utilization efficiency and enhance the overall nutritional pro-file of staple food crop-based food products,their current limitations must be acknowledged and addressed in future research.Fortunately,advancements in science and technology will facilitate pro-gress in food processing,enabling both the improvement of existing techniques as well as the develop-ment of entirely novel methodologies.This work aims to enhance the understanding of food practitioners on the way processing technologies may optimize nutrient utilization,thereby fostering innovation in food processing research and synergistic multi-technological strategies,ultimately providing valuable references to address global food security challenges.展开更多
Semiconductor electronic devices are prone to charge accumulation during production and transportation,which usually causes device breakdown.Ionizers are widely used for electrostatic elimination,and utilizing semicon...Semiconductor electronic devices are prone to charge accumulation during production and transportation,which usually causes device breakdown.Ionizers are widely used for electrostatic elimination,and utilizing semiconductor silicon for the discharge needle material in ionizers can effectively prevent metal contamination.To investigate the discharge characteristics of silicon needles and their mode modulation mechanism,this study has established an experimental platform for silicon needle-plate discharge under positive polarity voltage.Discharge pulse parameters and optical signals were measured at varying electrode spacings.The experimental results reveal that silicon needle discharge progresses through four regimes:the spontaneous streamer,the periodic streamer,the cluster streamer,and the glow discharge.Among these,the pulse amplitude is most uniform and stable in the periodic streamer regime.In addition,shorter-gap discharge exhibits higher pulse amplitude and repetition frequency but is easier to transition into the filament regime.The formation process of a single pulse is closely related to the field strength in the ionization region near the needle tip.Hence,parameters such as the pulse rising edge time and falling edge time show minimal variation with voltage.The amount of charge generated per unit time is primarily influenced by the repetition frequency.Consequently,the electrostatic ionizer produces the highest,most stable,and most uniform charges if it operates in the periodic streamer regime.展开更多
The aim of this study is to develop an understanding on the contributing influences that occur among qualities of public space,public space aesthetics,the comfort derived in public space and public space accessibility...The aim of this study is to develop an understanding on the contributing influences that occur among qualities of public space,public space aesthetics,the comfort derived in public space and public space accessibility in science cities.This study seeks to investigate the extent at which public space attributes impact on one another.The emphasis accruing to open greenery including public spaces in the physical development of science cities necessitates the selection of Cyberjaya Malaysia as the study area.Survey questionnaires were used to investigate potential respondent’s perceptions on public space utilization and the feedback was validated with SEM(structural equation modelling).The findings indicated that the accessibility attributes significantly influenced other public space utilization attributes while good quality of public space influenced the comfort derived from it.Attractiveness of public space was found not capable to predict the comfort and good quality of public space.展开更多
Background:Patients with cancer are confronted not only with physical changes and pain but also with significant psychological challenges,including distress,anxiety,and depression,as a consequence of their diagnosis a...Background:Patients with cancer are confronted not only with physical changes and pain but also with significant psychological challenges,including distress,anxiety,and depression,as a consequence of their diagnosis and treatment.This study aimed to identify the factors influencing anxiety or depression in patientswith cancer,examine the relationship between the duration since cancer diagnosis and psychological state,and explore the association between these factors and the use of Korean medicine(KM).Methods:This study utilized data from the 2018 Korea Health Panel spanning 2008 to 2018.The analysis focused on adult participants(aged 19 and above)diagnosed with cancer who responded to their psychological state(i.e.,anxiety or depression)and the duration since their cancer diagnosis.The dependent variables were the presence of anxiety or depression and the utilization of KM.Descriptive statistics and multiple logistic regression analysis were used to investigate factors influencing these variables.Results:A total of 773 participants were included in the final analysis,of whom 214 reported prior KM experience.Multiple logistic regression analysis indicated that the likelihood of experiencing anxiety or depression decreased as the duration since cancer diagnosis increased.Factors associated with anxiety or depression in patients with cancer included sex(odds ratio[OR]=2.06),number of chronic diseases(OR=1.17),Charlson Comorbidity Index score(CCI score of 2:OR=1.60),and EQ-5D(EuroQol Five Dimensions Questionnaire)index(OR<0.001).Cancer patients without anxiety or depression were more likely to use KM if they had been diagnosed within three years,were female(OR=2.11),and had a higher number of chronic conditions(OR=1.20).In contrast,patients with anxiety or depression were more likely to utilizeKMif theyhadbeendiagnosed formore thanfive years(OR=6.30)and resided in urban areas.Conclusions:The results suggest that patterns of KM utilization among patients with cancer are associated with their psychological state.Future research should focus on identifying direct correlations between psychological factors and KM use in patients with cancer.展开更多
Purpose–This study is dedicated to systematically collating the distribution and utilization circumstances of geothermal resources in China.Moreover,it endeavors to formulate a comprehensive utilization scheme for ge...Purpose–This study is dedicated to systematically collating the distribution and utilization circumstances of geothermal resources in China.Moreover,it endeavors to formulate a comprehensive utilization scheme for geothermal resources during the construction and operation phases of the railway,thereby furnishing robust support and valuable reference for the holistic utilization of geothermal resources along the railway corridor.Design/methodology/approach–Through an in-depth analysis of the extant utilization of geothermal resources in China,it is discerned that the current utilization modalities are relatively rudimentary,bereft of rational planning and characterized by a low utilization rate.Concurrently,by integrating the practical requisites of railway construction and operation and conducting theoretical dissections,a comprehensive utilization plan for the construction and operation periods of railway is proffered.Findings–In light of the railway’s construction and operation characteristics,geothermal utilization models are categorized.During construction,comprehensive modalities include tunnel illumination power generation,construction area heating,tunnel antifreeze using shallow geothermal energy,tunnel pavement antifreeze and construction concrete maintenance.During operation,they comprise operation tunnel antifreeze,railway roadbed antifreeze,railway switch snow melting and deicing,geothermal power station establishment and railway hot spring health tourism planning.Originality/value–According to the characteristics and actual needs of railway construction and operation,it is of great significance to rationally utilize geothermal resources to promote the construction and operation of green railways.展开更多
Tantalum nitride is widely considered as a promising photoanode material for its suitable band structure as well as the high theoretical conversion efficiency in solar water splitting.However,it is limited to ineffici...Tantalum nitride is widely considered as a promising photoanode material for its suitable band structure as well as the high theoretical conversion efficiency in solar water splitting.However,it is limited to inefficient photoinduced electron–hole pair separation and interfacial dynamics in the photoelectrochemical oxygen evolution reaction.Herein,multiple layers including Ti_(x)Si_(y) and NiFeCoO_(x) were fabricated based on band engineering to regulate tandem electric states for efficient transfer of energy carriers.Besides,photothermal local surface plasmon resonance was introduced to accelerate the kinetics of photoelectrochemical reactions at the interface when the special Ag nanoparticles were loaded to extend the absorbance to near infrared light.Consequently,a recordable photocurrent density of 12.73 mA cm^(-2) has been achieved at 1.23 V versus RHE,approaching a theoretical limit of the tantalum nitride photoanode with full-spectrum solar utilization.Meanwhile,compared to the applied bias photon-to-current efficiency of 1.36%without photothermal factor,a high applied bias photonto-current efficiency of 2.27%could be raised by applying local surface plasmon resonance to photoelectrochemical oxygen evolution reaction.The efficient design could maximize the use of solar light via the classification of spectrum and,therefore,may spark more innovative ideas for the future design and development of the next-generation photoelectrode.展开更多
Objective: To explore the effectiveness of applying an infusion project team in the safety risk management of indwelling needle use. Methods: A total of 200 patients who used intravenous indwelling needles during hosp...Objective: To explore the effectiveness of applying an infusion project team in the safety risk management of indwelling needle use. Methods: A total of 200 patients who used intravenous indwelling needles during hospital treatment from July to October 2022 were selected and randomly divided into an observation group and a control group, with 100 patients in each group. Patients in the control group received routine nursing methods, while those in the observation group were managed using the safety risk management method of the infusion project team. The tube blocking rate and tube removal rate were compared between the two groups. Results: The one-time puncture success rate and the standard implementation rate of intravenous indwelling needle use in the observation group were significantly higher than those in the control group. The total incidence of complications in the observation group was significantly lower than that in the control group, and patient satisfaction in the observation group was notably higher, with statistically significant differences (P < 0.05). Conclusion: The application of an infusion project team in the safety risk management of indwelling needle use is effective and has positive impacts on improving the one-time puncture success rate, the standard implementation rate of intravenous indwelling needle use, and patient satisfaction. It is a practice worth promoting in clinical settings.展开更多
BACKGROUND There is increasing incidence of alcohol-associated liver disease in females.Despite this recent increased incidence,there is a paucity of research on the clinical course and outcomes of alcohol-associated ...BACKGROUND There is increasing incidence of alcohol-associated liver disease in females.Despite this recent increased incidence,there is a paucity of research on the clinical course and outcomes of alcohol-associated hepatitis(AH)in females compared to males.AIM To assess if there may be sex differences in severity,outcomes,and healthcare utilization for patients hospitalized for AH.METHODS This study used ICD-9-CM and ICD-10-CM codes to retrospectively identify inpatient encounters for AH at the University of Kentucky from 2012-2021 and obtained data on patient demographics and clinical outcomes.Encounters were cohorted by patient sex and differences in patient demographics and clinical outcomes were assessed.Multivariate logistic regression models were constructed to assess risk of mortality,sepsis,and mechanical ventilation during the encounter.RESULTS Of 1386 subjects,511(36.9%)were female and 875(63.1%)were male.Both sexes had similar baseline characteristics of race/ethnicity,discriminant function score,model of end-stage liver disease score,and length of hospital stay.However,the incidence of urinary tract infection,sepsis,and norepinephrine administration was significantly higher for females.Males had a significantly higher incidence of esophageal variceal bleed.On multivariate logistic regression analysis,females had higher odds of encounter sepsis(OR 1.41;95%CI:1.064-1.869)and mechanical ventilation(OR 1.352;95%CI:1.006-1.816).Odds of encounter mortality were significantly increased in encounters with sepsis(OR 2.309;95%CI:1.419-3.757)and mechanical ventilation(OR 9.301;95%CI:5.724-15.114).CONCLUSION This study shows sex-based differences in AH outcomes at the University of Kentucky.Future studies are warranted to assess whether tailoring treatments will improve clinical outcomes in females with AH.展开更多
The regenerative braking energy utilization system(RBEUS)stands as a promising technique for improving the efficiency and power quality of electrified railways.Beyond the vital aspects of energy management and control...The regenerative braking energy utilization system(RBEUS)stands as a promising technique for improving the efficiency and power quality of electrified railways.Beyond the vital aspects of energy management and control strategies,ensuring fault protection is paramount for the secure and steady operation of the traction power supply system(TPSS)integrated with RBEUS.This paper introduces an innovative protection scheme tailored to diverse RBEUS application scenarios.Firstly,fault categories are streamlined into three levels:system,equipment,and warning.Subsequently,a novel multi-port active power differential protection method,aligned with RBEUS operational principles,is crafted to serve as a comprehensive and sensitive main protection.Building upon this foundation,a hierarchical protection structure for RBEUS is established,addressing the intricacies and variations in fault types while boosting anti-disturbance capabilities under faulty conditions.Embracing the principle of railway-oriented safety,a collaborative RBEUS-TPSS protection scheme is put forth.Finally,through simulated scenarios encompassing various fault conditions,the proposed scheme’s feasibility and effectiveness are convincingly validated.展开更多
Lignocellulosic biomass is one of the viable solutions to alleviate the global warming. However, the limited utilization of biomass majorly focused on cellulose and hemicellulose restricts the economic and environment...Lignocellulosic biomass is one of the viable solutions to alleviate the global warming. However, the limited utilization of biomass majorly focused on cellulose and hemicellulose restricts the economic and environmental feasibilities. To cope with this issue, we proposed an integrated process of co-producing 1,6-hexanediol(1,6-HDO) with tetrahydrofuran and adipic acid from biomass, referred to as Strategy A. To compare the impacts of lignin upgrading and feedstock, Strategy B, which co-produces tetrahydrofuran alone, and Strategy C, which is the traditional route to produce 1,6-HDO from fossil fuels, were used. Heat networks are also designed to reduce operating costs and indirect carbon emissions due to energy consumption, saving 87% and 83% of the heat and cooling requirements, respectively, in Strategy A. The market competitiveness of Strategy A was evaluated by determining the minimum selling price through techno-economic analysis, and sustainability was thoroughly investigated by quantifying the environmental impacts through both midpoint and endpoint life-cycle assessments(LCAs).Strategy A was found to be the most favorable both economically(USRDSCHARDOLLAR3,402/ton) and environmentally(-26.9 kg CO_(2)eq.). This indicates that lignin valorization is not only economically but also environmentally preferred. Finally, changes in economic and environmental feasibilities depending on economic, process, and environmental parameters were investigated using sensitivity and uncertainty analyses. The results of these analyses provide valuable insight into bio-based chemical production.展开更多
[Objectives] To evaluate the utilization and application value of vine plant resources,and enrich the urban vertical greening landscape.[Methods] Route survey and sample plot observation methods were employed to inves...[Objectives] To evaluate the utilization and application value of vine plant resources,and enrich the urban vertical greening landscape.[Methods] Route survey and sample plot observation methods were employed to investigate 96 greening sites in Shenyang area,China.[Results] There are 21 species of vines used in vertical greening,including 15 species of woody vines and 6 species of herbaceous vines.According to the biological characteristics of vine plants and the actual needs of vertical application in landscape greening,a comprehensive evaluation system with one target layer,three criterion layers and a total of 14 indicators was constructed,and the application value of 21 species of vines was evaluated.Based on the comprehensive evaluation value,the vine plants were divided into four grades,and four of them had good application prospects and could be used in urban vertical greening.[Conclusions] The evaluation model and evaluation results will provide a theoretical basis for the rational use of vine plant resources.展开更多
In order to further promote the chestnut industrial chain,a large number of chestnut byproducts(chestnut leaves,chestnut shells,chestnut flowers,etc.)are produced every year.These chestnut byproducts will be comprehen...In order to further promote the chestnut industrial chain,a large number of chestnut byproducts(chestnut leaves,chestnut shells,chestnut flowers,etc.)are produced every year.These chestnut byproducts will be comprehensively developed and utilized in different degrees,such as in-depth research and development in the fields of animal husbandry,agriculture,and cosmetics,so as to achieve the effects of accelerating the high-quality development of chestnut industry,realizing the green cycle of resources,reducing waste and promoting the development of rural industries.展开更多
Double-shaft-driven needle punching machine is a specialized equipment designed for processing C/C crucible preforms.Its main needle punching module is operated by two sets of reciprocating crank-slider mechanisms.The...Double-shaft-driven needle punching machine is a specialized equipment designed for processing C/C crucible preforms.Its main needle punching module is operated by two sets of reciprocating crank-slider mechanisms.The intense vibration during needle punching not only generates huge noise,but also substantially reduces the quality of the preform.It is imperative to perform a dynamic analysis and optimization of the entire needle punching machine.In this paper,the three-dimensional(3D)model of the entire double-shaft-driven needle punching machine for C/C crucible preforms is established.Based on the modal analysis theory,the modal characteristics of the needle punching machine under various operating conditions are analyzed and its natural frequencies and vibration modes are determined.The harmonic response analysis is then employed to obtain the amplitude of the needle plate at different frequencies,and the structural weak points of the needle punching machine are identified and improved.The feasibility of the optimized scheme is subsequently reevaluated and verified.The results indicate that the first six natural frequencies of the machine increase,and the maximum amplitude of the needle plate decreases by 70.3%.The enhanced dynamic characteristics of the machine significantly improve its performance,enabling more efficient needle punching of C/C crucible preforms.展开更多
OBJECTIVE:To investigate the effect of pestle needle therapy(PNT)on the posterior cervical muscle(PCM)in a rabbit model of cervical spondylosis(CS)and explore the underlying mechanisms.METHODS:Rabbits were divided int...OBJECTIVE:To investigate the effect of pestle needle therapy(PNT)on the posterior cervical muscle(PCM)in a rabbit model of cervical spondylosis(CS)and explore the underlying mechanisms.METHODS:Rabbits were divided into control,CS modelsⅠandⅡ(CS1 and CS2),electroacupuncture(EA),PNTⅠandⅡ(PN1 and PN2),activator(AVT),and PNT combined with activator(C-AVT)groups.A long-term neck immobilization technique was used to establish a rabbit model of CS.Following completion of modeling,the EA group received electroacupuncture intervention,whereas the CS1,CS2,and C-AVT groups received PNT intervention.The AVT and C-AVT groups received local 740 Y-P injections into the PCM daily.The inflammatory injury to PCM was evaluated based on pain threshold,morphological changes,and interleukin(IL)-1β,IL-6,and tumor necrosis factor(TNF)-αlevels.PCM fibrosis was evaluated by measuring the positive area(PA)of collagen fibrils(CFs)and collagen type 1 alpha 1(Col1α1)using Masson's and immunohistochemical staining.Terminal deoxynucleotidyl transferase-mediated d UTP nick-end labeling assay and transmission electron microscopy were used to identify apoptotic cells and assess autophagy,respectively.Western blotting was used to determine B-cell lymphoma-2(Bcl-2),Bcl-2 associated X protein(Bax),cysteine aspartate-specific protease(caspase)-3,sequestosome-1(P62),microtubuleassociated protein light chain 3(LC3-Ⅰ/Ⅱ),phosphatidylinositol 3-kinase(PI3K),protein kinase B(AKT),and mammalian target of rapamycin(mTOR)levels.Real-time quantitative polymerase chain reaction was used to determine mRNA expression levels of PI3K,AKT,mTOR,autophagy protein(ATG),and ATG7.RESULTS:PNT alleviated PCM cell degeneration and necrosis,inhibited inflammatory cell infiltration,decreased IL-1β,IL-6,and TNF-αlevels,and decreased the PA of CFs and Col1α1.In the PN1 group,cell apoptosis in the PCM decreased,autophagy increased,Bcl-2 and LC3-Ⅱ/Ⅰlevels increased,Bax,Caspase-3,and P62 levels decreased,and the mRNA expression of ATG5 and ATG7 increased.PNT inhibits protein and mRNA expression of PI3K,AKT,and mTOR.Finally,the trend in the results of the rescue experiment was consistent with previous results.CONCLUSION:PNT inhibited apoptosis and promoted autophagy of PCM cells in CS rabbits and alleviated inflammation and fibrosis injury of PCM by inhibiting the PI3K/AKT/mTOR pathway.展开更多
Under the background of the current energy crisis and environmental pollution,the development of green and sustainable materials has become particularly urgent.As one of the most abundant natural polymers on earth,cel...Under the background of the current energy crisis and environmental pollution,the development of green and sustainable materials has become particularly urgent.As one of the most abundant natural polymers on earth,cellulose has attracted wide attention due to its green recycling,sustainable development,degradability,and low cost.Therefore,cellulose and its derivatives were used as the starting point for comprehensive analysis.First,the basic structural properties of cellulose were discussed,and then the extraction and utilization methods of cellulose were reviewed,including Sodium Hydroxide based solvent system,N,N-Dimethylacetamide/Lithium Chloride System,N-Methylmorpholine-N-Oxide(NMMO)system,ionic liquids(ILs)system,and deep eutectic solvent(DES)system.Then,the functional modification techniques of cellulose are introduced,including nano-modification,small molecule modification,and macromolecular modification.Finally,the potential applications of cellulose in the fields of reinforcement materials,self-healing materials,radioactive cooling,nanogenerators,and biomedicine were discussed.At the end of this paper,the challenges and future development direction of cellulose materials are prospectively analyzed,aiming at providing guidance and inspiration for the research and application in related fields.展开更多
The effects of micro-ridge-furrow planting(MR)on yield and the efficiency of light,water,and thermal resource use in rapeseed were tested in a three-year field experiment comparing MR to conventional flat planting.MR ...The effects of micro-ridge-furrow planting(MR)on yield and the efficiency of light,water,and thermal resource use in rapeseed were tested in a three-year field experiment comparing MR to conventional flat planting.MR enhanced canopy heterogeneity by altering the leaf angle between plants on ridges and furrows.The heterogeneous canopy environment increased intercepted photosynthetic active radiation,alleviated canopy temperature stress,and optimized canopy humidity,leading to improvements in light-nitrogen matching and net photosynthetic rate.Consequently,dry matter and yield increased by 13.0%and 11.0%,respectively,while radiation,thermal,and precipitation utilization efficiency increased by 12.3%-16.2%.The corresponding improvements in yield and resource use efficiency were attributed to a heterogeneous canopy environment that improved microclimatic conditions.展开更多
基金supported by the following:“National Natural Science Foundation of China”(22478231)“Natural Science Foundation of Henan”(242300421449)“Fundamental Research Program of Shanxi Province”(202403021221011).
文摘Coal-based soild wastes(CBSWs)are industrial byproducts that can be harmful to the environment.The exploitation and utilization of CBsWs offer societal advantages such as resource conservation,pollution reduction,and cost-effective production.However,environmentally sustainable management remains a worldwide challenge due to the substantial production volume and limited disposal capacity of CBSWs.The physicochemical properties and utilization of CBSWs are summarized,including fly ash,coal gangue and coal gasification slag.It also presents the current global applications status of CBSWs resources and examines market supply and demand.Subsequently,the paper provides an overview of studies on ways to utilise CBSWs,highlighting the primary avenues of CBSWs resource utilization which are mainly from the fields of chemical materials,metallurgy and agriculture.Furthermore,a comparative evaluation of the various methods for CBSWs resource recovery is conducted,outlining their respective advantages and disadvantages.The future development of CBSWs recycling processes is also discussed.The review concludes that while there is a growing need for attention in CBSWs recycling,its utilization will involve a combination of both large-scale treatment and refinement processes.The paper aims to offer references and insights for the effective utilization and environmental protection of CBSWs.Future direction will focus on the collaborative utilization of CBSWs,emphasizing on the combination of large-scale and high-value utilization.In addition,there is a need to establish a comprehensive database based on on-site production practices,explore on-site solutions to reduce transportation costs,and improve physicochemical properties during the production process.
基金supported by the National Key Research and Development Program(No.2021YFD1300201)Jilin Provincial Department of Science and Technology Innovation Platform and Talent Special Project(No.20230508090RC).
文摘Background There is a growing focus on using various plant-derived agricultural by-products to increase the benefits of pig farming,but these feedstuffs are fibrous in nature.This study investigated the relationship between dietary fiber physicochemical properties and feedstuff fermentation characteristics and their effects on nutrient utilization,energy metabolism,and gut microbiota in growing pigs.Methods Thirty-six growing barrows(47.2±1.5 kg)were randomly allotted to 6 dietary treatments with 2 apparent viscosity levels and 3β-glucan-to-arabinoxylan ratios.In the experiment,nutrient utilization,energy metabolism,fecal microbial community,and production and absorption of short-chain fatty acid(SCFA)of pigs were investigated.In vitro digestion and fermentation models were used to compare the fermentation characteristics of feedstuffs and ileal digesta in the pig’s hindgut.Results The production dynamics of SCFA and dry matter corrected gas production of different feedstuffs during in vitro fermentation were different and closely related to the physical properties and chemical structure of the fiber.In animal experiments,increasing the dietary apparent viscosity and theβ-glucan-to-arabinoxylan ratios both increased the apparent ileal digestibility(AID),apparent total tract digestibility(ATTD),and hindgut digestibility of fiber components while decreasing the AID and ATTD of dry matter and organic matter(P<0.05).In addition,increasing dietary apparent viscosity andβ-glucan-to-arabinoxylan ratios both increased gas exchange,heat production,and protein oxidation,and decreased energy deposition(P<0.05).The dietary apparent viscosity andβ-glucanto-arabinoxylan ratios had linear interaction effects on the digestible energy,metabolizable energy,retained energy(RE),and net energy(NE)of the diets(P<0.05).At the same time,the increase of dietary apparent viscosity andβ-glucan-to-arabinoxylan ratios both increased SCFA production and absorption(P<0.05).Increasing the dietary apparent viscosity andβ-glucan-to-arabinoxylan ratios increased the diversity and abundance of bacteria(P<0.05)and the relative abundance of beneficial bacteria.Furthermore,increasing the dietaryβ-glucan-to-arabinoxylan ratios led to a linear increase in SCFA production during the in vitro fermentation of ileal digesta(P<0.001).Finally,the prediction equations for RE and NE were established.Conclusion Dietary fiber physicochemical properties alter dietary fermentation patterns and regulate nutrient utilization,energy metabolism,and pig gut microbiota composition and metabolites.
基金funded by National Natural Science Foundation of China(No.12172092,82174488,and 82305416)Shanghai Key Laboratory of Acupuncture Mechanism and Acupoint Function(No.21DZ2271800)+1 种基金Shanghai Municipal Science and Technology Commission(No.23YF1418300)Scientific Research Project on Traditional Chinese Medicine of Shanghai Municipal Health Commission—Youth Guidance Category(No.2022QN018).
文摘Objective The analgesic effect of acupuncture has been widely accepted.Nevertheless,the mechanism behind its analgesic effect remains elusive,thus impeding the progress of research geared toward enhancing the analgesic effect of acupuncture.This paper investigated the role of acupuncture needle surface textures on acupuncture’s analgesic effect by creating four experimental acupuncture needles with different patterns of surface augmentation.Methods Four types of acupuncture needles with different surface textures(the lined needle,circle needle,sandpaper needle,and threaded needle)were designed.Additionally,the force/torque measurement system used a robot arm and mechanical sensor to measure the force on the needle during insertion and manipulation.To perform acupuncture analgesia experiments,four experimental acupuncture needles and a normal needle were inserted into the Zusanli(ST36)acupoint of rats with inflammatory pain.By comparing the force and torque and the analgesic efficacy of the different acupuncture needles,these experiments tested the role of acupuncture needle body texture on acupuncture analgesia.Results The analgesic effects of different acupuncture needle body textures varied.Specifically,the force required to penetrate the skin with the lined needle was not greater than that for the normal needle;however,the needle with inscribed circles and the sandpaper-roughened needle both required greater force for insertion.Additionally,the torque of the lined needle reached 2×10^(-4)N·m under twisting manipulation,which was four times greater the torque of a normal needle(5×10^(-5)N·m).Furthermore,the lined needle improved pain threshold and mast cell degranulation rate compared to the normal needle.Conclusion Optimizing the texture of acupuncture needles can enhance acupuncture analgesia.The texture of our experimental acupuncture needles had a significant impact on the force needed to penetrate the skin and the torque needed to manipulate the needle;it was also linked to variable analgesic effects.This study provides a theoretical basis for enhancing the analgesic efficacy of acupuncture through the modification of needles and promoting the development of acupuncture therapy.
文摘BACKGROUND This is a randomized study to compare the diagnostic accuracy of endoscopic ultrasound(EUS)-guided sampling of pancreatic solid lesions obtained with the 22-gauge Franseen(EUS-fine needle biopsy)vs the 22-gauge standard needle(EUS-fine needle aspiration)without rapid onsite evaluation(ROSE),since,in most endoscopy units around the world ROSE is not routinely available.AIM To investigate the accuracy of EUS-guided sampling of pancreatic solid lesions obtained between two different needles without ROSE.METHODS Patients with a solid pancreatic were included.Patients were biopsied in a randomized order.The primary endpoint was the diagnostic sensitivity for pancreatic malignancy(PM).Secondary outcomes were adequacy of the sample,the mean tissue area,the mean tumor area,and the adverse event rate.RESULTS The final diagnosis was pancreatic adenocarcinoma in 38(76%),neuroendocrine tumor in 4(8%),chronic pancreatitis in 3(6%)patients.The sensitivity for PM with Franseen needle was 0.91[95%confidence interval(CI):0.80-0.98],vs 0.8(95%CI:0.67-0.91)(P=0.025)with standard needle.The specificity for PM did not differentiate.The accuracy of the standard needle for PM was 0.80(95%CI:0.66-0.90),and the Franseen group was 0.90(95%CI:0.78-0.97)(P=0.074).The technical success rates for the standard and Franseen needle groups were 94%(95%CI:0.83-0.99)and 100%(95%CI:0.92-1.00),respectively.The mean total tissue area in mm2(SD)was greater in the Franseen group,2.07(0.22)vs 1.16(0.17)(P<0.01).The mean tumor area in mm2(SD)was not different in Franseen group vs standard group,0.42(0.09)vs 0.47(0.09)(P=0.80).There were no adverse events.CONCLUSION The sensitivity for PM and mean total tissue area,was greater in the as compared with standard needle.The mean tumor area did not differ between the groups.
基金supported by the National Key Research and Development Program of China(2023YFD2100205)the Fujian Province Science and Technology Plan Project,China(2023N3008).
文摘With the rapid growth of the global population and the increasing demand for healthier diets,improving the nutrient utilization efficiency of staple food crops has become a critical scientific and industrial chal-lenge,prompting innovation in food processing technologies.This review introduces first the common nutritional challenges in the processing of staple food crops,followed by the comprehensive examination of research aiming to enhance the nutritional quality of staple food crop-based foods through innovative processing technologies,including microwave(MW),pulsed electric field(PEF),ultrasound,modern fer-mentation technology,and enzyme technology.Additionally,soybean processing is used as an example to underscore the importance of integrating innovative processing technologies for optimizing nutrient utilization in staple food crops.Although these innovative processing technologies have demonstrated a significant potential to improve nutrient utilization efficiency and enhance the overall nutritional pro-file of staple food crop-based food products,their current limitations must be acknowledged and addressed in future research.Fortunately,advancements in science and technology will facilitate pro-gress in food processing,enabling both the improvement of existing techniques as well as the develop-ment of entirely novel methodologies.This work aims to enhance the understanding of food practitioners on the way processing technologies may optimize nutrient utilization,thereby fostering innovation in food processing research and synergistic multi-technological strategies,ultimately providing valuable references to address global food security challenges.
基金financially supported by Wuxi Yanping Electronic Technology Co.Ltd.
文摘Semiconductor electronic devices are prone to charge accumulation during production and transportation,which usually causes device breakdown.Ionizers are widely used for electrostatic elimination,and utilizing semiconductor silicon for the discharge needle material in ionizers can effectively prevent metal contamination.To investigate the discharge characteristics of silicon needles and their mode modulation mechanism,this study has established an experimental platform for silicon needle-plate discharge under positive polarity voltage.Discharge pulse parameters and optical signals were measured at varying electrode spacings.The experimental results reveal that silicon needle discharge progresses through four regimes:the spontaneous streamer,the periodic streamer,the cluster streamer,and the glow discharge.Among these,the pulse amplitude is most uniform and stable in the periodic streamer regime.In addition,shorter-gap discharge exhibits higher pulse amplitude and repetition frequency but is easier to transition into the filament regime.The formation process of a single pulse is closely related to the field strength in the ionization region near the needle tip.Hence,parameters such as the pulse rising edge time and falling edge time show minimal variation with voltage.The amount of charge generated per unit time is primarily influenced by the repetition frequency.Consequently,the electrostatic ionizer produces the highest,most stable,and most uniform charges if it operates in the periodic streamer regime.
文摘The aim of this study is to develop an understanding on the contributing influences that occur among qualities of public space,public space aesthetics,the comfort derived in public space and public space accessibility in science cities.This study seeks to investigate the extent at which public space attributes impact on one another.The emphasis accruing to open greenery including public spaces in the physical development of science cities necessitates the selection of Cyberjaya Malaysia as the study area.Survey questionnaires were used to investigate potential respondent’s perceptions on public space utilization and the feedback was validated with SEM(structural equation modelling).The findings indicated that the accessibility attributes significantly influenced other public space utilization attributes while good quality of public space influenced the comfort derived from it.Attractiveness of public space was found not capable to predict the comfort and good quality of public space.
基金supported by a grant of the R&D Project through the Korea Health Industry Development Institute(KHIDI),funded by the Ministry of Health&Welfare,Republic of Korea(grant number:RS-2023-KH139376).
文摘Background:Patients with cancer are confronted not only with physical changes and pain but also with significant psychological challenges,including distress,anxiety,and depression,as a consequence of their diagnosis and treatment.This study aimed to identify the factors influencing anxiety or depression in patientswith cancer,examine the relationship between the duration since cancer diagnosis and psychological state,and explore the association between these factors and the use of Korean medicine(KM).Methods:This study utilized data from the 2018 Korea Health Panel spanning 2008 to 2018.The analysis focused on adult participants(aged 19 and above)diagnosed with cancer who responded to their psychological state(i.e.,anxiety or depression)and the duration since their cancer diagnosis.The dependent variables were the presence of anxiety or depression and the utilization of KM.Descriptive statistics and multiple logistic regression analysis were used to investigate factors influencing these variables.Results:A total of 773 participants were included in the final analysis,of whom 214 reported prior KM experience.Multiple logistic regression analysis indicated that the likelihood of experiencing anxiety or depression decreased as the duration since cancer diagnosis increased.Factors associated with anxiety or depression in patients with cancer included sex(odds ratio[OR]=2.06),number of chronic diseases(OR=1.17),Charlson Comorbidity Index score(CCI score of 2:OR=1.60),and EQ-5D(EuroQol Five Dimensions Questionnaire)index(OR<0.001).Cancer patients without anxiety or depression were more likely to use KM if they had been diagnosed within three years,were female(OR=2.11),and had a higher number of chronic conditions(OR=1.20).In contrast,patients with anxiety or depression were more likely to utilizeKMif theyhadbeendiagnosed formore thanfive years(OR=6.30)and resided in urban areas.Conclusions:The results suggest that patterns of KM utilization among patients with cancer are associated with their psychological state.Future research should focus on identifying direct correlations between psychological factors and KM use in patients with cancer.
文摘Purpose–This study is dedicated to systematically collating the distribution and utilization circumstances of geothermal resources in China.Moreover,it endeavors to formulate a comprehensive utilization scheme for geothermal resources during the construction and operation phases of the railway,thereby furnishing robust support and valuable reference for the holistic utilization of geothermal resources along the railway corridor.Design/methodology/approach–Through an in-depth analysis of the extant utilization of geothermal resources in China,it is discerned that the current utilization modalities are relatively rudimentary,bereft of rational planning and characterized by a low utilization rate.Concurrently,by integrating the practical requisites of railway construction and operation and conducting theoretical dissections,a comprehensive utilization plan for the construction and operation periods of railway is proffered.Findings–In light of the railway’s construction and operation characteristics,geothermal utilization models are categorized.During construction,comprehensive modalities include tunnel illumination power generation,construction area heating,tunnel antifreeze using shallow geothermal energy,tunnel pavement antifreeze and construction concrete maintenance.During operation,they comprise operation tunnel antifreeze,railway roadbed antifreeze,railway switch snow melting and deicing,geothermal power station establishment and railway hot spring health tourism planning.Originality/value–According to the characteristics and actual needs of railway construction and operation,it is of great significance to rationally utilize geothermal resources to promote the construction and operation of green railways.
基金financially supported by the Zhejiang Provincial Natural Science Foundation of China under Grant No.LQ24E060001the National Key Research and Development Project(2023YFC3710800)+2 种基金the National Natural Science Foundation of China under Grant No.52341602supported by funding from the Canada First Research Excellence Fund(CFRER-2015-00001)the University of Alberta’s Future Energy Systems research initiative(FES-T02-P03)。
文摘Tantalum nitride is widely considered as a promising photoanode material for its suitable band structure as well as the high theoretical conversion efficiency in solar water splitting.However,it is limited to inefficient photoinduced electron–hole pair separation and interfacial dynamics in the photoelectrochemical oxygen evolution reaction.Herein,multiple layers including Ti_(x)Si_(y) and NiFeCoO_(x) were fabricated based on band engineering to regulate tandem electric states for efficient transfer of energy carriers.Besides,photothermal local surface plasmon resonance was introduced to accelerate the kinetics of photoelectrochemical reactions at the interface when the special Ag nanoparticles were loaded to extend the absorbance to near infrared light.Consequently,a recordable photocurrent density of 12.73 mA cm^(-2) has been achieved at 1.23 V versus RHE,approaching a theoretical limit of the tantalum nitride photoanode with full-spectrum solar utilization.Meanwhile,compared to the applied bias photon-to-current efficiency of 1.36%without photothermal factor,a high applied bias photonto-current efficiency of 2.27%could be raised by applying local surface plasmon resonance to photoelectrochemical oxygen evolution reaction.The efficient design could maximize the use of solar light via the classification of spectrum and,therefore,may spark more innovative ideas for the future design and development of the next-generation photoelectrode.
文摘Objective: To explore the effectiveness of applying an infusion project team in the safety risk management of indwelling needle use. Methods: A total of 200 patients who used intravenous indwelling needles during hospital treatment from July to October 2022 were selected and randomly divided into an observation group and a control group, with 100 patients in each group. Patients in the control group received routine nursing methods, while those in the observation group were managed using the safety risk management method of the infusion project team. The tube blocking rate and tube removal rate were compared between the two groups. Results: The one-time puncture success rate and the standard implementation rate of intravenous indwelling needle use in the observation group were significantly higher than those in the control group. The total incidence of complications in the observation group was significantly lower than that in the control group, and patient satisfaction in the observation group was notably higher, with statistically significant differences (P < 0.05). Conclusion: The application of an infusion project team in the safety risk management of indwelling needle use is effective and has positive impacts on improving the one-time puncture success rate, the standard implementation rate of intravenous indwelling needle use, and patient satisfaction. It is a practice worth promoting in clinical settings.
文摘BACKGROUND There is increasing incidence of alcohol-associated liver disease in females.Despite this recent increased incidence,there is a paucity of research on the clinical course and outcomes of alcohol-associated hepatitis(AH)in females compared to males.AIM To assess if there may be sex differences in severity,outcomes,and healthcare utilization for patients hospitalized for AH.METHODS This study used ICD-9-CM and ICD-10-CM codes to retrospectively identify inpatient encounters for AH at the University of Kentucky from 2012-2021 and obtained data on patient demographics and clinical outcomes.Encounters were cohorted by patient sex and differences in patient demographics and clinical outcomes were assessed.Multivariate logistic regression models were constructed to assess risk of mortality,sepsis,and mechanical ventilation during the encounter.RESULTS Of 1386 subjects,511(36.9%)were female and 875(63.1%)were male.Both sexes had similar baseline characteristics of race/ethnicity,discriminant function score,model of end-stage liver disease score,and length of hospital stay.However,the incidence of urinary tract infection,sepsis,and norepinephrine administration was significantly higher for females.Males had a significantly higher incidence of esophageal variceal bleed.On multivariate logistic regression analysis,females had higher odds of encounter sepsis(OR 1.41;95%CI:1.064-1.869)and mechanical ventilation(OR 1.352;95%CI:1.006-1.816).Odds of encounter mortality were significantly increased in encounters with sepsis(OR 2.309;95%CI:1.419-3.757)and mechanical ventilation(OR 9.301;95%CI:5.724-15.114).CONCLUSION This study shows sex-based differences in AH outcomes at the University of Kentucky.Future studies are warranted to assess whether tailoring treatments will improve clinical outcomes in females with AH.
基金supported by the National Natural Science Foundation of China(Nos.52107126 and52077179)the Key Regional Innovation and Development Joint Fund Project(No.2023YFB2303901)the funding of Chengdu Guojia Electrical Engineering Co.,Ltd.(No.NEEC-2022-B11).
文摘The regenerative braking energy utilization system(RBEUS)stands as a promising technique for improving the efficiency and power quality of electrified railways.Beyond the vital aspects of energy management and control strategies,ensuring fault protection is paramount for the secure and steady operation of the traction power supply system(TPSS)integrated with RBEUS.This paper introduces an innovative protection scheme tailored to diverse RBEUS application scenarios.Firstly,fault categories are streamlined into three levels:system,equipment,and warning.Subsequently,a novel multi-port active power differential protection method,aligned with RBEUS operational principles,is crafted to serve as a comprehensive and sensitive main protection.Building upon this foundation,a hierarchical protection structure for RBEUS is established,addressing the intricacies and variations in fault types while boosting anti-disturbance capabilities under faulty conditions.Embracing the principle of railway-oriented safety,a collaborative RBEUS-TPSS protection scheme is put forth.Finally,through simulated scenarios encompassing various fault conditions,the proposed scheme’s feasibility and effectiveness are convincingly validated.
基金Material Parts Technology Development Program (20017461, Development and Performance Improvement of Air Operated Valve for 105 MPa Hydrogen Charging Station) funded by the Ministry of Trade,Industry and Energy(MOTIE, Republic of Korea)Korea Evaluation Institute of Industrial Technology (KEIT, Republic of Korea)+1 种基金financial support from the Korea Institute of Energy Technology Evaluation and Planning (KETEP)Ministry of Trade,Industry&Energy (MOTIE) of the Republic of Korea(RS-2024-00419764)。
文摘Lignocellulosic biomass is one of the viable solutions to alleviate the global warming. However, the limited utilization of biomass majorly focused on cellulose and hemicellulose restricts the economic and environmental feasibilities. To cope with this issue, we proposed an integrated process of co-producing 1,6-hexanediol(1,6-HDO) with tetrahydrofuran and adipic acid from biomass, referred to as Strategy A. To compare the impacts of lignin upgrading and feedstock, Strategy B, which co-produces tetrahydrofuran alone, and Strategy C, which is the traditional route to produce 1,6-HDO from fossil fuels, were used. Heat networks are also designed to reduce operating costs and indirect carbon emissions due to energy consumption, saving 87% and 83% of the heat and cooling requirements, respectively, in Strategy A. The market competitiveness of Strategy A was evaluated by determining the minimum selling price through techno-economic analysis, and sustainability was thoroughly investigated by quantifying the environmental impacts through both midpoint and endpoint life-cycle assessments(LCAs).Strategy A was found to be the most favorable both economically(USRDSCHARDOLLAR3,402/ton) and environmentally(-26.9 kg CO_(2)eq.). This indicates that lignin valorization is not only economically but also environmentally preferred. Finally, changes in economic and environmental feasibilities depending on economic, process, and environmental parameters were investigated using sensitivity and uncertainty analyses. The results of these analyses provide valuable insight into bio-based chemical production.
基金Scientific Research Funding Project of Educational Department of Liaoning Province in 2021(LJKZ1243).
文摘[Objectives] To evaluate the utilization and application value of vine plant resources,and enrich the urban vertical greening landscape.[Methods] Route survey and sample plot observation methods were employed to investigate 96 greening sites in Shenyang area,China.[Results] There are 21 species of vines used in vertical greening,including 15 species of woody vines and 6 species of herbaceous vines.According to the biological characteristics of vine plants and the actual needs of vertical application in landscape greening,a comprehensive evaluation system with one target layer,three criterion layers and a total of 14 indicators was constructed,and the application value of 21 species of vines was evaluated.Based on the comprehensive evaluation value,the vine plants were divided into four grades,and four of them had good application prospects and could be used in urban vertical greening.[Conclusions] The evaluation model and evaluation results will provide a theoretical basis for the rational use of vine plant resources.
基金Supported by The Fourth Batch of High-end Talent Project in Hebei ProvinceAgricultural Science and Technology Achievement Promotion Project in Hebei Province(JNK 24083).
文摘In order to further promote the chestnut industrial chain,a large number of chestnut byproducts(chestnut leaves,chestnut shells,chestnut flowers,etc.)are produced every year.These chestnut byproducts will be comprehensively developed and utilized in different degrees,such as in-depth research and development in the fields of animal husbandry,agriculture,and cosmetics,so as to achieve the effects of accelerating the high-quality development of chestnut industry,realizing the green cycle of resources,reducing waste and promoting the development of rural industries.
基金Open Project of Shanghai Key Laboratory of Lightweight Composite,China(No.2232021A4-04)。
文摘Double-shaft-driven needle punching machine is a specialized equipment designed for processing C/C crucible preforms.Its main needle punching module is operated by two sets of reciprocating crank-slider mechanisms.The intense vibration during needle punching not only generates huge noise,but also substantially reduces the quality of the preform.It is imperative to perform a dynamic analysis and optimization of the entire needle punching machine.In this paper,the three-dimensional(3D)model of the entire double-shaft-driven needle punching machine for C/C crucible preforms is established.Based on the modal analysis theory,the modal characteristics of the needle punching machine under various operating conditions are analyzed and its natural frequencies and vibration modes are determined.The harmonic response analysis is then employed to obtain the amplitude of the needle plate at different frequencies,and the structural weak points of the needle punching machine are identified and improved.The feasibility of the optimized scheme is subsequently reevaluated and verified.The results indicate that the first six natural frequencies of the machine increase,and the maximum amplitude of the needle plate decreases by 70.3%.The enhanced dynamic characteristics of the machine significantly improve its performance,enabling more efficient needle punching of C/C crucible preforms.
基金Suppoorted by Sichuan Provincial Administration of Traditional Chinese Medicine Key Project of Scientific Research in Traditional Chinese Medicine:Deep Learning-based Three-dimensional Finite Element Analysis of Pestle Needle Therapy for the Treatment of Cervical Spine Physiologic Curvature Abnormalities(2023zd025)Scientific Research Project of Sichuan Provincial Science and Technology Department:Improvement of cartilage Degeneration in Knee Osteoarthritis by Regulating Zn^(2+)Homeostasis via Autophagy in Duhuo Jisheng Decoction(23NFSC2298)。
文摘OBJECTIVE:To investigate the effect of pestle needle therapy(PNT)on the posterior cervical muscle(PCM)in a rabbit model of cervical spondylosis(CS)and explore the underlying mechanisms.METHODS:Rabbits were divided into control,CS modelsⅠandⅡ(CS1 and CS2),electroacupuncture(EA),PNTⅠandⅡ(PN1 and PN2),activator(AVT),and PNT combined with activator(C-AVT)groups.A long-term neck immobilization technique was used to establish a rabbit model of CS.Following completion of modeling,the EA group received electroacupuncture intervention,whereas the CS1,CS2,and C-AVT groups received PNT intervention.The AVT and C-AVT groups received local 740 Y-P injections into the PCM daily.The inflammatory injury to PCM was evaluated based on pain threshold,morphological changes,and interleukin(IL)-1β,IL-6,and tumor necrosis factor(TNF)-αlevels.PCM fibrosis was evaluated by measuring the positive area(PA)of collagen fibrils(CFs)and collagen type 1 alpha 1(Col1α1)using Masson's and immunohistochemical staining.Terminal deoxynucleotidyl transferase-mediated d UTP nick-end labeling assay and transmission electron microscopy were used to identify apoptotic cells and assess autophagy,respectively.Western blotting was used to determine B-cell lymphoma-2(Bcl-2),Bcl-2 associated X protein(Bax),cysteine aspartate-specific protease(caspase)-3,sequestosome-1(P62),microtubuleassociated protein light chain 3(LC3-Ⅰ/Ⅱ),phosphatidylinositol 3-kinase(PI3K),protein kinase B(AKT),and mammalian target of rapamycin(mTOR)levels.Real-time quantitative polymerase chain reaction was used to determine mRNA expression levels of PI3K,AKT,mTOR,autophagy protein(ATG),and ATG7.RESULTS:PNT alleviated PCM cell degeneration and necrosis,inhibited inflammatory cell infiltration,decreased IL-1β,IL-6,and TNF-αlevels,and decreased the PA of CFs and Col1α1.In the PN1 group,cell apoptosis in the PCM decreased,autophagy increased,Bcl-2 and LC3-Ⅱ/Ⅰlevels increased,Bax,Caspase-3,and P62 levels decreased,and the mRNA expression of ATG5 and ATG7 increased.PNT inhibits protein and mRNA expression of PI3K,AKT,and mTOR.Finally,the trend in the results of the rescue experiment was consistent with previous results.CONCLUSION:PNT inhibited apoptosis and promoted autophagy of PCM cells in CS rabbits and alleviated inflammation and fibrosis injury of PCM by inhibiting the PI3K/AKT/mTOR pathway.
基金supported by Research Fund for the Doctoral Program of Higher Education of China(20134420120009)Science and Technology Planning Project of Guangdong(2014A010105047)Science and Technology Planning Project of Guangzhou City(201707010367).
文摘Under the background of the current energy crisis and environmental pollution,the development of green and sustainable materials has become particularly urgent.As one of the most abundant natural polymers on earth,cellulose has attracted wide attention due to its green recycling,sustainable development,degradability,and low cost.Therefore,cellulose and its derivatives were used as the starting point for comprehensive analysis.First,the basic structural properties of cellulose were discussed,and then the extraction and utilization methods of cellulose were reviewed,including Sodium Hydroxide based solvent system,N,N-Dimethylacetamide/Lithium Chloride System,N-Methylmorpholine-N-Oxide(NMMO)system,ionic liquids(ILs)system,and deep eutectic solvent(DES)system.Then,the functional modification techniques of cellulose are introduced,including nano-modification,small molecule modification,and macromolecular modification.Finally,the potential applications of cellulose in the fields of reinforcement materials,self-healing materials,radioactive cooling,nanogenerators,and biomedicine were discussed.At the end of this paper,the challenges and future development direction of cellulose materials are prospectively analyzed,aiming at providing guidance and inspiration for the research and application in related fields.
基金supported by the National Key Research and Development Program of China (2021YFD1901200)the Key Research and Development Program of Hubei Province of China (2023BBB028)+1 种基金the Earmarked Fund of Hubei province of Chinathe Fundamental Research Funds for the Central Universities (2662024ZKQD005)
文摘The effects of micro-ridge-furrow planting(MR)on yield and the efficiency of light,water,and thermal resource use in rapeseed were tested in a three-year field experiment comparing MR to conventional flat planting.MR enhanced canopy heterogeneity by altering the leaf angle between plants on ridges and furrows.The heterogeneous canopy environment increased intercepted photosynthetic active radiation,alleviated canopy temperature stress,and optimized canopy humidity,leading to improvements in light-nitrogen matching and net photosynthetic rate.Consequently,dry matter and yield increased by 13.0%and 11.0%,respectively,while radiation,thermal,and precipitation utilization efficiency increased by 12.3%-16.2%.The corresponding improvements in yield and resource use efficiency were attributed to a heterogeneous canopy environment that improved microclimatic conditions.
