Kansu （KS） profile is located in the east of Yili basin, western Xinjiang, where typical loess sediments are distributed. The magnetic parameters （such as IRM, SIRM SOFT, and M） and grain size in the KS profile we...Kansu （KS） profile is located in the east of Yili basin, western Xinjiang, where typical loess sediments are distributed. The magnetic parameters （such as IRM, SIRM SOFT, and M） and grain size in the KS profile were analyzed in the study. The results showed that the magnetic property of KS loess is dominated by ferrimagnetic minerals, such as magnetite and maghemite. Antiferromagnetic and superparamagnetic minerals also exist in the profile, but had less impact on magnetic susceptibility. Compared with the typical loess sediments of the central Loess Plateau in China, the strata of Kansu profile contained more magnetic minerals and hard magnetic minerals. The analysis of grain size for magnetic minerals indicated that the properties of loess and paleosol were respectively dominated by PSD/MD and coarse SSD magnetite. The research found that the contents of magnetic minerals in loess and paleosol sequences in Kansu profile were similar, but the proportion of fine grained magnetite and soft magnetic minerals were varying, which implies a positive relationship between the value of magnetic susceptibility and intensity of pedogenesis.展开更多
Considering the actual magnetic field configuration in a Hall thruster, the effect of magnetic mirror on the radial profile of near-wall conductivity （NWC） is studied in this paper. The plasma electron dynamic proce...Considering the actual magnetic field configuration in a Hall thruster, the effect of magnetic mirror on the radial profile of near-wall conductivity （NWC） is studied in this paper. The plasma electron dynamic process is described by the test particle method. The Monte Carlo scheme is used to solve this model. The radial profile of electron mobility is obtained and the role of magnetic mirror in NWC is analysed both theoretically and numerically. The numerical results show that the electron mobility peak due to NWC is inversely proportional to the magnetic mirror ratio and the asymmetry of electron mobility along the radial direction gets greater when the magnetic mirror is considered. This effect indicates that apart from the disparity in the magnetic field strength, the difference in the magnetic mirror ratio near the inner and outer walls would actually augment the asymmetry of the radial profile of NWC in Hall thrusters.展开更多
Due to long-term water injection,often oilfields enter the so-called medium and high water cut stage,and it is difficult to achieve good oil recovery and water reduction through standard methods(single profile control...Due to long-term water injection,often oilfields enter the so-called medium and high water cut stage,and it is difficult to achieve good oil recovery and water reduction through standard methods(single profile control and flooding measures).Therefore,in this study,a novel method based on“plugging,profile control,and flooding”being implemented at the same time is proposed.To assess the performances of this approach,physical simulations,computer tomography,and nuclear magnetic resonance are used.The results show that the combination of a gel plugging agent,a polymer microsphere flooding agent,and a high-efficiency oil displacement agent leads to better results in terms of oil recovery with respect to the situation in which these approaches are used separately(the oil recovery is increased by 15.37%).Computer tomography scan results show that with the combined approach,a larger sweep volume and higher oil washing efficiency are obtained.The remaining oil in the cluster form can be recovered in the middle and low permeability layer,increasing the proportion of the columnar and blind end states of the oil.The nuclear magnetic resonance test results show that the combined“plugging,profile control,and flooding”treatment can also be used to control more effectively the dominant channels of the high permeability layer and further expand the recovery degree of the remaining oil in the pores of different sizes in the middle and low permeability layers.However,for the low permeability layer(permeability difference of 20),the benefits in terms of oil recovery are limited.展开更多
The resonant magnetic perturbation （RMP） coils have been successfully designed and installed on the Experimental Advanced Superconducting Tokamak （EAST）. Using the reflectometer systems, the density profile and th...The resonant magnetic perturbation （RMP） coils have been successfully designed and installed on the Experimental Advanced Superconducting Tokamak （EAST）. Using the reflectometer systems, the density profile and the density fluctuations during magnetic perturbations （MPs） phase have been investigated. During the experiments, two different cases are studied separately： steady MPs and rotating MPs. In both cases, a strongly density pump-out has been observed. In the steady MPs cases, an enhancement of the low frequency （〈60 kHz） density fluctuations in H-mode phase has been observed. The plasma density boundary out-shifts 5~ caused by the MPs. The pedestal density gradient is reduced by 50%, while the radial location nearly stays unchanged. In the rotating MPs, the line-averaged density, the D~ emission at the divertor region and the spectrum of the density fluctuations are modulated. The results suggest that the low frequency （〈60 kHz） density fluctuations may contribute to the strong density pump-out.展开更多
BACKGROUND Down syndrome(DS)is one of the most common causes of intellectual disability.Children with DS have varying intelligence quotient(IQ)that can predict their learning abilities.AIM To assess the brain metaboli...BACKGROUND Down syndrome(DS)is one of the most common causes of intellectual disability.Children with DS have varying intelligence quotient(IQ)that can predict their learning abilities.AIM To assess the brain metabolic profiles of children with DS and compare them to standard controls,using magnetic resonance spectroscopy(MRS)and correlating the results with IQ.METHODS This case-control study included 40 children with DS aged 6-15 years and 40 age and sex-matched healthy children as controls.MRS was used to evaluate ratios of choline/creatine(Cho/Cr),N-acetyl aspartic acid/creatine(NAA/Cr),and myoinositol/creatine(MI/Cr(in the frontal,temporal,and occipital lobes and basal ganglia and compared to controls and correlated with IQ.RESULTS Children with DS showed significant reductions in NAA/Cr and MI/Cr and a non-significant reduction in Cho/Cr in frontal lobes compared to controls.Additionally,we observed significant decreases in NAA/Cr,MI/Cr,and Cho/Cr in the temporal and occipital lobes and basal ganglia in children with DS compared to controls.Furthermore,there was a significant correlation between IQ and metabolic ratios in the brains of children with DS.CONCLUSION Brain metabolic profile could be a good predictor of IQ in children with DS.展开更多
Quasi-hemispherical magnetized collisionless shocks have been generated at the SG-II laser facility through the interaction between a laserproduced supersonic plasma flow and a magnetized ambient plasma,exhibiting an ...Quasi-hemispherical magnetized collisionless shocks have been generated at the SG-II laser facility through the interaction between a laserproduced supersonic plasma flow and a magnetized ambient plasma,exhibiting an angular asymmetric shock profile accompanied by asymmetric ion acceleration.We have conducted test particle simulations using the electromagnetic fields derived from 2D MHD simulations to investigate the asymmetry of ion acceleration.The simulations reproduce the angular asymmetry of the shock and the ion acceleration observed in experiments.The results indicate that shock drift acceleration is the primary mechanism for ion energization in the present quasiperpendicular magnetized shock.The asymmetric shock structure caused by nonuniform ambient plasma forms an asymmetric accelerated electric field,ultimately leading to angular asymmetric ion acceleration,which is consistent with space observations and our experimental results.Our study provides a plausible explanation for the discrepancies reported in previous ion acceleration experiments,and could contribute to understanding of the collisionless shock acceleration.展开更多
Astragali Radix(AR) is one of the most popular herbal medicines in traditional Chinese medicine(TCM). Wild AR is believed to be of high quality, and substitution with cultivated AR is frequently encountered in the mar...Astragali Radix(AR) is one of the most popular herbal medicines in traditional Chinese medicine(TCM). Wild AR is believed to be of high quality, and substitution with cultivated AR is frequently encountered in the market. In the present study, two types of ARs(wild and cultivated) from Astragalus membranaceus(Fisch.) Bge. and A. membranaceus var. mongholicus(Bge.) Hsiao, growing in different regions of China, were analyzed by NMR profiling coupled with multivariate analysis. Results showed that both could be differentiated successfully and cultivation patterns or growing years might have greater impact on the metabolite compositions than the variety; the metabolites responsible for the separation were identified. In addition, three extraction methods were compared and the method(M1) was used for further analysis. In M1, the extraction solvent composed of water, methanol, and chloroform in the ratio of 1 : 1 : 2 was used to obtain the aqueous methanol(upper layer) and chloroform(lower layer) fractions, respectively, showing the best separation. The differential metabolites among different methods were also revealed. Moreover, the sucrose/glucose ratio could be used as a simple index to differentiate wild and cultivated AR. Meanwhile, the changes of correlation pattern among the differential metabolites of the two varieties were found. The work demonstrated that NMR-based non-targeted profiling approach, combined with multivariate statistical analysis, can be used as a powerful tool for differentiating AR of different cultivation types or growing years.展开更多
AIM: To establish if a distinct urinary metabolic profile could be identified in Bangladeshi hepatitis-B hepatocellular carcinoma (HCC) patients compared to cirrhosis patients and controls.METHODS: Urine samples from ...AIM: To establish if a distinct urinary metabolic profile could be identified in Bangladeshi hepatitis-B hepatocellular carcinoma (HCC) patients compared to cirrhosis patients and controls.METHODS: Urine samples from 42 Bangladeshi patients with HCC (39 patients with hepatitis-B HCC), 47 with cirrhosis on a background of hepatitis B, 46 with chronic hepatitis B, and seven ethnically-matched healthy controls were analyzed using nuclear magnetic resonance (NMR) spectroscopy. A full dietary and medication history was recorded for each subject. The urinary NMR data were analyzed using principal component analysis (PCA) and orthogonal partial least squared discriminant analysis (OPLS-DA) techniques. Differences in relative signal levels of the most discriminatory metabolites identified by PCA and OPLS-DA were compared between subject groups using an independent samples Kruskal-Wallis one-way analysis of variance (ANOVA) test with all pairwise multiple comparisons. Within the patient subgroups, the Mann-Whitney U test was used to compare metabolite levels depending on hepatitis B e-antigen (HBeAg) status and treatment with anti-viral therapy. A Benjamini-Hochberg adjustment was applied to acquire the level of significance for multiple testing, with a declared level of statistical significance of P < 0.05.RESULTS: There were significant differences in age (P < 0.001), weight (P < 0.001), and body mass index (P < 0.001) across the four clinical subgroups. Serum alanine aminotransferase (ALT) was significantly higher in the HCC group compared to controls (P < 0.001); serum α-fetoprotein was generally markedly elevated in HCC compared to controls; and serum creatinine levels were significantly reduced in the HCC group compared to the cirrhosis group (P = 0.004). A three-factor PCA scores plot showed clustering of the urinary NMR spectra from the four subgroups. Metabolites that contributed to the discrimination between the subgroups included acetate, creatine, creatinine, dimethyamine (DMA), formate, glycine, hippurate, and trimethylamine-N-oxide (TMAO). A comparison of relative metabolite levels confirmed that carnitine was significantly increased in HCC; and creatinine, hippurate, and TMAO were significantly reduced in HCC compared to the other subgroups. HBeAg negative patients showed a significant increase in creatinine (P = 0.001) compared to HBeAg positive patients in the chronic hepatitis B subgroup, whilst HBeAg negative patients showed a significant decrease in DMA (P = 0.004) in the cirrhosis subgroup compared to HBeAg positive patients. There were no differences in metabolite levels in HCC patients who did or did not receive antiviral treatment.CONCLUSION: Urinary NMR changes in Bangladeshi HCC were identified, corroborating previous findings from Egypt and West Africa. These findings could form the basis for the development of a cost-effective HCC dipstick screening test.展开更多
Numerical simulation of the effect of the anode magnetic shielding on the magnetic field and ion beam in a cylindrical Hall thruster is presented. The results show that after the anode is shielded by the magnetic shie...Numerical simulation of the effect of the anode magnetic shielding on the magnetic field and ion beam in a cylindrical Hall thruster is presented. The results show that after the anode is shielded by the magnetic shield, the magnetic field lines near the anode surface are obviously convex curved, the ratio of the magnetic mirror is enhanced, the width of the positive magnetic field gradient becomes larger than that without the anode magnetic shielding, the radial magnetic field component is enhanced, and the discharge plasma turbulence is reduced as a result of keeping the original saddle field profile and the important role the other two saddle field profiles play in restricting electrons. The results of the particle in cell （PIC） numerical simulation show that both the ion number and the energy of the ion beam increase after the anode is shielded by the magnetic shield. In other words, the specific impulse of the cylindrical Hall thruster is enhanced.展开更多
Although the water-soluble metabolite profile of human mesenchymal stem cells is known, the lipid profile still needs further investigation. In this study, methanol-chloroform was used to extract lipid-soluble metabol...Although the water-soluble metabolite profile of human mesenchymal stem cells is known, the lipid profile still needs further investigation. In this study, methanol-chloroform was used to extract lipid-soluble metabolites and perchloric acid was used to extract water-soluble metabolites. Fur- thermore, a dual phase extraction method using methanol-chloroform and water was used to obtain both water and lipid fractions simultaneously. All metabolite extractions were analyzed on a 9.4T high-resolution nuclear magnetic resonance spectrometer. Metabolite resonance peaks were as- signed in the acquired spectra according to the chemical shift, and the extraction efficiency of dif- ferent methods was compared. Results showed that in the spectra of water-soluble extracts, major metabolites comprised low molecular weight metabolites, including lactate, acetic acid, fatty acids, threonine, glutamic acid, creatine, choline and its derivatives, while in the spectra of lipid-soluble extracts, most metabolites were assigned to fatty acids. Among the different extraction procedures, perchloric acid was more efficient in extracting water-soluble metabolites and methanol-chloroform was efficient in extracting organic components compared with the dual phase extraction method. Nuclear magnetic resonance spectroscopy showed that as low as 0.7 mg organic yield was enough to obtain clear resonance peaks, while about 6.0 mg water-soluble yield was needed to obtain rela- tively favorable spectral lines. These results show that the efficiency of extracting water and lipid fractions is higher using perchloric acid and methanol-chloroform compared with dual phase ex- traction and that nuclear magnetic resonance spectroscopy is highly sensitive for analyzing lipid-soluble extracts.展开更多
One of the measurement geophysical methods to investigate kimberlite pipes is by using the magnetic method. The acquired field data in this study uses <span style="font-family:Verdana;">two proton-prec...One of the measurement geophysical methods to investigate kimberlite pipes is by using the magnetic method. The acquired field data in this study uses <span style="font-family:Verdana;">two proton-precession magnetometers for the mapping of magnetic anomalies</span><span style="font-family:Verdana;"> due to kimberlites. Three different magnetic maps are obtained from the result of total magnetic field data processing on Oásis Montaj software programme. These maps include magnetic anomaly maps through statistical analyses, total magnetic field intensity map and map of the analytic signal. Based on the interpretation of these maps a structure is identified with SWW-NEE directions in which magnetic signatures that indicate the presence of kimberlite pipes are observed. As the interpretation of the magnetic anomalies is a complicated process due to their dipolar nature, the analytic signal is generated, where is possible to observe the typical shape of these anomalies.</span>展开更多
Up to now, exact measurements of chromospheric magnetic fields have not been as successful as those done in the photosphere. We are currently engaging in diagnostics of chromospheric magnetic fields with the Mg b2 lin...Up to now, exact measurements of chromospheric magnetic fields have not been as successful as those done in the photosphere. We are currently engaging in diagnostics of chromospheric magnetic fields with the Mg b2 line by employing the Multi-Channel Solar Telescope at Huairou Solar Observing Station. Therefore, how to improve accuracy in the measurement is the main issue of our present study. To this end, we first study linear calibration coefficients for longitudinal and transverse components of chromospheric fields, which vary with wavelength, in the case of a weak field assumption. Then the polarization crosstalk introduced by instruments is analyzed in detail with two numerical simulation methods. Comparisons of the po- larization signals between cases with and without correction are presented. The result indicates that polarization accuracy is greatly improved after crosstalk correction.展开更多
A set of two-dimensional Stokes spectral data of NOAA AR 10197 obtained by the Solar Stokes Spectral Telescope （S^3T） at the Yunnan Observatory are quafitatively analyzed. The three components of the vector magnetic...A set of two-dimensional Stokes spectral data of NOAA AR 10197 obtained by the Solar Stokes Spectral Telescope （S^3T） at the Yunnan Observatory are quafitatively analyzed. The three components of the vector magnetic field, the strength H, inclination 7 and azimuth X, are derived. Based on the three components, we contour the distributions of the longitudinal magnetic field and transverse magnetic field. The active region （AR） has two different magnetic polarities apparent in the longitudinal magnetic map due to projection effect. There is a basic agreement on the longitudinal magnetic fields between the S^3T and SOHO/MDI magnetograms, with a correlation coefficient PBl = 0.911. The transverse magnetic field of the AR has a radial distribution from a center located in the southwest of the AR. It is also found that the transverse magnetic fields obtained by Huairou Solar Observing Station （HRSOS） have a similar radial distribution. The distributions of transverse magnetic field obtained by S^3T and HRSOS have correlation coefficients, PAzimu = 0.86 and PBt =0.883, in regard to the azimuthal angle and intensity.展开更多
Intracranial incidental findings on magnetic resonance imaging(MRI)of the brain continue to generate interest in healthy control,research,and clinical subjects.However,in clinical practice,the discovery of incidental ...Intracranial incidental findings on magnetic resonance imaging(MRI)of the brain continue to generate interest in healthy control,research,and clinical subjects.However,in clinical practice,the discovery of incidental findings acts as a"distractor".This review is based on existing heterogeneous reports,their clinical implications,and how the results of incidental findings influence clinical management.This draws attention to the followings:(1)the prevalence of clinically significant incidental findings is low;(2)there is a lack of a systematic approach to classification;and discusses(3)how to deal with the detected incidental findings based a proposed common clinical profile.Individualized neurological care requires an active discussion regarding the need for neuroimaging.Clinical significance of incidental findings should be decided based on lesion's neuroradiologic characteristics in the given clinical context.Available evidence suggests that the outcome of an incidentally found"serious lesion in children"is excellent.Future studies of intracranial incidental findings on pediatric brain MRI should be focused on a homogeneous population.The study should address this clinical knowledge based review powered by the statistical analyses.展开更多
Ground magnetic, ground penetrating radar (GPR), and dipole-dipole resistivity were carried out to environmentally investigate a landfill. In this context, these geophysical techniques were conducted to identify the s...Ground magnetic, ground penetrating radar (GPR), and dipole-dipole resistivity were carried out to environmentally investigate a landfill. In this context, these geophysical techniques were conducted to identify the subsurface contents of the landfill, furthermore, specify any possible leakage and/or contamination in the study area. The ground-magnetic survey carried out in the study area comprised 31 profiles each 120 m in length. Different wavelength filters were applied to the measured data. Vertical derivative, downward continuation, apparent susceptibility, band-pass, and analytical signal filters separated successfully the shallow sources. Whereas, upward continuation and low-pass Gaussian filters isolated significantly the deep magnetic sources. 3D Euler deconvolution (SI = 3) remarkably estimated the depths of the shallow sources (0 - 10 m) of the landfill contents. The conducted GPR and dipole-dipole resistivity allocated tangibly the locations and depths of the near surface anomalies. Both techniques didn’t reveal any possible leakage and/or contamination. Noteworthy, integration among magnetic, GPR, and dipole-dipole resistivity confirmed positively the results of each method. Nevertheless, some anomalies were recognized successfully by one technique and not by the others.展开更多
基金funded by the National 973 Project (2009CB421308)the Natural Science Foundation of China (40871080 and 90502008)
文摘Kansu （KS） profile is located in the east of Yili basin, western Xinjiang, where typical loess sediments are distributed. The magnetic parameters （such as IRM, SIRM SOFT, and M） and grain size in the KS profile were analyzed in the study. The results showed that the magnetic property of KS loess is dominated by ferrimagnetic minerals, such as magnetite and maghemite. Antiferromagnetic and superparamagnetic minerals also exist in the profile, but had less impact on magnetic susceptibility. Compared with the typical loess sediments of the central Loess Plateau in China, the strata of Kansu profile contained more magnetic minerals and hard magnetic minerals. The analysis of grain size for magnetic minerals indicated that the properties of loess and paleosol were respectively dominated by PSD/MD and coarse SSD magnetite. The research found that the contents of magnetic minerals in loess and paleosol sequences in Kansu profile were similar, but the proportion of fine grained magnetite and soft magnetic minerals were varying, which implies a positive relationship between the value of magnetic susceptibility and intensity of pedogenesis.
基金supported by Changjiang Scholars and Innovative Research Team in University of China (PCSIRT)(No.IRT0520)National Natural Science Foundation of China (No.60671012)
文摘Considering the actual magnetic field configuration in a Hall thruster, the effect of magnetic mirror on the radial profile of near-wall conductivity （NWC） is studied in this paper. The plasma electron dynamic process is described by the test particle method. The Monte Carlo scheme is used to solve this model. The radial profile of electron mobility is obtained and the role of magnetic mirror in NWC is analysed both theoretically and numerically. The numerical results show that the electron mobility peak due to NWC is inversely proportional to the magnetic mirror ratio and the asymmetry of electron mobility along the radial direction gets greater when the magnetic mirror is considered. This effect indicates that apart from the disparity in the magnetic field strength, the difference in the magnetic mirror ratio near the inner and outer walls would actually augment the asymmetry of the radial profile of NWC in Hall thrusters.
基金The authors gratefully acknowledge the financial support from the National Science and Technology Major Special Project(2016ZX05058-003).
文摘Due to long-term water injection,often oilfields enter the so-called medium and high water cut stage,and it is difficult to achieve good oil recovery and water reduction through standard methods(single profile control and flooding measures).Therefore,in this study,a novel method based on“plugging,profile control,and flooding”being implemented at the same time is proposed.To assess the performances of this approach,physical simulations,computer tomography,and nuclear magnetic resonance are used.The results show that the combination of a gel plugging agent,a polymer microsphere flooding agent,and a high-efficiency oil displacement agent leads to better results in terms of oil recovery with respect to the situation in which these approaches are used separately(the oil recovery is increased by 15.37%).Computer tomography scan results show that with the combined approach,a larger sweep volume and higher oil washing efficiency are obtained.The remaining oil in the cluster form can be recovered in the middle and low permeability layer,increasing the proportion of the columnar and blind end states of the oil.The nuclear magnetic resonance test results show that the combined“plugging,profile control,and flooding”treatment can also be used to control more effectively the dominant channels of the high permeability layer and further expand the recovery degree of the remaining oil in the pores of different sizes in the middle and low permeability layers.However,for the low permeability layer(permeability difference of 20),the benefits in terms of oil recovery are limited.
基金supported by the National Magnetic Confinement Fusion Science Program of China(Nos.2014GB106000,2014GB106003 and2015GB110001)National Natural Science Foundation of China(Nos.11275234,11305215,11305208,11405214 and 11505221)
文摘The resonant magnetic perturbation （RMP） coils have been successfully designed and installed on the Experimental Advanced Superconducting Tokamak （EAST）. Using the reflectometer systems, the density profile and the density fluctuations during magnetic perturbations （MPs） phase have been investigated. During the experiments, two different cases are studied separately： steady MPs and rotating MPs. In both cases, a strongly density pump-out has been observed. In the steady MPs cases, an enhancement of the low frequency （〈60 kHz） density fluctuations in H-mode phase has been observed. The plasma density boundary out-shifts 5~ caused by the MPs. The pedestal density gradient is reduced by 50%, while the radial location nearly stays unchanged. In the rotating MPs, the line-averaged density, the D~ emission at the divertor region and the spectrum of the density fluctuations are modulated. The results suggest that the low frequency （〈60 kHz） density fluctuations may contribute to the strong density pump-out.
文摘BACKGROUND Down syndrome(DS)is one of the most common causes of intellectual disability.Children with DS have varying intelligence quotient(IQ)that can predict their learning abilities.AIM To assess the brain metabolic profiles of children with DS and compare them to standard controls,using magnetic resonance spectroscopy(MRS)and correlating the results with IQ.METHODS This case-control study included 40 children with DS aged 6-15 years and 40 age and sex-matched healthy children as controls.MRS was used to evaluate ratios of choline/creatine(Cho/Cr),N-acetyl aspartic acid/creatine(NAA/Cr),and myoinositol/creatine(MI/Cr(in the frontal,temporal,and occipital lobes and basal ganglia and compared to controls and correlated with IQ.RESULTS Children with DS showed significant reductions in NAA/Cr and MI/Cr and a non-significant reduction in Cho/Cr in frontal lobes compared to controls.Additionally,we observed significant decreases in NAA/Cr,MI/Cr,and Cho/Cr in the temporal and occipital lobes and basal ganglia in children with DS compared to controls.Furthermore,there was a significant correlation between IQ and metabolic ratios in the brains of children with DS.CONCLUSION Brain metabolic profile could be a good predictor of IQ in children with DS.
基金supported by the National Natural Science Foundation of China(Grant Nos.12205298 and 12175230)the Natural Science Foundation of Heilongjiang Province of China(Grant No.LH2024A010)+1 种基金the Fundamental Research Funds for the Central Universities,Controversial and Disruptive Projects of the Chinese Academy of Sciences(Grant No.FGSDFX-0001)the USTC Research Funds of the Double First-Class Initiative(Grant No.YD2140002006).
文摘Quasi-hemispherical magnetized collisionless shocks have been generated at the SG-II laser facility through the interaction between a laserproduced supersonic plasma flow and a magnetized ambient plasma,exhibiting an angular asymmetric shock profile accompanied by asymmetric ion acceleration.We have conducted test particle simulations using the electromagnetic fields derived from 2D MHD simulations to investigate the asymmetry of ion acceleration.The simulations reproduce the angular asymmetry of the shock and the ion acceleration observed in experiments.The results indicate that shock drift acceleration is the primary mechanism for ion energization in the present quasiperpendicular magnetized shock.The asymmetric shock structure caused by nonuniform ambient plasma forms an asymmetric accelerated electric field,ultimately leading to angular asymmetric ion acceleration,which is consistent with space observations and our experimental results.Our study provides a plausible explanation for the discrepancies reported in previous ion acceleration experiments,and could contribute to understanding of the collisionless shock acceleration.
基金supported by the Ministry of Agriculture for providing New Application for Herbal Research Grant Scheme(NRGS)(No.NH1014D040)the National 12th 5-Year Science and Technology Support Program(No.2011BA107B01)+1 种基金the Science and Technology Innovation Team of Shanxi Province(No.2013131015)the National Natural Science Foundation of China(No.31570346)
文摘Astragali Radix(AR) is one of the most popular herbal medicines in traditional Chinese medicine(TCM). Wild AR is believed to be of high quality, and substitution with cultivated AR is frequently encountered in the market. In the present study, two types of ARs(wild and cultivated) from Astragalus membranaceus(Fisch.) Bge. and A. membranaceus var. mongholicus(Bge.) Hsiao, growing in different regions of China, were analyzed by NMR profiling coupled with multivariate analysis. Results showed that both could be differentiated successfully and cultivation patterns or growing years might have greater impact on the metabolite compositions than the variety; the metabolites responsible for the separation were identified. In addition, three extraction methods were compared and the method(M1) was used for further analysis. In M1, the extraction solvent composed of water, methanol, and chloroform in the ratio of 1 : 1 : 2 was used to obtain the aqueous methanol(upper layer) and chloroform(lower layer) fractions, respectively, showing the best separation. The differential metabolites among different methods were also revealed. Moreover, the sucrose/glucose ratio could be used as a simple index to differentiate wild and cultivated AR. Meanwhile, the changes of correlation pattern among the differential metabolites of the two varieties were found. The work demonstrated that NMR-based non-targeted profiling approach, combined with multivariate statistical analysis, can be used as a powerful tool for differentiating AR of different cultivation types or growing years.
文摘AIM: To establish if a distinct urinary metabolic profile could be identified in Bangladeshi hepatitis-B hepatocellular carcinoma (HCC) patients compared to cirrhosis patients and controls.METHODS: Urine samples from 42 Bangladeshi patients with HCC (39 patients with hepatitis-B HCC), 47 with cirrhosis on a background of hepatitis B, 46 with chronic hepatitis B, and seven ethnically-matched healthy controls were analyzed using nuclear magnetic resonance (NMR) spectroscopy. A full dietary and medication history was recorded for each subject. The urinary NMR data were analyzed using principal component analysis (PCA) and orthogonal partial least squared discriminant analysis (OPLS-DA) techniques. Differences in relative signal levels of the most discriminatory metabolites identified by PCA and OPLS-DA were compared between subject groups using an independent samples Kruskal-Wallis one-way analysis of variance (ANOVA) test with all pairwise multiple comparisons. Within the patient subgroups, the Mann-Whitney U test was used to compare metabolite levels depending on hepatitis B e-antigen (HBeAg) status and treatment with anti-viral therapy. A Benjamini-Hochberg adjustment was applied to acquire the level of significance for multiple testing, with a declared level of statistical significance of P < 0.05.RESULTS: There were significant differences in age (P < 0.001), weight (P < 0.001), and body mass index (P < 0.001) across the four clinical subgroups. Serum alanine aminotransferase (ALT) was significantly higher in the HCC group compared to controls (P < 0.001); serum α-fetoprotein was generally markedly elevated in HCC compared to controls; and serum creatinine levels were significantly reduced in the HCC group compared to the cirrhosis group (P = 0.004). A three-factor PCA scores plot showed clustering of the urinary NMR spectra from the four subgroups. Metabolites that contributed to the discrimination between the subgroups included acetate, creatine, creatinine, dimethyamine (DMA), formate, glycine, hippurate, and trimethylamine-N-oxide (TMAO). A comparison of relative metabolite levels confirmed that carnitine was significantly increased in HCC; and creatinine, hippurate, and TMAO were significantly reduced in HCC compared to the other subgroups. HBeAg negative patients showed a significant increase in creatinine (P = 0.001) compared to HBeAg positive patients in the chronic hepatitis B subgroup, whilst HBeAg negative patients showed a significant decrease in DMA (P = 0.004) in the cirrhosis subgroup compared to HBeAg positive patients. There were no differences in metabolite levels in HCC patients who did or did not receive antiviral treatment.CONCLUSION: Urinary NMR changes in Bangladeshi HCC were identified, corroborating previous findings from Egypt and West Africa. These findings could form the basis for the development of a cost-effective HCC dipstick screening test.
基金supported by National Natural Science Foundation of China (No. 10675040)College Scientific Research and Development Fund (No. C122009015) of China
文摘Numerical simulation of the effect of the anode magnetic shielding on the magnetic field and ion beam in a cylindrical Hall thruster is presented. The results show that after the anode is shielded by the magnetic shield, the magnetic field lines near the anode surface are obviously convex curved, the ratio of the magnetic mirror is enhanced, the width of the positive magnetic field gradient becomes larger than that without the anode magnetic shielding, the radial magnetic field component is enhanced, and the discharge plasma turbulence is reduced as a result of keeping the original saddle field profile and the important role the other two saddle field profiles play in restricting electrons. The results of the particle in cell （PIC） numerical simulation show that both the ion number and the energy of the ion beam increase after the anode is shielded by the magnetic shield. In other words, the specific impulse of the cylindrical Hall thruster is enhanced.
基金supported by the Key Program of the National Natural Science Foundation of China,No.30930027the National Natural Science Foundation of China,No.60971075the Foundation for Basic and Clinical Medicine (2010) of Shantou University Medical College,China
文摘Although the water-soluble metabolite profile of human mesenchymal stem cells is known, the lipid profile still needs further investigation. In this study, methanol-chloroform was used to extract lipid-soluble metabolites and perchloric acid was used to extract water-soluble metabolites. Fur- thermore, a dual phase extraction method using methanol-chloroform and water was used to obtain both water and lipid fractions simultaneously. All metabolite extractions were analyzed on a 9.4T high-resolution nuclear magnetic resonance spectrometer. Metabolite resonance peaks were as- signed in the acquired spectra according to the chemical shift, and the extraction efficiency of dif- ferent methods was compared. Results showed that in the spectra of water-soluble extracts, major metabolites comprised low molecular weight metabolites, including lactate, acetic acid, fatty acids, threonine, glutamic acid, creatine, choline and its derivatives, while in the spectra of lipid-soluble extracts, most metabolites were assigned to fatty acids. Among the different extraction procedures, perchloric acid was more efficient in extracting water-soluble metabolites and methanol-chloroform was efficient in extracting organic components compared with the dual phase extraction method. Nuclear magnetic resonance spectroscopy showed that as low as 0.7 mg organic yield was enough to obtain clear resonance peaks, while about 6.0 mg water-soluble yield was needed to obtain rela- tively favorable spectral lines. These results show that the efficiency of extracting water and lipid fractions is higher using perchloric acid and methanol-chloroform compared with dual phase ex- traction and that nuclear magnetic resonance spectroscopy is highly sensitive for analyzing lipid-soluble extracts.
文摘One of the measurement geophysical methods to investigate kimberlite pipes is by using the magnetic method. The acquired field data in this study uses <span style="font-family:Verdana;">two proton-precession magnetometers for the mapping of magnetic anomalies</span><span style="font-family:Verdana;"> due to kimberlites. Three different magnetic maps are obtained from the result of total magnetic field data processing on Oásis Montaj software programme. These maps include magnetic anomaly maps through statistical analyses, total magnetic field intensity map and map of the analytic signal. Based on the interpretation of these maps a structure is identified with SWW-NEE directions in which magnetic signatures that indicate the presence of kimberlite pipes are observed. As the interpretation of the magnetic anomalies is a complicated process due to their dipolar nature, the analytic signal is generated, where is possible to observe the typical shape of these anomalies.</span>
基金Supported by the National Natural Science Foundation of China
文摘Up to now, exact measurements of chromospheric magnetic fields have not been as successful as those done in the photosphere. We are currently engaging in diagnostics of chromospheric magnetic fields with the Mg b2 line by employing the Multi-Channel Solar Telescope at Huairou Solar Observing Station. Therefore, how to improve accuracy in the measurement is the main issue of our present study. To this end, we first study linear calibration coefficients for longitudinal and transverse components of chromospheric fields, which vary with wavelength, in the case of a weak field assumption. Then the polarization crosstalk introduced by instruments is analyzed in detail with two numerical simulation methods. Comparisons of the po- larization signals between cases with and without correction are presented. The result indicates that polarization accuracy is greatly improved after crosstalk correction.
基金Supported by the National Natural Science Foundation of China.
文摘A set of two-dimensional Stokes spectral data of NOAA AR 10197 obtained by the Solar Stokes Spectral Telescope （S^3T） at the Yunnan Observatory are quafitatively analyzed. The three components of the vector magnetic field, the strength H, inclination 7 and azimuth X, are derived. Based on the three components, we contour the distributions of the longitudinal magnetic field and transverse magnetic field. The active region （AR） has two different magnetic polarities apparent in the longitudinal magnetic map due to projection effect. There is a basic agreement on the longitudinal magnetic fields between the S^3T and SOHO/MDI magnetograms, with a correlation coefficient PBl = 0.911. The transverse magnetic field of the AR has a radial distribution from a center located in the southwest of the AR. It is also found that the transverse magnetic fields obtained by Huairou Solar Observing Station （HRSOS） have a similar radial distribution. The distributions of transverse magnetic field obtained by S^3T and HRSOS have correlation coefficients, PAzimu = 0.86 and PBt =0.883, in regard to the azimuthal angle and intensity.
文摘Intracranial incidental findings on magnetic resonance imaging(MRI)of the brain continue to generate interest in healthy control,research,and clinical subjects.However,in clinical practice,the discovery of incidental findings acts as a"distractor".This review is based on existing heterogeneous reports,their clinical implications,and how the results of incidental findings influence clinical management.This draws attention to the followings:(1)the prevalence of clinically significant incidental findings is low;(2)there is a lack of a systematic approach to classification;and discusses(3)how to deal with the detected incidental findings based a proposed common clinical profile.Individualized neurological care requires an active discussion regarding the need for neuroimaging.Clinical significance of incidental findings should be decided based on lesion's neuroradiologic characteristics in the given clinical context.Available evidence suggests that the outcome of an incidentally found"serious lesion in children"is excellent.Future studies of intracranial incidental findings on pediatric brain MRI should be focused on a homogeneous population.The study should address this clinical knowledge based review powered by the statistical analyses.
文摘Ground magnetic, ground penetrating radar (GPR), and dipole-dipole resistivity were carried out to environmentally investigate a landfill. In this context, these geophysical techniques were conducted to identify the subsurface contents of the landfill, furthermore, specify any possible leakage and/or contamination in the study area. The ground-magnetic survey carried out in the study area comprised 31 profiles each 120 m in length. Different wavelength filters were applied to the measured data. Vertical derivative, downward continuation, apparent susceptibility, band-pass, and analytical signal filters separated successfully the shallow sources. Whereas, upward continuation and low-pass Gaussian filters isolated significantly the deep magnetic sources. 3D Euler deconvolution (SI = 3) remarkably estimated the depths of the shallow sources (0 - 10 m) of the landfill contents. The conducted GPR and dipole-dipole resistivity allocated tangibly the locations and depths of the near surface anomalies. Both techniques didn’t reveal any possible leakage and/or contamination. Noteworthy, integration among magnetic, GPR, and dipole-dipole resistivity confirmed positively the results of each method. Nevertheless, some anomalies were recognized successfully by one technique and not by the others.
