Credit card companies must be able to identify fraudulent credit card transactions so that clients are not charged for items they did not purchase. Previously, many machine learning approaches and classifiers were use...Credit card companies must be able to identify fraudulent credit card transactions so that clients are not charged for items they did not purchase. Previously, many machine learning approaches and classifiers were used to detect fraudulent transactions. However, because fraud patterns are always changing, it is becoming increasingly vital to investigate new frauds and develop the model based on the new patterns. The purpose of this research is to create a machine learning classifier that not only detects fraud but also detects legitimate transactions. As a result, the model should have excellent accuracy, precision, recall, and f1-score. As a result, we began with a large dataset in this study and used four machine learning classifiers: Support Vector Machine (SVM), Decision Tree, Naïve Bayes, and Random Forest. The random forest classifier scored 99.96% overall accuracy with the best precision, recall, f1-score, and Matthews correlation coefficient in the experiments.展开更多
为了更好的进行垃圾邮件过滤 ,介绍了NaiveBayes (N B )算法 ,并结合N B 算法和垃圾邮件过滤对N B 算法作了一些改进。之后 ,详细介绍了N B 算法在垃圾邮件智能过滤中的应用和实现 ,同时给出了应用的评估算法和评估结果。实验结果显示 ,...为了更好的进行垃圾邮件过滤 ,介绍了NaiveBayes (N B )算法 ,并结合N B 算法和垃圾邮件过滤对N B 算法作了一些改进。之后 ,详细介绍了N B 算法在垃圾邮件智能过滤中的应用和实现 ,同时给出了应用的评估算法和评估结果。实验结果显示 ,把N B展开更多
Cancer is a complex disease associated with multiple gene mutations and malignant phenotypes,and multi-target drugs provide a promising therapy idea for the treatment of cancer.Natural products with abundant chemical ...Cancer is a complex disease associated with multiple gene mutations and malignant phenotypes,and multi-target drugs provide a promising therapy idea for the treatment of cancer.Natural products with abundant chemical structure types and rich pharmacological characteristics could be ideal sources for screening multi-target antineoplastic drugs.In this paper,50 tumor-related targets were collected by searching the Therapeutic Target Database and Thomson Reuters Integrity database,and a multi-target anti-cancer prediction system based on mt-QSAR models was constructed by using naïve Bayesian and recursive partitioning algorithm for the first time.Through the multi-target anti-cancer prediction system,some dominant fragments that act on multiple tumor-related targets were analyzed,which could be helpful in designing multi-target anti-cancer drugs.Anti-cancer traditional Chinese medicine(TCM)and its natural products were collected to form a TCM formula-based natural products library,and the potential targets of the natural products in the library were predicted by multi-target anti-cancer prediction system.As a result,alkaloids,flavonoids and terpenoids were predicted to act on multiple tumor-related targets.The predicted targets of some representative compounds were verified according to literature review and most of the selected natural compounds were found to exert certain anti-cancer activity in vitro biological experiments.In conclusion,the multi-target anti-cancer prediction system is very effective and reliable,and it could be further used for elucidating the functional mechanism of anti-cancer TCM formula and screening for multi-target anti-cancer drugs.The anti-cancer natural compounds found in this paper will lay important information for further study.展开更多
文摘Credit card companies must be able to identify fraudulent credit card transactions so that clients are not charged for items they did not purchase. Previously, many machine learning approaches and classifiers were used to detect fraudulent transactions. However, because fraud patterns are always changing, it is becoming increasingly vital to investigate new frauds and develop the model based on the new patterns. The purpose of this research is to create a machine learning classifier that not only detects fraud but also detects legitimate transactions. As a result, the model should have excellent accuracy, precision, recall, and f1-score. As a result, we began with a large dataset in this study and used four machine learning classifiers: Support Vector Machine (SVM), Decision Tree, Naïve Bayes, and Random Forest. The random forest classifier scored 99.96% overall accuracy with the best precision, recall, f1-score, and Matthews correlation coefficient in the experiments.
基金supported by the National Great Science Technology Projects(2018ZX09711001-003-002,2018ZX09711001-012)the National Natural Science Foundation of China(No.81673480)+2 种基金the Beijing National Science Foundation(7192134)CAMS Initiative for Innovative Medicine(CAMS-IZM)(2016-IZM-3-007)CAMS Major collaborative innovation fund for major frontier research(2020-I2M-1-003).
文摘Cancer is a complex disease associated with multiple gene mutations and malignant phenotypes,and multi-target drugs provide a promising therapy idea for the treatment of cancer.Natural products with abundant chemical structure types and rich pharmacological characteristics could be ideal sources for screening multi-target antineoplastic drugs.In this paper,50 tumor-related targets were collected by searching the Therapeutic Target Database and Thomson Reuters Integrity database,and a multi-target anti-cancer prediction system based on mt-QSAR models was constructed by using naïve Bayesian and recursive partitioning algorithm for the first time.Through the multi-target anti-cancer prediction system,some dominant fragments that act on multiple tumor-related targets were analyzed,which could be helpful in designing multi-target anti-cancer drugs.Anti-cancer traditional Chinese medicine(TCM)and its natural products were collected to form a TCM formula-based natural products library,and the potential targets of the natural products in the library were predicted by multi-target anti-cancer prediction system.As a result,alkaloids,flavonoids and terpenoids were predicted to act on multiple tumor-related targets.The predicted targets of some representative compounds were verified according to literature review and most of the selected natural compounds were found to exert certain anti-cancer activity in vitro biological experiments.In conclusion,the multi-target anti-cancer prediction system is very effective and reliable,and it could be further used for elucidating the functional mechanism of anti-cancer TCM formula and screening for multi-target anti-cancer drugs.The anti-cancer natural compounds found in this paper will lay important information for further study.
