Wavelet method is often used in analyzing trend and period of time sequence. When using wavelet method one serious problem is different chosen wavelet basis and scale would lead to different results. Sometimes, the re...Wavelet method is often used in analyzing trend and period of time sequence. When using wavelet method one serious problem is different chosen wavelet basis and scale would lead to different results. Sometimes, the results vary greatly. To overcome this problem and to improve the accuracy and efficiency, a new method denoted by Natural-based Wavelet Method is introduced and extended. It can be proved that the proposed method in fact is a special class of discrete wavelet. At first, two numerical examples are designed to show the capacity of the novel method. Second, this method is applied to a precipitation series. According to wavelet analysis and short-range precipitation prediction, this precipitation exists a faintly increasing trend. Through the analysis, the studied precipitation has two major periods: 11 and 41 years. The results validate that the Natural-based Wavelet Method used in application of multi-complicated observed data is suitable. It is easy to write the source code of the proposed method. When new information appears, new information can be easily added into the original sequence, this is another advantage of the proposed method.展开更多
Antimicrobial resistance is becoming a serious public health problem that needs to be eradicated.In this context,the use of natural sources with antimicrobial properties is proposed as an alternative to conventional s...Antimicrobial resistance is becoming a serious public health problem that needs to be eradicated.In this context,the use of natural sources with antimicrobial properties is proposed as an alternative to conventional synthetic antimicrobials,thus avoiding their adverse effects.To improve the controlled and targeted release of these compounds,it is essential to incorporate them into matrices,which in turn improves their stability and bioac-tivity.Starch-based matrices as carriers of antimicrobial compounds have shown great potential in many ap-plications,especially in active packaging for food safety.This review examines recent advances in the use of these matrices,highlighting natural sources with antimicrobial properties and starch types such as corn,cassava,and modified starch,the latter being particularly relevant for its improved solubility properties and functionality.Starch plays a crucial role in improving the stability and solubility of antimicrobial compounds,and the controlled release depends on the structure of the starch and on the properties of the environment.In food packaging,starch-based films loaded with antimicrobials are effective in inhibiting bacterial growth and extending shelf life.The applications of the bioactive compounds combined with starch matrices,such as plant extracts and essential oils,are also analyzed,providing a sustainable solution to antimicrobial resistance.This analysis highlights the advantages and potential of starch matrices in the development of antimicrobial controlled release systems.展开更多
Bone defects caused by trauma, infection or bone tumor resection, are highly prevalent. A small number(5%–10%) of these injuries fail to heal due to non-union and require surgical intervention. Currently, the princip...Bone defects caused by trauma, infection or bone tumor resection, are highly prevalent. A small number(5%–10%) of these injuries fail to heal due to non-union and require surgical intervention. Currently, the principal treatment options for these defects are autografts, allografts, xenografts or synthetic grafts. The main problems associated with these therapies include pain,infection and donor site morbidity. Bone tissue engineering is a diverse field that focuses on the regeneration of bone by combining cells, scaffolds, growth factors and dynamic forces. There have been many recent studies utilizing biomineralized polymer matrix composites which mimic the natural structure of bone. The principal focus of this review is on recent advances in the synthesis of various types of biomineralized polymer matrix composite. Examples of the biomineralization of naturallyderived and synthetic polymers widely used for bone engineering are also summarized.展开更多
Gelatin based adhesives have been used in the last decades in different biomedical applications due to the excellent biocompatibility,easy processability,transparency,non-toxicity,and reasonable mechanical properties ...Gelatin based adhesives have been used in the last decades in different biomedical applications due to the excellent biocompatibility,easy processability,transparency,non-toxicity,and reasonable mechanical properties to mimic the extracellular matrix(ECM).Gelatin adhesives can be easily tuned to gain different viscoelastic and mechanical properties that facilitate its ocular application.We herein grafted glycidyl methacrylate on the gelatin backbone with a simple chemical modification of the precursor,utilizing epoxide ring-opening reactions and visible light-crosslinking.This chemical modification allows the obtaining of an elastic protein-based hydrogel(GELGYM)with excellent biomimetic properties,approaching those of the native tissue.GELGYM can be modulated to be stretched up to 4 times its initial length and withstand high tensile stresses up to 1.95 MPa with compressive strains as high as 80%compared to Gelatin-methacryloyl(GeIMA),the most studied derivative of gelatin used as a bioadhesive.GELGYM is also highly biocompatible and supports cellular adhesion,proliferation,and migration in both 2 and 3-dimensional cell-cultures.These characteristics along with its super adhesion to biological tissues such as cornea,aorta,heart,muscle,kidney,liver,and spleen suggest widespread applications of this hydrogel in many biomedical areas such as transplantation,tissue adhesive,wound dressing,bioprinting,and drug and cell delivery.展开更多
基金Sponsored by the National Natural Science Foundation of China(Grant Nos.11461026,11361024,51378206 and 11661036)the Provincial Natural Science Foundation(Grant No.2017BAB201009)
文摘Wavelet method is often used in analyzing trend and period of time sequence. When using wavelet method one serious problem is different chosen wavelet basis and scale would lead to different results. Sometimes, the results vary greatly. To overcome this problem and to improve the accuracy and efficiency, a new method denoted by Natural-based Wavelet Method is introduced and extended. It can be proved that the proposed method in fact is a special class of discrete wavelet. At first, two numerical examples are designed to show the capacity of the novel method. Second, this method is applied to a precipitation series. According to wavelet analysis and short-range precipitation prediction, this precipitation exists a faintly increasing trend. Through the analysis, the studied precipitation has two major periods: 11 and 41 years. The results validate that the Natural-based Wavelet Method used in application of multi-complicated observed data is suitable. It is easy to write the source code of the proposed method. When new information appears, new information can be easily added into the original sequence, this is another advantage of the proposed method.
基金supported by the Ministerio de Economía y Com-petitividad(MINECO,Spain),under Grants PID2020-119087RB-I00 and MCINN-24-PID2023-149453OB-I00co-financed by Agen-cia de Ciencia,Competitividad Empresarial e Innovaccion Asturiana-SEKUENS(SEK-25-GRU-GIC-24-079)。
文摘Antimicrobial resistance is becoming a serious public health problem that needs to be eradicated.In this context,the use of natural sources with antimicrobial properties is proposed as an alternative to conventional synthetic antimicrobials,thus avoiding their adverse effects.To improve the controlled and targeted release of these compounds,it is essential to incorporate them into matrices,which in turn improves their stability and bioac-tivity.Starch-based matrices as carriers of antimicrobial compounds have shown great potential in many ap-plications,especially in active packaging for food safety.This review examines recent advances in the use of these matrices,highlighting natural sources with antimicrobial properties and starch types such as corn,cassava,and modified starch,the latter being particularly relevant for its improved solubility properties and functionality.Starch plays a crucial role in improving the stability and solubility of antimicrobial compounds,and the controlled release depends on the structure of the starch and on the properties of the environment.In food packaging,starch-based films loaded with antimicrobials are effective in inhibiting bacterial growth and extending shelf life.The applications of the bioactive compounds combined with starch matrices,such as plant extracts and essential oils,are also analyzed,providing a sustainable solution to antimicrobial resistance.This analysis highlights the advantages and potential of starch matrices in the development of antimicrobial controlled release systems.
基金supported by the National Key Research and Development Program of China (2017YFC1103500, 2017YFC1103502)the National Natural Science Foundation of China (31525009)+2 种基金Sichuan Innovative Research Team Program for Young Scientists (2016TD0004)Distinguished Young Scholars of Sichuan University (2011SCU04B18)Sichuan Science and Technology Project (2017GZ0429)
文摘Bone defects caused by trauma, infection or bone tumor resection, are highly prevalent. A small number(5%–10%) of these injuries fail to heal due to non-union and require surgical intervention. Currently, the principal treatment options for these defects are autografts, allografts, xenografts or synthetic grafts. The main problems associated with these therapies include pain,infection and donor site morbidity. Bone tissue engineering is a diverse field that focuses on the regeneration of bone by combining cells, scaffolds, growth factors and dynamic forces. There have been many recent studies utilizing biomineralized polymer matrix composites which mimic the natural structure of bone. The principal focus of this review is on recent advances in the synthesis of various types of biomineralized polymer matrix composite. Examples of the biomineralization of naturallyderived and synthetic polymers widely used for bone engineering are also summarized.
基金the Boston-KPro research fund and NIH/NEI P30EY003790(Core-PA)R.S.was supported in part by the K99 grant from NIH award no.K99 EY030553+3 种基金the Center for Nanoscale Systems(CNS),Harvard University,a member of the National Nanotechnology Coordinated Infrastructure Network(NNCI)the National Science Foundation under NSF award no.1541959.F.R-O and D.A-M were supported by the research project ICI19/00006funded by Instituto de Salud CarlosⅢand co-funded by European Union(ERDF/ESF,"A way to make Europe"/"Investing in your future")F.R-O additionally acknowledges funding from Plan Andaluz de Investigaci´on,Desarrollo e Innovaci´on(PAIDI2020)Fellowship supported by Consejería de Economía,Conocimiento,Empresas y Universidad,Junta de Andalucía co-funded by Fondo Social Europeo de Andalucía 2014-2020.
文摘Gelatin based adhesives have been used in the last decades in different biomedical applications due to the excellent biocompatibility,easy processability,transparency,non-toxicity,and reasonable mechanical properties to mimic the extracellular matrix(ECM).Gelatin adhesives can be easily tuned to gain different viscoelastic and mechanical properties that facilitate its ocular application.We herein grafted glycidyl methacrylate on the gelatin backbone with a simple chemical modification of the precursor,utilizing epoxide ring-opening reactions and visible light-crosslinking.This chemical modification allows the obtaining of an elastic protein-based hydrogel(GELGYM)with excellent biomimetic properties,approaching those of the native tissue.GELGYM can be modulated to be stretched up to 4 times its initial length and withstand high tensile stresses up to 1.95 MPa with compressive strains as high as 80%compared to Gelatin-methacryloyl(GeIMA),the most studied derivative of gelatin used as a bioadhesive.GELGYM is also highly biocompatible and supports cellular adhesion,proliferation,and migration in both 2 and 3-dimensional cell-cultures.These characteristics along with its super adhesion to biological tissues such as cornea,aorta,heart,muscle,kidney,liver,and spleen suggest widespread applications of this hydrogel in many biomedical areas such as transplantation,tissue adhesive,wound dressing,bioprinting,and drug and cell delivery.
