Narrow electroluminescence is essential for enhancing the performance of modern optoelectronic devices,particularly in applications demanding high color purity,efficient optical communication and precise phototherapy[...Narrow electroluminescence is essential for enhancing the performance of modern optoelectronic devices,particularly in applications demanding high color purity,efficient optical communication and precise phototherapy[1].In commercial organic light-emitting diodes(OLEDs),additional color filters are usually implemented for selectively transmitting primary colors,thus resulting in narrowed emission,generally with a full width at half maximum(FWHM)value around 30 nm.展开更多
This is a crucial moment for China’s textile export industry, which is in the midst of deep economic downturn. In the January-Novem- ber 2009 period, the decline in accumulated textile and apparel exports was being ...This is a crucial moment for China’s textile export industry, which is in the midst of deep economic downturn. In the January-Novem- ber 2009 period, the decline in accumulated textile and apparel exports was being constantly reduced and the tendency of rebound展开更多
Titanium alloy has the advantages of high strength,strong corrosion resistance,excellent high and low temperature mechanical properties,etc.,and is widely used in aerospace,shipbuilding,weapons and equipment,and other...Titanium alloy has the advantages of high strength,strong corrosion resistance,excellent high and low temperature mechanical properties,etc.,and is widely used in aerospace,shipbuilding,weapons and equipment,and other fields.In recent years,with the continuous increase in demand for medium-thick plate titanium alloys,corresponding welding technologies have also continued to develop.Therefore,this article reviews the research progress of deep penetration welding technology for medium-thick plate titanium alloys,mainly covering traditional arc welding,high-energy beam welding,and other welding technologies.Among many methods,narrow gap welding,hybrid welding,and external energy field assistance welding all contribute to improving the welding efficiency and quality of medium-thick plate titanium alloys.Finally,the development trend of deep penetration welding technology for mediumthick plate titanium alloys is prospected.展开更多
BACKGROUND Early esophageal neuroendocrine carcinoma(E-NEC)is a rare but aggressive malignancy with poorly understood endoscopic features.Despite advancements in multi-model endoscopy,including white light endoscopy,m...BACKGROUND Early esophageal neuroendocrine carcinoma(E-NEC)is a rare but aggressive malignancy with poorly understood endoscopic features.Despite advancements in multi-model endoscopy,including white light endoscopy,magnifying end-oscopy narrow-band imaging(NBI),and endoscopic ultrasonography(EUS),the diagnostic characteristics of early E-NEC remain unclear.Comprehensive evalu-ation using these techniques can improve early detection and guide clinical management.This study aimed to investigate the endoscopic features of early E-NEC using multiple imaging modalities.We hypothesized that specific endos-copic patterns,such as irregular microvascular morphology or signs of submu-cosal invasion,could reliably distinguish early E-NEC from other esophageal lesions.AIM To characterize early E-NEC using multi-model endoscopy and identify diag-nostic endoscopic features.METHODS Clinical data of four patients with esophageal submucosal lesions identified by gastroscopy and pathologically diagnosed as E-NEC in the Department of Gastroenterology,The First Affiliated Hospital of Zhejiang University School of Medicine between January 2020 and August 2024 were retrospectively analyzed,and their manifestations under multi-model endoscopy were observed.Grayscale values of ultrasound images in three patients with E-NEC and eight with esophageal leiomyoma were calculated using Image J software and compared using the Mann-Whitney U test.Neuroendocrine neoplasms(NENs)are a rare heterogeneous group of epithelial tumors that originate from peptidergic neurons and neuroendocrine cells,and are characterized by neuroendocrine differentiation.NENs include well-differen-tiated neuroendocrine tumors(NETs),poorly differentiated neuroendocrine carcinomas(NECs),and mixed neuroen-docrine-non-NENs[1],which exhibit a wide range of biological behaviors,from indolent,slow-growing lesions to highly aggressive and metastatic malignancies[2].NENs have the capacity for whole-body distribution,with gastroenteropan-creatic NENs comprising approximately 60%-75%of cases,followed by those in the lungs and mediastinum[3].Eso-phageal NENs(E-NENs)are extremely rare,accounting for only approximately 1.6%of all NENs and occurring far less frequently than other gastrointestinal NENs[4].However,with advancements in early cancer screening and diagnostic techniques,the incidence of E-NENs has gradually increased in recent decades[5].Among E-NENs,<1%are well-differ-entiated NETs,with the vast majority being poorly differentiated small cell NECs[6,7].Nevertheless,esophageal NEC(E-NEC)accounts for only 0.05%-7.6%of all esophageal malignant tumors[8,9],and is characterized by aggressive behavior,rapid progression,and early metastasis.E-NEC primarily affects middle-aged and older individuals,with a higher prevalence in males[10].The tumor-node-metastasis staging system of E-NEC mirrors that of esophageal squamous cell carcinoma(ESCC)[11,12].Early E-NEC is defined as lesions limited to the mucosal or submucosal layer(stages T1a and T1b),with or without nodal metastasis.Clinically,we found that early E-NEC often presents with absent or non-specific symptoms,such as mild dysphagia or retrosternal discomfort,which are easily overlooked or mistaken for benign esophageal conditions such as leiomyoma.Conventional imaging and tumor markers frequently fail to detect early lesions,and endoscopic biopsy results may be inconclusive due to submucosal tumor growth and the overlying normal epithelium[13].As a result,E-NEC is frequently diagnosed at an advanced stage(31%-90%of cases)when regional lymph node or distant metastases have already occurred,contributing to its poor prognosis[2,13,14].Studies have reported a median survival of approximately 11 months and 5-year survival rate of<10%[14].Given these challenges,early detection using endoscopy is essential for improving patient outcomes.展开更多
Kitaev quantum spin liquids have attracted significant attention in condensed matter physics over the past decade.To understand their emergent quantum phenomena,high-quality single crystals of substantial size are ess...Kitaev quantum spin liquids have attracted significant attention in condensed matter physics over the past decade.To understand their emergent quantum phenomena,high-quality single crystals of substantial size are essential.Here,we report the synthesis of single crystals of the Kitaev quantum spin liquid candidate RuBr_(3),achieving millimeter-sized crystals through a self-flux method under high pressure and high temperature conditions.The crystals exhibit well-defined cleavage planes with a lustrous appearance.Transport characterizations exhibit a narrow band-gap semiconducting behavior with 0.13 eV and 0.11 eV band-gap in ab plane and along𝑐axis,respectively.Magnetic measurement shows a transition to antiferromagnetic(AFM)state at approximately 29K both in ab plane and along the c axis.Notably,the N′eel temperature increases to 34K with an applied magnetic field of up to 7T in the ab plane,but without any change along𝑐axis.The large size and high quality of RuBr3 single crystals provide a valuable platform for investigating various interactions,particularly the Kitaev interaction,and for elucidating the intrinsic physical properties of Kitaev quantum spin liquids.展开更多
BACKGROUND Intracranial blister-like microaneurysms are an extremely rare disease.Rupture of intracranial aneurysms can lead to subarachnoid hemorrhage(SAH).Patients with SAH may experience severe neurological symptom...BACKGROUND Intracranial blister-like microaneurysms are an extremely rare disease.Rupture of intracranial aneurysms can lead to subarachnoid hemorrhage(SAH).Patients with SAH may experience severe neurological symptoms,including severe headache,nausea,vomiting,transient or persistent loss of consciousness,limb weakness,and blurred vision.Ruptured aneurysms should be surgically treated as soon as possible.Intravascular electrocoagulation is becoming a promising treatment method for intracranial blister-like microaneurysms.The short-term follow-up results demonstrated that this method is safe and effective.This article presents a case of endovascular electrocoagulation for the treatment of a blisterlike microaneurysm.CASE SUMMARY This article reports the case of 71-year-old female patient with an intracranial aneurysm.The patient experienced a sudden headache with vomiting for 3 hours.Brain computed tomography(CT)scan showed a subarachnoid hemorrhage.She was diagnosed with rupture of an aneurysm and subarachnoid hemorrhage.The aneurysm was located in the choroidal segment of the right internal carotid artery.The size of the aneurysm was 2.00 mm×1.80 mm×1.97 mm,and the neck of the aneurysm was less than 0.5 mm wide.We successfully treated this aneurysm with endovascular electrocoagulation,and the patient was safely returned to the ward and discharged after subsequent supportive treatment.CT angiography reexamination 3 months after surgery revealed no contrast agent extravasation in the original lesion,with a good prognosis.CONCLUSION Endovascular electrocoagulation is an effective and safe method for the treatment of intracranial blister-like microaneurysms.展开更多
Narrow backfill earth pressure estimation is applied to study the stability of supporting structures in the vicinity of existing buildings.Previous narrow backfill earth pressure studies have neglected seismic-unsatur...Narrow backfill earth pressure estimation is applied to study the stability of supporting structures in the vicinity of existing buildings.Previous narrow backfill earth pressure studies have neglected seismic-unsaturated seepage multi-field coupling,resulting in inaccurate estimates.To address these deficiencies,this paper proposed a calculation method for seismic passive earth pressure in unsaturated narrow backfill,based on inclined thin-layer units.It considers the interlayer shear stress,arching effect,and the multi-field coupling of seismic-unsaturated seepage.Additionally,this paper includes a parametric sensitivity analysis.The outcomes indicate that the earthquake passive ground pressure of unsaturated narrow backfill can be reduced by increasing the aspect ratio,seismic acceleration coefficient,and unsaturation parameterα.It can also be reduced by decreasing the effective interior friction angle,soil cohesion,wallearth friction angle,and vertical discharge.Furthermore,for any width soil,lowering the elevation of the action point of passive thrust can be attained by raising the effective interior friction angle,wall-earth friction angle,and unsaturation parameterα.Reducing soil cohesion,seismic acceleration coefficient,and vertical discharge can also lower the height of the application point of passive thrust.展开更多
We present the first theoretical study on heavy-flavor jet angularities(λ_(α)^(κ))in Pb+Pb collisions at√SNN=5.02 Te V.The initial production of heavy-flavor jets was carried out using the POWHEG+PYTHIA8 prescript...We present the first theoretical study on heavy-flavor jet angularities(λ_(α)^(κ))in Pb+Pb collisions at√SNN=5.02 Te V.The initial production of heavy-flavor jets was carried out using the POWHEG+PYTHIA8 prescription.In contrast,the SHELL transport model describes jet evolution in the quark-gluon plasma(QGP).In p+p collisions,we observed narrower angularity distributions for D ^(0)-tagged jets than for inclusive jets,consistent with the ALICE preliminary results.We then demonstrate that jet quenching in the QGP slightly widens the angularity distribution of D ^(0)-tagged jets in Pb+Pb collisions relative to that in p+p collisions for a jet transverse momentum of 10<pch/T,jet<20 Ge V/c.In contrast,the angularity distributions of the inclusive and D ^(0)-tagged jets become narrower in Pb+Pb collisions relative to p+p atpch/T,jet>20 Ge V/c because of the strong influence of selection bias.Additionally,by comparing the average angularities<λ_(α)^(κ)>of the inclusive,D ^(0)-tagged,and B ^(0)-tagged jets with varyingαandκ,we show that the larger the quark mass,the lower the jet’s<λ_(α)^(κ)>values are.As a result of the slenderer initial distribution,we predict that compared with inclusive jets,heavy-flavor jets,especially B~0-tagged ones,will suffer stronger modifications of<λ_(α)^(κ)>in Pb+Pb relative to p+p at 10<pch/T,jet<20 Ge V/c.For a larger jet radius,a more significant broadening of the jet angularities was predicted because of the enhanced contribution of the wide-angle particles.展开更多
Aim:To review the selection of treatment methods for symptomatic intracranial atherosclerotic stenosis(sICAS)in the acute phase and the progress of research on sICAS interventional therapy based on the latest research...Aim:To review the selection of treatment methods for symptomatic intracranial atherosclerotic stenosis(sICAS)in the acute phase and the progress of research on sICAS interventional therapy based on the latest research technology development.Intracranial atherosclerotic stenosis(ICAS)is the most common cause of ischemic stroke in our country.Currently,treatment is primarily based on pharmacotherapy.In recent years,with the changes and development of endovascular treatment techniques,materials,and treatment concepts,many new research findings have emerged.This article will review the selection of treatment methods for symptomatic intracranial atherosclerotic stenosis(sICAS)in the acute phase and the progress of research on sICAS interventional therapy based on the latest research technology development.展开更多
BACKGROUND Dysplasia surveillance in inflammatory bowel disease(IBD)has evolved significantly with the adoption of advanced endoscopic technologies.AIM To synthesize evidence on image-enhanced endoscopy techniques,bio...BACKGROUND Dysplasia surveillance in inflammatory bowel disease(IBD)has evolved significantly with the adoption of advanced endoscopic technologies.AIM To synthesize evidence on image-enhanced endoscopy techniques,biopsy protocols,and surveillance practices optimizing dysplasia detection in IBD.METHODS A scoping review was conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.A comprehensive search of PubMed and EMBASE from inception to June 2025 identified studies reporting on endoscopic dysplasia detection or characterization in IBD.Forty-five studies were included for qualitative synthesis,covering dye-based chromoendoscopy(DCE),virtual chromoendoscopy(VCE),confocal laser endomicroscopy,artificial intelligence-based tools,and panoramic endoscopy.RESULTS DCE consistently demonstrated high dysplasia detection rates,especially when indigo carmine was used,and enabled accurate pit-pattern-based lesion characterization.High definition(HD)DCE may offer procedural benefits over HD white light endoscopy(WLE),though superiority in dysplasia detection remains inconsistent across studies.In comparative studies,DCE outperformed or matched white-light approaches,with higher dysplasia yield in selected trials(e.g.,9.7%vs 1.9%,P=0.004),while HD WLE with segmental re-inspection was non-inferior to DCE in expert settings.Virtual chromoendoscopy modalities such as i-SCAN and narrow band imaging showed comparable performance to DCE in several trials,with artificial intelligence-assisted computer-aided detection systems demonstrating equivalent sensitivity but lower specificity.Studies comparing biopsy protocols revealed that targeted biopsies under imageenhanced endoscopy,particularly DCE,were generally superior or equivalent to random biopsies,with random sampling offering marginal benefit in select high-risk subgroups.Multimodal imaging and panoramic endoscopy further improved dysplasia yield in challenging cases.Cost-effectiveness analyses favored DCE over WLE,and long-term surveillance data confirmed declining colorectal cancer rates with high-quality endoscopic programs.However,real-world practice audits revealed substantial variation in surveillance quality and guideline adherence.CONCLUSION Image-enhanced targeted surveillance-particularly using DCE or validated virtual platforms-has improved dysplasia detection in IBD and may allow for a reduction in random biopsies.Despite technological advancements,major quality gaps and interobserver variability persist in clinical practice.Standardized training,quality benchmarks,and cost-effective implementation of advanced endoscopic techniques are needed to optimize colorectal cancer prevention in IBD.展开更多
Integrating electrocatalytic and photocatalytic functionalities into a single-component system offers a promising strategy for enhancing catalytic activity in photo-assisted electrocatalysis.This synergy is critical f...Integrating electrocatalytic and photocatalytic functionalities into a single-component system offers a promising strategy for enhancing catalytic activity in photo-assisted electrocatalysis.This synergy is critical for advancing energy conversion efficiency,yet significant challenges persist,particularly in optimizing individual layers and minimizing charge recombination.In this work,we present a novel singlecomponent photo-assisted electrocatalytic system based on Ni-or Co-doped CeO_(2),which simultaneously functions as a light absorber and electrocatalyst.We elucidate the critical relationship between bandgap engineering and d-band states,demonstrating that controlled modulation of dopant-derived 3d states within the CeO_(2)bandgap facilitates visible-light harvesting and optimizes the adsorption energetics of key reaction intermediates.Specifically,Ni-doped CeO_(2)introduces additional 3d states near the Fermi level,narrowing the bandgap from 3.0 to 2.7 eV.This modification not only enhances visible-light absorption but also improves charge transfer efficiency at the catalyst-electrolyte interface.Density functional theory(DFT)calculations and spectroscopic analyses reveal that Ni doping significantly enhances performance,achieving a 64 mV reduction in overpotential at 50 mA/cm^(2)under illumination,while Co-doped CeO_(2)exhibits a 35 mV reduction in 1 M NaOH.Our findings demonstrate that a simple doping strategy can tailor 3d states to promote efficient charge carrier separation and intermediate transfer,offering a versatile and scalable approach to designing advanced electrocatalysts for water splitting.展开更多
Organic-inorganic hybrid solar cells consisting of organic conjugated materials and inorganic quantum dots(QDs)have been of great interest during the past two decades.However,it is still challenging to select desired ...Organic-inorganic hybrid solar cells consisting of organic conjugated materials and inorganic quantum dots(QDs)have been of great interest during the past two decades.However,it is still challenging to select desired organic functional materials for fabricating hybrid films to maximize their photovoltaic performance.Herein,we report the synthesis of three narrow bandgap non-fullerene conjugated polymers and further demonstrate the importance and impact of polymer crystallinity in tuning the organic-inorganic hybrid interface towards improved photovoltaic performance.In specific,we develop an organic-inorganic hybrid active layer using a newly synthesized polymer with relatively weaker crystallinity and FAPbI_(3)QDs,enabling complementary absorption and favorable interface/morphology for efficient charge separation and transport.The champion PCDOT-T/FAPbI_(3)QD hybrid device achieves a record-high efficiency of 13.11%based on the one-step coating organic/QD hybrid bulk heterojunction blend,which is significantly improved relative to the semi-crystalline polymer PYIT-based hybrid device(11.23%)and pristine QD(10.51%).We believe these findings would provide new insight into the organic/QD interface to construct desired hybrid films for high-performing optoelectronic applications.展开更多
With the growing demand for offshore energy,deepwater drilling has become a vital technology in petroleum engineering.However,conventional drilling systems often face limitations such as delayed bottomhole pressure re...With the growing demand for offshore energy,deepwater drilling has become a vital technology in petroleum engineering.However,conventional drilling systems often face limitations such as delayed bottomhole pressure response and low control precision,particularly under narrow pressure window and complex formation conditions.To address these challenges,Dual-layer Pipe dual-gradient drilling(DGD)technology has been introduced,utilizing a dual-pipe structure and downhole lift pumps to extend the pressure control range.Despite these advantages,current DGD systems lack fast and precise bottomhole pressure control due to their reliance on indirect flow-based methods.This study proposes a bottomhole pressure control method based on backpressure regulation using a hybrid fuzzy-PID control strategy.A dynamic pressure calculation model is developed for the Dual-layer Pipe DGD system,incorporating coupling among choke valve opening,surface backpressure,and bottomhole pressure.The fuzzy-PID controller adjusts valve operation in real-time based on pressure deviation and its rate of change,improving response speed and control accuracy.Simulink-based simulations demonstrate that the proposed system achieves rapid pressure regulation with an overshoot below 5%and steady-state error under 0.12%.Compared to conventional PID control,the fuzzy-PID system shows superior adaptability to pressure variations.This research enhances the theoretical foundation of backpressure control in deepwater DGD operations and provides a practical approach for improving safety and efficiency in complex drilling environments.展开更多
An alternating magnetic field(AMF)was introduced into the narrow gap laser-arc hybrid welding process for 2205 duplex stainless steel thick plates.The corrosion performance of the welded joints was evaluated through e...An alternating magnetic field(AMF)was introduced into the narrow gap laser-arc hybrid welding process for 2205 duplex stainless steel thick plates.The corrosion performance of the welded joints was evaluated through electrochemical studies.The results revealed that joints welded with the application of AMF had a lower corrosion current density compared to those welded without an external AMF.Additionally,these joints showed higher pitting potential and polarization resistance.Microscopic electrochemical analysis indicated that joints subjected to AMF exhibited minimal cathodic current in simulated seawater,with only slight fluctuations in the anodic current peak.Overall,the corrosion levels on the joint surfaces were relatively low.After 4 h of immersion in the corrosive medium,the average impedance of joints exposed to AMF increased by 60.7%compared to those not influenced by a magnetic field.These findings suggest that applying AMF during the narrow gap laser-arc hybrid welding process can significantly improve the corrosion resistance of duplex stainless steel welded joints,reducing their susceptibility to stress corrosion in seawater-like environments.展开更多
Endoscopic submucosal dissection(ESD)has emerged as a pivotal therapeutic modality for early gastrointestinal(GI)cancers,providing a minimally invasive approach with curative potential.This technique enables the en bl...Endoscopic submucosal dissection(ESD)has emerged as a pivotal therapeutic modality for early gastrointestinal(GI)cancers,providing a minimally invasive approach with curative potential.This technique enables the en bloc resection of neoplastic lesions confined to the mucosa and submucosa,thereby preserving organ function and reducing the need for more radical surgical interventions.ESD provides diagnostic clarity and enhances patient survival rates when performed by skilled practitioners in the early stages of GI cancers such as esophageal,gastric,and colorectal carcinomas.This article examines the indications,procedural advancements,technical considerations,and outcomes associated with ESD in early GI cancers.The challenges and complications that can arise are also highlighted.Additionally,we discuss the evolving role of novel techniques and adjunctive therapies to improve safety and efficacy.As the field progresses,ESD remains a cornerstone in managing early GI cancers,offering patients a promising option for organ preservation and long-term survival.展开更多
Flapping-Wing Micro Air Vehicles(FMAVs)are compact and agile,capable of accessing narrow spaces that conventional vehicles struggle to reach,such as ruins,caves,or the interiors of complex structures,making them ideal...Flapping-Wing Micro Air Vehicles(FMAVs)are compact and agile,capable of accessing narrow spaces that conventional vehicles struggle to reach,such as ruins,caves,or the interiors of complex structures,making them ideal tools for reconnaissance and rescue missions.1 However,the operation of FMAVs relies on coordinating multiple forces with different scaling effects,posing challenges to miniaturization design.展开更多
Piezoelectric transduction technology enables the direct conversion between mechanical and electrical energy,finding extensive applications in sensing,acoustics,imaging,actuation,and energy harvesting[1].Previous stud...Piezoelectric transduction technology enables the direct conversion between mechanical and electrical energy,finding extensive applications in sensing,acoustics,imaging,actuation,and energy harvesting[1].Previous studies on piezoelectric materials have primarily focused on ceramics or single-crystal materials characterized by wide band gaps(E_(g)>2.0 e V[2])and low electrical conductivity.In contrast,narrow-bandgap(E_(g)<0.5 eV[3])semiconductor materials typically exhibit high electrical conductivity,which is unfavorable for the effective accumulation of charges required to establish a stable voltage response.Consequently,experimental investigations into the piezoelectric effect of narrow-bandgap semiconductors are scarce.展开更多
Cardiac resynchronization therapy(CRT)reduces heart failure(HF)hospitaliz-ations and all-cause mortality in patients with HF with reduced ejection fraction with left bundle branch(LBB)block.Biventricular pacing(BVP)is...Cardiac resynchronization therapy(CRT)reduces heart failure(HF)hospitaliz-ations and all-cause mortality in patients with HF with reduced ejection fraction with left bundle branch(LBB)block.Biventricular pacing(BVP)is considered the gold standard for achieving CRT;however,approximately 30%–40%of patients do not respond to BVP-CRT.Recent studies have demonstrated that LBB pacing(LBBP)produces remarkable results in CRT.In this meta-analysis,LBBP-CRT showed better outcomes than conventional BVP-CRT,including greater QRS duration reduction and left ventricular ejection fraction improvement,along with consistently lower pacing thresholds on follow-up.Additionally,there was a grea-ter reduction in New York Heart Association class and brain natriuretic peptide levels.This study contributes to the growing body of encouraging data on LBBP-CRT from recent years.With ongoing technological advancements and increasing operator expertise,the day may not be far when LBBP-CRT becomes the standard of care rather than the exception.展开更多
基金supported by the National Natural Science Foundation of China(52130308)the Shenzhen Science and Technology Program(ZDSYS20210623091813040)。
文摘Narrow electroluminescence is essential for enhancing the performance of modern optoelectronic devices,particularly in applications demanding high color purity,efficient optical communication and precise phototherapy[1].In commercial organic light-emitting diodes(OLEDs),additional color filters are usually implemented for selectively transmitting primary colors,thus resulting in narrowed emission,generally with a full width at half maximum(FWHM)value around 30 nm.
文摘This is a crucial moment for China’s textile export industry, which is in the midst of deep economic downturn. In the January-Novem- ber 2009 period, the decline in accumulated textile and apparel exports was being constantly reduced and the tendency of rebound
基金financially supported by the Key Research and Development Program of Ningbo(Grant No.2023Z098)Natural Science Foundation of Inner Mongolia(Grant No.2023MS05040)+1 种基金Shenyang Collaborative Innovation Center Project for Multiple Energy Fields Composite Processing of Special Materials(Grant No.JG210027)Shenyang Key Technology Special Project of The Open Competition Mechanism to Select the Best Solution(Grant Nos.2022210101000827,2022-0-43-048).
文摘Titanium alloy has the advantages of high strength,strong corrosion resistance,excellent high and low temperature mechanical properties,etc.,and is widely used in aerospace,shipbuilding,weapons and equipment,and other fields.In recent years,with the continuous increase in demand for medium-thick plate titanium alloys,corresponding welding technologies have also continued to develop.Therefore,this article reviews the research progress of deep penetration welding technology for medium-thick plate titanium alloys,mainly covering traditional arc welding,high-energy beam welding,and other welding technologies.Among many methods,narrow gap welding,hybrid welding,and external energy field assistance welding all contribute to improving the welding efficiency and quality of medium-thick plate titanium alloys.Finally,the development trend of deep penetration welding technology for mediumthick plate titanium alloys is prospected.
基金Supported by National Natural Science Foundation of China,No.82370570.
文摘BACKGROUND Early esophageal neuroendocrine carcinoma(E-NEC)is a rare but aggressive malignancy with poorly understood endoscopic features.Despite advancements in multi-model endoscopy,including white light endoscopy,magnifying end-oscopy narrow-band imaging(NBI),and endoscopic ultrasonography(EUS),the diagnostic characteristics of early E-NEC remain unclear.Comprehensive evalu-ation using these techniques can improve early detection and guide clinical management.This study aimed to investigate the endoscopic features of early E-NEC using multiple imaging modalities.We hypothesized that specific endos-copic patterns,such as irregular microvascular morphology or signs of submu-cosal invasion,could reliably distinguish early E-NEC from other esophageal lesions.AIM To characterize early E-NEC using multi-model endoscopy and identify diag-nostic endoscopic features.METHODS Clinical data of four patients with esophageal submucosal lesions identified by gastroscopy and pathologically diagnosed as E-NEC in the Department of Gastroenterology,The First Affiliated Hospital of Zhejiang University School of Medicine between January 2020 and August 2024 were retrospectively analyzed,and their manifestations under multi-model endoscopy were observed.Grayscale values of ultrasound images in three patients with E-NEC and eight with esophageal leiomyoma were calculated using Image J software and compared using the Mann-Whitney U test.Neuroendocrine neoplasms(NENs)are a rare heterogeneous group of epithelial tumors that originate from peptidergic neurons and neuroendocrine cells,and are characterized by neuroendocrine differentiation.NENs include well-differen-tiated neuroendocrine tumors(NETs),poorly differentiated neuroendocrine carcinomas(NECs),and mixed neuroen-docrine-non-NENs[1],which exhibit a wide range of biological behaviors,from indolent,slow-growing lesions to highly aggressive and metastatic malignancies[2].NENs have the capacity for whole-body distribution,with gastroenteropan-creatic NENs comprising approximately 60%-75%of cases,followed by those in the lungs and mediastinum[3].Eso-phageal NENs(E-NENs)are extremely rare,accounting for only approximately 1.6%of all NENs and occurring far less frequently than other gastrointestinal NENs[4].However,with advancements in early cancer screening and diagnostic techniques,the incidence of E-NENs has gradually increased in recent decades[5].Among E-NENs,<1%are well-differ-entiated NETs,with the vast majority being poorly differentiated small cell NECs[6,7].Nevertheless,esophageal NEC(E-NEC)accounts for only 0.05%-7.6%of all esophageal malignant tumors[8,9],and is characterized by aggressive behavior,rapid progression,and early metastasis.E-NEC primarily affects middle-aged and older individuals,with a higher prevalence in males[10].The tumor-node-metastasis staging system of E-NEC mirrors that of esophageal squamous cell carcinoma(ESCC)[11,12].Early E-NEC is defined as lesions limited to the mucosal or submucosal layer(stages T1a and T1b),with or without nodal metastasis.Clinically,we found that early E-NEC often presents with absent or non-specific symptoms,such as mild dysphagia or retrosternal discomfort,which are easily overlooked or mistaken for benign esophageal conditions such as leiomyoma.Conventional imaging and tumor markers frequently fail to detect early lesions,and endoscopic biopsy results may be inconclusive due to submucosal tumor growth and the overlying normal epithelium[13].As a result,E-NEC is frequently diagnosed at an advanced stage(31%-90%of cases)when regional lymph node or distant metastases have already occurred,contributing to its poor prognosis[2,13,14].Studies have reported a median survival of approximately 11 months and 5-year survival rate of<10%[14].Given these challenges,early detection using endoscopy is essential for improving patient outcomes.
基金supported by the National Key Research and Development Program of China(Grant Nos.2023YFA1406000 and 2022YFA1403800)the National Natural Science Foundation of China(Grant Nos.12474002,22171283,22203031,12434005,12204515,and 12074175)support of the Young Elite Scientists Sponsorship Program by CAST(Grant No.2022QNRC001)。
文摘Kitaev quantum spin liquids have attracted significant attention in condensed matter physics over the past decade.To understand their emergent quantum phenomena,high-quality single crystals of substantial size are essential.Here,we report the synthesis of single crystals of the Kitaev quantum spin liquid candidate RuBr_(3),achieving millimeter-sized crystals through a self-flux method under high pressure and high temperature conditions.The crystals exhibit well-defined cleavage planes with a lustrous appearance.Transport characterizations exhibit a narrow band-gap semiconducting behavior with 0.13 eV and 0.11 eV band-gap in ab plane and along𝑐axis,respectively.Magnetic measurement shows a transition to antiferromagnetic(AFM)state at approximately 29K both in ab plane and along the c axis.Notably,the N′eel temperature increases to 34K with an applied magnetic field of up to 7T in the ab plane,but without any change along𝑐axis.The large size and high quality of RuBr3 single crystals provide a valuable platform for investigating various interactions,particularly the Kitaev interaction,and for elucidating the intrinsic physical properties of Kitaev quantum spin liquids.
文摘BACKGROUND Intracranial blister-like microaneurysms are an extremely rare disease.Rupture of intracranial aneurysms can lead to subarachnoid hemorrhage(SAH).Patients with SAH may experience severe neurological symptoms,including severe headache,nausea,vomiting,transient or persistent loss of consciousness,limb weakness,and blurred vision.Ruptured aneurysms should be surgically treated as soon as possible.Intravascular electrocoagulation is becoming a promising treatment method for intracranial blister-like microaneurysms.The short-term follow-up results demonstrated that this method is safe and effective.This article presents a case of endovascular electrocoagulation for the treatment of a blisterlike microaneurysm.CASE SUMMARY This article reports the case of 71-year-old female patient with an intracranial aneurysm.The patient experienced a sudden headache with vomiting for 3 hours.Brain computed tomography(CT)scan showed a subarachnoid hemorrhage.She was diagnosed with rupture of an aneurysm and subarachnoid hemorrhage.The aneurysm was located in the choroidal segment of the right internal carotid artery.The size of the aneurysm was 2.00 mm×1.80 mm×1.97 mm,and the neck of the aneurysm was less than 0.5 mm wide.We successfully treated this aneurysm with endovascular electrocoagulation,and the patient was safely returned to the ward and discharged after subsequent supportive treatment.CT angiography reexamination 3 months after surgery revealed no contrast agent extravasation in the original lesion,with a good prognosis.CONCLUSION Endovascular electrocoagulation is an effective and safe method for the treatment of intracranial blister-like microaneurysms.
基金Project(42277175)supported by the National Natural Science Foundation of ChinaProject(NRMSSHR-2022-Z08)supported by the Key Laboratory of Natural Resources Monitoring and Supervision in Southern Hilly Region,Ministry of Natural Resources,China。
文摘Narrow backfill earth pressure estimation is applied to study the stability of supporting structures in the vicinity of existing buildings.Previous narrow backfill earth pressure studies have neglected seismic-unsaturated seepage multi-field coupling,resulting in inaccurate estimates.To address these deficiencies,this paper proposed a calculation method for seismic passive earth pressure in unsaturated narrow backfill,based on inclined thin-layer units.It considers the interlayer shear stress,arching effect,and the multi-field coupling of seismic-unsaturated seepage.Additionally,this paper includes a parametric sensitivity analysis.The outcomes indicate that the earthquake passive ground pressure of unsaturated narrow backfill can be reduced by increasing the aspect ratio,seismic acceleration coefficient,and unsaturation parameterα.It can also be reduced by decreasing the effective interior friction angle,soil cohesion,wallearth friction angle,and vertical discharge.Furthermore,for any width soil,lowering the elevation of the action point of passive thrust can be attained by raising the effective interior friction angle,wall-earth friction angle,and unsaturation parameterα.Reducing soil cohesion,seismic acceleration coefficient,and vertical discharge can also lower the height of the application point of passive thrust.
基金supported by the Guangdong Major Project of Basic and Applied Basic Research(Grant No.2020B0301030008)the National Natural Science Foundation of China(Grant Nos.11935007 and 12035007)+1 种基金supported by the Open Foundation of the Key Laboratory of Quark and Lepton Physics(MOE)(Grant No.QLPL2023P01)the Talent Scientific Star-up Foundation of the China Three Gorges University(CTGU)(Grant No.2024RCKJ013)。
文摘We present the first theoretical study on heavy-flavor jet angularities(λ_(α)^(κ))in Pb+Pb collisions at√SNN=5.02 Te V.The initial production of heavy-flavor jets was carried out using the POWHEG+PYTHIA8 prescription.In contrast,the SHELL transport model describes jet evolution in the quark-gluon plasma(QGP).In p+p collisions,we observed narrower angularity distributions for D ^(0)-tagged jets than for inclusive jets,consistent with the ALICE preliminary results.We then demonstrate that jet quenching in the QGP slightly widens the angularity distribution of D ^(0)-tagged jets in Pb+Pb collisions relative to that in p+p collisions for a jet transverse momentum of 10<pch/T,jet<20 Ge V/c.In contrast,the angularity distributions of the inclusive and D ^(0)-tagged jets become narrower in Pb+Pb collisions relative to p+p atpch/T,jet>20 Ge V/c because of the strong influence of selection bias.Additionally,by comparing the average angularities<λ_(α)^(κ)>of the inclusive,D ^(0)-tagged,and B ^(0)-tagged jets with varyingαandκ,we show that the larger the quark mass,the lower the jet’s<λ_(α)^(κ)>values are.As a result of the slenderer initial distribution,we predict that compared with inclusive jets,heavy-flavor jets,especially B~0-tagged ones,will suffer stronger modifications of<λ_(α)^(κ)>in Pb+Pb relative to p+p at 10<pch/T,jet<20 Ge V/c.For a larger jet radius,a more significant broadening of the jet angularities was predicted because of the enhanced contribution of the wide-angle particles.
文摘Aim:To review the selection of treatment methods for symptomatic intracranial atherosclerotic stenosis(sICAS)in the acute phase and the progress of research on sICAS interventional therapy based on the latest research technology development.Intracranial atherosclerotic stenosis(ICAS)is the most common cause of ischemic stroke in our country.Currently,treatment is primarily based on pharmacotherapy.In recent years,with the changes and development of endovascular treatment techniques,materials,and treatment concepts,many new research findings have emerged.This article will review the selection of treatment methods for symptomatic intracranial atherosclerotic stenosis(sICAS)in the acute phase and the progress of research on sICAS interventional therapy based on the latest research technology development.
文摘BACKGROUND Dysplasia surveillance in inflammatory bowel disease(IBD)has evolved significantly with the adoption of advanced endoscopic technologies.AIM To synthesize evidence on image-enhanced endoscopy techniques,biopsy protocols,and surveillance practices optimizing dysplasia detection in IBD.METHODS A scoping review was conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.A comprehensive search of PubMed and EMBASE from inception to June 2025 identified studies reporting on endoscopic dysplasia detection or characterization in IBD.Forty-five studies were included for qualitative synthesis,covering dye-based chromoendoscopy(DCE),virtual chromoendoscopy(VCE),confocal laser endomicroscopy,artificial intelligence-based tools,and panoramic endoscopy.RESULTS DCE consistently demonstrated high dysplasia detection rates,especially when indigo carmine was used,and enabled accurate pit-pattern-based lesion characterization.High definition(HD)DCE may offer procedural benefits over HD white light endoscopy(WLE),though superiority in dysplasia detection remains inconsistent across studies.In comparative studies,DCE outperformed or matched white-light approaches,with higher dysplasia yield in selected trials(e.g.,9.7%vs 1.9%,P=0.004),while HD WLE with segmental re-inspection was non-inferior to DCE in expert settings.Virtual chromoendoscopy modalities such as i-SCAN and narrow band imaging showed comparable performance to DCE in several trials,with artificial intelligence-assisted computer-aided detection systems demonstrating equivalent sensitivity but lower specificity.Studies comparing biopsy protocols revealed that targeted biopsies under imageenhanced endoscopy,particularly DCE,were generally superior or equivalent to random biopsies,with random sampling offering marginal benefit in select high-risk subgroups.Multimodal imaging and panoramic endoscopy further improved dysplasia yield in challenging cases.Cost-effectiveness analyses favored DCE over WLE,and long-term surveillance data confirmed declining colorectal cancer rates with high-quality endoscopic programs.However,real-world practice audits revealed substantial variation in surveillance quality and guideline adherence.CONCLUSION Image-enhanced targeted surveillance-particularly using DCE or validated virtual platforms-has improved dysplasia detection in IBD and may allow for a reduction in random biopsies.Despite technological advancements,major quality gaps and interobserver variability persist in clinical practice.Standardized training,quality benchmarks,and cost-effective implementation of advanced endoscopic techniques are needed to optimize colorectal cancer prevention in IBD.
基金the support of the Henry Royce Institute for Advanced Materials through the Industrial Collaboration Programme(RICP-R4-100061)and MATcelerateZero(MATZ0)funded from a grant provided by the Engineering and Physical Sciences Research Council EP/X527257/1+6 种基金the Department for Energy Security and Net Zero(Project ID:NEXTCCUS)University College London’s Research,Innovation and Global Engagement,University of Sydney–University College London Partnership Collaboration AwardsUCL-Peking University Strategic Partner FundsCornell-UCL Global Strategic Collaboration Awards and IISc-UCL Joint seed fund for their financial supportthe ACT program(Accelerating CCS Technologies,Horizon2020 Project No.691712)for the financial support of the NEXTCCUS project(project ID:327327)Cambridge Royce facilities grant EP/P024947/1Sir Henry Royce Institute–recurrent grant EP/R00661X/1。
文摘Integrating electrocatalytic and photocatalytic functionalities into a single-component system offers a promising strategy for enhancing catalytic activity in photo-assisted electrocatalysis.This synergy is critical for advancing energy conversion efficiency,yet significant challenges persist,particularly in optimizing individual layers and minimizing charge recombination.In this work,we present a novel singlecomponent photo-assisted electrocatalytic system based on Ni-or Co-doped CeO_(2),which simultaneously functions as a light absorber and electrocatalyst.We elucidate the critical relationship between bandgap engineering and d-band states,demonstrating that controlled modulation of dopant-derived 3d states within the CeO_(2)bandgap facilitates visible-light harvesting and optimizes the adsorption energetics of key reaction intermediates.Specifically,Ni-doped CeO_(2)introduces additional 3d states near the Fermi level,narrowing the bandgap from 3.0 to 2.7 eV.This modification not only enhances visible-light absorption but also improves charge transfer efficiency at the catalyst-electrolyte interface.Density functional theory(DFT)calculations and spectroscopic analyses reveal that Ni doping significantly enhances performance,achieving a 64 mV reduction in overpotential at 50 mA/cm^(2)under illumination,while Co-doped CeO_(2)exhibits a 35 mV reduction in 1 M NaOH.Our findings demonstrate that a simple doping strategy can tailor 3d states to promote efficient charge carrier separation and intermediate transfer,offering a versatile and scalable approach to designing advanced electrocatalysts for water splitting.
基金financially supported by the National Key Research and Development Program of China(2022YFE0110300)the National Natural Science Foundation of China(52261145696 and 52473187)+1 种基金the“111”Projectthe Collaborative Innovation Center of Suzhou Nano Science and Technology,Soochow University。
文摘Organic-inorganic hybrid solar cells consisting of organic conjugated materials and inorganic quantum dots(QDs)have been of great interest during the past two decades.However,it is still challenging to select desired organic functional materials for fabricating hybrid films to maximize their photovoltaic performance.Herein,we report the synthesis of three narrow bandgap non-fullerene conjugated polymers and further demonstrate the importance and impact of polymer crystallinity in tuning the organic-inorganic hybrid interface towards improved photovoltaic performance.In specific,we develop an organic-inorganic hybrid active layer using a newly synthesized polymer with relatively weaker crystallinity and FAPbI_(3)QDs,enabling complementary absorption and favorable interface/morphology for efficient charge separation and transport.The champion PCDOT-T/FAPbI_(3)QD hybrid device achieves a record-high efficiency of 13.11%based on the one-step coating organic/QD hybrid bulk heterojunction blend,which is significantly improved relative to the semi-crystalline polymer PYIT-based hybrid device(11.23%)and pristine QD(10.51%).We believe these findings would provide new insight into the organic/QD interface to construct desired hybrid films for high-performing optoelectronic applications.
基金the Sichuan Provincial Key R&D Program(Regional Innovation Coop-eration Project 2025YFHZ0306)Open Fund(PLN 2022-46)of State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation(Southwest Petroleum University)Special Support for Sichuan Postdoctoral Research Projects.
文摘With the growing demand for offshore energy,deepwater drilling has become a vital technology in petroleum engineering.However,conventional drilling systems often face limitations such as delayed bottomhole pressure response and low control precision,particularly under narrow pressure window and complex formation conditions.To address these challenges,Dual-layer Pipe dual-gradient drilling(DGD)technology has been introduced,utilizing a dual-pipe structure and downhole lift pumps to extend the pressure control range.Despite these advantages,current DGD systems lack fast and precise bottomhole pressure control due to their reliance on indirect flow-based methods.This study proposes a bottomhole pressure control method based on backpressure regulation using a hybrid fuzzy-PID control strategy.A dynamic pressure calculation model is developed for the Dual-layer Pipe DGD system,incorporating coupling among choke valve opening,surface backpressure,and bottomhole pressure.The fuzzy-PID controller adjusts valve operation in real-time based on pressure deviation and its rate of change,improving response speed and control accuracy.Simulink-based simulations demonstrate that the proposed system achieves rapid pressure regulation with an overshoot below 5%and steady-state error under 0.12%.Compared to conventional PID control,the fuzzy-PID system shows superior adaptability to pressure variations.This research enhances the theoretical foundation of backpressure control in deepwater DGD operations and provides a practical approach for improving safety and efficiency in complex drilling environments.
基金supported by the National Natural Science Foundation of China(No.52265054)the Inner Mongolia Autonomous Region Natural Science Foundation Project(No.2022ZD03)+3 种基金the Inner Mongolia Autonomous Region Science and Technology Plan Project(No.2020GG0313)the Inner Mongolia Autonomous Region Natural Science Foundation Doctoral Fund Project,(No.2021BS05016)the Construction project of integrated research and development platform for key technologies in the development and processing of new nonferrous metal materials(No.RZ2300001971)the Basic Research Business Fee Project for Autonomous Region Directly Affiliated Universities(Nos.JY20220199 and JY20220028).
文摘An alternating magnetic field(AMF)was introduced into the narrow gap laser-arc hybrid welding process for 2205 duplex stainless steel thick plates.The corrosion performance of the welded joints was evaluated through electrochemical studies.The results revealed that joints welded with the application of AMF had a lower corrosion current density compared to those welded without an external AMF.Additionally,these joints showed higher pitting potential and polarization resistance.Microscopic electrochemical analysis indicated that joints subjected to AMF exhibited minimal cathodic current in simulated seawater,with only slight fluctuations in the anodic current peak.Overall,the corrosion levels on the joint surfaces were relatively low.After 4 h of immersion in the corrosive medium,the average impedance of joints exposed to AMF increased by 60.7%compared to those not influenced by a magnetic field.These findings suggest that applying AMF during the narrow gap laser-arc hybrid welding process can significantly improve the corrosion resistance of duplex stainless steel welded joints,reducing their susceptibility to stress corrosion in seawater-like environments.
文摘Endoscopic submucosal dissection(ESD)has emerged as a pivotal therapeutic modality for early gastrointestinal(GI)cancers,providing a minimally invasive approach with curative potential.This technique enables the en bloc resection of neoplastic lesions confined to the mucosa and submucosa,thereby preserving organ function and reducing the need for more radical surgical interventions.ESD provides diagnostic clarity and enhances patient survival rates when performed by skilled practitioners in the early stages of GI cancers such as esophageal,gastric,and colorectal carcinomas.This article examines the indications,procedural advancements,technical considerations,and outcomes associated with ESD in early GI cancers.The challenges and complications that can arise are also highlighted.Additionally,we discuss the evolving role of novel techniques and adjunctive therapies to improve safety and efficacy.As the field progresses,ESD remains a cornerstone in managing early GI cancers,offering patients a promising option for organ preservation and long-term survival.
基金supported by the Scientific Research Innovation Capability Support Project for Young Faculty,China(No.ZYGXQNJSKYCXNLZCXM-D1)the National Natural Science Foundation of China(No.52272384).
文摘Flapping-Wing Micro Air Vehicles(FMAVs)are compact and agile,capable of accessing narrow spaces that conventional vehicles struggle to reach,such as ruins,caves,or the interiors of complex structures,making them ideal tools for reconnaissance and rescue missions.1 However,the operation of FMAVs relies on coordinating multiple forces with different scaling effects,posing challenges to miniaturization design.
文摘Piezoelectric transduction technology enables the direct conversion between mechanical and electrical energy,finding extensive applications in sensing,acoustics,imaging,actuation,and energy harvesting[1].Previous studies on piezoelectric materials have primarily focused on ceramics or single-crystal materials characterized by wide band gaps(E_(g)>2.0 e V[2])and low electrical conductivity.In contrast,narrow-bandgap(E_(g)<0.5 eV[3])semiconductor materials typically exhibit high electrical conductivity,which is unfavorable for the effective accumulation of charges required to establish a stable voltage response.Consequently,experimental investigations into the piezoelectric effect of narrow-bandgap semiconductors are scarce.
文摘Cardiac resynchronization therapy(CRT)reduces heart failure(HF)hospitaliz-ations and all-cause mortality in patients with HF with reduced ejection fraction with left bundle branch(LBB)block.Biventricular pacing(BVP)is considered the gold standard for achieving CRT;however,approximately 30%–40%of patients do not respond to BVP-CRT.Recent studies have demonstrated that LBB pacing(LBBP)produces remarkable results in CRT.In this meta-analysis,LBBP-CRT showed better outcomes than conventional BVP-CRT,including greater QRS duration reduction and left ventricular ejection fraction improvement,along with consistently lower pacing thresholds on follow-up.Additionally,there was a grea-ter reduction in New York Heart Association class and brain natriuretic peptide levels.This study contributes to the growing body of encouraging data on LBBP-CRT from recent years.With ongoing technological advancements and increasing operator expertise,the day may not be far when LBBP-CRT becomes the standard of care rather than the exception.
