Introduction With ever-increasing of power sources, the capabilityof power supply was further enforced in 2007. This met thestrong demand of national economy development. Restruc-turing of power sources was deepening,...Introduction With ever-increasing of power sources, the capabilityof power supply was further enforced in 2007. This met thestrong demand of national economy development. Restruc-turing of power sources was deepening, of which "substi-tuting large power units for small ones" started well, theinstalled capacity of wind power was doubled and obviousresults were achieved in the energy-conservation and pollu-展开更多
This editorial comments on the article by Desai et al,which investigates the impact of coronavirus disease 2019(COVID-19)on in-hospital mortality among patients with recurrent stroke using data from the 2020 National ...This editorial comments on the article by Desai et al,which investigates the impact of coronavirus disease 2019(COVID-19)on in-hospital mortality among patients with recurrent stroke using data from the 2020 National Inpatient Sample.The findings reveal significantly higher mortality rates in COVID-19-positive patients compared to non-COVID-19 patients,particularly among middle-aged individuals,males,and ethnic minorities.This editorial explores the underlying mechanisms contributing to these outcomes and discusses the clinical implications for targeted management strategies in high-risk groups.The results emphasize the need for comprehensive approaches to mitigate the heightened risks faced by recurrent stroke patients during the COVID-19 pandemic.展开更多
Evidence regarding the impact of ozone on age-related macular degeneration(AMD)remains limited.We conducted a nationwide cohort analysis of 27,923 participants in China,along with a random control animal toxicological...Evidence regarding the impact of ozone on age-related macular degeneration(AMD)remains limited.We conducted a nationwide cohort analysis of 27,923 participants in China,along with a random control animal toxicological study,to elucidate the temporal relationship between ozone exposure and AMD as well as the underlying biological explanation.In the population study,5,149 participants were diagnosed with incident AMD during a 348,701 person-month follow-up.The participants were divided into low-,medium-,and high-exposure groups.Fully adjusted Cox regression models showed that the risk of AMD increased by 28%for the medium-and 101%for the high-exposure groups relative to the low-exposure group(p for trend<0.001).The exposure-response curves exhibited a J-shaped trend.Sensitivity analyses confirmed these results,revealing stronger associations among participants older than 65 years old and those living in rural or northern China.In the toxicological study,the mice were randomized to inhale ozone or filtered air,and those exposed to ozone had photoreceptor damage and vision impairment,which are hallmarks of AMD.We further clarified that ozone exposure contributes to AMD by activating systemic inflammation and detailing how external air-pollutant-induced inflammation factors reach the retina,which is the innermost layer of the eye,and cause retinal disease.Our comprehensive studies provide key evidence on the temporal relationship between ozone exposure and increased AMD risk,suggesting the visual health benefits of collaboratively enforcing necessary ozone pollution control policies,especially in regions with high ozone concentrations,within the context of a globally aging population.展开更多
文摘Introduction With ever-increasing of power sources, the capabilityof power supply was further enforced in 2007. This met thestrong demand of national economy development. Restruc-turing of power sources was deepening, of which "substi-tuting large power units for small ones" started well, theinstalled capacity of wind power was doubled and obviousresults were achieved in the energy-conservation and pollu-
文摘This editorial comments on the article by Desai et al,which investigates the impact of coronavirus disease 2019(COVID-19)on in-hospital mortality among patients with recurrent stroke using data from the 2020 National Inpatient Sample.The findings reveal significantly higher mortality rates in COVID-19-positive patients compared to non-COVID-19 patients,particularly among middle-aged individuals,males,and ethnic minorities.This editorial explores the underlying mechanisms contributing to these outcomes and discusses the clinical implications for targeted management strategies in high-risk groups.The results emphasize the need for comprehensive approaches to mitigate the heightened risks faced by recurrent stroke patients during the COVID-19 pandemic.
基金supported by the National Key R&D Programof China(2022YFC2502800)the National Natural Science Foundation of China(82388101,82471130,82173613,and 82373681)+1 种基金the Shanghai Municipal Health Commission(GWVI-11.2-XD18)the Shanghai Hospital Development Centre(SHDC2023CRS032).
文摘Evidence regarding the impact of ozone on age-related macular degeneration(AMD)remains limited.We conducted a nationwide cohort analysis of 27,923 participants in China,along with a random control animal toxicological study,to elucidate the temporal relationship between ozone exposure and AMD as well as the underlying biological explanation.In the population study,5,149 participants were diagnosed with incident AMD during a 348,701 person-month follow-up.The participants were divided into low-,medium-,and high-exposure groups.Fully adjusted Cox regression models showed that the risk of AMD increased by 28%for the medium-and 101%for the high-exposure groups relative to the low-exposure group(p for trend<0.001).The exposure-response curves exhibited a J-shaped trend.Sensitivity analyses confirmed these results,revealing stronger associations among participants older than 65 years old and those living in rural or northern China.In the toxicological study,the mice were randomized to inhale ozone or filtered air,and those exposed to ozone had photoreceptor damage and vision impairment,which are hallmarks of AMD.We further clarified that ozone exposure contributes to AMD by activating systemic inflammation and detailing how external air-pollutant-induced inflammation factors reach the retina,which is the innermost layer of the eye,and cause retinal disease.Our comprehensive studies provide key evidence on the temporal relationship between ozone exposure and increased AMD risk,suggesting the visual health benefits of collaboratively enforcing necessary ozone pollution control policies,especially in regions with high ozone concentrations,within the context of a globally aging population.
