Lipid nanoparticles(LNPs)and extracellular vesicles(EVs)have emerged as powerful therapeutic platforms,each offering distinct advantages.LNPs,composed of four essential lipid components,enable efficient delivery of dr...Lipid nanoparticles(LNPs)and extracellular vesicles(EVs)have emerged as powerful therapeutic platforms,each offering distinct advantages.LNPs,composed of four essential lipid components,enable efficient delivery of drugs and genetic materials,underpinning FDA-approved therapies such as Onpattro and the COVID-19 mRNA vaccines.EVs,naturally secreted by cells,transport bioactive molecules with remarkable delivery efficiency and reduced off-target effects,as exemplified by the EV-based Bexsero vaccine.Given their small size and intrinsic heterogeneity,precise characterization is critical.Compared to conventional techniques like nanoparticle tracking analysis(NTA)and dynamic light scattering(DLS),flow cytometry(FCM)offers a more comprehensive analytical profile for both LNPs and EVs.In the present study,we leveraged a nano-FCM to advance detection strategies for nanoscale therapeutics.A detailed workflow is presented to ensure analytical precision and reproducibility.展开更多
The degradation of organic pollutants in water is a critical environmental challenge.The iron-doped MoS_(2) catalysts have demonstrated potential in activating peroxymonosulfate(PMS)for environmental remediation,but t...The degradation of organic pollutants in water is a critical environmental challenge.The iron-doped MoS_(2) catalysts have demonstrated potential in activating peroxymonosulfate(PMS)for environmental remediation,but they face challenges such as poor conductivity,limited electron transfer efficiency,and a scarcity of active sites.To address these issues,we successfully synthesized a nano-flowers FeS/MoS_(2) composite derived from polyoxometalates(NH_(4))_(3)[Fe(III)Mo_(6)O_(24)H_(6)]⋅6H_(2)O(denoted as FeMo6)as the bimetallic precursors.This synthesis strategy enhances the interaction between FeS and MoS_(2),thereby facilitating electron transfer.Notably,the introduction of sulfur vacancies in FeS/MoS_(2) exposes additional Mo4t active sites,promoting the redox cycle of Fe^(2+)/Fe^(3+) and accelerating the regeneration of Fe^(2+),which in turn enhances PMS activation.Therefore,a catalytic oxidation system of FeS/MoS_(2)/PMS is presented that primarily relies on SO_(4)^(⋅-)and⋅OH,with ^(1)O_(2) as a supplementary oxidant.This system exhibits exceptional degradation efficiency for p-chlorophenol(4-CP),achieving 100% degradation within 10 min over a wide pH range of 2.4–8.4.The robust performance and wide applicability of FeS/MoS_(2) catalyst make it a promising candidate in advanced oxidation processes(AOPs)for environmental remediation.展开更多
We report a facile solution method to form titanium oxide(TiO_(2))nano-flower structure on the titanium(Ti)substrates for realizing good physical sterilization and biocompatibility.We first prepare TiO_(2) nanotubes(N...We report a facile solution method to form titanium oxide(TiO_(2))nano-flower structure on the titanium(Ti)substrates for realizing good physical sterilization and biocompatibility.We first prepare TiO_(2) nanotubes(NT)with a diameter of about 80-100 nm and a length of about 5μm on Ti substrates by anodization,which is utilized as precursor.Then,we employ immersion treatment in different concentrations of phosphoric acid solution at 75℃ for 5 h to realize the transformation from TiO_(2) NT to TiO_(2) nano-flower structure.In addition,we studied the effects of phosphoric acid concentration(1 wt%,2.5 wt%,5 wt% and 10 wt%)on the TiO_(2) nano-flower structure,and the antibacterial properties and biocompatibility of the TiO_(2) nano-flower structure.The results show that TiO_(2) nano-flower structure become larger and thicker with the increase in the phosphoric acid concentration,and the thickness of the coating can reach 6.88μm.Meanwhile,the TiO_(2) nano-flower structure shows good physical sterilization effect,especially for the TiO_(2) nano-flower structure formed in 10 wt%H^(3)PO_(4) solution,the antibacterial rate can reach 95%.In addition,the TiO_(2) nano-flower structure have no toxicity to the osteoblasts and support cell growth.展开更多
Cytochrome P450 enzyme-copper phosphate hybrid materials with flower-like shape were prepared with a simple but efficient coprecipitation method.The growth process of the hybrid flowers can be divided into three succe...Cytochrome P450 enzyme-copper phosphate hybrid materials with flower-like shape were prepared with a simple but efficient coprecipitation method.The growth process of the hybrid flowers can be divided into three successive steps：coordination/nucleation,growth,and further ripen.The concentration of enzymes in the mother liquor exerted great influence on the morphology and surface enzyme content of the nano-composites.The catalytic performance in the reaction of selective oxidation of sulfide to sulfoxide was also investigated.The hybrid flowers exhibited superior catalytic performance：satisfied thioanisole conversion and selectivity to methyl phenyl sulfoxide （both above 97%） with H2O2 as oxidant under mild reaction conditions,excellent stability and recyclability,and wide scope of substrates.Such results indicate that the hybrid materials are potentially good candidates in the industrial enzyme catalysis.展开更多
文章设计了微通道流动与传热实验平台,针对定制的Fe_(3)O_(4)纳米颗粒强化相变微胶囊悬浮液(micro-encapsulated phase change material slurry,MPCS)开展循环流动实验,分别从微通道压降、摩擦阻力系数、对流换热系数、微通道板温度等4...文章设计了微通道流动与传热实验平台,针对定制的Fe_(3)O_(4)纳米颗粒强化相变微胶囊悬浮液(micro-encapsulated phase change material slurry,MPCS)开展循环流动实验,分别从微通道压降、摩擦阻力系数、对流换热系数、微通道板温度等4个方面探究MPCS在微通道中的流动与传热特性。实验结果表明:MPCS在微通道中的压降随质量分数的增加而增大,且明显高于去离子水;与之相比,Fe_(3)O_(4)-MPCS在微通道中的压降并无显著变化。此外,微尺度流动可能更有利于在Re较小时产生湍流;MPCS的对流换热系数高于去离子水,且随Re及质量分数的增大而增大,微通道的板温度更低,表现出更好的冷却效果;相同质量分数的Fe_(3)O_(4)-MPCS具有更高的对流换热系数,传热性能更佳;在低Re下较低的热流密度更有利于传热,在Re较高时高热流密度下传热效果更佳。展开更多
文摘Lipid nanoparticles(LNPs)and extracellular vesicles(EVs)have emerged as powerful therapeutic platforms,each offering distinct advantages.LNPs,composed of four essential lipid components,enable efficient delivery of drugs and genetic materials,underpinning FDA-approved therapies such as Onpattro and the COVID-19 mRNA vaccines.EVs,naturally secreted by cells,transport bioactive molecules with remarkable delivery efficiency and reduced off-target effects,as exemplified by the EV-based Bexsero vaccine.Given their small size and intrinsic heterogeneity,precise characterization is critical.Compared to conventional techniques like nanoparticle tracking analysis(NTA)and dynamic light scattering(DLS),flow cytometry(FCM)offers a more comprehensive analytical profile for both LNPs and EVs.In the present study,we leveraged a nano-FCM to advance detection strategies for nanoscale therapeutics.A detailed workflow is presented to ensure analytical precision and reproducibility.
基金financially supported by the National Natural Science Foundation of China(52063024 and 51868052)the Natural Science Foundation of Jiangxi Province(20192ACBL21046)the National Science Foundation of State Key Laboratory of Structural Chemistry(20160013).
文摘The degradation of organic pollutants in water is a critical environmental challenge.The iron-doped MoS_(2) catalysts have demonstrated potential in activating peroxymonosulfate(PMS)for environmental remediation,but they face challenges such as poor conductivity,limited electron transfer efficiency,and a scarcity of active sites.To address these issues,we successfully synthesized a nano-flowers FeS/MoS_(2) composite derived from polyoxometalates(NH_(4))_(3)[Fe(III)Mo_(6)O_(24)H_(6)]⋅6H_(2)O(denoted as FeMo6)as the bimetallic precursors.This synthesis strategy enhances the interaction between FeS and MoS_(2),thereby facilitating electron transfer.Notably,the introduction of sulfur vacancies in FeS/MoS_(2) exposes additional Mo4t active sites,promoting the redox cycle of Fe^(2+)/Fe^(3+) and accelerating the regeneration of Fe^(2+),which in turn enhances PMS activation.Therefore,a catalytic oxidation system of FeS/MoS_(2)/PMS is presented that primarily relies on SO_(4)^(⋅-)and⋅OH,with ^(1)O_(2) as a supplementary oxidant.This system exhibits exceptional degradation efficiency for p-chlorophenol(4-CP),achieving 100% degradation within 10 min over a wide pH range of 2.4–8.4.The robust performance and wide applicability of FeS/MoS_(2) catalyst make it a promising candidate in advanced oxidation processes(AOPs)for environmental remediation.
基金jointly supported by the Four“Batches”Innovation Project of Invigorating Medical through Science and Technology of Shanxi Province(2022XM12)the Central Leading Science and Technology Development Foundation of Shanxi Province(YDZJSX2021A019)+1 种基金the Key Research and Development Program of Shanxi Province(202102130501007)the Natural Science Foundation of Shanxi Province(202103021223102,202203021222127).
文摘We report a facile solution method to form titanium oxide(TiO_(2))nano-flower structure on the titanium(Ti)substrates for realizing good physical sterilization and biocompatibility.We first prepare TiO_(2) nanotubes(NT)with a diameter of about 80-100 nm and a length of about 5μm on Ti substrates by anodization,which is utilized as precursor.Then,we employ immersion treatment in different concentrations of phosphoric acid solution at 75℃ for 5 h to realize the transformation from TiO_(2) NT to TiO_(2) nano-flower structure.In addition,we studied the effects of phosphoric acid concentration(1 wt%,2.5 wt%,5 wt% and 10 wt%)on the TiO_(2) nano-flower structure,and the antibacterial properties and biocompatibility of the TiO_(2) nano-flower structure.The results show that TiO_(2) nano-flower structure become larger and thicker with the increase in the phosphoric acid concentration,and the thickness of the coating can reach 6.88μm.Meanwhile,the TiO_(2) nano-flower structure shows good physical sterilization effect,especially for the TiO_(2) nano-flower structure formed in 10 wt%H^(3)PO_(4) solution,the antibacterial rate can reach 95%.In addition,the TiO_(2) nano-flower structure have no toxicity to the osteoblasts and support cell growth.
文摘Cytochrome P450 enzyme-copper phosphate hybrid materials with flower-like shape were prepared with a simple but efficient coprecipitation method.The growth process of the hybrid flowers can be divided into three successive steps：coordination/nucleation,growth,and further ripen.The concentration of enzymes in the mother liquor exerted great influence on the morphology and surface enzyme content of the nano-composites.The catalytic performance in the reaction of selective oxidation of sulfide to sulfoxide was also investigated.The hybrid flowers exhibited superior catalytic performance：satisfied thioanisole conversion and selectivity to methyl phenyl sulfoxide （both above 97%） with H2O2 as oxidant under mild reaction conditions,excellent stability and recyclability,and wide scope of substrates.Such results indicate that the hybrid materials are potentially good candidates in the industrial enzyme catalysis.
文摘文章设计了微通道流动与传热实验平台,针对定制的Fe_(3)O_(4)纳米颗粒强化相变微胶囊悬浮液(micro-encapsulated phase change material slurry,MPCS)开展循环流动实验,分别从微通道压降、摩擦阻力系数、对流换热系数、微通道板温度等4个方面探究MPCS在微通道中的流动与传热特性。实验结果表明:MPCS在微通道中的压降随质量分数的增加而增大,且明显高于去离子水;与之相比,Fe_(3)O_(4)-MPCS在微通道中的压降并无显著变化。此外,微尺度流动可能更有利于在Re较小时产生湍流;MPCS的对流换热系数高于去离子水,且随Re及质量分数的增大而增大,微通道的板温度更低,表现出更好的冷却效果;相同质量分数的Fe_(3)O_(4)-MPCS具有更高的对流换热系数,传热性能更佳;在低Re下较低的热流密度更有利于传热,在Re较高时高热流密度下传热效果更佳。
