The lack of effective methods of diagnosis and treatment presents a major barrier to combat against tumor.The biomimetic concept is an emerging field that expresses great application potential in tumor fighting.Strate...The lack of effective methods of diagnosis and treatment presents a major barrier to combat against tumor.The biomimetic concept is an emerging field that expresses great application potential in tumor fighting.Strategy for combining nano-systems with biomimetic technology has gained increasing attention that is proved bioinspired,environmentally benign,and promising.Herein,we provide an up-to-date review of biomimetic nanosystems as well as their applications in tumor therapy.In addition,the challenges and future directions of biomimetic nano-systems to achieve clinical translation are also pointed out.展开更多
Microassembly platforms have attracted significant attention recently because of their potential for developing microsystems and devices for a wide range of applications.Despite their considerable poten-tial,existing ...Microassembly platforms have attracted significant attention recently because of their potential for developing microsystems and devices for a wide range of applications.Despite their considerable poten-tial,existing techniques are mainly used in laboratory research settings.This review provides an over-view of the fundamentals,techniques,and applications of microassemblies.Manipulation techniques based on magnetic,optical,acoustic fields,and mechanical systems are discussed,and control systems that rely on machine vision and force feedback are introduced.Additionally,recent applications of microassemblies in microstructure fabrication,microelectromechanical operation,and biomedical engi-neering are examined.This review also highlights unmet technical demands and emerging trends,as well as new research opportunities in this expanding field of research driven by allied technologies such as microrobotics.展开更多
We investigated graphene structures grafted with fullerenes. The size of the graphene sheets ranges from 6400 to 640,000 atoms. The fullerenes (C60 and C240) are placed on top of the graphene sheets, using different i...We investigated graphene structures grafted with fullerenes. The size of the graphene sheets ranges from 6400 to 640,000 atoms. The fullerenes (C60 and C240) are placed on top of the graphene sheets, using different impact velocities we could distinguish three types of impact. Furthermore, we investigated the changes of the vibrational properties. The modified graphene planes show additional features in the vibronic density of states.展开更多
Silicon carbide and graphene possess extraordinary chemical and physical properties. Here, these different systems are linked and the changes in structural and dynamic properties are investigated. For the simulations ...Silicon carbide and graphene possess extraordinary chemical and physical properties. Here, these different systems are linked and the changes in structural and dynamic properties are investigated. For the simulations performed a classical molecular dynamic (MD) approach was used. In this approach, a graphene layer (N = 240 atoms) was grafted at different distances on top of a 6H-SiC structure (N = 2400 atoms) and onto a 3C-SiC structure (N = 1728 atoms). The distances between the graphene and the 6H are 1.0, 1.3 and 1.5 Åand the distances between the graphene layer and the 3C-SiC are 2.0, 2.3, and 2.5 Å. Each system has been equilibrated at room temperature until no further relaxation was observed. The 6H-SiC structure in combination with graphene proves to be more stable compared to the combination with 3C-SiC. This can be seen well in the determined energies. Pair distribution functions were influenced slightly by the graphene layer due to steric and energetic changes. This becomes clear from the small shifts of the C-C distances. Interactions as well as bonds between graphene and SiC lead to the fact that small shoulders of the high-frequency SiC-peaks are visible in the spectra and at the same time the high-frequency peaks of graphene are completely absent.展开更多
Multifunctional bismuth sulfide(Bi_(2)S_(3))nanomate rials exhibit significant potential as na no medicines for the diagnosis and treatment of cancer.These nanomaterials act as excellent photothermal agents and radiat...Multifunctional bismuth sulfide(Bi_(2)S_(3))nanomate rials exhibit significant potential as na no medicines for the diagnosis and treatment of cancer.These nanomaterials act as excellent photothermal agents and radiation sensitizers for the treatment of tumors,and they can also act as contrast agents for computed tomography(CT)imaging,photoacoustic imaging(PA),and other forms of imaging to provide real-time tumor monitoring and testing guidance.Compared with other nanomaterials,Bi2S3 nanomaterials can readily adapt to different applications by virtue of the fact that they can be easily functionalized.However,these nanomaterials have some limitations that cannot be ignored and need to be addressed,such as poor biocompatibility,toxicity,and low chemical stability.It is widely believed that appropriate functionalization of Bi_(2)S_(3) nanomaterials could remedy such defects and significantly improve performance.This review summarizes the ways in which Bi_(2)S_(3) nanomaterials can be functionalized and discusses their applications in cancer theranostics over the last few years,focusing particularly on imaging and therapy.We also discuss issues relating to how Bi_(2)S_(3) nanomaterials can be analyzed,including how we might be able to use these systems to inhibit and treat tumors and how current limitations might be ove rcome to improve treatment efficacy.Finally,we hope to provide inspiration and guidance as to how we might create a mo re optimized multifunctio nal nano-system for the diagnosis and treatment of tumors.展开更多
基金We are grateful to financial support from National Natural Science Foundation of China(81202480,81302723)Natural Science Foundation of Liaoning Province(2015020749).
文摘The lack of effective methods of diagnosis and treatment presents a major barrier to combat against tumor.The biomimetic concept is an emerging field that expresses great application potential in tumor fighting.Strategy for combining nano-systems with biomimetic technology has gained increasing attention that is proved bioinspired,environmentally benign,and promising.Herein,we provide an up-to-date review of biomimetic nanosystems as well as their applications in tumor therapy.In addition,the challenges and future directions of biomimetic nano-systems to achieve clinical translation are also pointed out.
基金supported by Shanghai Municipal Science and Technology Major Project(2021SHZDZX)also in part supported by the Science and Technology Commission of Shanghai Municipality(20DZ2220400).
文摘Microassembly platforms have attracted significant attention recently because of their potential for developing microsystems and devices for a wide range of applications.Despite their considerable poten-tial,existing techniques are mainly used in laboratory research settings.This review provides an over-view of the fundamentals,techniques,and applications of microassemblies.Manipulation techniques based on magnetic,optical,acoustic fields,and mechanical systems are discussed,and control systems that rely on machine vision and force feedback are introduced.Additionally,recent applications of microassemblies in microstructure fabrication,microelectromechanical operation,and biomedical engi-neering are examined.This review also highlights unmet technical demands and emerging trends,as well as new research opportunities in this expanding field of research driven by allied technologies such as microrobotics.
文摘We investigated graphene structures grafted with fullerenes. The size of the graphene sheets ranges from 6400 to 640,000 atoms. The fullerenes (C60 and C240) are placed on top of the graphene sheets, using different impact velocities we could distinguish three types of impact. Furthermore, we investigated the changes of the vibrational properties. The modified graphene planes show additional features in the vibronic density of states.
文摘Silicon carbide and graphene possess extraordinary chemical and physical properties. Here, these different systems are linked and the changes in structural and dynamic properties are investigated. For the simulations performed a classical molecular dynamic (MD) approach was used. In this approach, a graphene layer (N = 240 atoms) was grafted at different distances on top of a 6H-SiC structure (N = 2400 atoms) and onto a 3C-SiC structure (N = 1728 atoms). The distances between the graphene and the 6H are 1.0, 1.3 and 1.5 Åand the distances between the graphene layer and the 3C-SiC are 2.0, 2.3, and 2.5 Å. Each system has been equilibrated at room temperature until no further relaxation was observed. The 6H-SiC structure in combination with graphene proves to be more stable compared to the combination with 3C-SiC. This can be seen well in the determined energies. Pair distribution functions were influenced slightly by the graphene layer due to steric and energetic changes. This becomes clear from the small shifts of the C-C distances. Interactions as well as bonds between graphene and SiC lead to the fact that small shoulders of the high-frequency SiC-peaks are visible in the spectra and at the same time the high-frequency peaks of graphene are completely absent.
文摘Multifunctional bismuth sulfide(Bi_(2)S_(3))nanomate rials exhibit significant potential as na no medicines for the diagnosis and treatment of cancer.These nanomaterials act as excellent photothermal agents and radiation sensitizers for the treatment of tumors,and they can also act as contrast agents for computed tomography(CT)imaging,photoacoustic imaging(PA),and other forms of imaging to provide real-time tumor monitoring and testing guidance.Compared with other nanomaterials,Bi2S3 nanomaterials can readily adapt to different applications by virtue of the fact that they can be easily functionalized.However,these nanomaterials have some limitations that cannot be ignored and need to be addressed,such as poor biocompatibility,toxicity,and low chemical stability.It is widely believed that appropriate functionalization of Bi_(2)S_(3) nanomaterials could remedy such defects and significantly improve performance.This review summarizes the ways in which Bi_(2)S_(3) nanomaterials can be functionalized and discusses their applications in cancer theranostics over the last few years,focusing particularly on imaging and therapy.We also discuss issues relating to how Bi_(2)S_(3) nanomaterials can be analyzed,including how we might be able to use these systems to inhibit and treat tumors and how current limitations might be ove rcome to improve treatment efficacy.Finally,we hope to provide inspiration and guidance as to how we might create a mo re optimized multifunctio nal nano-system for the diagnosis and treatment of tumors.
