BACKGROUND Nasolabial fold(NLF)depression can affect the facial appearance of patients to some extent and increase their psychological burdens.In recent years,autologous fat grafting(AFG)combined with botulinum toxin ...BACKGROUND Nasolabial fold(NLF)depression can affect the facial appearance of patients to some extent and increase their psychological burdens.In recent years,autologous fat grafting(AFG)combined with botulinum toxin A(BTX-A)injection(AFG+BTX-A injection)has been gradually applied in the treatment of patients with NLF depression.Although studies have been conducted on the efficacy and safety of AFG+BTX-A injection in treating NLF depression,the experimental design,observational indicators,and sample enrollment criteria vary remarkably,making it difficult to draw convincing and consistent conclusions.Thus,further relevant research is warranted.AIM To assess the esthetic improvement,efficacy,and safety of AFG+BTX-A injections in patients with NLF depression.METHODS This study included 60 patients with NLF depression who were treated in our hospital from February 2019 to April 2021.These patients were categorized into control(n=30)and observation(n=30)groups.The observation group received AFG+BTX-A injection,whereas the control group underwent AFG only.All patients were evaluated using the wrinkle severity rating scale(WSRS)and global aesthetic improvement scale.The compactness of facial contours,skin evaluation indexes,adverse reactions,and satisfaction of the two groups were evaluated 3 months postoperatively.RESULTS The WSRS scores of the observation group at 1,3,and 6 months postoperatively were lower than those of the control group(P<0.05).Three months postoperatively,facial fine lines and pores showed obvious improvement and the skin index score was higher in the observation group than in the control group(P<0.05).The compactness of facial contours was better in the observation group than in the control group(P<0.05).In addition,no remarkable differences were noted in the incidence of postoperative adverse reactions such as facial stiffness,facial asymmetry,facial bruising,and facial concavity inequality(P>0.05).CONCLUSION AFG+BTX-A injection is a highly safe,cost-effective,effective,and long-lasting treatment for NLF depression with high esthetic value,which should be promoted in the future.展开更多
Nasolabial cysts are uncommonly diagnosed non-odontogenic soft tissue lesions occurring close to the nasal alar region of the face. Patients usually present with a slowly enlarging asymptomatic swelling. Diagnosis is ...Nasolabial cysts are uncommonly diagnosed non-odontogenic soft tissue lesions occurring close to the nasal alar region of the face. Patients usually present with a slowly enlarging asymptomatic swelling. Diagnosis is usually made in the early stages because of the esthetic effects. Histologically, the lesion is lined with non-keratinized squamous epithelium or, more frequently, pseudostratified columnar epithelium with goblet cells. These cysts are most often diagnosed in the fourth decade of life. However, we report a case of nasolabial cyst in an 80-year-old woman, and discuss the diagnosis, differential diagnosis, and treatment with reference to the literature.展开更多
Objective To explore an ideal method for the correction of the secondary nasolabial deformities of bilateral cleft lip. Methods From January 2013 to December 2018 ,repairing nose and lip in median of the median upper ...Objective To explore an ideal method for the correction of the secondary nasolabial deformities of bilateral cleft lip. Methods From January 2013 to December 2018 ,repairing nose and lip in median of the median upper lip flap and lower lip Abbe flap in 13 patients with secondary nasolabial deformity of cleft lip, implanting artificial nose prosthesis when necessary. Results All the flaps were survived and nose appearance was greatly improved. The shape of the upper lip turned more similar to normal. Coordination between upper lip and lower lip was appropriate. Conclusion The median upper lip flap combined with lower lip Abbe flap to repair the secondary nasolabial deformities of bilateral cleft lip is effective . Goo d cosmetic results can be obtained.展开更多
Background: The US FDA has recently approved autologous cultured fibroblast cells (ACF) as treatment for cutaneous contour defects. ACF provides an alternative to synthetic fillers or fat grafting with the significant...Background: The US FDA has recently approved autologous cultured fibroblast cells (ACF) as treatment for cutaneous contour defects. ACF provides an alternative to synthetic fillers or fat grafting with the significant advantage of producing longer lasting effect. Methods: This was a prospective open label single group clinical study to demonstrate the clinical efficacy of ACF that we have replicated in our lab. The study enrolled 18 patients with nasolabial folds from 2 centres in Malaysia in 2011-2012. ACF at dose of 23 or 92 million cells were injected on 3 occasions at 4 weeks interval. Efficacy at 6- and 12-month post treatment was assessed using a standardized 7-point scale which was performed by the 2 investigators as well as a panel of 7 independent evaluators. Results: We obtained a successful outcome (primary endpoint), defined as improvement in the appearance of the nasolabial fold of at least 2 points on the 7-point scale, in 33% of patients as assessed by investigators at 12-month follow-up and in 22% of patients assessed by independent evaluators. Investigators also found 78% of patients having had a 1-point improvement from baseline while independent evaluators found 83% of patients having improved by as much. Patients were uniformly (100%) satisfied with the improvement in their appearance. No treatment-related adverse event was reported. Baseline score and follow-up duration had significant effect on treatment response. The greater the baseline severity and the longer the post-treatment follow-up, the better the response to ACF. Larger dose of cells (92 million cells) has little additional effect suggesting that the 1 mL dose (23 million cells) is near optimal. Older patients showed a trend towards poorer response but this was not statistically significant. Conclusions: We have successfully replicated the laboratory method and clinical procedure to perform ACF treatment which was effective in improving the appearance of nasolabial folds in some patients.展开更多
Background: Wrinkling of face is a common feature of aging and each individual could have his own feature of disease. Objective: To categorize the wrinkles of each individual in order to find the characteristic pictur...Background: Wrinkling of face is a common feature of aging and each individual could have his own feature of disease. Objective: To categorize the wrinkles of each individual in order to find the characteristic picture of each individual aiming to find so called a print of aging. Patients and Methods: An observational study was done on 1011 cases their ages more than 30 years. 679 subjects (67.2%) were males and 332 (32.8%) were females. Their ages ranged between 30 - 86 years. Cases attended Department of Dermatology/Baghdad Teaching Hospital, Baghdad, Iraq in period from April 2012 to April 2013. The distribution and the types of wrinkling were mapped in all individuals. Regional variations including forehead, glabellae, periorbital, nasolabial, perioral and sides of the face were well studied. Results: Forehead horizontal pattern was presented in 860 (85%) subjects, forehead vertical pattern in 84 (8.3%), glabella horizontal pattern in 705 (69.7%) and glabella vertical in 698 (69%). Periorbital pattern was presented in 885 (87.5%) subjects and nasolabial angle in 540 (53.4%). Glabella vertical and horizontal patters were significantly more in males than females. Also, the males were significantly more affected by periorbital and nasolabial folds. Conclusion: Each individual or group of individual has characteristic morphological pattern of wrinkling that starts early in life and becomes mature often with time and this pattern might deserve the name of a print.展开更多
We report a case of 77 years old male patient who presented to our hospital with bleeding from a fungating mass of the nose. Investigations revealed the lesion to be moderately differentiated basaloid type squamous ce...We report a case of 77 years old male patient who presented to our hospital with bleeding from a fungating mass of the nose. Investigations revealed the lesion to be moderately differentiated basaloid type squamous cell carcinoma, with lung, liver and spleen metastasis. Oncologists started palliative chemotherapy for the patient. Excision of the tumour required removal of most of the nose including the lateral nasal cartilages and the nasal septum. Nasal reconstruction was done by using left nasolabial flap after deepithelialising 3 parts of it and covering that flap with a forehead flap. Residual tumour of the upper lip required further excision later on and coverage with a fan flap. The patient survived about 6 months after the surgery in a good appearance and was accepted and approached well by his family. We think that this type of reconstruction is suitable for late stages cancer nose considering the life expectancy of this category of patients.展开更多
Klestadt’s cyst, more commonly known as the nasolabial cyst, is an uncommon, non-odontogenic, and soft tissue cyst. It is classified as a fissural cyst, found outside the bone, and on the region corresponding to the ...Klestadt’s cyst, more commonly known as the nasolabial cyst, is an uncommon, non-odontogenic, and soft tissue cyst. It is classified as a fissural cyst, found outside the bone, and on the region corresponding to the nasolabial furrow and alar nose. Following its description first by Zukuerkandl in 1882, only 267 cases have been found in English literature. In spite of the low occurrence of nasolabial cysts, it is important to recognize the clinical characteristics of this lesion. The purpose of this report is to review the literature and discuss the histomorphology and etiology of this condition, and also its management by surgical excision. As per our experience, sublabial approach is the best for complete and scarless excision of this cyst.展开更多
FACILLE modified sodium hyaluronate gel was designed to be used for nasolabial fold (NLF) correction. However, no study has investigated the long-term safety and effectiveness of FACILLE. Thus, a retrospective study o...FACILLE modified sodium hyaluronate gel was designed to be used for nasolabial fold (NLF) correction. However, no study has investigated the long-term safety and effectiveness of FACILLE. Thus, a retrospective study of 14 aesthetic clinics in China was conducted. This was the first large-scale, postmarketing study on FACILLE to evaluate the occurrence of adverse events (AEs) and provide essential information on the satisfaction of patients with FACILLE injections. This study recruited participants aged >18 years. FACILLE was injected into the NLFs on both sides of each participant’s face. The primary endpoint for safety was systemic or severe AEs at an injection site. Effectiveness was assessed on the basis of the participants’ subjective perceptions and satisfaction levels. Safety and effectiveness data were collected on the day of injection and at 2 weeks and 1, 3, 6, 9, 12, 18, 24, 30 and 36 months postinjection. In total, 1552 participants were enrolled (mean age, 29.1 years), and most of them (96.5%) were women. The mean injection volume was 1.39 ± 0.658 mL, and the average number of injections was 2.4 ± 1.68. AEs were reported by 205 participants (13.2%). All AEs occurred at local injection sites. No systemic or severe AEs were observed. Local pain was the most frequently reported AE regardless of the number of injections or the injection volume. Only eight AE cases were correlated with FACILLE administration, with two cases involving local allergic reactions. The participants self-reported that they perceived the procedure to have an effectiveness of ≥90% within 6 months postinjection although this percentage decreased substantially after 9 months. Their satisfaction level was >90% within 1 month postinjection but decreased gradually after 3 months. Our results indicate that the long-term safety of FACILLE injection is adequate. The high self-reported perceived effectiveness and satisfaction levels indicate the considerable potential of FACILLE injections for correcting NLFs.展开更多
Treatment aimed at preventing and reversing the facial aging process has grown in popularity.The aging midface is defined by classic deepening of the nasolabial folds,formation of marionette lines around the mouth,and...Treatment aimed at preventing and reversing the facial aging process has grown in popularity.The aging midface is defined by classic deepening of the nasolabial folds,formation of marionette lines around the mouth,and significant atrophy of deep facial fat.While surgical options have been investigated with satisfactory and long-lasting results,nonsurgical alternatives such as soft tissue fillers are a safe and effective strategy for facial rejuvenation.This review focuses on a variety of injectable fillers available for the treatment of the aging midface,including hyaluronic acid,calcium hydroxylapatite,poly-L-lactic acid,and polymethyl methacrylate.Mechanism of action,relevant anatomy,indications/contraindications,technique,and any evidence of efficacy and safety are described.The benefits of injectable fillers include reduced patient discomfort and shorter recovery times.Understanding the advantages and limitations of injectable fillers for midface augmentation can allow providers to counsel and treat patients seeking care appropriately.展开更多
基金Supported by Medical and Health Science and Technology Project of Hangzhou,No.B20230855Hangzhou Science and Technology Plan Development Project,No.20210133X01.
文摘BACKGROUND Nasolabial fold(NLF)depression can affect the facial appearance of patients to some extent and increase their psychological burdens.In recent years,autologous fat grafting(AFG)combined with botulinum toxin A(BTX-A)injection(AFG+BTX-A injection)has been gradually applied in the treatment of patients with NLF depression.Although studies have been conducted on the efficacy and safety of AFG+BTX-A injection in treating NLF depression,the experimental design,observational indicators,and sample enrollment criteria vary remarkably,making it difficult to draw convincing and consistent conclusions.Thus,further relevant research is warranted.AIM To assess the esthetic improvement,efficacy,and safety of AFG+BTX-A injections in patients with NLF depression.METHODS This study included 60 patients with NLF depression who were treated in our hospital from February 2019 to April 2021.These patients were categorized into control(n=30)and observation(n=30)groups.The observation group received AFG+BTX-A injection,whereas the control group underwent AFG only.All patients were evaluated using the wrinkle severity rating scale(WSRS)and global aesthetic improvement scale.The compactness of facial contours,skin evaluation indexes,adverse reactions,and satisfaction of the two groups were evaluated 3 months postoperatively.RESULTS The WSRS scores of the observation group at 1,3,and 6 months postoperatively were lower than those of the control group(P<0.05).Three months postoperatively,facial fine lines and pores showed obvious improvement and the skin index score was higher in the observation group than in the control group(P<0.05).The compactness of facial contours was better in the observation group than in the control group(P<0.05).In addition,no remarkable differences were noted in the incidence of postoperative adverse reactions such as facial stiffness,facial asymmetry,facial bruising,and facial concavity inequality(P>0.05).CONCLUSION AFG+BTX-A injection is a highly safe,cost-effective,effective,and long-lasting treatment for NLF depression with high esthetic value,which should be promoted in the future.
文摘Nasolabial cysts are uncommonly diagnosed non-odontogenic soft tissue lesions occurring close to the nasal alar region of the face. Patients usually present with a slowly enlarging asymptomatic swelling. Diagnosis is usually made in the early stages because of the esthetic effects. Histologically, the lesion is lined with non-keratinized squamous epithelium or, more frequently, pseudostratified columnar epithelium with goblet cells. These cysts are most often diagnosed in the fourth decade of life. However, we report a case of nasolabial cyst in an 80-year-old woman, and discuss the diagnosis, differential diagnosis, and treatment with reference to the literature.
文摘Objective To explore an ideal method for the correction of the secondary nasolabial deformities of bilateral cleft lip. Methods From January 2013 to December 2018 ,repairing nose and lip in median of the median upper lip flap and lower lip Abbe flap in 13 patients with secondary nasolabial deformity of cleft lip, implanting artificial nose prosthesis when necessary. Results All the flaps were survived and nose appearance was greatly improved. The shape of the upper lip turned more similar to normal. Coordination between upper lip and lower lip was appropriate. Conclusion The median upper lip flap combined with lower lip Abbe flap to repair the secondary nasolabial deformities of bilateral cleft lip is effective . Goo d cosmetic results can be obtained.
文摘Background: The US FDA has recently approved autologous cultured fibroblast cells (ACF) as treatment for cutaneous contour defects. ACF provides an alternative to synthetic fillers or fat grafting with the significant advantage of producing longer lasting effect. Methods: This was a prospective open label single group clinical study to demonstrate the clinical efficacy of ACF that we have replicated in our lab. The study enrolled 18 patients with nasolabial folds from 2 centres in Malaysia in 2011-2012. ACF at dose of 23 or 92 million cells were injected on 3 occasions at 4 weeks interval. Efficacy at 6- and 12-month post treatment was assessed using a standardized 7-point scale which was performed by the 2 investigators as well as a panel of 7 independent evaluators. Results: We obtained a successful outcome (primary endpoint), defined as improvement in the appearance of the nasolabial fold of at least 2 points on the 7-point scale, in 33% of patients as assessed by investigators at 12-month follow-up and in 22% of patients assessed by independent evaluators. Investigators also found 78% of patients having had a 1-point improvement from baseline while independent evaluators found 83% of patients having improved by as much. Patients were uniformly (100%) satisfied with the improvement in their appearance. No treatment-related adverse event was reported. Baseline score and follow-up duration had significant effect on treatment response. The greater the baseline severity and the longer the post-treatment follow-up, the better the response to ACF. Larger dose of cells (92 million cells) has little additional effect suggesting that the 1 mL dose (23 million cells) is near optimal. Older patients showed a trend towards poorer response but this was not statistically significant. Conclusions: We have successfully replicated the laboratory method and clinical procedure to perform ACF treatment which was effective in improving the appearance of nasolabial folds in some patients.
文摘Background: Wrinkling of face is a common feature of aging and each individual could have his own feature of disease. Objective: To categorize the wrinkles of each individual in order to find the characteristic picture of each individual aiming to find so called a print of aging. Patients and Methods: An observational study was done on 1011 cases their ages more than 30 years. 679 subjects (67.2%) were males and 332 (32.8%) were females. Their ages ranged between 30 - 86 years. Cases attended Department of Dermatology/Baghdad Teaching Hospital, Baghdad, Iraq in period from April 2012 to April 2013. The distribution and the types of wrinkling were mapped in all individuals. Regional variations including forehead, glabellae, periorbital, nasolabial, perioral and sides of the face were well studied. Results: Forehead horizontal pattern was presented in 860 (85%) subjects, forehead vertical pattern in 84 (8.3%), glabella horizontal pattern in 705 (69.7%) and glabella vertical in 698 (69%). Periorbital pattern was presented in 885 (87.5%) subjects and nasolabial angle in 540 (53.4%). Glabella vertical and horizontal patters were significantly more in males than females. Also, the males were significantly more affected by periorbital and nasolabial folds. Conclusion: Each individual or group of individual has characteristic morphological pattern of wrinkling that starts early in life and becomes mature often with time and this pattern might deserve the name of a print.
文摘We report a case of 77 years old male patient who presented to our hospital with bleeding from a fungating mass of the nose. Investigations revealed the lesion to be moderately differentiated basaloid type squamous cell carcinoma, with lung, liver and spleen metastasis. Oncologists started palliative chemotherapy for the patient. Excision of the tumour required removal of most of the nose including the lateral nasal cartilages and the nasal septum. Nasal reconstruction was done by using left nasolabial flap after deepithelialising 3 parts of it and covering that flap with a forehead flap. Residual tumour of the upper lip required further excision later on and coverage with a fan flap. The patient survived about 6 months after the surgery in a good appearance and was accepted and approached well by his family. We think that this type of reconstruction is suitable for late stages cancer nose considering the life expectancy of this category of patients.
文摘Klestadt’s cyst, more commonly known as the nasolabial cyst, is an uncommon, non-odontogenic, and soft tissue cyst. It is classified as a fissural cyst, found outside the bone, and on the region corresponding to the nasolabial furrow and alar nose. Following its description first by Zukuerkandl in 1882, only 267 cases have been found in English literature. In spite of the low occurrence of nasolabial cysts, it is important to recognize the clinical characteristics of this lesion. The purpose of this report is to review the literature and discuss the histomorphology and etiology of this condition, and also its management by surgical excision. As per our experience, sublabial approach is the best for complete and scarless excision of this cyst.
文摘FACILLE modified sodium hyaluronate gel was designed to be used for nasolabial fold (NLF) correction. However, no study has investigated the long-term safety and effectiveness of FACILLE. Thus, a retrospective study of 14 aesthetic clinics in China was conducted. This was the first large-scale, postmarketing study on FACILLE to evaluate the occurrence of adverse events (AEs) and provide essential information on the satisfaction of patients with FACILLE injections. This study recruited participants aged >18 years. FACILLE was injected into the NLFs on both sides of each participant’s face. The primary endpoint for safety was systemic or severe AEs at an injection site. Effectiveness was assessed on the basis of the participants’ subjective perceptions and satisfaction levels. Safety and effectiveness data were collected on the day of injection and at 2 weeks and 1, 3, 6, 9, 12, 18, 24, 30 and 36 months postinjection. In total, 1552 participants were enrolled (mean age, 29.1 years), and most of them (96.5%) were women. The mean injection volume was 1.39 ± 0.658 mL, and the average number of injections was 2.4 ± 1.68. AEs were reported by 205 participants (13.2%). All AEs occurred at local injection sites. No systemic or severe AEs were observed. Local pain was the most frequently reported AE regardless of the number of injections or the injection volume. Only eight AE cases were correlated with FACILLE administration, with two cases involving local allergic reactions. The participants self-reported that they perceived the procedure to have an effectiveness of ≥90% within 6 months postinjection although this percentage decreased substantially after 9 months. Their satisfaction level was >90% within 1 month postinjection but decreased gradually after 3 months. Our results indicate that the long-term safety of FACILLE injection is adequate. The high self-reported perceived effectiveness and satisfaction levels indicate the considerable potential of FACILLE injections for correcting NLFs.
文摘Treatment aimed at preventing and reversing the facial aging process has grown in popularity.The aging midface is defined by classic deepening of the nasolabial folds,formation of marionette lines around the mouth,and significant atrophy of deep facial fat.While surgical options have been investigated with satisfactory and long-lasting results,nonsurgical alternatives such as soft tissue fillers are a safe and effective strategy for facial rejuvenation.This review focuses on a variety of injectable fillers available for the treatment of the aging midface,including hyaluronic acid,calcium hydroxylapatite,poly-L-lactic acid,and polymethyl methacrylate.Mechanism of action,relevant anatomy,indications/contraindications,technique,and any evidence of efficacy and safety are described.The benefits of injectable fillers include reduced patient discomfort and shorter recovery times.Understanding the advantages and limitations of injectable fillers for midface augmentation can allow providers to counsel and treat patients seeking care appropriately.
