In a superconductor embedded with a quantum magnetic impurity,the Kondo effect is involved,leading to the competition between the Kondo singlet phase and the superconductivity phase.By means of the natural orbitals re...In a superconductor embedded with a quantum magnetic impurity,the Kondo effect is involved,leading to the competition between the Kondo singlet phase and the superconductivity phase.By means of the natural orbitals renormalization group(NORG)method,we revisit the problem of a quantum magnetic impurity coupled with a conventional s-wave superconductor.Here we present a detailed study focusing on the impurity spin polarization and susceptibility,the Kondo screening cloud,as well as the number and structures of the active natural orbitals(ANOs).In the superconducting phase,the impurity spin is partially polarized,indicating that the impurity remains partially screened by the quantum fluctuations.Furthermore,the impurity spin susceptibility becomes divergent,resulting from the presence of residual local moment formed at the impurity site.Correspondingly,a non-integral(incomplete)Kondo cloud is formed,although the ground state is a spin doublet in this phase.In comparison,the Kondo cloud is complete in the Kondo singlet phase as expected.We also quantify the critical point,where the quantum phase transition from a Kondo singlet phase to a superconducting phase occurs,which is consistent with that in previous works.On the other hand,it is illustrated that only one ANO emerges in both quantum phases.The structures of the ANO,projected into both the real space and momentum space,are distinct in the Kondo singlet phase from that in the superconducting phase.More specifically,in the Kondo singlet phase,the ANO keeps fully active with half-occupied,and the superconducting gap has negligible influence on its structure.On the contrary,in the superconducting phase,the ANO tends to be inactive and its structure changes significantly as the superconducting gap increases.Additionally,our investigation demonstrates that the NORG method is reliable and convenient to solve the quantum impurity problems in superconductors as well,which will promote further theoretical studies on the Kondo problems in such systems using numerical methods.展开更多
Natural Gas Industry B创刊于2014年,是天然气工业杂志社与KeAi公司合作出版的国际OA期刊,在爱思唯尔旗下的ScienceDirect平台上双月出版。论文聚焦天然气、氢气、氦气、地热等地质能源,涵盖地质勘探、气藏开发、工程技术、储运利用、...Natural Gas Industry B创刊于2014年,是天然气工业杂志社与KeAi公司合作出版的国际OA期刊,在爱思唯尔旗下的ScienceDirect平台上双月出版。论文聚焦天然气、氢气、氦气、地热等地质能源,涵盖地质勘探、气藏开发、工程技术、储运利用、净化化工、产业趋势等专业方向。期刊服务全球天然气产业,并积极推动能源行业碳减排和低碳转型的发展。展开更多
Natural Gas Industry B创刊于2014年,是天然气工业杂志社与KeAi公司合作出版的国际OA期刊,在爱思唯尔旗下的Science Direct平台上双月出版。论文聚焦天然气、氢气、氦气、地热等地质能源,涵盖地质勘探、气藏开发、工程技术、储运利用...Natural Gas Industry B创刊于2014年,是天然气工业杂志社与KeAi公司合作出版的国际OA期刊,在爱思唯尔旗下的Science Direct平台上双月出版。论文聚焦天然气、氢气、氦气、地热等地质能源,涵盖地质勘探、气藏开发、工程技术、储运利用、净化化工、产业趋势等专业方向。期刊服务全球天然气产业,并积极推动能源行业碳减排和低碳转型的发展。展开更多
CHINA.Dinghu Mountain National Nature Reserve.Located in Zhaoqing,Guangdong Province,Dinghu Mountain National Nature Reserve is a pristine natural sanctuary spanning 1,133 hectares within the low mountain ranges of th...CHINA.Dinghu Mountain National Nature Reserve.Located in Zhaoqing,Guangdong Province,Dinghu Mountain National Nature Reserve is a pristine natural sanctuary spanning 1,133 hectares within the low mountain ranges of the Dayunwu Mountains.展开更多
Knee osteoarthritis(KOA)is a prevalent chronic degenerative joint disorder characterized by an imbalance between articular cartilage degradation and synthesis,a central mechanism in KOA pathogenesis.Given the absence ...Knee osteoarthritis(KOA)is a prevalent chronic degenerative joint disorder characterized by an imbalance between articular cartilage degradation and synthesis,a central mechanism in KOA pathogenesis.Given the absence of disease-modifying therapies,there is a critical need to elucidate the underlying pathological processes,establish reliable biomarkers for early detection and prognosis,and identify safer,more effective therapeutic agents.In recent years,natural products have attracted considerable interest due to their low toxicity,cost-effectiveness,and distinct biological activities,demonstrating significant potential in KOA management.These compounds can impede KOA progression through multiple mechanisms,including promoting cartilage matrix synthesis,mitigating inflammation,reducing oxidative stress,suppressing chondrocyte apoptosis,and modulating autophagy,thereby supporting their translational application.This review summarizes biomarkers relevant to early diagnosis and phenotypic stratification in KOA,with a focus on elucidating the pharmacological actions and molecular mechanisms of natural products,such as flavonoids,alkaloids,saponins,terpenes,and traditional Chinese medicine(TCM)formulas,in KOA intervention,aiming to provide evidence-based strategies for improved disease management.展开更多
Vegetation plays an important role in the environmental transport behavior of organic pollutants,however,the different roles of crops and natural vegetation have been ignored in most previous studies.In this study,we ...Vegetation plays an important role in the environmental transport behavior of organic pollutants,however,the different roles of crops and natural vegetation have been ignored in most previous studies.In this study,we developed the BETR-Urban-Rural-Veg model to quantitatively evaluate the influences of both natural vegetation and crops on the multimedia transport processes of Phenanthrene(PHE)and Benzo(a)pyrene(BaP)in mainland of China.The geographic distribution of polycyclic aromatic hydrocarbon(PAH)emissions and concentrations were consistent,displaying higher levels in northern China while lower levels in southern China.Under seasonal simulations,for both natural vegetation and crops,PAH concentrations in winter and spring were 1.5 to 27-fold higher than in summer and autumn,especially for PHE.Owing to the higher leaf area index(LAI)of natural vegetation and harvesting of crops,the filter and sequestration effect of natural vegetation was stronger than crops,while the seasonal changes of PAH concentrations in crops were more significant than natural vegetation.Temperature,precipitation rates and LAI might have important influences on seasonal concentrations and overall persistence of PAHs.PHE was more sensitive to the impacts of seasonal environmental parameters.Under different landscape scenarios,average annual PAH concentrations in natural vegetation were always a little higher than those in crops,and the overall persistence of BaP was greatly affected increasing by 15.15%-16.47%.This improved model provides a useful tool for environmental management.The results of this study are expected to support land use plans and decision-making in China's mainland.展开更多
Mesenchymal stem cells(MSCs) are widely utilized in disease treatment and regenerative medicine due to their potent immunomodulatory properties and capacity for tissue repair.However, limitations—including insufficie...Mesenchymal stem cells(MSCs) are widely utilized in disease treatment and regenerative medicine due to their potent immunomodulatory properties and capacity for tissue repair.However, limitations—including insufficient migratory capacity, suboptimal survival, proliferation, differentiation potential, and variable immunomodulatory responses—significantly hinder their clinical translation and therapeutic impact. Natural products have been shown to enhance MSC homing, stress resilience, immune regulation, and lineage-specific differentiation through multi-target mechanisms, thereby emerging as promising, safe, and practical strategies to improve the in vivo performance of MSC-based therapies. This review examines the key translational challenges associated with MSCs, elucidates the mechanistic basis by which natural products regulate the in vivo fate of MSCs, and explores the potential of integrating natural product adjuvants with MSC therapy for enhanced clinical outcomes.展开更多
Inflammatory bowel disease(IBD),which includes Crohn’s disease(CD)and ulcerative colitis(UC),is a chronic inflammatory condition affecting the gastrointestinal tract.The global incidence and prevalence of IBD continu...Inflammatory bowel disease(IBD),which includes Crohn’s disease(CD)and ulcerative colitis(UC),is a chronic inflammatory condition affecting the gastrointestinal tract.The global incidence and prevalence of IBD continue to increase.While multiple clinical treatments exist,conventional therapies frequently present limitations and adverse effects.Natural polysaccharides(PSs)have emerged as a significant focus of research interest due to their therapeutic potential and applications in functional foods and health products.This review synthesizes current understanding of IBD pathophysiology and the mechanisms by which natural PSs counter IBD,including their capacity to restore immune homeostasis and intestinal barrier function,modulate gut microbiota and metabolites,reduce oxidative stress,and address irregularities in autophagy and endoplasmic reticulum stress(ERS).The review examines the structure-activity relationships of PSs demonstrating anti-IBD effects and identifies promising therapeutic products.The discussion encompasses pharmacokinetics,safety evaluations,and clinical applications of these compounds.This comprehensive review establishes a theoretical foundation for developing natural PS-based therapeutic approaches for IBD management.展开更多
Osteoporosis is a systemic skeletal disorder characterized by reduced bone mass,compromised bone microstructure,and an increased risk of fractures,primarily due to excessive osteoclast-mediated bone resorption relativ...Osteoporosis is a systemic skeletal disorder characterized by reduced bone mass,compromised bone microstructure,and an increased risk of fractures,primarily due to excessive osteoclast-mediated bone resorption relative to osteoblast-mediated bone formation.While current anti-osteoporosis drugs,such as bisphosphonates and denosumab,predominantly focus on reducing bone resorption,osteoanabolic approaches are essential for restoring bone microarchitecture and ultimately reducing fracture risk.Traditional Chinese medicines(TCMs)and their active ingredients have long been used in China for osteoporosis prevention and treatment.This review provides a comprehensive evaluation of the effects and molecular mechanisms of 65 natural products across 24 categories on osteoblast-mediated bone formation.These compounds promote bone formation by regulating key transcription factors(RUNX2 and Osterix)and signaling pathways,including WNT/β-catenin,bone morphogenic protein(BMP),mitogen-activated protein kinase(MAPK),phosphoinositide 3-kinase/protein kinase B(PI3K/AKT),oxidative stress,autophagy,and epigenetic regulation.Notably,certain natural products[e.g.,icariin(ICA)]exert their effects through multiple targets and pathways.Many of these natural products have demonstrated significant therapeutic efficacy in animal models,such as ovariectomized(OVX)mice.Our findings suggest that natural products with kidney-tonifying,anti-inflammatory,and antioxidant properties,as well as those inhibiting adipocyte differentiation,may hold promise for osteoporosis treatment.Additionally,we highlight current research gaps and propose future directions,including high-throughput screening and validation in diverse animal models,development of novel bone-targeting delivery systems,and identification of natural compounds targeting osteocytes.展开更多
Modulations of mitochondrial dysfunction,which involve a series of dynamic processes such as mitochondrial biogenesis,mitochondrial fusion and fission,mitochondrial transport,mitochondrial autophagy,mitochondrial apop...Modulations of mitochondrial dysfunction,which involve a series of dynamic processes such as mitochondrial biogenesis,mitochondrial fusion and fission,mitochondrial transport,mitochondrial autophagy,mitochondrial apoptosis,and oxidative stress,play an important role in the onset and progression of stroke.With a better understanding of the critical role of mitochondrial dysfunction modulations in post-stroke neurological injury,these modulations have emerged as a potential target for stroke prevention and treatment.Additionally,since effective treatments for stroke are extremely limited and natural products currently offer some outstanding advantages,we focused on the findings and mechanisms of action related to the use of natural products for targeting mitochondrial dysfunction in the treatment of stroke.Natural products achieve neuroprotective through multi-target regulation of mitochondrial dysfunction encompassing the following processes:(1)Mitochondrial biogenesis:Cordyceps and hydroxysafflor yellow A activate the peroxisome proliferator-activated receptor gamma coactivator 1-alpha/nuclear respiratory factor pathway,promote mitochondrial DNA replication and respiratory chain protein synthesis,and thereby restore energy supply in the ischemic penumbra.(2)Mitochondrial dynamics balance:Ginsenoside Rb3 promotes Opa1-mediated neural stem cell migration and diffusion for recovery of damaged brain tissue.(3)Mitochondrial autophagy:Gypenoside XVII selectively eliminates damaged mitochondria via the phosphatase and tensin homolog-induced kinase 1/Parkin pathway and blocks reactive oxygen species and the NOD-like receptor protein 3 inflammasome cascade,thereby alleviating blood-brain barrier damage.(4)Anti-apoptotic mechanisms:Ginkgolide K inhibits Bax mitochondrial translocation and downregulates caspase-3/9 activity,reducing neuronal programmed death induced by ischemia-reperfusion.(5)Oxidative stress regulation:Scutellarin exerts antioxidant properties and improves neurological function by modulating the extracellular signal-regulated kinase 5-Kruppel-like factor 2-endothelial nitric oxide synthase signaling pathway.(6)Intercellular mitochondrial transport:Neuroprotective effects of Chrysophanol are associated with accelerated mitochondrial transfer from astrocytes to neurons.Existing studies have confirmed that natural products exhibit neuroprotective effects through multidimensional interventions targeting mitochondrial dysfunction in both ischemic and hemorrhagic stroke models.However,their clinical translation still faces challenges,such as the difficulty in standardization due to component complexity,insufficient cross-regional clinical data,and the lack of long-term safety evaluations.Future research should aim to integrate new technologies,such as single-cell sequencing and organoid models,to deeply explore the mitochondria-targeting mechanisms of natural products and validate their efficacy through multicenter clinical trials,providing theoretical support and translational pathways for the development of novel anti-stroke drugs.展开更多
Natural product(NPT)derived from traditional Chinese medicine has a rich history as an integral part of Chinese healthcare for thousands of years.Recently,the application of NPT in sonodynamic antibacterial therapy(SD...Natural product(NPT)derived from traditional Chinese medicine has a rich history as an integral part of Chinese healthcare for thousands of years.Recently,the application of NPT in sonodynamic antibacterial therapy(SDAT)has emerged as a promising area of research.This perspective summarizes the recent NPT-based sonosensitizers in SDAT.Currently,common NPT-based sonosensitizers include curcumin,chlorophyll derivatives,hypericin,and berberine.Compared with other sonosensitizers,natural sources of NPT-based sonosensitizers with reactive oxide species production performance under ultrasound conditions,low biotoxicity,and other additional biological activity make them have application prospects in bacterial removal.Finally,the potential benefits and challenges of NPT-based nanosonosensitizers were also discussed.展开更多
Pulmonary fibrosis(PF)is a progressive,fatal fibrotic disease caused by respiratory conditions.The condition can ultimately lead to severe organ failure and mortality,and is associated with multiple risk factors.Growi...Pulmonary fibrosis(PF)is a progressive,fatal fibrotic disease caused by respiratory conditions.The condition can ultimately lead to severe organ failure and mortality,and is associated with multiple risk factors.Growing evidence highlights the immune system’s role in PF,with various immune components participating in inflammatory and fibrotic processes.Different immune cells,including neutrophils,lymphocytes,and macrophages,demonstrate distinct effects on PF progression and development.Furthermore,key immune system cytokines,including the interleukin(IL)family,tumor necrosis factor(TNF)-α,interferon(IFN)-γ,transforming growth factor(TGF)-β,and connective tissue growth factor(CTGF),contribute to PF initiation and progression through independent mechanisms and mutual regulation.Currently,limited effective treatments exist for PF,with several treatments causing severe adverse reactions.Natural products,characterized by multi-target effects,holistic regulation,and low toxicity,have emerged as a research focus.This review compiles the mechanisms,therapeutic potential,and active components of various natural products.These compounds can ameliorate pulmonary inflammation,epithelial-mesenchymal transition,and collagen deposition through diverse immune mechanisms,acting at specific stages or throughout the fibrotic process,thereby supporting PF management.This review examines current scientific understanding of natural products’immunological effects in PF,which is crucial for developing future anti-PF therapeutics.展开更多
Thiswork explores aMagnetohydrodynamic(MHD)flowin a triangular cavitywith a thermally insulated baffle.Enclosure’s inclined wall is hotter,whereas the vertical border is adiabatic and the bottom is cooler.The study a...Thiswork explores aMagnetohydrodynamic(MHD)flowin a triangular cavitywith a thermally insulated baffle.Enclosure’s inclined wall is hotter,whereas the vertical border is adiabatic and the bottom is cooler.The study aims to clarify how geometric changes affect thermal performance and offers new perspectives on how to improve heat dissipation mechanisms.A COMSOL Multiphysics version 6.2 has been used to solve numerical solutions.Streamlines and thermal distributions are examined systematically in order to understand how the unique geometry and baffle size of triangular cavities can influence the fluid flow.This influence can result in optimized flow patterns,promoting efficient heat transfer by directing the fluid to specific areas that require more cooling.In comparison with conventional designs,this optimization results in more efficient convective heat transfer,which raises cooling efficiency and lowers thermal resistance.Furthermore,by strengthening heat transfer characteristics in heat transfer systems,these geometries increase thermal efficiency,which helps several sectors,including the production of electricity,HVAC,and the automobile industry.展开更多
This paper develops a semi-analytical solution for pile penetration in natural soft clays using the strain path method(SPM).The stress-strain behavior of soils is characterized by the S-CLAY1S model,which can capture ...This paper develops a semi-analytical solution for pile penetration in natural soft clays using the strain path method(SPM).The stress-strain behavior of soils is characterized by the S-CLAY1S model,which can capture the anisotropic evolution and destructuring nature of soft clays.By integrating the S-CLAY1S model into the theoretical framework of the SPM,a set of ordinary differential equations is formulated with respect to the vertical coordinate of soil particles.The distribution of excess pore water pressure(EPWP)following pile installation is approximated through one-dimensional(1D)radial integration around the pile shaft.The distribution of stresses and EPWP,along with the evolution of fabric anisotropy within the soil surrounding the pile,is presented to illustrate the response of pile penetration in natural soft clays.The proposed solution is validated against existing theoretical solutions using the SPM and cavity expansion method(CEM),along with experimental data.The findings demonstrate that the SPM reveals lower radial effective stresses and EPWP at the pile shaft than that of CEM.Pile penetration alters the soil's anisotropic properties,inducing rotational hardening and affecting post-installation stress distribution.Soil destructuration eliminates bonding among particles near the pile,resulting in a complete disruption of soil structure at the pile surface,which is particularly pronounced for higher initial soil structure ratios.Minimal variation was observed in the three principal stresses and shear stress on the cone side surface as the angle increased from 18°to 60°,except for a slight reduction in EPWP.展开更多
This study aims to mitigate crosswind-induced performance degradation in Natural Draft Dry Cooling Towers used in power plants by developing and assessing windbreak configurations that enhance ventilation while minimi...This study aims to mitigate crosswind-induced performance degradation in Natural Draft Dry Cooling Towers used in power plants by developing and assessing windbreak configurations that enhance ventilation while minimizing additional airflow resistance.Three novel windbreak designs,namely single-windbreak configuration with curved profile,double-windbreak configuration with curved profile,and double-windbreak configuration with inverted curved profile,are proposed accordingly and evaluated against conventional solutions.Three-dimensional numerical models of a 120 m high NDDCT equipped with these windbreaks,together with a conventional Y-shaped windbreak,are developed for systematic comparison.The results demonstrate that windbreak effectiveness strongly depends on crosswind intensity.At low crosswind speeds of 0-6 m/s,the Y-shaped windbreak provides the greatest enhancement,increasing the ventilation rate by 25.45%and the heat rejection rate by 21.37%at 6 m/s compared with the no-windbreak configuration.In contrast,under moderate to strong crosswinds of 6-18 m/s,the single-windbreak configuration with curved profile exhibits superior performance.At 18 m/s,it increases the ventilation rate by 148.88%and the heat rejection rate by 79.74%relative to the baseline case,outperforming the Y-shaped windbreak by 26.59%in ventilation rate and 17.01%in heat rejection capacity.Analysis of airflow structure,temperature fields,and velocity distributions confirms that the single-windbreak configuration with curved profile more effectively suppresses crosswind penetration and promotes stable upward airflow at higher wind speeds.Based on a comprehensive assessment of aerodynamic and thermal performance,the Y-shaped windbreak is recommended for regions where crosswind speeds remain below 6 m/s,whereas the single-windbreak configuration with curved profile is preferable for sites exposed to stronger crosswinds exceeding this threshold.展开更多
Background:In mental health,recovery is emphasized,and qualitative analyses of service users’narratives have accumulated;however,while qualitative approaches excel at capturing rich context and generating new concept...Background:In mental health,recovery is emphasized,and qualitative analyses of service users’narratives have accumulated;however,while qualitative approaches excel at capturing rich context and generating new concepts,they are limited in generalizability and feasible data volume.This study aimed to quantify the subjective life history narratives of users of psychiatric home-visit nursing using natural language processing(NLP)and to clarify the relationships between linguistic features and recovery-related indicators.Methods:We conducted audio-recorded and transcribed semi-structured interviews on daily life verbatim and collected self-report questionnaires(Recovery Assessment Scale[RAS])and clinician ratings(Global Assessment of Functioning[GAF])from Japanese users of psychiatric home-visit nursing.Using the artificial intelligence-based topic-modeling method BERTopic,we extracted topics from the interview texts and calculated each participant’s topic proportions,and then examined associations between topic proportions and recovery-related indicators using Pearson correlation analyses.Results:“School”showed a significant positive correlation with RAS(r=0.39,p=0.05),whereas“Family”showed a significant negative correlation(r=–0.46,p=0.02).GAF was positively correlated with word count(r=0.44,p=0.02)and“Hospital”(r=0.42,p=0.03),and negatively correlated with“Backchannels”(aizuchi)(r=–0.41,p=0.03).Conclusion:The present results suggest that the quantity,quality,and content of narratives can serve as useful indicators of mental health and recovery,and that objective NLP-based analysis of service users’narratives can complement traditional self-report scales and clinician ratings to inform the design of recovery-oriented care in psychiatric home-visit nursing.展开更多
In winter 2018,an aerosol physicochemical experiment was conducted in the Western Pacific Ocean(WPO)aboard the Research Vessel KEXUE of Chinese Academy of Sciences.This study systematically investigated both natural a...In winter 2018,an aerosol physicochemical experiment was conducted in the Western Pacific Ocean(WPO)aboard the Research Vessel KEXUE of Chinese Academy of Sciences.This study systematically investigated both natural and anthropogenic effects on marine aerosols optical properties,as well as the applicability of multi-satellite products and IMPROVE equation.The averaged aerosol optical depth(AOD500 nm)was 0.31±0.16 andÅngström exponent440–675 nm was 0.29±0.30.In offshore China,significant anthropogenic emissions affected the marine environment.In remote WPO,dust aerosols transported from northern China,Siberia,Central Asia,and those settling from the upper troposphere originating from north Africa,Arabian peninsula,and western India,were dominant.The spatial trends of AOD were opposite in the mid-latitude and southern seas of WPO.The highest AOD,0.32±0.23,appeared along the coast of South Asia at mid-latitude,decreasing from offshore seas to remote oceans.In low-latitude and equatorial seas,AOD significantly increased from coast to remote oceans.Ångström exponent dropped significantly from the coast to remote oceans as anthropogenic influence diminished across the entire WPO.Correlation analysis showed that both MODIS-C6 and Himawari AOD prod-ucts showed similar applicability in coastal urban areas,while Himawari AOD is highly recommended for coastal background and marine environment due to its finer resolution.The extinction coefficient derived from PM_(2.5) chemical compositions using IMPROVE algorithm exhibited a significant correlation(R^(2)=0.58)with the con-currently measured AOD in the absence of long-distance transport,suggesting that the IMPROVE is a reasonable proxy of the columnar average of marine aerosol extinctions free from transport influences.展开更多
As natural killer(NK)cells eliminate cancer cells and virus-infected cells,as well as modulate various other medical conditions,including aging-associated conditions such as neurodegenerative disorders,understanding N...As natural killer(NK)cells eliminate cancer cells and virus-infected cells,as well as modulate various other medical conditions,including aging-associated conditions such as neurodegenerative disorders,understanding NK cell regulation is of considerable clinical importance.This article reviews the role of circadian processes(melatonin and the cortisol system),aryl hydrocarbon receptor,and vagal nerve in the modulation of NK cell function,highlighting the importance of the endogenous mitochondrial melatonergic pathway in NK cells.As circadian and exogenous melatonin increase NK cell cytotoxicity,the presence of the endogenous melatonergic pathway may be of some importance not only to NK function and immune checkpoint regulation but also from the efflux of melatonin,which decreases tumor cell survival,proliferation,and metastasis,as well as decreasing immune checkpoint ligands,such as programmed cell ligand 1(PD-L1).NK cell melatonergic pathway regulation may therefore have significant impacts not only on NK cell cytotoxicity but also on the intercellular interactions within tumors and other pathological microenvironments.As melatonin has anti-viral effects,the regulation of the NK cell melatonergic pathway can have wider impacts on how NK cells regulate viral infections,including in the course of viral-induced susceptibility to neurodegenerative conditions.Recent data indicate that the endogenous melatonergic pathway is regulated by interactions of signal transducer and activator of transcription(STAT)3 and nuclear factor kappa-light-chain-enhancer of activated B cells(NF-κB)dimer composition.As both STAT3 and NF-κB dimer composition modulate NK cells,their interaction in the modulation of the NK cell melatonergic pathway will be important to determine.This has significant future research and treatment implications,including improving the clinical efficacy of current treatment approaches such as immune checkpoint inhibition and chimeric antigen receptor(CAR)NK cell therapy,and may accelerate a means of preventing cancer.展开更多
Typically used thermal insulation materials such as foam insulation and fibreglass may pose notable health risks and environmental impacts thereby resulting in respiratory irritation andwaste disposal issues,respectiv...Typically used thermal insulation materials such as foam insulation and fibreglass may pose notable health risks and environmental impacts thereby resulting in respiratory irritation andwaste disposal issues,respectively.While these materials are affordable and display good thermal insulation,their unsustainable traits pertaining to an intensive manufacturing process and poor disposability are major concerns.Alternative insulation materials with enhanced sustainable characteristics are therefore being explored,and one type of material which has gained notable attention owing to its low carbon footprint and low thermal conductivity is natural fibre.Among the few review studies conducted on Natural Fibre Reinforced Composite(NFRC)insulation boards,the multitude of factors and underlying mechanisms affecting their thermal conductivity performance have been sparsely covered.This review study aimed to address this gap by providing a holistic overview of some of the key intrinsic and extrinsic factors affecting the thermal conductivity performance of NFRCs.Key intrinsic factors pertaining to the microstructural features and to the physico-mechanical traits of NFRCs,namely the fibre lumen size,α,and the fibre-matrix thermal conductivity ratio,β,respectively,were found to largely affect the Transverse Thermal Conductivity(TTC)in NFRC boards.Extrinsic factors,which were found to indirectly affect NFRCs’thermal conductivity,such as fibre pre-processing,composite manufacturing and environmental factors,were also covered.Some of the noteworthy NFRC featureswhich were found to affect their thermal conductivity are volume fraction of fibres,bulk density and porosity.The findings of this study highlight the need for additional research investigation to address the foregoing limitations observed in NFRC thermal insulation boards by considering appropriate natural fibres,composition and fabrication techniques.The fabrication of high-grade NFRC boards,which will display an optimum balance between enhanced thermal insulation and long-term durability performance,could further replace conventionally used thermal insulation boards in the modern building and construction industry.展开更多
The migration,accumulation,and high yield of hydrocarbons in tight sandstone reservoirs are closely tied to the natural fracture systems within the reservoirs.Large-scale fracture networks not only enhance reservoir s...The migration,accumulation,and high yield of hydrocarbons in tight sandstone reservoirs are closely tied to the natural fracture systems within the reservoirs.Large-scale fracture networks not only enhance reservoir seepage capacity but also influence effective productivity and subsequent fracturing reconstruction.Given the diverse mechanical behaviors,such as migration,penetration,or fracture arrest,traditional assumptions about fracture interaction criteria fail to address this complexity.To resolve these issues,a global cohesive element method is proposed to model random natural fractures.This approach verifies intersection models based on real-time stress conditions rather than pre-set criteria,enabling better characterization of interactions between hydraulic and natural fractures.Research has shown that the elastic modulus,horizontal stress difference,and fracturing fluid pumping rate significantly promote the expansion of hydraulic fractures.The use of low viscosity fracturing fluid can observe a decrease in the width of fractures near the wellbore,which may cause fractures to deflect when interacting with natural fractures.However,simulations under these conditions did not form a“complex network of fractures”.It is worth noting that when the local stress difference is zero,the result is close to the formation of this network.Excessive spacing will reduce the interaction between fractures,resulting in a decrease in the total length of fractures.By comprehensively analyzing these factors,an optimal combination can be identified,increasing the likelihood of achieving a“complex fracture network”.This paper thoroughly investigates hydraulic fracture propagation in naturally fractured reservoirs under various conditions,offering insights for developing efficient fracturing methods.展开更多
基金Project supported by the National Natural Science Foundation of China(Grant Nos.12104247 and 11934020)。
文摘In a superconductor embedded with a quantum magnetic impurity,the Kondo effect is involved,leading to the competition between the Kondo singlet phase and the superconductivity phase.By means of the natural orbitals renormalization group(NORG)method,we revisit the problem of a quantum magnetic impurity coupled with a conventional s-wave superconductor.Here we present a detailed study focusing on the impurity spin polarization and susceptibility,the Kondo screening cloud,as well as the number and structures of the active natural orbitals(ANOs).In the superconducting phase,the impurity spin is partially polarized,indicating that the impurity remains partially screened by the quantum fluctuations.Furthermore,the impurity spin susceptibility becomes divergent,resulting from the presence of residual local moment formed at the impurity site.Correspondingly,a non-integral(incomplete)Kondo cloud is formed,although the ground state is a spin doublet in this phase.In comparison,the Kondo cloud is complete in the Kondo singlet phase as expected.We also quantify the critical point,where the quantum phase transition from a Kondo singlet phase to a superconducting phase occurs,which is consistent with that in previous works.On the other hand,it is illustrated that only one ANO emerges in both quantum phases.The structures of the ANO,projected into both the real space and momentum space,are distinct in the Kondo singlet phase from that in the superconducting phase.More specifically,in the Kondo singlet phase,the ANO keeps fully active with half-occupied,and the superconducting gap has negligible influence on its structure.On the contrary,in the superconducting phase,the ANO tends to be inactive and its structure changes significantly as the superconducting gap increases.Additionally,our investigation demonstrates that the NORG method is reliable and convenient to solve the quantum impurity problems in superconductors as well,which will promote further theoretical studies on the Kondo problems in such systems using numerical methods.
文摘Natural Gas Industry B创刊于2014年,是天然气工业杂志社与KeAi公司合作出版的国际OA期刊,在爱思唯尔旗下的ScienceDirect平台上双月出版。论文聚焦天然气、氢气、氦气、地热等地质能源,涵盖地质勘探、气藏开发、工程技术、储运利用、净化化工、产业趋势等专业方向。期刊服务全球天然气产业,并积极推动能源行业碳减排和低碳转型的发展。
文摘Natural Gas Industry B创刊于2014年,是天然气工业杂志社与KeAi公司合作出版的国际OA期刊,在爱思唯尔旗下的Science Direct平台上双月出版。论文聚焦天然气、氢气、氦气、地热等地质能源,涵盖地质勘探、气藏开发、工程技术、储运利用、净化化工、产业趋势等专业方向。期刊服务全球天然气产业,并积极推动能源行业碳减排和低碳转型的发展。
文摘CHINA.Dinghu Mountain National Nature Reserve.Located in Zhaoqing,Guangdong Province,Dinghu Mountain National Nature Reserve is a pristine natural sanctuary spanning 1,133 hectares within the low mountain ranges of the Dayunwu Mountains.
基金supported by the National Science Foundation of China(No.82474144)the Zhejiang Province Technological Leading Talents Fund Project(No.2022R52031)。
文摘Knee osteoarthritis(KOA)is a prevalent chronic degenerative joint disorder characterized by an imbalance between articular cartilage degradation and synthesis,a central mechanism in KOA pathogenesis.Given the absence of disease-modifying therapies,there is a critical need to elucidate the underlying pathological processes,establish reliable biomarkers for early detection and prognosis,and identify safer,more effective therapeutic agents.In recent years,natural products have attracted considerable interest due to their low toxicity,cost-effectiveness,and distinct biological activities,demonstrating significant potential in KOA management.These compounds can impede KOA progression through multiple mechanisms,including promoting cartilage matrix synthesis,mitigating inflammation,reducing oxidative stress,suppressing chondrocyte apoptosis,and modulating autophagy,thereby supporting their translational application.This review summarizes biomarkers relevant to early diagnosis and phenotypic stratification in KOA,with a focus on elucidating the pharmacological actions and molecular mechanisms of natural products,such as flavonoids,alkaloids,saponins,terpenes,and traditional Chinese medicine(TCM)formulas,in KOA intervention,aiming to provide evidence-based strategies for improved disease management.
基金supported by the National Natural Science Foundation of China(Nos.42107420,U23A20157,and U1910207)Shanxi Province Science Foundation for Young Scholars(No.20210302124363).
文摘Vegetation plays an important role in the environmental transport behavior of organic pollutants,however,the different roles of crops and natural vegetation have been ignored in most previous studies.In this study,we developed the BETR-Urban-Rural-Veg model to quantitatively evaluate the influences of both natural vegetation and crops on the multimedia transport processes of Phenanthrene(PHE)and Benzo(a)pyrene(BaP)in mainland of China.The geographic distribution of polycyclic aromatic hydrocarbon(PAH)emissions and concentrations were consistent,displaying higher levels in northern China while lower levels in southern China.Under seasonal simulations,for both natural vegetation and crops,PAH concentrations in winter and spring were 1.5 to 27-fold higher than in summer and autumn,especially for PHE.Owing to the higher leaf area index(LAI)of natural vegetation and harvesting of crops,the filter and sequestration effect of natural vegetation was stronger than crops,while the seasonal changes of PAH concentrations in crops were more significant than natural vegetation.Temperature,precipitation rates and LAI might have important influences on seasonal concentrations and overall persistence of PAHs.PHE was more sensitive to the impacts of seasonal environmental parameters.Under different landscape scenarios,average annual PAH concentrations in natural vegetation were always a little higher than those in crops,and the overall persistence of BaP was greatly affected increasing by 15.15%-16.47%.This improved model provides a useful tool for environmental management.The results of this study are expected to support land use plans and decision-making in China's mainland.
基金supported by the Leading Technology Foundation Research Project of Jiangsu Province (No. BK20232035)the Key Project of Basic Research Program of Jiangsu Province(No. BK20243061)+1 种基金the Project of State Key Laboratory of Natural Medicines,China Pharmaceutical University (No.SKLNMZZ202302)the Haihe Laboratory of Cell Ecosystem Innovation Fund (No. 22HHXBSS00005)。
文摘Mesenchymal stem cells(MSCs) are widely utilized in disease treatment and regenerative medicine due to their potent immunomodulatory properties and capacity for tissue repair.However, limitations—including insufficient migratory capacity, suboptimal survival, proliferation, differentiation potential, and variable immunomodulatory responses—significantly hinder their clinical translation and therapeutic impact. Natural products have been shown to enhance MSC homing, stress resilience, immune regulation, and lineage-specific differentiation through multi-target mechanisms, thereby emerging as promising, safe, and practical strategies to improve the in vivo performance of MSC-based therapies. This review examines the key translational challenges associated with MSCs, elucidates the mechanistic basis by which natural products regulate the in vivo fate of MSCs, and explores the potential of integrating natural product adjuvants with MSC therapy for enhanced clinical outcomes.
基金supported by the National Natural Science Foundation of China(Nos.82003977,82274134 and 82274139)the National Key Research and Development Plan(No.2017YFC1702200)+1 种基金the Key Research and Development Program of Zhejiang Province(No.2020C04020)the Science and Technology Program of Zhejiang Province(No.2025C02183).
文摘Inflammatory bowel disease(IBD),which includes Crohn’s disease(CD)and ulcerative colitis(UC),is a chronic inflammatory condition affecting the gastrointestinal tract.The global incidence and prevalence of IBD continue to increase.While multiple clinical treatments exist,conventional therapies frequently present limitations and adverse effects.Natural polysaccharides(PSs)have emerged as a significant focus of research interest due to their therapeutic potential and applications in functional foods and health products.This review synthesizes current understanding of IBD pathophysiology and the mechanisms by which natural PSs counter IBD,including their capacity to restore immune homeostasis and intestinal barrier function,modulate gut microbiota and metabolites,reduce oxidative stress,and address irregularities in autophagy and endoplasmic reticulum stress(ERS).The review examines the structure-activity relationships of PSs demonstrating anti-IBD effects and identifies promising therapeutic products.The discussion encompasses pharmacokinetics,safety evaluations,and clinical applications of these compounds.This comprehensive review establishes a theoretical foundation for developing natural PS-based therapeutic approaches for IBD management.
基金supported by the National Natural Science Foundation of China(No.31800059)。
文摘Osteoporosis is a systemic skeletal disorder characterized by reduced bone mass,compromised bone microstructure,and an increased risk of fractures,primarily due to excessive osteoclast-mediated bone resorption relative to osteoblast-mediated bone formation.While current anti-osteoporosis drugs,such as bisphosphonates and denosumab,predominantly focus on reducing bone resorption,osteoanabolic approaches are essential for restoring bone microarchitecture and ultimately reducing fracture risk.Traditional Chinese medicines(TCMs)and their active ingredients have long been used in China for osteoporosis prevention and treatment.This review provides a comprehensive evaluation of the effects and molecular mechanisms of 65 natural products across 24 categories on osteoblast-mediated bone formation.These compounds promote bone formation by regulating key transcription factors(RUNX2 and Osterix)and signaling pathways,including WNT/β-catenin,bone morphogenic protein(BMP),mitogen-activated protein kinase(MAPK),phosphoinositide 3-kinase/protein kinase B(PI3K/AKT),oxidative stress,autophagy,and epigenetic regulation.Notably,certain natural products[e.g.,icariin(ICA)]exert their effects through multiple targets and pathways.Many of these natural products have demonstrated significant therapeutic efficacy in animal models,such as ovariectomized(OVX)mice.Our findings suggest that natural products with kidney-tonifying,anti-inflammatory,and antioxidant properties,as well as those inhibiting adipocyte differentiation,may hold promise for osteoporosis treatment.Additionally,we highlight current research gaps and propose future directions,including high-throughput screening and validation in diverse animal models,development of novel bone-targeting delivery systems,and identification of natural compounds targeting osteocytes.
基金supported by the National Natural Science Foundation of China,No.82204663(to TZ)the Natural Science Foundation of Shandong Province,No.ZR2022QH058(to TZ).
文摘Modulations of mitochondrial dysfunction,which involve a series of dynamic processes such as mitochondrial biogenesis,mitochondrial fusion and fission,mitochondrial transport,mitochondrial autophagy,mitochondrial apoptosis,and oxidative stress,play an important role in the onset and progression of stroke.With a better understanding of the critical role of mitochondrial dysfunction modulations in post-stroke neurological injury,these modulations have emerged as a potential target for stroke prevention and treatment.Additionally,since effective treatments for stroke are extremely limited and natural products currently offer some outstanding advantages,we focused on the findings and mechanisms of action related to the use of natural products for targeting mitochondrial dysfunction in the treatment of stroke.Natural products achieve neuroprotective through multi-target regulation of mitochondrial dysfunction encompassing the following processes:(1)Mitochondrial biogenesis:Cordyceps and hydroxysafflor yellow A activate the peroxisome proliferator-activated receptor gamma coactivator 1-alpha/nuclear respiratory factor pathway,promote mitochondrial DNA replication and respiratory chain protein synthesis,and thereby restore energy supply in the ischemic penumbra.(2)Mitochondrial dynamics balance:Ginsenoside Rb3 promotes Opa1-mediated neural stem cell migration and diffusion for recovery of damaged brain tissue.(3)Mitochondrial autophagy:Gypenoside XVII selectively eliminates damaged mitochondria via the phosphatase and tensin homolog-induced kinase 1/Parkin pathway and blocks reactive oxygen species and the NOD-like receptor protein 3 inflammasome cascade,thereby alleviating blood-brain barrier damage.(4)Anti-apoptotic mechanisms:Ginkgolide K inhibits Bax mitochondrial translocation and downregulates caspase-3/9 activity,reducing neuronal programmed death induced by ischemia-reperfusion.(5)Oxidative stress regulation:Scutellarin exerts antioxidant properties and improves neurological function by modulating the extracellular signal-regulated kinase 5-Kruppel-like factor 2-endothelial nitric oxide synthase signaling pathway.(6)Intercellular mitochondrial transport:Neuroprotective effects of Chrysophanol are associated with accelerated mitochondrial transfer from astrocytes to neurons.Existing studies have confirmed that natural products exhibit neuroprotective effects through multidimensional interventions targeting mitochondrial dysfunction in both ischemic and hemorrhagic stroke models.However,their clinical translation still faces challenges,such as the difficulty in standardization due to component complexity,insufficient cross-regional clinical data,and the lack of long-term safety evaluations.Future research should aim to integrate new technologies,such as single-cell sequencing and organoid models,to deeply explore the mitochondria-targeting mechanisms of natural products and validate their efficacy through multicenter clinical trials,providing theoretical support and translational pathways for the development of novel anti-stroke drugs.
基金supported by the Innovation and Entrepreneurship Training Program for College Students(X2025102911746,X2025102910483).
文摘Natural product(NPT)derived from traditional Chinese medicine has a rich history as an integral part of Chinese healthcare for thousands of years.Recently,the application of NPT in sonodynamic antibacterial therapy(SDAT)has emerged as a promising area of research.This perspective summarizes the recent NPT-based sonosensitizers in SDAT.Currently,common NPT-based sonosensitizers include curcumin,chlorophyll derivatives,hypericin,and berberine.Compared with other sonosensitizers,natural sources of NPT-based sonosensitizers with reactive oxide species production performance under ultrasound conditions,low biotoxicity,and other additional biological activity make them have application prospects in bacterial removal.Finally,the potential benefits and challenges of NPT-based nanosonosensitizers were also discussed.
基金supported by the National Natural Science Foundation of China(No.82260820)the Natural Science Foundation of Jilin Province,Jilin,China(No.YDZJ202201ZYTS155).
文摘Pulmonary fibrosis(PF)is a progressive,fatal fibrotic disease caused by respiratory conditions.The condition can ultimately lead to severe organ failure and mortality,and is associated with multiple risk factors.Growing evidence highlights the immune system’s role in PF,with various immune components participating in inflammatory and fibrotic processes.Different immune cells,including neutrophils,lymphocytes,and macrophages,demonstrate distinct effects on PF progression and development.Furthermore,key immune system cytokines,including the interleukin(IL)family,tumor necrosis factor(TNF)-α,interferon(IFN)-γ,transforming growth factor(TGF)-β,and connective tissue growth factor(CTGF),contribute to PF initiation and progression through independent mechanisms and mutual regulation.Currently,limited effective treatments exist for PF,with several treatments causing severe adverse reactions.Natural products,characterized by multi-target effects,holistic regulation,and low toxicity,have emerged as a research focus.This review compiles the mechanisms,therapeutic potential,and active components of various natural products.These compounds can ameliorate pulmonary inflammation,epithelial-mesenchymal transition,and collagen deposition through diverse immune mechanisms,acting at specific stages or throughout the fibrotic process,thereby supporting PF management.This review examines current scientific understanding of natural products’immunological effects in PF,which is crucial for developing future anti-PF therapeutics.
文摘Thiswork explores aMagnetohydrodynamic(MHD)flowin a triangular cavitywith a thermally insulated baffle.Enclosure’s inclined wall is hotter,whereas the vertical border is adiabatic and the bottom is cooler.The study aims to clarify how geometric changes affect thermal performance and offers new perspectives on how to improve heat dissipation mechanisms.A COMSOL Multiphysics version 6.2 has been used to solve numerical solutions.Streamlines and thermal distributions are examined systematically in order to understand how the unique geometry and baffle size of triangular cavities can influence the fluid flow.This influence can result in optimized flow patterns,promoting efficient heat transfer by directing the fluid to specific areas that require more cooling.In comparison with conventional designs,this optimization results in more efficient convective heat transfer,which raises cooling efficiency and lowers thermal resistance.Furthermore,by strengthening heat transfer characteristics in heat transfer systems,these geometries increase thermal efficiency,which helps several sectors,including the production of electricity,HVAC,and the automobile industry.
基金support from the National Natural Science Foundation of China(Grant No.42407256)the State Key Laboratory of Hydraulics and Mountain River Engineering,China(Grant No.SKHL2113)the Sichuan Science and Technology Program(Grant No.2024YFHZ0341).
文摘This paper develops a semi-analytical solution for pile penetration in natural soft clays using the strain path method(SPM).The stress-strain behavior of soils is characterized by the S-CLAY1S model,which can capture the anisotropic evolution and destructuring nature of soft clays.By integrating the S-CLAY1S model into the theoretical framework of the SPM,a set of ordinary differential equations is formulated with respect to the vertical coordinate of soil particles.The distribution of excess pore water pressure(EPWP)following pile installation is approximated through one-dimensional(1D)radial integration around the pile shaft.The distribution of stresses and EPWP,along with the evolution of fabric anisotropy within the soil surrounding the pile,is presented to illustrate the response of pile penetration in natural soft clays.The proposed solution is validated against existing theoretical solutions using the SPM and cavity expansion method(CEM),along with experimental data.The findings demonstrate that the SPM reveals lower radial effective stresses and EPWP at the pile shaft than that of CEM.Pile penetration alters the soil's anisotropic properties,inducing rotational hardening and affecting post-installation stress distribution.Soil destructuration eliminates bonding among particles near the pile,resulting in a complete disruption of soil structure at the pile surface,which is particularly pronounced for higher initial soil structure ratios.Minimal variation was observed in the three principal stresses and shear stress on the cone side surface as the angle increased from 18°to 60°,except for a slight reduction in EPWP.
基金supported by the National Natural Science Foundation of China(Grant No.52476206)the Key R&D Program of Shandong Province,China(Grant No.2025CXGC010203)+1 种基金the Guangdong Basic and Applied Basic Research Foundation(Grant No.2025A1515012123)the Shandong Natural Science Foundation(Grant No.ZR2022ME008).
文摘This study aims to mitigate crosswind-induced performance degradation in Natural Draft Dry Cooling Towers used in power plants by developing and assessing windbreak configurations that enhance ventilation while minimizing additional airflow resistance.Three novel windbreak designs,namely single-windbreak configuration with curved profile,double-windbreak configuration with curved profile,and double-windbreak configuration with inverted curved profile,are proposed accordingly and evaluated against conventional solutions.Three-dimensional numerical models of a 120 m high NDDCT equipped with these windbreaks,together with a conventional Y-shaped windbreak,are developed for systematic comparison.The results demonstrate that windbreak effectiveness strongly depends on crosswind intensity.At low crosswind speeds of 0-6 m/s,the Y-shaped windbreak provides the greatest enhancement,increasing the ventilation rate by 25.45%and the heat rejection rate by 21.37%at 6 m/s compared with the no-windbreak configuration.In contrast,under moderate to strong crosswinds of 6-18 m/s,the single-windbreak configuration with curved profile exhibits superior performance.At 18 m/s,it increases the ventilation rate by 148.88%and the heat rejection rate by 79.74%relative to the baseline case,outperforming the Y-shaped windbreak by 26.59%in ventilation rate and 17.01%in heat rejection capacity.Analysis of airflow structure,temperature fields,and velocity distributions confirms that the single-windbreak configuration with curved profile more effectively suppresses crosswind penetration and promotes stable upward airflow at higher wind speeds.Based on a comprehensive assessment of aerodynamic and thermal performance,the Y-shaped windbreak is recommended for regions where crosswind speeds remain below 6 m/s,whereas the single-windbreak configuration with curved profile is preferable for sites exposed to stronger crosswinds exceeding this threshold.
文摘Background:In mental health,recovery is emphasized,and qualitative analyses of service users’narratives have accumulated;however,while qualitative approaches excel at capturing rich context and generating new concepts,they are limited in generalizability and feasible data volume.This study aimed to quantify the subjective life history narratives of users of psychiatric home-visit nursing using natural language processing(NLP)and to clarify the relationships between linguistic features and recovery-related indicators.Methods:We conducted audio-recorded and transcribed semi-structured interviews on daily life verbatim and collected self-report questionnaires(Recovery Assessment Scale[RAS])and clinician ratings(Global Assessment of Functioning[GAF])from Japanese users of psychiatric home-visit nursing.Using the artificial intelligence-based topic-modeling method BERTopic,we extracted topics from the interview texts and calculated each participant’s topic proportions,and then examined associations between topic proportions and recovery-related indicators using Pearson correlation analyses.Results:“School”showed a significant positive correlation with RAS(r=0.39,p=0.05),whereas“Family”showed a significant negative correlation(r=–0.46,p=0.02).GAF was positively correlated with word count(r=0.44,p=0.02)and“Hospital”(r=0.42,p=0.03),and negatively correlated with“Backchannels”(aizuchi)(r=–0.41,p=0.03).Conclusion:The present results suggest that the quantity,quality,and content of narratives can serve as useful indicators of mental health and recovery,and that objective NLP-based analysis of service users’narratives can complement traditional self-report scales and clinician ratings to inform the design of recovery-oriented care in psychiatric home-visit nursing.
基金supported by the CAS Strategic Priority Research Program(No.XDB0760102),the Ministry of Science and Technology of China(No.2022YFF0802501)the Major Science and Technology Infrastructure Maintenance and Transformation Project of the Chinese Academy of Sciences,Shanghai Science and Technology Innovation Action Plan-Phospherus Project(No.23YF1426200)the National Key Research and Development Program of China(No.2024YFE0212200).
文摘In winter 2018,an aerosol physicochemical experiment was conducted in the Western Pacific Ocean(WPO)aboard the Research Vessel KEXUE of Chinese Academy of Sciences.This study systematically investigated both natural and anthropogenic effects on marine aerosols optical properties,as well as the applicability of multi-satellite products and IMPROVE equation.The averaged aerosol optical depth(AOD500 nm)was 0.31±0.16 andÅngström exponent440–675 nm was 0.29±0.30.In offshore China,significant anthropogenic emissions affected the marine environment.In remote WPO,dust aerosols transported from northern China,Siberia,Central Asia,and those settling from the upper troposphere originating from north Africa,Arabian peninsula,and western India,were dominant.The spatial trends of AOD were opposite in the mid-latitude and southern seas of WPO.The highest AOD,0.32±0.23,appeared along the coast of South Asia at mid-latitude,decreasing from offshore seas to remote oceans.In low-latitude and equatorial seas,AOD significantly increased from coast to remote oceans.Ångström exponent dropped significantly from the coast to remote oceans as anthropogenic influence diminished across the entire WPO.Correlation analysis showed that both MODIS-C6 and Himawari AOD prod-ucts showed similar applicability in coastal urban areas,while Himawari AOD is highly recommended for coastal background and marine environment due to its finer resolution.The extinction coefficient derived from PM_(2.5) chemical compositions using IMPROVE algorithm exhibited a significant correlation(R^(2)=0.58)with the con-currently measured AOD in the absence of long-distance transport,suggesting that the IMPROVE is a reasonable proxy of the columnar average of marine aerosol extinctions free from transport influences.
文摘As natural killer(NK)cells eliminate cancer cells and virus-infected cells,as well as modulate various other medical conditions,including aging-associated conditions such as neurodegenerative disorders,understanding NK cell regulation is of considerable clinical importance.This article reviews the role of circadian processes(melatonin and the cortisol system),aryl hydrocarbon receptor,and vagal nerve in the modulation of NK cell function,highlighting the importance of the endogenous mitochondrial melatonergic pathway in NK cells.As circadian and exogenous melatonin increase NK cell cytotoxicity,the presence of the endogenous melatonergic pathway may be of some importance not only to NK function and immune checkpoint regulation but also from the efflux of melatonin,which decreases tumor cell survival,proliferation,and metastasis,as well as decreasing immune checkpoint ligands,such as programmed cell ligand 1(PD-L1).NK cell melatonergic pathway regulation may therefore have significant impacts not only on NK cell cytotoxicity but also on the intercellular interactions within tumors and other pathological microenvironments.As melatonin has anti-viral effects,the regulation of the NK cell melatonergic pathway can have wider impacts on how NK cells regulate viral infections,including in the course of viral-induced susceptibility to neurodegenerative conditions.Recent data indicate that the endogenous melatonergic pathway is regulated by interactions of signal transducer and activator of transcription(STAT)3 and nuclear factor kappa-light-chain-enhancer of activated B cells(NF-κB)dimer composition.As both STAT3 and NF-κB dimer composition modulate NK cells,their interaction in the modulation of the NK cell melatonergic pathway will be important to determine.This has significant future research and treatment implications,including improving the clinical efficacy of current treatment approaches such as immune checkpoint inhibition and chimeric antigen receptor(CAR)NK cell therapy,and may accelerate a means of preventing cancer.
文摘Typically used thermal insulation materials such as foam insulation and fibreglass may pose notable health risks and environmental impacts thereby resulting in respiratory irritation andwaste disposal issues,respectively.While these materials are affordable and display good thermal insulation,their unsustainable traits pertaining to an intensive manufacturing process and poor disposability are major concerns.Alternative insulation materials with enhanced sustainable characteristics are therefore being explored,and one type of material which has gained notable attention owing to its low carbon footprint and low thermal conductivity is natural fibre.Among the few review studies conducted on Natural Fibre Reinforced Composite(NFRC)insulation boards,the multitude of factors and underlying mechanisms affecting their thermal conductivity performance have been sparsely covered.This review study aimed to address this gap by providing a holistic overview of some of the key intrinsic and extrinsic factors affecting the thermal conductivity performance of NFRCs.Key intrinsic factors pertaining to the microstructural features and to the physico-mechanical traits of NFRCs,namely the fibre lumen size,α,and the fibre-matrix thermal conductivity ratio,β,respectively,were found to largely affect the Transverse Thermal Conductivity(TTC)in NFRC boards.Extrinsic factors,which were found to indirectly affect NFRCs’thermal conductivity,such as fibre pre-processing,composite manufacturing and environmental factors,were also covered.Some of the noteworthy NFRC featureswhich were found to affect their thermal conductivity are volume fraction of fibres,bulk density and porosity.The findings of this study highlight the need for additional research investigation to address the foregoing limitations observed in NFRC thermal insulation boards by considering appropriate natural fibres,composition and fabrication techniques.The fabrication of high-grade NFRC boards,which will display an optimum balance between enhanced thermal insulation and long-term durability performance,could further replace conventionally used thermal insulation boards in the modern building and construction industry.
基金supported by the National Natural Science Foundation of China(52074313).
文摘The migration,accumulation,and high yield of hydrocarbons in tight sandstone reservoirs are closely tied to the natural fracture systems within the reservoirs.Large-scale fracture networks not only enhance reservoir seepage capacity but also influence effective productivity and subsequent fracturing reconstruction.Given the diverse mechanical behaviors,such as migration,penetration,or fracture arrest,traditional assumptions about fracture interaction criteria fail to address this complexity.To resolve these issues,a global cohesive element method is proposed to model random natural fractures.This approach verifies intersection models based on real-time stress conditions rather than pre-set criteria,enabling better characterization of interactions between hydraulic and natural fractures.Research has shown that the elastic modulus,horizontal stress difference,and fracturing fluid pumping rate significantly promote the expansion of hydraulic fractures.The use of low viscosity fracturing fluid can observe a decrease in the width of fractures near the wellbore,which may cause fractures to deflect when interacting with natural fractures.However,simulations under these conditions did not form a“complex network of fractures”.It is worth noting that when the local stress difference is zero,the result is close to the formation of this network.Excessive spacing will reduce the interaction between fractures,resulting in a decrease in the total length of fractures.By comprehensively analyzing these factors,an optimal combination can be identified,increasing the likelihood of achieving a“complex fracture network”.This paper thoroughly investigates hydraulic fracture propagation in naturally fractured reservoirs under various conditions,offering insights for developing efficient fracturing methods.
