The fast pace of today’s world has presented several challenges in the area of healthcare. Depression, hypertension, diabetes, cancers and several infectious diseases are just some of the common outcomes associated w...The fast pace of today’s world has presented several challenges in the area of healthcare. Depression, hypertension, diabetes, cancers and several infectious diseases are just some of the common outcomes associated with the high speed stress-filled lifestyle. Early diagnosis has been the goal for prompt arrest and management of these health conditions. This has been a challenge in recent times. However, great scientific advancement with improved potential in medical diagnosis has equally been a giant stride in times like these. Early disease detection even before symptoms’ presentation, improved imaging of internal body structure, as well as ease of diagnostic procedures, have been developed with the help of a new branch of laboratory medicine termed nanodiagnostics. Use of microchips, biosensors, nanorobots, nano identification of single celled structures, and microelectromechanical systems are current techniques being developed for use in nanodiagnostics. This piece of write up takes a panoramic view of available nanotechnological advances in current use for medical diagnosis and projecting into future possibilities and potentials for an improved health care delivery.展开更多
Nanotechnology has become integral in the improvement of methodology used to identify and treat various cancers.Nanoparticles(NPs)exhibit unique features that enhance sensitivity and selectivity and subsequently reduc...Nanotechnology has become integral in the improvement of methodology used to identify and treat various cancers.Nanoparticles(NPs)exhibit unique features that enhance sensitivity and selectivity and subsequently reduce the time required to detect early-stage cancer through biomarkers.NPs improve the therapeutic efficiency of anticancer agents when compared with conventional methods,such as chemotherapy,and thereby eliminate toxicity and side effects,which helps improve the stability,solubility,half-life,and tumor aggregation of an anticancer drug.This also helps expedite the treatment cycle by enabling a real-time assessment,quickly circumventing various biological barriers,improving vectorization and delivery,overcoming drug resistance,and developing various paths for the manufacturing of new synthetic vaccines.Nanomedicine has usually involved studies on solid-state cancers because it can increase the cell permeability and retention effect experienced within the tumor areas to improve regional accumulation and efficacy.Nanomedicine for leukemia and lymphoma is addressed differently from solid-state cancers because of the absence of the enhanced permeability and retention effect.Nevertheless,nanomedicine has enabled the development of various modern innovative techniques for simple and noninvasive procedures for prior analysis of cancers with subsequent diffuse tumor treatment.In this assessment,we consider various unique constructs on NPs that can predominantly enhance therapeutic treatment over diffused tumors by increasing control,from preclinical testing to medicinal trials.Nanotechnology combines nanodiagnostics,nanotherapeutics,and nanotheranostics for improved imaging and diagnoses of early stage cancers.Furthermore,the primacy of nanoplatforms has been discussed for an invaluable position in this blended method.There are many types of NPs,such as organic,inorganic,and hybrid NPs.The minute size of NPs makes them ideal for intracellular uptake,and the large surface area ratio allows functional interactions with various compounds.This review also covers targeting cancerous cells via inducing lysosomal autophagy using gold NPs.展开更多
文摘The fast pace of today’s world has presented several challenges in the area of healthcare. Depression, hypertension, diabetes, cancers and several infectious diseases are just some of the common outcomes associated with the high speed stress-filled lifestyle. Early diagnosis has been the goal for prompt arrest and management of these health conditions. This has been a challenge in recent times. However, great scientific advancement with improved potential in medical diagnosis has equally been a giant stride in times like these. Early disease detection even before symptoms’ presentation, improved imaging of internal body structure, as well as ease of diagnostic procedures, have been developed with the help of a new branch of laboratory medicine termed nanodiagnostics. Use of microchips, biosensors, nanorobots, nano identification of single celled structures, and microelectromechanical systems are current techniques being developed for use in nanodiagnostics. This piece of write up takes a panoramic view of available nanotechnological advances in current use for medical diagnosis and projecting into future possibilities and potentials for an improved health care delivery.
文摘Nanotechnology has become integral in the improvement of methodology used to identify and treat various cancers.Nanoparticles(NPs)exhibit unique features that enhance sensitivity and selectivity and subsequently reduce the time required to detect early-stage cancer through biomarkers.NPs improve the therapeutic efficiency of anticancer agents when compared with conventional methods,such as chemotherapy,and thereby eliminate toxicity and side effects,which helps improve the stability,solubility,half-life,and tumor aggregation of an anticancer drug.This also helps expedite the treatment cycle by enabling a real-time assessment,quickly circumventing various biological barriers,improving vectorization and delivery,overcoming drug resistance,and developing various paths for the manufacturing of new synthetic vaccines.Nanomedicine has usually involved studies on solid-state cancers because it can increase the cell permeability and retention effect experienced within the tumor areas to improve regional accumulation and efficacy.Nanomedicine for leukemia and lymphoma is addressed differently from solid-state cancers because of the absence of the enhanced permeability and retention effect.Nevertheless,nanomedicine has enabled the development of various modern innovative techniques for simple and noninvasive procedures for prior analysis of cancers with subsequent diffuse tumor treatment.In this assessment,we consider various unique constructs on NPs that can predominantly enhance therapeutic treatment over diffused tumors by increasing control,from preclinical testing to medicinal trials.Nanotechnology combines nanodiagnostics,nanotherapeutics,and nanotheranostics for improved imaging and diagnoses of early stage cancers.Furthermore,the primacy of nanoplatforms has been discussed for an invaluable position in this blended method.There are many types of NPs,such as organic,inorganic,and hybrid NPs.The minute size of NPs makes them ideal for intracellular uptake,and the large surface area ratio allows functional interactions with various compounds.This review also covers targeting cancerous cells via inducing lysosomal autophagy using gold NPs.
