Heavy metals are transferred from the abiotic environment to living organisms, accumulate in food, contaminate the food chain, and are an important route of human exposure involving a potential health risk. In this st...Heavy metals are transferred from the abiotic environment to living organisms, accumulate in food, contaminate the food chain, and are an important route of human exposure involving a potential health risk. In this study, the concentrations of heavy metals (Cd, Fe, Pb, Zn and As) in agricultural soils and tubers of <em>Solanum tuberosum spp. andigena</em> (native potato) were evaluated. Also, an assessment of the health risk associated with the daily intake by the local population was performed in the four districts of the department of Junín, between altitudes of 3800 m to 4200 m. The heavy metals concentrations in soils with native potato cultivation followed the following decreasing order of Fe > Zn > Pb > As > Cd, with values below national standards. The heavy metals content in native potatoes was below the limits recommended by international standards with the exception of Pb. The bioconcentration factor (BCF) for the two native potato varieties in decreasing order was Zn > Cd > Pb > As > Fe, all less than 0.5. The estimated daily intake of metals (EDIM) in adults and children through the consumption of native potatoes was higher for Fe and Zn. The threshold carcinogenic risk values (TCR) for As exceeded the safety limits 1 × 10<sup>-4</sup>. It is concluded that the residents in the four high Andean localities would be exposed to carcinogenic adverse health effects associated with the intake of native potatoes. It is important to monitor the concentration of As and other heavy metals in the Andean soils and crops in order to implement a soil and crop management program to ensure food quality.展开更多
Breast cancer is one of the most diagnosed neoplasms worldwide,especially in women.The disease occurs due to genetic variations that modify cell behavior in various cellular aspects,increasing proliferation and preven...Breast cancer is one of the most diagnosed neoplasms worldwide,especially in women.The disease occurs due to genetic variations that modify cell behavior in various cellular aspects,increasing proliferation and preventing cell death among them.Breast cancer presents an average response rate to conventional treatments of between 50%and 60%,given that in the long term,it may present natural or tumor-acquired resistance ar.Diets that include foods that contribute to enhance the molecular mechanism of anti-tumoral medications or stop the development of tumor recurrence,could be important in improving patient survival.Among foods with anti-tumor biological activities such as antiproliferative or antioxidant activity,those with high phenolic content and a purple color have gained prominence in recent years.In the present research,it has been found that purple and pink-colored Chilean native potato genotypes possess high concentrations of total phenolic content and antho-cyanins.The results showed that the potato extract modified the antioxidant response of breast cancer cells.Additionally,three high-pigmented potatoes induce significant cell death in two different breast cancer cell lines.As a molecular mechanism,the extract with high anti-tumoral activities can modulate the gene expression of Bax and Bcl-2,both associated with cell death.In summary,the results demonstrate the important biological ac-tivities of native potato genotypes on breast cancer cell viability.It is important to highlight the great biomedical potential of these potatoes,which could be cultivated extensively,be used worldwide for nutrition and may be an excellent complementary option for patients undergoing breast cancer treatments.展开更多
文摘Heavy metals are transferred from the abiotic environment to living organisms, accumulate in food, contaminate the food chain, and are an important route of human exposure involving a potential health risk. In this study, the concentrations of heavy metals (Cd, Fe, Pb, Zn and As) in agricultural soils and tubers of <em>Solanum tuberosum spp. andigena</em> (native potato) were evaluated. Also, an assessment of the health risk associated with the daily intake by the local population was performed in the four districts of the department of Junín, between altitudes of 3800 m to 4200 m. The heavy metals concentrations in soils with native potato cultivation followed the following decreasing order of Fe > Zn > Pb > As > Cd, with values below national standards. The heavy metals content in native potatoes was below the limits recommended by international standards with the exception of Pb. The bioconcentration factor (BCF) for the two native potato varieties in decreasing order was Zn > Cd > Pb > As > Fe, all less than 0.5. The estimated daily intake of metals (EDIM) in adults and children through the consumption of native potatoes was higher for Fe and Zn. The threshold carcinogenic risk values (TCR) for As exceeded the safety limits 1 × 10<sup>-4</sup>. It is concluded that the residents in the four high Andean localities would be exposed to carcinogenic adverse health effects associated with the intake of native potatoes. It is important to monitor the concentration of As and other heavy metals in the Andean soils and crops in order to implement a soil and crop management program to ensure food quality.
基金supported by grants FONDECYT 1201635 and Fondo de Innovacion para la competitividad de la Regi´on de Los Rios(FICR-Papas PLUS-20-39 and FICR-BDCM 22-22)Vicerrectoría de Inves-tigacion,Desarrollo y Creacion Artística(VIDCA),Centro Inter-disciplinario de Estudios del Sistema Nervioso(CISNe).
文摘Breast cancer is one of the most diagnosed neoplasms worldwide,especially in women.The disease occurs due to genetic variations that modify cell behavior in various cellular aspects,increasing proliferation and preventing cell death among them.Breast cancer presents an average response rate to conventional treatments of between 50%and 60%,given that in the long term,it may present natural or tumor-acquired resistance ar.Diets that include foods that contribute to enhance the molecular mechanism of anti-tumoral medications or stop the development of tumor recurrence,could be important in improving patient survival.Among foods with anti-tumor biological activities such as antiproliferative or antioxidant activity,those with high phenolic content and a purple color have gained prominence in recent years.In the present research,it has been found that purple and pink-colored Chilean native potato genotypes possess high concentrations of total phenolic content and antho-cyanins.The results showed that the potato extract modified the antioxidant response of breast cancer cells.Additionally,three high-pigmented potatoes induce significant cell death in two different breast cancer cell lines.As a molecular mechanism,the extract with high anti-tumoral activities can modulate the gene expression of Bax and Bcl-2,both associated with cell death.In summary,the results demonstrate the important biological ac-tivities of native potato genotypes on breast cancer cell viability.It is important to highlight the great biomedical potential of these potatoes,which could be cultivated extensively,be used worldwide for nutrition and may be an excellent complementary option for patients undergoing breast cancer treatments.
