Recent advancements in AI have spurred interest in ferroelectric memristors for neuromorphic chips due to their ability to precisely control resistive states through polarization flip-flop without electroforming.Howev...Recent advancements in AI have spurred interest in ferroelectric memristors for neuromorphic chips due to their ability to precisely control resistive states through polarization flip-flop without electroforming.However,oxygen vacancies in these devices often cause high leakage current,low endurance,and dispersed switching voltages.Here,we introduce a silicon-based integrated(Ba_(0.6)Sr_(0.4)TiO_(3))_(0.5)(Nd_(2)O_(3))_(0.5)(BSTN)nanoscaffolded ferroelectric thin film memristor with a vertically self-assembled nanocomposite structure(VSNs)optimally oriented on La_(0.67)Sr_(0.33)MnO_(3)/SrTiO_(3)/Psingle bondSi substrates.This device demonstrates a widely tunable ferroelectric domain range(0°-180°),high remnant polarization(21.04μC/cm^(2)),and a greater number of unitary states(16 states or 4 bits).It exhibits high durability,enduring over 109 switching cycles.The switching mechanism combines ferroelectric polarization and oxygen vacancy migration,enabling the simulation of biological synaptic functions via bi-directional conductance tunability.Additionally,we implemented a low-power(0.57 pJ per event)multi-factor secure encryption system for smart locks using 16×16 BSTN memristor crossbar arrays and a pressure sensor.Under multiple factors(disordered inputs,specific users,and corresponding passwords)the system recognized passwords with 97.6%accuracy and a 3.8%loss rate after 500 iterations.Overall,this work establishes a robust foundation for advancing multilevel storage,neuromorphic computing,and AI chip applications based on ferroelectric memristors.展开更多
Mesenchymal stem cell(MSC)transplantation has been explored for the clinical treatment of various diseases.However,the current two-dimensional(2D)culture method lacks a natural spatial microenvironment in vitro.This l...Mesenchymal stem cell(MSC)transplantation has been explored for the clinical treatment of various diseases.However,the current two-dimensional(2D)culture method lacks a natural spatial microenvironment in vitro.This limitation restricts the stable establishment and adaptive maintenance of MSC stemness.Using natural polymers with biocompatibility for constructing stereoscopic MSC microenvironments may have significant application potential.This study used chitin-based nanoscaffolds to establish a novel MSC three-dimensional(3D)culture.We compared 2D and 3D cultured human umbilical cord-derived MSCs(UCMSCs),including dif-ferentiation assays,cell markers,proliferation,and angiogenesis.When UCMSCs are in 3D culture,they can differentiate into bone,cartilage,and fat.In 3D culture condition,cell proliferation is enhanced,accompanied by an elevation in the secretion of paracrine factors,including vascular endothelial growth factor(VEGF),hepa-tocyte growth factor(HGF),Interleukin-6(IL-6),and Interleukin-8(IL-8)by UCMSCs.Additionally,a 3D culture environment promotes angiogenesis and duct formation with HUVECs(Human Umbilical Vein Endothelial Cells),showing greater luminal area,total length,and branching points of tubule formation than a 2D culture.MSCs cultured in a 3D environment exhibit enhanced undifferentiated,as well as higher cell activity,making them a promising candidate for regenerative medicine and therapeutic applications.展开更多
基金supported by the National Key R&D Plan“Nano Frontier”Key Special Project(Grant No.2021YFA1200502 and 2024YFA1208400)Cultivation Projects of National Major R&D Project(Grant No.92164109)+19 种基金Disruptive Technology Innovation Project of the National Key R&D Program(Grant No.DT01202402075)the National Natural Science Foundation of China(Grant Nos.61874158,62004056,and 62104058)the Special Project of Strategic Leading Science and Technology of Chinese Academy of Sciences(Grant No.XDB44000000-7)Key Projects Supported by the Regional Innovation and Development Joint Fund(Grant No.U23A20365)Yanzhao Young Scientist Project of Hebei Province(Grant No.F2023201076)Key R&D Plan Projects in Hebei Province(Grant No.22311101D)Hebei Basic Research Special Key Project(Grant No.F2021201045)the Support Program for the Top Young Talents of Hebei Province(Grant No.70280011807)the Supporting Plan for 100 Excellent Innovative Talents in Colleges and Universities of Hebei Province(Grant No.SLRC2019018)the Interdisciplinary Research Program of Natural Science of Hebei University(No.DXK202101)the Institute of Life Sciences and Green Development(No.521100311)the Natural Science Foundation of Hebei Province(Nos.F2022201002,F2022201054 and F2021201022,F2021201045)Baoding Science and Technology Plan Project(Grant Nos.2172P011,2272P014)Baoding Science and Technology Plan Project(Grant Nos.2172P011,2272P014)the Outstanding Young Scientific Research and Innovation Team of Hebei University(Grant No.605020521001)the Special Support Funds for National High Level Talents(Grant No.041500120001)the Advanced Talents Incubation Program of the Hebei University(Grant Nos.521000981426,521100221071,and 521000981363)the Science and Technology Project of Hebei Education Department(Grant Nos.QN2020178 and QN2021026)Hebei Province High-level Talent Funding Program(Grant Nos.B20231003)Post-graduate's Innovation Fund Project of Hebei University(HBU2024SS029).
文摘Recent advancements in AI have spurred interest in ferroelectric memristors for neuromorphic chips due to their ability to precisely control resistive states through polarization flip-flop without electroforming.However,oxygen vacancies in these devices often cause high leakage current,low endurance,and dispersed switching voltages.Here,we introduce a silicon-based integrated(Ba_(0.6)Sr_(0.4)TiO_(3))_(0.5)(Nd_(2)O_(3))_(0.5)(BSTN)nanoscaffolded ferroelectric thin film memristor with a vertically self-assembled nanocomposite structure(VSNs)optimally oriented on La_(0.67)Sr_(0.33)MnO_(3)/SrTiO_(3)/Psingle bondSi substrates.This device demonstrates a widely tunable ferroelectric domain range(0°-180°),high remnant polarization(21.04μC/cm^(2)),and a greater number of unitary states(16 states or 4 bits).It exhibits high durability,enduring over 109 switching cycles.The switching mechanism combines ferroelectric polarization and oxygen vacancy migration,enabling the simulation of biological synaptic functions via bi-directional conductance tunability.Additionally,we implemented a low-power(0.57 pJ per event)multi-factor secure encryption system for smart locks using 16×16 BSTN memristor crossbar arrays and a pressure sensor.Under multiple factors(disordered inputs,specific users,and corresponding passwords)the system recognized passwords with 97.6%accuracy and a 3.8%loss rate after 500 iterations.Overall,this work establishes a robust foundation for advancing multilevel storage,neuromorphic computing,and AI chip applications based on ferroelectric memristors.
文摘Mesenchymal stem cell(MSC)transplantation has been explored for the clinical treatment of various diseases.However,the current two-dimensional(2D)culture method lacks a natural spatial microenvironment in vitro.This limitation restricts the stable establishment and adaptive maintenance of MSC stemness.Using natural polymers with biocompatibility for constructing stereoscopic MSC microenvironments may have significant application potential.This study used chitin-based nanoscaffolds to establish a novel MSC three-dimensional(3D)culture.We compared 2D and 3D cultured human umbilical cord-derived MSCs(UCMSCs),including dif-ferentiation assays,cell markers,proliferation,and angiogenesis.When UCMSCs are in 3D culture,they can differentiate into bone,cartilage,and fat.In 3D culture condition,cell proliferation is enhanced,accompanied by an elevation in the secretion of paracrine factors,including vascular endothelial growth factor(VEGF),hepa-tocyte growth factor(HGF),Interleukin-6(IL-6),and Interleukin-8(IL-8)by UCMSCs.Additionally,a 3D culture environment promotes angiogenesis and duct formation with HUVECs(Human Umbilical Vein Endothelial Cells),showing greater luminal area,total length,and branching points of tubule formation than a 2D culture.MSCs cultured in a 3D environment exhibit enhanced undifferentiated,as well as higher cell activity,making them a promising candidate for regenerative medicine and therapeutic applications.
