Until now,although nanomedicines have gained much success in tumor treatment by reducing severe toxic side effects of drugs and improving the therapeutic efficiency of drugs,they are still faced with thorny challenges...Until now,although nanomedicines have gained much success in tumor treatment by reducing severe toxic side effects of drugs and improving the therapeutic efficiency of drugs,they are still faced with thorny challenges in targeted drug delivery including insufficient targeting accuracy,poor penetration into tumor core,and systemic toxicity issues.Recently,engineering nano/microrobots with multiple remarkable properties such as real-time sensing,interacting and manipulating capabilities,and programmability,have received increasing attention in biomedical applications ranging from disease diagnosis,targeted drug delivery,medical imaging,and surgery.More importantly,in different driven modes,nano/microrobots are capable of performing a wide variety of powerful functions,such as enhancing tissue penetration and payload retention in deep-seated tumors with active navigation,being programmable to release drugs or performing specific tasks directly at the tumor site with high precision and accuracy,automating repeated tumor treatment without the need for frequent interventions,and minimizing out-of-target tissue damage,leading to a huge exploration potential in tumor treatment.In this review,we delve into the recent progress and the development direction of nano/microrobots for tumor treatment and emphasize the working mechanisms and the unique functionalities of different driven modes in detail.Meanwhile,we elaborate on the application of nano/microrobots fabricated from various types of materials in tumor therapy.Finally,the key factors to be considered in the clinical translation of the above nano/microrobots are proposed.展开更多
Microrobotic systems are emerging as transformative technology for minimally invasive medicine,driven by innovations in actuation mechanisms,advanced fabrication paradigms,and multifunctional system integration.This c...Microrobotic systems are emerging as transformative technology for minimally invasive medicine,driven by innovations in actuation mechanisms,advanced fabrication paradigms,and multifunctional system integration.This comprehensive review analyzes the evolution of microrobotic technologies through three critical dimensions:(1)actuation modalities,including magnetic,optical,acoustic,chemical,and biological actuation,with a focus on the synergistic advantages of hybrid actuation strategies in complex internal physiological environments;(2)Fabrication methods cover technolo-gies such as photolithography,microinjection molding,self-assembly,and 3D printing,emphasizing innovative strategies involving multi-technology integration and collaborative manufacturing of bio/non-bio hybrid materials;(3)Internal phys-iological applications involve disease diagnosis,targeted drug delivery,minimally invasive surgery,tissue engineering,and cell manipulation,highlighting the broad prospects of microrobots in precision medicine.Despite remarkable progress,critical challenges remain,including low actuation efficiency,as seen in acoustic systems,limited biocompatibility,exem-plified by the toxicity of hydrogen peroxide in chemical actuation,delayed clinical translation,and other related challenges that must be addressed to advance the field.展开更多
Microrobots powered by an external magnetic field could be used for sophisticated medical applications such as cell treatment,micromanipulation,and noninvasive surgery inside the body.Untethered microrobot application...Microrobots powered by an external magnetic field could be used for sophisticated medical applications such as cell treatment,micromanipulation,and noninvasive surgery inside the body.Untethered microrobot applications can benefit from haptic technology and telecommunication,enabling telemedical micro-manipulation.Users can manipulate the microrobots with haptic feedback by interacting with the robot operating system remotely in such applications.Artificially created haptic forces based on wirelessly transmitted data and model-based guidance can aid human operators with haptic sensations while manipulating microrobots.The system presented here includes a haptic device and a magnetic tweezer system linked together using a network-based teleoperation method with motion models in fluids.The magnetic microrobots can be controlled remotely,and the haptic interactions with the remote environment can be felt in real time.A time-domain passivity controller is applied to overcome network delay and ensure stability of communication.This study develops and tests a motion model for microrobots and evaluates two image-based 3D tracking algorithms to improve tracking accuracy in various Newtonian fluids.Additionally,it demonstrates that microrobots can group together to transport multiple larger objects,move through microfluidic channels for detailed tasks,and use a novel method for disassembly,greatly expanding their range of use in microscale operations.Remote medical treatment in multiple locations,remote delivery of medication without the need for physical penetration of the skin,and remotely controlled cell manipulations are some of the possible uses of the proposed technology.展开更多
Locomotion performance degradation after carrying payloads is a significant challenge for insect-scale microrobots.Previously,a legged microrobot named BHMbot with a high load-carrying capacity based on front-leg actu...Locomotion performance degradation after carrying payloads is a significant challenge for insect-scale microrobots.Previously,a legged microrobot named BHMbot with a high load-carrying capacity based on front-leg actuation configuration and efficient running gait was proposed.However,insects,mammals and reptiles in nature typically use their powerful rear legs to achieve rapid running gaits for predation or risk evasion.In this work,the load-carrying capacity of the BHMbots with front-leg actuation and rear-leg actuation configurations is comparatively studied.Simulations based on a dynamic model with four degrees of freedom,along with experiments,have been conducted to analyze the locomotion characteristics of the two configurations under different payload masses.Both simulation and experimental results indicate that the load-carrying capacity of the microrobots is closely related to their actuation configurations,which leads to different dynamic responses of the microrobots after carrying varying payload masses.For microrobots with body lengths of 15 mm,the rear-leg actuation configuration exhibits a 31.2%enhancement in running speed compared to the front-leg actuation configuration when unloaded.Conversely,when carrying payloads exceeding 5.7 times the body mass(350 mg),the rear-leg actuation configuration demonstrates an 80.1%reduction in running speed relative to the front-leg actuation configuration under the same payload conditions.展开更多
Bio-inspired magnetic helical microrobots have great potential for biomedical and micromanipulation applications. Precise interaction with objects in liquid environments is an important prerequisite and challenge for ...Bio-inspired magnetic helical microrobots have great potential for biomedical and micromanipulation applications. Precise interaction with objects in liquid environments is an important prerequisite and challenge for helical microrobots to perform various tasks. In this study, an automatic control method is proposed to realize the axial docking of helical microrobots with arbitrarily placed cylindrical objects in liquid environments. The docking process is divided into ascent, approach, alignment, and insertion stages. First, a 3D docking path is planned according to the positions and orientations of the microrobot and the target object. Second, a steering-based 3D path-following controller guides the helical microrobot to rise away from the container bottom and approach the target along the path. Third, based on path design with gravity compensation and steering output limits, alignment of position and orientation can be accomplished simultaneously. Finally, the helical microrobot completes the docking under the rotating magnetic field along the target orientation. Experiments verified the automatic docking of the helical microrobot with static targets, including connecting with micro-shafts and inserting into micro-tubes. The object grasping of a reconfigurable helical microrobot aided by 3D automatic docking was also demonstrated. This method enables precise docking of helical microrobots with objects, which might be used for capture and sampling, in vivo navigation control, and functional assembly of microrobots.展开更多
Pipelines are extensively used in environments such as nuclear power plants,chemical factories,and medical devices to transport gases and liquids.These tubular environments often feature complex geometries,confined sp...Pipelines are extensively used in environments such as nuclear power plants,chemical factories,and medical devices to transport gases and liquids.These tubular environments often feature complex geometries,confined spaces,and millimeter-scale height restrictions,presenting significant challenges to conventional inspection methods.Here,we present an ultrasonic microrobot(weight,80 mg;dimensions,24 mm×7 mm;thickness,210μm)to realize agile and bidirectional navigation in narrow pipelines.The ultrathin structural design of the robot is achieved through a high-performance piezoelectric composite film microstructure based on MEMS technology.The robot exhibits various vibration modes when driven by ultrasonic frequency signals,its motion speed reaches81 cm s-1 at 54.8 k Hz,exceeding that of the fastest piezoelectric microrobots,and its forward and backward motion direction is controllable through frequency modulation,while the minimum driving voltage for initial movement can be as low as 3 VP-P.Additionally,the robot can effortlessly climb slopes up to 24.25°and carry loads more than 36 times its weight.The robot is capable of agile navigation through curved L-shaped pipes,pipes made of various materials(acrylic,stainless steel,and polyvinyl chloride),and even over water.To further demonstrate its inspection capabilities,a micro-endoscope camera is integrated into the robot,enabling real-time image capture inside glass pipes.展开更多
Strategically coupling nanoparticle hybrids and internal thermosensitive molecular switches establishes an innovative paradigm for constructing micro/nanoscale-reconfigurable robots,facilitating energyefficient CO_(2)...Strategically coupling nanoparticle hybrids and internal thermosensitive molecular switches establishes an innovative paradigm for constructing micro/nanoscale-reconfigurable robots,facilitating energyefficient CO_(2) management in life-support systems of confined space.Here,a micro/nano-reconfigurable robot is constructed from the CO_(2) molecular hunters,temperature-sensitive molecular switch,solar photothermal conversion,and magnetically-driven function engines.The molecular hunters within the molecular extension state can capture 6.19 mmol g^(−1) of CO_(2) to form carbamic acid and ammonium bicarbonate.Interestingly,the molecular switch of the robot activates a molecular curling state that facilitates CO_(2) release through nano-reconfiguration,which is mediated by the temperature-sensitive curling of Pluronic F127 molecular chains during the photothermal desorption.Nano-reconfiguration of robot alters the amino microenvironment,including increasing surface electrostatic potential of the amino group and decreasing overall lowest unoccupied molecular orbital energy level.This weakened the nucleophilic attack ability of the amino group toward the adsorption product derivatives,thereby inhibiting the side reactions that generate hard-to-decompose urea structures,achieving the lowest regeneration temperature of 55℃ reported to date.The engine of the robot possesses non-contact magnetically-driven micro-reconfiguration capability to achieve efficient photothermal regeneration while avoiding local overheating.Notably,the robot successfully prolonged the survival time of mice in the sealed container by up to 54.61%,effectively addressing the issue of carbon suffocation in confined spaces.This work significantly enhances life-support systems for deep-space exploration,while stimulating innovations in sustainable carbon management technologies for terrestrial extreme environments.展开更多
针对香菇育种过程中表型性状考察困难、人工测量费时费力的问题,提出一种适用于Jetson Orin Nano平台部署的香菇菌棒表型测量方法。使用手机和工业相机对3种不同数据来源的香菇菌棒进行图像采集,标注香菇菌落数据集并进行增强;比较了Bis...针对香菇育种过程中表型性状考察困难、人工测量费时费力的问题,提出一种适用于Jetson Orin Nano平台部署的香菇菌棒表型测量方法。使用手机和工业相机对3种不同数据来源的香菇菌棒进行图像采集,标注香菇菌落数据集并进行增强;比较了Bisenet、Stdcseg、U-net、Deeplabv3p、PP-liteseg 5个分割模型在Test-A、Test-B和Test-C测试集上的分割效果,结果表明PP-liteseg的普适性优于其他网络,PP-liteseg分割模型在3个测试集上的平均交并比超过97.53%,平均像素准确率高于99.49%,推理单幅图像耗时660 ms;为进一步平衡模型准确性和实时性,采用量化蒸馏方式对PP-liteseg模型进行压缩,并部署到Jetson Orin Nano平台上,压缩后的模型在Test-B测试集上的平均交并比和平均像素准确率分别为97.50%和99.51%,推理单幅图像耗时43.63 ms,比压缩前缩短近64%;采用PP-liteseg分割香菇菌棒图像,提取菌落表型,再根据菌落径向长度和轴向宽度得到菌丝生长长度,与人工测量值相比,菌丝生长长度平均绝对百分比误差、均方根误差和决定系数分别为1.874%、0.148 cm、0.918;采用该方法测量了6个菌株在连续4 d内的菌丝生长长度,结果表明,6个菌株的菌丝生长速度无论在单日还是在整个培养期内均有差异,其中49号和168号菌株差异最大。研究表明,本文方法适用于香菇菌棒表型测量,并能够以良好的准确性和实时性在Jetson Orin Nano平台上运行。展开更多
Hydrogels with stimuli-responsive capabilities are gaining more and more attention nowadays with prospective applications in biomedical engineering,bioelectronics,microrobot,etc.We develop a photothermal responsive hy...Hydrogels with stimuli-responsive capabilities are gaining more and more attention nowadays with prospective applications in biomedical engineering,bioelectronics,microrobot,etc.We develop a photothermal responsive hydrogel based on N-isopropylacrylamide that achieved a fast and reversible deformation manipulated only by near-infrared(NIR)light.The hydrogel was fabricated by the projection micro stereolithography based 3D printing technique,which can rapidly prototype complex 3D structures.Furthermore,with the variation of the grayscale while manufacturing the hydrogel,the deformation of the hydrogel structure can be freely tuned within a few seconds by losing and absorbing water through adjusting the intensity and the irradiation direction of the NIR light,showing a potential application in ultra-fast object grabbing and transportation.The present study provides a new method for designing ultrafast photothermal responsive hydrogel based microrobot working in water.展开更多
It is our target to develop underwater microrobots for medical and industrial applications.This kind of underwater microrobots should have the characteristics of flexibility,good response and safety.Its structure shou...It is our target to develop underwater microrobots for medical and industrial applications.This kind of underwater microrobots should have the characteristics of flexibility,good response and safety.Its structure should be simple and it can be driven by low voltage and produces no pollution or noise.The low actuating voltage and quick bending responses of Ionic Conducting Polymer Film(ICPF)are considered very useful and attractive for constructing various types of actuators and sensors.In this paper,we will first study the characteristics of the ICPF actuator used in underwater microrobot to realize swimming and walking.Then,we propose a new prototype model of underwater swimming microrobot utilizing only one piece of ICPF as the servo actuator.Through theoretic analysis,the motion mechanism of the microrobot is illustrated.It can swim forward and vertically.The relationships between moving speed and signal voltage amplitude and signal frequency is obtained after experimental study.Lastly,we present a novel underwater crab-like walking microrobot named crabliker-1.It has eight legs,and each leg is made up of two pieces of ICPF.Three sample processes of the octopod gait are proposed with a new analyzing method.The experimental results indicate that the crab-like underwater microrobot can perform transverse and rotation movement when the legs of the crab collaborate.展开更多
Disorders of the musculoskeletal system are the major contributors to the global burden of disease and current treatments show limited efficacy.Patients often suffer chronic pain and might eventually have to undergo e...Disorders of the musculoskeletal system are the major contributors to the global burden of disease and current treatments show limited efficacy.Patients often suffer chronic pain and might eventually have to undergo end-stage surgery.Therefore,future treatments should focus on early detection and intervention of regional lesions.Microrobots have been gradually used in organisms due to their advantages of intelligent,precise and minimally invasive targeted delivery.Through the combination of control and imaging systems,microrobots with good biosafety can be delivered to the desired area for treatment.In the musculoskeletal system,microrobots are mainly utilized to transport stem cells/drugs or to remove hazardous substances from the body.Compared to traditional biomaterial and tissue engineering strategies,active motion improves the efficiency and penetration of local targeting of cells/drugs.This review discusses the frontier applications of microrobotic systems in different tissues of the musculoskeletal system.We summarize the challenges and barriers that hinder clinical translation by evaluating the characteristics of different microrobots and finally point out the future direction of microrobots in the musculoskeletal system.展开更多
A simple autonomous docking method based on infrared sensors for mobile self-reconfigurable relay microrobots is proposed in the paper.The IR guidance system composed of an IR receiver and four IR emitters is designed...A simple autonomous docking method based on infrared sensors for mobile self-reconfigurable relay microrobots is proposed in the paper.The IR guidance system composed of an IR receiver and four IR emitters is designed,analyzed and developed.The autonomous docking control method based on centering alignment and dynamic motion planning is adopted so that it has high efficiency and reliability.Two basic microrobot prototypes are developed,and related docking experiments are done to verify the feasibility of the approach.展开更多
For a significant duration,enhancing the efficacy of cancer therapy has remained a critical concern.Magnetotactic bacteria(MTB),often likened to micro-robots,hold substantial promise as a drug delivery system.MTB,clas...For a significant duration,enhancing the efficacy of cancer therapy has remained a critical concern.Magnetotactic bacteria(MTB),often likened to micro-robots,hold substantial promise as a drug delivery system.MTB,classified as anaerobic,aquatic,and gram-negative microorganisms,exhibit remarkable motility and precise control over their internal biomineralization processes.This unique ability results in the formation of magnetic nanoparticles arranged along filamentous structures in a catenary fashion,enclosed within a membrane.These bacteria possess distinctive biochemical properties that facilitate their precise positioning within complex environments.By harnessing these biochemical attributes,MTB could potentially offer substantial advantages in the realm of cancer therapy.This article reviews the drug delivery capabilities of MTB in tumor treatment and explores various applications based on their inherent properties.The objective is to provide a comprehensive understanding of MTB-driven drug delivery and stimulate innovative insights in this field.展开更多
基金supported by the National Science Foundation of China(8217070298,81773283).
文摘Until now,although nanomedicines have gained much success in tumor treatment by reducing severe toxic side effects of drugs and improving the therapeutic efficiency of drugs,they are still faced with thorny challenges in targeted drug delivery including insufficient targeting accuracy,poor penetration into tumor core,and systemic toxicity issues.Recently,engineering nano/microrobots with multiple remarkable properties such as real-time sensing,interacting and manipulating capabilities,and programmability,have received increasing attention in biomedical applications ranging from disease diagnosis,targeted drug delivery,medical imaging,and surgery.More importantly,in different driven modes,nano/microrobots are capable of performing a wide variety of powerful functions,such as enhancing tissue penetration and payload retention in deep-seated tumors with active navigation,being programmable to release drugs or performing specific tasks directly at the tumor site with high precision and accuracy,automating repeated tumor treatment without the need for frequent interventions,and minimizing out-of-target tissue damage,leading to a huge exploration potential in tumor treatment.In this review,we delve into the recent progress and the development direction of nano/microrobots for tumor treatment and emphasize the working mechanisms and the unique functionalities of different driven modes in detail.Meanwhile,we elaborate on the application of nano/microrobots fabricated from various types of materials in tumor therapy.Finally,the key factors to be considered in the clinical translation of the above nano/microrobots are proposed.
基金National Natural Science Foundation of China(Grant No.61903157)the Foundation of State Key Laboratory of Robotics(Grand No.2024-O08).
文摘Microrobotic systems are emerging as transformative technology for minimally invasive medicine,driven by innovations in actuation mechanisms,advanced fabrication paradigms,and multifunctional system integration.This comprehensive review analyzes the evolution of microrobotic technologies through three critical dimensions:(1)actuation modalities,including magnetic,optical,acoustic,chemical,and biological actuation,with a focus on the synergistic advantages of hybrid actuation strategies in complex internal physiological environments;(2)Fabrication methods cover technolo-gies such as photolithography,microinjection molding,self-assembly,and 3D printing,emphasizing innovative strategies involving multi-technology integration and collaborative manufacturing of bio/non-bio hybrid materials;(3)Internal phys-iological applications involve disease diagnosis,targeted drug delivery,minimally invasive surgery,tissue engineering,and cell manipulation,highlighting the broad prospects of microrobots in precision medicine.Despite remarkable progress,critical challenges remain,including low actuation efficiency,as seen in acoustic systems,limited biocompatibility,exem-plified by the toxicity of hydrogen peroxide in chemical actuation,delayed clinical translation,and other related challenges that must be addressed to advance the field.
基金supported by National Science Foundation Grant No.2123824.
文摘Microrobots powered by an external magnetic field could be used for sophisticated medical applications such as cell treatment,micromanipulation,and noninvasive surgery inside the body.Untethered microrobot applications can benefit from haptic technology and telecommunication,enabling telemedical micro-manipulation.Users can manipulate the microrobots with haptic feedback by interacting with the robot operating system remotely in such applications.Artificially created haptic forces based on wirelessly transmitted data and model-based guidance can aid human operators with haptic sensations while manipulating microrobots.The system presented here includes a haptic device and a magnetic tweezer system linked together using a network-based teleoperation method with motion models in fluids.The magnetic microrobots can be controlled remotely,and the haptic interactions with the remote environment can be felt in real time.A time-domain passivity controller is applied to overcome network delay and ensure stability of communication.This study develops and tests a motion model for microrobots and evaluates two image-based 3D tracking algorithms to improve tracking accuracy in various Newtonian fluids.Additionally,it demonstrates that microrobots can group together to transport multiple larger objects,move through microfluidic channels for detailed tasks,and use a novel method for disassembly,greatly expanding their range of use in microscale operations.Remote medical treatment in multiple locations,remote delivery of medication without the need for physical penetration of the skin,and remotely controlled cell manipulations are some of the possible uses of the proposed technology.
基金supported in part by Beijing Natural Science Foundation under Grant 3232010in part by the National Natural Science Foundation of China under Grant 12002017+2 种基金in part by AECC Industry-university Collocation Fund under Grant HFZL2023CXY026in part by Beihang Outstanding Young Scholars Project under Grant YWF-23-L-1201in part by 111 Project under Grant B08009.
文摘Locomotion performance degradation after carrying payloads is a significant challenge for insect-scale microrobots.Previously,a legged microrobot named BHMbot with a high load-carrying capacity based on front-leg actuation configuration and efficient running gait was proposed.However,insects,mammals and reptiles in nature typically use their powerful rear legs to achieve rapid running gaits for predation or risk evasion.In this work,the load-carrying capacity of the BHMbots with front-leg actuation and rear-leg actuation configurations is comparatively studied.Simulations based on a dynamic model with four degrees of freedom,along with experiments,have been conducted to analyze the locomotion characteristics of the two configurations under different payload masses.Both simulation and experimental results indicate that the load-carrying capacity of the microrobots is closely related to their actuation configurations,which leads to different dynamic responses of the microrobots after carrying varying payload masses.For microrobots with body lengths of 15 mm,the rear-leg actuation configuration exhibits a 31.2%enhancement in running speed compared to the front-leg actuation configuration when unloaded.Conversely,when carrying payloads exceeding 5.7 times the body mass(350 mg),the rear-leg actuation configuration demonstrates an 80.1%reduction in running speed relative to the front-leg actuation configuration under the same payload conditions.
基金supported by the National Natural Science Foundation of China(No.62273117)Pre-research Task(No.SKLRS202418B)of State Key Laboratory of Robotics and Systems(HIT).
文摘Bio-inspired magnetic helical microrobots have great potential for biomedical and micromanipulation applications. Precise interaction with objects in liquid environments is an important prerequisite and challenge for helical microrobots to perform various tasks. In this study, an automatic control method is proposed to realize the axial docking of helical microrobots with arbitrarily placed cylindrical objects in liquid environments. The docking process is divided into ascent, approach, alignment, and insertion stages. First, a 3D docking path is planned according to the positions and orientations of the microrobot and the target object. Second, a steering-based 3D path-following controller guides the helical microrobot to rise away from the container bottom and approach the target along the path. Third, based on path design with gravity compensation and steering output limits, alignment of position and orientation can be accomplished simultaneously. Finally, the helical microrobot completes the docking under the rotating magnetic field along the target orientation. Experiments verified the automatic docking of the helical microrobot with static targets, including connecting with micro-shafts and inserting into micro-tubes. The object grasping of a reconfigurable helical microrobot aided by 3D automatic docking was also demonstrated. This method enables precise docking of helical microrobots with objects, which might be used for capture and sampling, in vivo navigation control, and functional assembly of microrobots.
基金supported by the National Key Research and Development Program of China(No.2024YFB3212901)National Natural Science Foundation of China(12072189)the Medicine and Engineering Interdisciplinary Research Fund of Shanghai Jiao Tong University(No.YG2025ZD05)。
文摘Pipelines are extensively used in environments such as nuclear power plants,chemical factories,and medical devices to transport gases and liquids.These tubular environments often feature complex geometries,confined spaces,and millimeter-scale height restrictions,presenting significant challenges to conventional inspection methods.Here,we present an ultrasonic microrobot(weight,80 mg;dimensions,24 mm×7 mm;thickness,210μm)to realize agile and bidirectional navigation in narrow pipelines.The ultrathin structural design of the robot is achieved through a high-performance piezoelectric composite film microstructure based on MEMS technology.The robot exhibits various vibration modes when driven by ultrasonic frequency signals,its motion speed reaches81 cm s-1 at 54.8 k Hz,exceeding that of the fastest piezoelectric microrobots,and its forward and backward motion direction is controllable through frequency modulation,while the minimum driving voltage for initial movement can be as low as 3 VP-P.Additionally,the robot can effortlessly climb slopes up to 24.25°and carry loads more than 36 times its weight.The robot is capable of agile navigation through curved L-shaped pipes,pipes made of various materials(acrylic,stainless steel,and polyvinyl chloride),and even over water.To further demonstrate its inspection capabilities,a micro-endoscope camera is integrated into the robot,enabling real-time image capture inside glass pipes.
基金supported by the National Natural Science Foundation of China(22168008,22378085)the Guangxi Natural Science Foundation(2024GXNSFDA010053)+1 种基金the Technology Development Project of Guangxi Bossco Environmental Protection Technology Co.,Ltd(202100039)Innovation Project of Guangxi Graduate Education(YCBZ2024065).
文摘Strategically coupling nanoparticle hybrids and internal thermosensitive molecular switches establishes an innovative paradigm for constructing micro/nanoscale-reconfigurable robots,facilitating energyefficient CO_(2) management in life-support systems of confined space.Here,a micro/nano-reconfigurable robot is constructed from the CO_(2) molecular hunters,temperature-sensitive molecular switch,solar photothermal conversion,and magnetically-driven function engines.The molecular hunters within the molecular extension state can capture 6.19 mmol g^(−1) of CO_(2) to form carbamic acid and ammonium bicarbonate.Interestingly,the molecular switch of the robot activates a molecular curling state that facilitates CO_(2) release through nano-reconfiguration,which is mediated by the temperature-sensitive curling of Pluronic F127 molecular chains during the photothermal desorption.Nano-reconfiguration of robot alters the amino microenvironment,including increasing surface electrostatic potential of the amino group and decreasing overall lowest unoccupied molecular orbital energy level.This weakened the nucleophilic attack ability of the amino group toward the adsorption product derivatives,thereby inhibiting the side reactions that generate hard-to-decompose urea structures,achieving the lowest regeneration temperature of 55℃ reported to date.The engine of the robot possesses non-contact magnetically-driven micro-reconfiguration capability to achieve efficient photothermal regeneration while avoiding local overheating.Notably,the robot successfully prolonged the survival time of mice in the sealed container by up to 54.61%,effectively addressing the issue of carbon suffocation in confined spaces.This work significantly enhances life-support systems for deep-space exploration,while stimulating innovations in sustainable carbon management technologies for terrestrial extreme environments.
文摘针对香菇育种过程中表型性状考察困难、人工测量费时费力的问题,提出一种适用于Jetson Orin Nano平台部署的香菇菌棒表型测量方法。使用手机和工业相机对3种不同数据来源的香菇菌棒进行图像采集,标注香菇菌落数据集并进行增强;比较了Bisenet、Stdcseg、U-net、Deeplabv3p、PP-liteseg 5个分割模型在Test-A、Test-B和Test-C测试集上的分割效果,结果表明PP-liteseg的普适性优于其他网络,PP-liteseg分割模型在3个测试集上的平均交并比超过97.53%,平均像素准确率高于99.49%,推理单幅图像耗时660 ms;为进一步平衡模型准确性和实时性,采用量化蒸馏方式对PP-liteseg模型进行压缩,并部署到Jetson Orin Nano平台上,压缩后的模型在Test-B测试集上的平均交并比和平均像素准确率分别为97.50%和99.51%,推理单幅图像耗时43.63 ms,比压缩前缩短近64%;采用PP-liteseg分割香菇菌棒图像,提取菌落表型,再根据菌落径向长度和轴向宽度得到菌丝生长长度,与人工测量值相比,菌丝生长长度平均绝对百分比误差、均方根误差和决定系数分别为1.874%、0.148 cm、0.918;采用该方法测量了6个菌株在连续4 d内的菌丝生长长度,结果表明,6个菌株的菌丝生长速度无论在单日还是在整个培养期内均有差异,其中49号和168号菌株差异最大。研究表明,本文方法适用于香菇菌棒表型测量,并能够以良好的准确性和实时性在Jetson Orin Nano平台上运行。
基金the National Natural Science Foundation of China(52006056)the Key-Area Research and Development Program of Guangdong Province(2020B090923003)the Natural Science Foundation of Hunan through Grant No.2020JJ3012。
文摘Hydrogels with stimuli-responsive capabilities are gaining more and more attention nowadays with prospective applications in biomedical engineering,bioelectronics,microrobot,etc.We develop a photothermal responsive hydrogel based on N-isopropylacrylamide that achieved a fast and reversible deformation manipulated only by near-infrared(NIR)light.The hydrogel was fabricated by the projection micro stereolithography based 3D printing technique,which can rapidly prototype complex 3D structures.Furthermore,with the variation of the grayscale while manufacturing the hydrogel,the deformation of the hydrogel structure can be freely tuned within a few seconds by losing and absorbing water through adjusting the intensity and the irradiation direction of the NIR light,showing a potential application in ultra-fast object grabbing and transportation.The present study provides a new method for designing ultrafast photothermal responsive hydrogel based microrobot working in water.
文摘It is our target to develop underwater microrobots for medical and industrial applications.This kind of underwater microrobots should have the characteristics of flexibility,good response and safety.Its structure should be simple and it can be driven by low voltage and produces no pollution or noise.The low actuating voltage and quick bending responses of Ionic Conducting Polymer Film(ICPF)are considered very useful and attractive for constructing various types of actuators and sensors.In this paper,we will first study the characteristics of the ICPF actuator used in underwater microrobot to realize swimming and walking.Then,we propose a new prototype model of underwater swimming microrobot utilizing only one piece of ICPF as the servo actuator.Through theoretic analysis,the motion mechanism of the microrobot is illustrated.It can swim forward and vertically.The relationships between moving speed and signal voltage amplitude and signal frequency is obtained after experimental study.Lastly,we present a novel underwater crab-like walking microrobot named crabliker-1.It has eight legs,and each leg is made up of two pieces of ICPF.Three sample processes of the octopod gait are proposed with a new analyzing method.The experimental results indicate that the crab-like underwater microrobot can perform transverse and rotation movement when the legs of the crab collaborate.
基金supported by the National Natural Science Foundation of China(No.81572187,No.81871812 and No.52205590)the Natural Science Foundation of Jiangsu Province(No.BK20220834)+1 种基金project supported by Ruihua Charity Foundation(YL20220525)the Start-up Research Fund of Southeast University(No.RF1028623098).
文摘Disorders of the musculoskeletal system are the major contributors to the global burden of disease and current treatments show limited efficacy.Patients often suffer chronic pain and might eventually have to undergo end-stage surgery.Therefore,future treatments should focus on early detection and intervention of regional lesions.Microrobots have been gradually used in organisms due to their advantages of intelligent,precise and minimally invasive targeted delivery.Through the combination of control and imaging systems,microrobots with good biosafety can be delivered to the desired area for treatment.In the musculoskeletal system,microrobots are mainly utilized to transport stem cells/drugs or to remove hazardous substances from the body.Compared to traditional biomaterial and tissue engineering strategies,active motion improves the efficiency and penetration of local targeting of cells/drugs.This review discusses the frontier applications of microrobotic systems in different tissues of the musculoskeletal system.We summarize the challenges and barriers that hinder clinical translation by evaluating the characteristics of different microrobots and finally point out the future direction of microrobots in the musculoskeletal system.
基金Supported by the National High Technology Research and Development Programme of China(No.2007AA04Z340)
文摘A simple autonomous docking method based on infrared sensors for mobile self-reconfigurable relay microrobots is proposed in the paper.The IR guidance system composed of an IR receiver and four IR emitters is designed,analyzed and developed.The autonomous docking control method based on centering alignment and dynamic motion planning is adopted so that it has high efficiency and reliability.Two basic microrobot prototypes are developed,and related docking experiments are done to verify the feasibility of the approach.
基金supported by the National Natural Science Foundation of China(No.3190110313 to K.Ma)Special Foundation of President of the Chinese Academy of Sciences(No.YZJJ2022QN_(4)4)+2 种基金HFIPS Director’s Fund(Nos.E16CWK123X1YZJJQY202201)the Heye Health Technology Chong Ming Project(No.HYCMP-2022012 to Y.Wang)。
文摘For a significant duration,enhancing the efficacy of cancer therapy has remained a critical concern.Magnetotactic bacteria(MTB),often likened to micro-robots,hold substantial promise as a drug delivery system.MTB,classified as anaerobic,aquatic,and gram-negative microorganisms,exhibit remarkable motility and precise control over their internal biomineralization processes.This unique ability results in the formation of magnetic nanoparticles arranged along filamentous structures in a catenary fashion,enclosed within a membrane.These bacteria possess distinctive biochemical properties that facilitate their precise positioning within complex environments.By harnessing these biochemical attributes,MTB could potentially offer substantial advantages in the realm of cancer therapy.This article reviews the drug delivery capabilities of MTB in tumor treatment and explores various applications based on their inherent properties.The objective is to provide a comprehensive understanding of MTB-driven drug delivery and stimulate innovative insights in this field.
