Tuberculosis has global presence and no part of human body is immune to it,most frequent site beings lungs.Nasopharyngeal tuberculosis is a rare type oJ extrapulmonary tuberculosis comprising onlv less than 1%of tuber...Tuberculosis has global presence and no part of human body is immune to it,most frequent site beings lungs.Nasopharyngeal tuberculosis is a rare type oJ extrapulmonary tuberculosis comprising onlv less than 1%of tuberculosis found in the upper respiratory tract.The authors are presenting here a case of primary tubereulousis affecting the nasopharynx(adenoids) which is one of the rare differential diagnosis of nasopharyngeal mass.Isolated nasopharyngeal tuberculosis is a rare condition even in the endemic areas.In literature there are varied clinical presentations of nasopharyngeal luberculosis.Tuberculosis should be one of the differential diagnosis of nasopharyngeal lesion.Biopsy and histologic study should be performed in every patient to avoid misdiagnosis.When treated properly,nasopharyngeal luberculosis carries a excellent progno.sis,and complete resolution of disease is the rule.展开更多
Background: Tuberculosis (TB) of the nose and nasopharynx are rare localizations for tuberculosis to manifest. Aim: We hope to present a case of tuberculosis of the nasopharynx and its rare presentation. Case presenta...Background: Tuberculosis (TB) of the nose and nasopharynx are rare localizations for tuberculosis to manifest. Aim: We hope to present a case of tuberculosis of the nasopharynx and its rare presentation. Case presentation: This patient presented with a long standing history of headache and neck pain prior to being seen. Imaging showed a mass at the nasopharynx and a biopsy con-firmed tuberculosis. Patient was initiated on anti-tuberculosis therapy with improvement in her symptoms on follow up. Conclusion: A high index of suspicion is imperative for early diagnosis.展开更多
A tumor-like presentation of systemic amyloidosis in the nasopharynx is exceedingly rare. A male of 52-year-old with a recurrent mass in the nasopharynx underwent surgical resection 2 years ago. Immunohistochemical ex...A tumor-like presentation of systemic amyloidosis in the nasopharynx is exceedingly rare. A male of 52-year-old with a recurrent mass in the nasopharynx underwent surgical resection 2 years ago. Immunohistochemical examination revealed M protein band and kappa immunoglobulin light chain. The sections of the biopsy of the mass in the nasopharynx and anterior abdominal wall were stained with Congo red and examined with microscopy. Amyloid deposits were found. It was diagnosed as systemic amyloidoma. Colchicine, melphalan and prednisone were administered. The mass decreased its size in the 8 months of follow-up. This case suggests that a solitary tumor in the nasopharynx might be an early sign of systemic amyloidosis because of the slow progression of the disease. The existence of a solitary amyloidoma in any location of the body should lead the doctor to look for other symptoms and signs of systemic amyloidosis.展开更多
Primary salivary gland-type carcinoma of the nasopharynx is a rare malignancy with aggressive clinical behavior and poor prognosis. Few cases have been reported in the literature. We report the case of a salivary glan...Primary salivary gland-type carcinoma of the nasopharynx is a rare malignancy with aggressive clinical behavior and poor prognosis. Few cases have been reported in the literature. We report the case of a salivary gland-type carcinoma of the nasopharynx diagnosed in a 70-year-old woman managed in department of radiotherapy at Hassan II University Hospital in Morocco. The patient received a total of 70 Gy of radiations, which were divided into 2 Gy per session during 7 weeks. Follow-up was performed regularly, including nasal endoscopic examination and nasopharyngeal CT. Evolution was marked by disease control after 12 months of follow-up. The aim of this work is to show the rarity of this entity, describe clinical, radiological and histological features and finally discuss the treatment management.展开更多
Background Microbial colonization in the nasopharynx and nasal cavity plays a defensive role in children.The coronavirus disease 2019(COVID-19)pandemic may have an influence on the nasopharynx and nasal cavity microbi...Background Microbial colonization in the nasopharynx and nasal cavity plays a defensive role in children.The coronavirus disease 2019(COVID-19)pandemic may have an influence on the nasopharynx and nasal cavity microbiota.This study aimed to identify and compare the microbiota in the nasopharynx and nasal cavity before and during the COVID-19 pandemic in a healthy pediatric population.Methods Separate mucosal swabs were collected from the nasopharynx and nasal cavity of healthy children before and during the COVID-19 pandemic.A 16S ribosomal RNA-based metagenomic approach was employed to characterize and analyze alterations in the nasopharyngeal and nasal microbiota to determine whether isolation measures,such as mask wearing,influence microbial ecology.Results The richness and diversity of the nasopharyngeal and nasal microbiota decreased during the COVID-19 pandemic compared with before the pandemic.Firmicutes and Proteobacteria were the most abundant phyla in the nasopharyngeal and nasal microbiota,respectively,both before and during the pandemic.Corynebacterium and Moraxella were the dominant genera in the nasopharyngeal and nasal microbiota during the COVID-19 pandemic,whereas Pseudomonas and Corynebacterium were dominant before the pandemic.Compared with pre-pandemic conditions,microbial colonization differed significantly for Cyanobacteria/Chloroplast and Bacteroidetes in the nasopharynx and for Planctomycetes in the nasal cavity during the COVID-19 pandemic.Conclusions This study revealed a lower microbiota diversity during COVID-19,possibly accompanied by microbiota dysbiosis,increased risk of respiratory infections and inflammatory responses in healthy children.This study underscores the importance of reestablishing microbiota balance and highlights the need for personalized treatment and prophylactic strategies in routine public health practice.展开更多
Oncocytic metaplasia is a well-established pathological entity that may occur in many organs;including salivary glands, thyroid, parathyroid and kidney. The occurrence of oncocytic metaplasia in the nasopharynx is unc...Oncocytic metaplasia is a well-established pathological entity that may occur in many organs;including salivary glands, thyroid, parathyroid and kidney. The occurrence of oncocytic metaplasia in the nasopharynx is uncommon and metaplasia with melanin pigmentation is extremely rare, no more than twenty cases having been reported to date.展开更多
罗道病（Rosai-Dorfman病）又称窦组织细胞增生伴巨大淋巴结病（sinus hisliocytosis with massive lymphadenopathy,SHML）是一种良性淋巴组织增生性疾病，1966年Azoury和Reed首先报道，1969年Rosai和Dorfman对其做了详细研究，并正式...罗道病（Rosai-Dorfman病）又称窦组织细胞增生伴巨大淋巴结病（sinus hisliocytosis with massive lymphadenopathy,SHML）是一种良性淋巴组织增生性疾病，1966年Azoury和Reed首先报道，1969年Rosai和Dorfman对其做了详细研究，并正式命名。展开更多
文摘Tuberculosis has global presence and no part of human body is immune to it,most frequent site beings lungs.Nasopharyngeal tuberculosis is a rare type oJ extrapulmonary tuberculosis comprising onlv less than 1%of tuberculosis found in the upper respiratory tract.The authors are presenting here a case of primary tubereulousis affecting the nasopharynx(adenoids) which is one of the rare differential diagnosis of nasopharyngeal mass.Isolated nasopharyngeal tuberculosis is a rare condition even in the endemic areas.In literature there are varied clinical presentations of nasopharyngeal luberculosis.Tuberculosis should be one of the differential diagnosis of nasopharyngeal lesion.Biopsy and histologic study should be performed in every patient to avoid misdiagnosis.When treated properly,nasopharyngeal luberculosis carries a excellent progno.sis,and complete resolution of disease is the rule.
文摘Background: Tuberculosis (TB) of the nose and nasopharynx are rare localizations for tuberculosis to manifest. Aim: We hope to present a case of tuberculosis of the nasopharynx and its rare presentation. Case presentation: This patient presented with a long standing history of headache and neck pain prior to being seen. Imaging showed a mass at the nasopharynx and a biopsy con-firmed tuberculosis. Patient was initiated on anti-tuberculosis therapy with improvement in her symptoms on follow up. Conclusion: A high index of suspicion is imperative for early diagnosis.
文摘A tumor-like presentation of systemic amyloidosis in the nasopharynx is exceedingly rare. A male of 52-year-old with a recurrent mass in the nasopharynx underwent surgical resection 2 years ago. Immunohistochemical examination revealed M protein band and kappa immunoglobulin light chain. The sections of the biopsy of the mass in the nasopharynx and anterior abdominal wall were stained with Congo red and examined with microscopy. Amyloid deposits were found. It was diagnosed as systemic amyloidoma. Colchicine, melphalan and prednisone were administered. The mass decreased its size in the 8 months of follow-up. This case suggests that a solitary tumor in the nasopharynx might be an early sign of systemic amyloidosis because of the slow progression of the disease. The existence of a solitary amyloidoma in any location of the body should lead the doctor to look for other symptoms and signs of systemic amyloidosis.
文摘Primary salivary gland-type carcinoma of the nasopharynx is a rare malignancy with aggressive clinical behavior and poor prognosis. Few cases have been reported in the literature. We report the case of a salivary gland-type carcinoma of the nasopharynx diagnosed in a 70-year-old woman managed in department of radiotherapy at Hassan II University Hospital in Morocco. The patient received a total of 70 Gy of radiations, which were divided into 2 Gy per session during 7 weeks. Follow-up was performed regularly, including nasal endoscopic examination and nasopharyngeal CT. Evolution was marked by disease control after 12 months of follow-up. The aim of this work is to show the rarity of this entity, describe clinical, radiological and histological features and finally discuss the treatment management.
基金supported by the National Natural Science Foundation of China(Grant nos.81800903,82171135,82371140,81970881,82271160)Science and Technology Innovation Plan of Shanghai Science and Technology Commission(Grant no.21Y31900504)National Key R&D Program of China(2024YFC2511100).
文摘Background Microbial colonization in the nasopharynx and nasal cavity plays a defensive role in children.The coronavirus disease 2019(COVID-19)pandemic may have an influence on the nasopharynx and nasal cavity microbiota.This study aimed to identify and compare the microbiota in the nasopharynx and nasal cavity before and during the COVID-19 pandemic in a healthy pediatric population.Methods Separate mucosal swabs were collected from the nasopharynx and nasal cavity of healthy children before and during the COVID-19 pandemic.A 16S ribosomal RNA-based metagenomic approach was employed to characterize and analyze alterations in the nasopharyngeal and nasal microbiota to determine whether isolation measures,such as mask wearing,influence microbial ecology.Results The richness and diversity of the nasopharyngeal and nasal microbiota decreased during the COVID-19 pandemic compared with before the pandemic.Firmicutes and Proteobacteria were the most abundant phyla in the nasopharyngeal and nasal microbiota,respectively,both before and during the pandemic.Corynebacterium and Moraxella were the dominant genera in the nasopharyngeal and nasal microbiota during the COVID-19 pandemic,whereas Pseudomonas and Corynebacterium were dominant before the pandemic.Compared with pre-pandemic conditions,microbial colonization differed significantly for Cyanobacteria/Chloroplast and Bacteroidetes in the nasopharynx and for Planctomycetes in the nasal cavity during the COVID-19 pandemic.Conclusions This study revealed a lower microbiota diversity during COVID-19,possibly accompanied by microbiota dysbiosis,increased risk of respiratory infections and inflammatory responses in healthy children.This study underscores the importance of reestablishing microbiota balance and highlights the need for personalized treatment and prophylactic strategies in routine public health practice.
文摘Oncocytic metaplasia is a well-established pathological entity that may occur in many organs;including salivary glands, thyroid, parathyroid and kidney. The occurrence of oncocytic metaplasia in the nasopharynx is uncommon and metaplasia with melanin pigmentation is extremely rare, no more than twenty cases having been reported to date.
文摘罗道病（Rosai-Dorfman病）又称窦组织细胞增生伴巨大淋巴结病（sinus hisliocytosis with massive lymphadenopathy,SHML）是一种良性淋巴组织增生性疾病，1966年Azoury和Reed首先报道，1969年Rosai和Dorfman对其做了详细研究，并正式命名。
