针对香菇育种过程中表型性状考察困难、人工测量费时费力的问题,提出一种适用于Jetson Orin Nano平台部署的香菇菌棒表型测量方法。使用手机和工业相机对3种不同数据来源的香菇菌棒进行图像采集,标注香菇菌落数据集并进行增强;比较了Bis...针对香菇育种过程中表型性状考察困难、人工测量费时费力的问题,提出一种适用于Jetson Orin Nano平台部署的香菇菌棒表型测量方法。使用手机和工业相机对3种不同数据来源的香菇菌棒进行图像采集,标注香菇菌落数据集并进行增强;比较了Bisenet、Stdcseg、U-net、Deeplabv3p、PP-liteseg 5个分割模型在Test-A、Test-B和Test-C测试集上的分割效果,结果表明PP-liteseg的普适性优于其他网络,PP-liteseg分割模型在3个测试集上的平均交并比超过97.53%,平均像素准确率高于99.49%,推理单幅图像耗时660 ms;为进一步平衡模型准确性和实时性,采用量化蒸馏方式对PP-liteseg模型进行压缩,并部署到Jetson Orin Nano平台上,压缩后的模型在Test-B测试集上的平均交并比和平均像素准确率分别为97.50%和99.51%,推理单幅图像耗时43.63 ms,比压缩前缩短近64%;采用PP-liteseg分割香菇菌棒图像,提取菌落表型,再根据菌落径向长度和轴向宽度得到菌丝生长长度,与人工测量值相比,菌丝生长长度平均绝对百分比误差、均方根误差和决定系数分别为1.874%、0.148 cm、0.918;采用该方法测量了6个菌株在连续4 d内的菌丝生长长度,结果表明,6个菌株的菌丝生长速度无论在单日还是在整个培养期内均有差异,其中49号和168号菌株差异最大。研究表明,本文方法适用于香菇菌棒表型测量,并能够以良好的准确性和实时性在Jetson Orin Nano平台上运行。展开更多
Micro/nano hierarchical structures could endow materials with various surface functions.However,the multilayer and multiscale characteristics of micro/nano hierarchical structures bring difficulties for their one step...Micro/nano hierarchical structures could endow materials with various surface functions.However,the multilayer and multiscale characteristics of micro/nano hierarchical structures bring difficulties for their one step and controllable fabrication.Accordingly,based on tip-based fabrication techniques,this study proposed a micro-amplitude vibration-assisted scratching method by introducing a periodic backward displacement into the conventional scratching process,which enabled the synchronous creation of the microscale V-groove and nanoscale ripples,i.e.a typical micro/nano hierarchical structure.The experiments and finite element modeling were employed to explore the formation process and mechanism of the micro/nano hierarchical structures.Being different from conventional cutting,this method was mainly based on the plow mechanism,and it could accurately replicate the shape of the indenter on the material surface.The microscale V-groove was formed due to the scratching action,and the nanoscale ripple was formed due to the extrusion action of the indenter on the microscale V-groove’s surface.Furthermore,the relationships between the processing parameters and the dimensions of the micro/nano hierarchical structures were established through experiments,and optimized processing parameters were determined to achieve regular micro/nano hierarchical structures.By this method,complex patterns constructed by various micro/nano hierarchical structures were fabricated on both flat and curved surfaces,achieving diverse surface structural colors.展开更多
Acute lung injury(ALI)is a critical respiratory disorder with a high mortality rate and is caused by several factors.Addressing oxidative stress and infiammation is a pivotal strategy for ALI treatment.In this study,w...Acute lung injury(ALI)is a critical respiratory disorder with a high mortality rate and is caused by several factors.Addressing oxidative stress and infiammation is a pivotal strategy for ALI treatment.In this study,we introduced a novel nanotherapeutic approach involving a curcumin-loaded ceria nanoenzyme delivery system tailored to counteract the multifaceted aspects of ALI.This system leverages the individual and combined effects of the components to provide a comprehensive therapeutic solution.The dual-action capability of this nanosystem was manifested by mitigating mitochondrial oxidative stress in lung epithelial cells and inhibiting the transient receptor potential melanosome-associated protein 2(TRPM2)-NOD-like receptor thermal protein domain associated protein 3(NLRP3)signaling pathway,offering a highly effective therapeutic approach to ALI.Our findings reveal the underlying mechanisms of this innovative nanodelivery system,showcasing its potential as a versatile strategy for ALI treatment and encouraging further exploration of nanoenzyme-based therapies for ALI.展开更多
Under the background of the new era,people’s research on nanomaterials continues to deepen,and new nanomaterials continue to develop,which plays an important role and value in many fields.Especially in the field of m...Under the background of the new era,people’s research on nanomaterials continues to deepen,and new nanomaterials continue to develop,which plays an important role and value in many fields.Especially in the field of medicine,nano-new materials have shown great value and potential in the field of biomedicine due to their unique chemical and physical properties,which promote the occurrence of many changes.This article will start with the types of new nano materials,and gradually go into their applications in the field of medical biology.Finally,it will briefly analyze the current problems of new nano materials applied in the field of biomedicine and put forward relevant solutions.It will further show the important scientific significance and wide application prospects of new nano materials,in order to contribute to the development of medicine in the future.This paper will provide a meaningful reference for other researchers.展开更多
The earthworm-based vermiremediation facilitated with benign chemicals such as nano zero-valent iron(nZVI)is a promising approach for the remediation of a variety of soil contaminants including cyanotoxins.As themost ...The earthworm-based vermiremediation facilitated with benign chemicals such as nano zero-valent iron(nZVI)is a promising approach for the remediation of a variety of soil contaminants including cyanotoxins.As themost toxic cyanotoxin,microcystin-LR(MC-LR)enter soil via runoff,irrigated surface water and sewage,and the application of cyanobacterial biofertilizers as part of the sustainable agricultural practice.Earthworms in such remediation systems must sustain the potential risk from both nZVI and MC-LR.In the present study,earthworms(Eisenia fetida)were exposed up to 14 days to MC-LR and nZVI(individually and inmixture),and the toxicity was investigated at both the organismal andmetabolic levels,including growth,tissue damage,oxidative stress,metabolic response and gut microbiota.Results showed that co-exposure of MC-LR and nZVI is less potent to earthworms than that of separate exposure.Histological observations in the co-exposure group revealed only minor epidermal brokenness,and KEGG enrichment analysis showed that co-exposure induced earthworms to regulate glutathione biosynthesis for detoxification and reduced adverse effects from MC-LR.The combined use of nZVI promoted the growth and reproduction of soil and earthworm gut bacteria(e.g.,Sphingobacterium and Acinetobacter)responsible for the degradation of MC-LR,whichmight explain the observed antagonism between nZVI and MC-LR in earthworm microcosm.Our study suggests the beneficial use of nZVI to detoxify pollutants in earthworm-based vermiremediation systems where freshwater containing cyanobacterial blooms is frequently used to irrigate soil and supply water for the growth and metabolism of earthworms.展开更多
Nanolipid carriers and traditional emulsion containing chemical sunscreens were prepared using emulsification combined with ultrasonic technology.The nanolipid carriers showed superior performance in sunscreen encapsu...Nanolipid carriers and traditional emulsion containing chemical sunscreens were prepared using emulsification combined with ultrasonic technology.The nanolipid carriers showed superior performance in sunscreen encapsulation,slow release and skin impermeability,and provided an excellent nanolipid slow-release encapsulation system for sunscreens.As observed by transmission electron microscopy,the nanolipid carriers were spherical shape,with smooth surface and uniform distribution,and the particle sizes were mainly concentrated in the range of 230 to 250 nm without agglomeration.The nanolipid carriers significantly improved the sunscreen performance through the synergistic effect of scattering and chemical absorption,and showed better UV stability than traditional sunscreen,indicating their photoprotective function.In vitro release experiments showed that the nano-lipidic carriers exhibited better release control when loaded with octyl methoxycinnamate(OMC)and butylmethoxydibenzoylmethane(BDFM)sunscreens than traditional traditional emulsions,with the cumulative release rate of OMC in the nano-lipidic carriers decreasing by 17.17% to 30.24% within 12 hours,and that of BDFM decreasing by 26.67% to 44.67%.26.67% to 44.16%.The results of the in vitro permeation experiment further confirmed that the nanolipid carriers could effectively encapsulate the sunscreens and prevent them from penetrating the skin barrier,thus reducing the skin irritation.Compared with traditional traditional emulsion,the cumulative penetration of OMC in nanostructured lipid carriers was 2.24μg/cm^(2)in 4 hours,while the cumulative penetration was reduced by 68.05%.The cumulative penetration of BDFM in the nanostructured lipid carrier was 3.24μg/cm^(2),with a 64.04%reduction in cumulative penetration.展开更多
建立Sin-QuECh ERS Nano-超高效液相色谱串联质谱法测定坚果中吡噻菌胺酰胺类杀菌剂残留的方法。采用电喷雾正离子模式下多反应监测(MRM)模式进行检测,外标法定量。结果表明,吡噻菌胺在质量浓度10~500μg/L内具有良好的线性关系,R2>0...建立Sin-QuECh ERS Nano-超高效液相色谱串联质谱法测定坚果中吡噻菌胺酰胺类杀菌剂残留的方法。采用电喷雾正离子模式下多反应监测(MRM)模式进行检测,外标法定量。结果表明,吡噻菌胺在质量浓度10~500μg/L内具有良好的线性关系,R2>0.999。在0.25,0.50,2.50μg/kg 3个加标水平下,回收率为92.3%~117.0%,RSD<4.0%(n=6),定量限(LOQ)0.25μg/kg,使用该方法对进口坚果、超市售坚果和小摊贩售坚果进行检测,发现阳性样品检出率为1.0%,小摊贩售样阳性样品检出率高达4.0%。该方法前处理快速简单、灵敏度和准确度高,可满足坚果中吡噻菌胺残留检测的要求。展开更多
This review explores multi-directional functionally graded(MDFG)nanostructures,focusing on their material characteristics,modeling approaches,and mechanical behavior.It starts by classifying different types of functio...This review explores multi-directional functionally graded(MDFG)nanostructures,focusing on their material characteristics,modeling approaches,and mechanical behavior.It starts by classifying different types of functionally graded(FG)materials such as conventional,axial,bi-directional,and tri-directional,and the material distribution models like power-law,exponential,trigonometric,polynomial functions,etc.It also discusses the application of advanced size-dependent theories like Eringen’s nonlocal elasticity,nonlocal strain gradient,modified couple stress,and consistent couple stress theories,which are essential to predict the behavior of structures at small scales.The review covers the mechanical analysis of MDFG nanostructures in nanobeams,nanopipes,nanoplates,and nanoshells and their dynamic and static responses under different loading conditions.The effect of multi-directional material gradation on stiffness,stability and vibration is discussed.Moreover,the review highlights the need for more advanced analytical,semi-analytical,and numerical methods to solve the complex vibration problems ofMDFG nanostructures.It is evident that the continued development of these methods is crucial for the design,optimization,and real-world application of MDFG nanostructures in advanced engineering fields like aerospace,biomedicine,and micro/nanoelectromechanical systems(MEMS/NEMS).This study is a reference for researchers and engineers working in the domain of MDFG nanostructures.展开更多
Nanoferrites of the CoMn_(x)Fe_(2-x)O_(4) series(x=0.00,0.05,0.10,0.15,0.20)were synthesized in this study using the sol-gel auto-combustion approach.The lattice constants were computed within the range of 8.312-8.406...Nanoferrites of the CoMn_(x)Fe_(2-x)O_(4) series(x=0.00,0.05,0.10,0.15,0.20)were synthesized in this study using the sol-gel auto-combustion approach.The lattice constants were computed within the range of 8.312-8.406Å,while crystallite sizes were estimated to range between 55.20 and 31.40 nm using the Scherrer method.The different functional groups were found to correlate with various ab-sorption bands using Fourier transform infrared(FTIR)spectroscopy.Five active modes were identified by Raman spectroscopy,reveal-ing vibration modes of O2-ions at tetrahedral and octahedral locations.The ferromagnetic hysteresis loop was observed in all the synthes-ized samples,which can be explained by Neel’s model.The results showed that AC conductivity decreased with increasing Mn^(2+)content at the Fe^(2+)site,while the dielectric constant and dielectric loss increased with increasing frequency.Furthermore,the saturation magnetiz-ation(Ms),remnant magnetization(M_(r)),and coercivity(H_(c))all showed declining trends with the increase in Mn^(2+)doping.Finally,the CoMn_(0.20)Fe_(1.8)O_(4) samples showed Ms and M_(r) values ranging from 73.12 to 66.84 emu/g and from 37.77 to 51.89 emu/g,respectively,while Hc values ranged from 1939 to 1312 Oe,after which coercivity increased.Thus,the CoMn_(0.20)Fe_(1.8)O_(4) sample can be considered a prom-ising candidate for magnetic applications.展开更多
Low-cost and biodegradable photothermal wound dressings with remarkable therapeutic effects are highly desirable for next-generation wound healing.Herein,we report an efficient photothermal wound dressing mat made of ...Low-cost and biodegradable photothermal wound dressings with remarkable therapeutic effects are highly desirable for next-generation wound healing.Herein,we report an efficient photothermal wound dressing mat made of tellurium nanosheet(TeNS)-loaded electrospun polycaprolactone/gelatin(PCL/GEL)nanofibers.The TeNS-loaded PCL/GEL nanofibrous architectures showed antibacterial efficacy against Escherichia coli and Staphylococcus aureus of 87.68%and 94.57%,respectively.Under near-infrared+(NIR)light illumination,they can facilitate cell proliferation as revealed by in vitro scratch assay.The results from in vivo skin wounds combined with tissue staining experiments further showed that the TeNS-loaded dressing could substantially promote wound healing under photothermal conditions.Using immunohistochemical analysis,we found that the TeNS-loaded PCL/GEL nanofibers NIR group have a high expression of specific antigens in epidermal growth factor(EGF)(P<0.001)and endothelial cell adhesion molecule-31(CD31,P<0.05),verifying that the nanofibrous mat can stimulate EGF generation and microvessel proliferation.Furthermore,the PCL/GEL/TeNIR group has the lowest expression in endothelial cell adhesion molecule-68(CD68,P<0.001),suggesting that the nanofibrous mats have a high anti-inflammatory efficiency.Our work sheds light on the development of novel nonanti-inflammatory wound dressings via photothermal sterilization and the promotion of cell growth using two-dimensional(2D)nanosheets.展开更多
文摘针对香菇育种过程中表型性状考察困难、人工测量费时费力的问题,提出一种适用于Jetson Orin Nano平台部署的香菇菌棒表型测量方法。使用手机和工业相机对3种不同数据来源的香菇菌棒进行图像采集,标注香菇菌落数据集并进行增强;比较了Bisenet、Stdcseg、U-net、Deeplabv3p、PP-liteseg 5个分割模型在Test-A、Test-B和Test-C测试集上的分割效果,结果表明PP-liteseg的普适性优于其他网络,PP-liteseg分割模型在3个测试集上的平均交并比超过97.53%,平均像素准确率高于99.49%,推理单幅图像耗时660 ms;为进一步平衡模型准确性和实时性,采用量化蒸馏方式对PP-liteseg模型进行压缩,并部署到Jetson Orin Nano平台上,压缩后的模型在Test-B测试集上的平均交并比和平均像素准确率分别为97.50%和99.51%,推理单幅图像耗时43.63 ms,比压缩前缩短近64%;采用PP-liteseg分割香菇菌棒图像,提取菌落表型,再根据菌落径向长度和轴向宽度得到菌丝生长长度,与人工测量值相比,菌丝生长长度平均绝对百分比误差、均方根误差和决定系数分别为1.874%、0.148 cm、0.918;采用该方法测量了6个菌株在连续4 d内的菌丝生长长度,结果表明,6个菌株的菌丝生长速度无论在单日还是在整个培养期内均有差异,其中49号和168号菌株差异最大。研究表明,本文方法适用于香菇菌棒表型测量,并能够以良好的准确性和实时性在Jetson Orin Nano平台上运行。
基金supported by the Jilin Province Key Research and Development Plan Project(20240302066GX)the National Natural Science Foundation of China(Grant No.52075221)the Fundamental Research Funds for the Central Universities(2023-JCXK-02)。
文摘Micro/nano hierarchical structures could endow materials with various surface functions.However,the multilayer and multiscale characteristics of micro/nano hierarchical structures bring difficulties for their one step and controllable fabrication.Accordingly,based on tip-based fabrication techniques,this study proposed a micro-amplitude vibration-assisted scratching method by introducing a periodic backward displacement into the conventional scratching process,which enabled the synchronous creation of the microscale V-groove and nanoscale ripples,i.e.a typical micro/nano hierarchical structure.The experiments and finite element modeling were employed to explore the formation process and mechanism of the micro/nano hierarchical structures.Being different from conventional cutting,this method was mainly based on the plow mechanism,and it could accurately replicate the shape of the indenter on the material surface.The microscale V-groove was formed due to the scratching action,and the nanoscale ripple was formed due to the extrusion action of the indenter on the microscale V-groove’s surface.Furthermore,the relationships between the processing parameters and the dimensions of the micro/nano hierarchical structures were established through experiments,and optimized processing parameters were determined to achieve regular micro/nano hierarchical structures.By this method,complex patterns constructed by various micro/nano hierarchical structures were fabricated on both flat and curved surfaces,achieving diverse surface structural colors.
基金funded by the National Natural Science Foundation of China(Nos.82103885,81871521,82273672)Natural Science Foundation of Shanghai(Nos.21ZR1477700,20ZR1470300)+1 种基金the Shanghai Municipal Health Commission-Outstanding Youth Foundation of Public Health(No.GWV-10.2-YQ48)Sci Tech Funding by CSPFTZ Lingang Special Area Marine Biomedical Innovation Platform。
文摘Acute lung injury(ALI)is a critical respiratory disorder with a high mortality rate and is caused by several factors.Addressing oxidative stress and infiammation is a pivotal strategy for ALI treatment.In this study,we introduced a novel nanotherapeutic approach involving a curcumin-loaded ceria nanoenzyme delivery system tailored to counteract the multifaceted aspects of ALI.This system leverages the individual and combined effects of the components to provide a comprehensive therapeutic solution.The dual-action capability of this nanosystem was manifested by mitigating mitochondrial oxidative stress in lung epithelial cells and inhibiting the transient receptor potential melanosome-associated protein 2(TRPM2)-NOD-like receptor thermal protein domain associated protein 3(NLRP3)signaling pathway,offering a highly effective therapeutic approach to ALI.Our findings reveal the underlying mechanisms of this innovative nanodelivery system,showcasing its potential as a versatile strategy for ALI treatment and encouraging further exploration of nanoenzyme-based therapies for ALI.
文摘Under the background of the new era,people’s research on nanomaterials continues to deepen,and new nanomaterials continue to develop,which plays an important role and value in many fields.Especially in the field of medicine,nano-new materials have shown great value and potential in the field of biomedicine due to their unique chemical and physical properties,which promote the occurrence of many changes.This article will start with the types of new nano materials,and gradually go into their applications in the field of medical biology.Finally,it will briefly analyze the current problems of new nano materials applied in the field of biomedicine and put forward relevant solutions.It will further show the important scientific significance and wide application prospects of new nano materials,in order to contribute to the development of medicine in the future.This paper will provide a meaningful reference for other researchers.
基金supported by the National Natural Science Foundation of China(No.21777139)the National Key Research and Development Program of China(No.2017YFA0207003).
文摘The earthworm-based vermiremediation facilitated with benign chemicals such as nano zero-valent iron(nZVI)is a promising approach for the remediation of a variety of soil contaminants including cyanotoxins.As themost toxic cyanotoxin,microcystin-LR(MC-LR)enter soil via runoff,irrigated surface water and sewage,and the application of cyanobacterial biofertilizers as part of the sustainable agricultural practice.Earthworms in such remediation systems must sustain the potential risk from both nZVI and MC-LR.In the present study,earthworms(Eisenia fetida)were exposed up to 14 days to MC-LR and nZVI(individually and inmixture),and the toxicity was investigated at both the organismal andmetabolic levels,including growth,tissue damage,oxidative stress,metabolic response and gut microbiota.Results showed that co-exposure of MC-LR and nZVI is less potent to earthworms than that of separate exposure.Histological observations in the co-exposure group revealed only minor epidermal brokenness,and KEGG enrichment analysis showed that co-exposure induced earthworms to regulate glutathione biosynthesis for detoxification and reduced adverse effects from MC-LR.The combined use of nZVI promoted the growth and reproduction of soil and earthworm gut bacteria(e.g.,Sphingobacterium and Acinetobacter)responsible for the degradation of MC-LR,whichmight explain the observed antagonism between nZVI and MC-LR in earthworm microcosm.Our study suggests the beneficial use of nZVI to detoxify pollutants in earthworm-based vermiremediation systems where freshwater containing cyanobacterial blooms is frequently used to irrigate soil and supply water for the growth and metabolism of earthworms.
文摘Nanolipid carriers and traditional emulsion containing chemical sunscreens were prepared using emulsification combined with ultrasonic technology.The nanolipid carriers showed superior performance in sunscreen encapsulation,slow release and skin impermeability,and provided an excellent nanolipid slow-release encapsulation system for sunscreens.As observed by transmission electron microscopy,the nanolipid carriers were spherical shape,with smooth surface and uniform distribution,and the particle sizes were mainly concentrated in the range of 230 to 250 nm without agglomeration.The nanolipid carriers significantly improved the sunscreen performance through the synergistic effect of scattering and chemical absorption,and showed better UV stability than traditional sunscreen,indicating their photoprotective function.In vitro release experiments showed that the nano-lipidic carriers exhibited better release control when loaded with octyl methoxycinnamate(OMC)and butylmethoxydibenzoylmethane(BDFM)sunscreens than traditional traditional emulsions,with the cumulative release rate of OMC in the nano-lipidic carriers decreasing by 17.17% to 30.24% within 12 hours,and that of BDFM decreasing by 26.67% to 44.67%.26.67% to 44.16%.The results of the in vitro permeation experiment further confirmed that the nanolipid carriers could effectively encapsulate the sunscreens and prevent them from penetrating the skin barrier,thus reducing the skin irritation.Compared with traditional traditional emulsion,the cumulative penetration of OMC in nanostructured lipid carriers was 2.24μg/cm^(2)in 4 hours,while the cumulative penetration was reduced by 68.05%.The cumulative penetration of BDFM in the nanostructured lipid carrier was 3.24μg/cm^(2),with a 64.04%reduction in cumulative penetration.
文摘建立Sin-QuECh ERS Nano-超高效液相色谱串联质谱法测定坚果中吡噻菌胺酰胺类杀菌剂残留的方法。采用电喷雾正离子模式下多反应监测(MRM)模式进行检测,外标法定量。结果表明,吡噻菌胺在质量浓度10~500μg/L内具有良好的线性关系,R2>0.999。在0.25,0.50,2.50μg/kg 3个加标水平下,回收率为92.3%~117.0%,RSD<4.0%(n=6),定量限(LOQ)0.25μg/kg,使用该方法对进口坚果、超市售坚果和小摊贩售坚果进行检测,发现阳性样品检出率为1.0%,小摊贩售样阳性样品检出率高达4.0%。该方法前处理快速简单、灵敏度和准确度高,可满足坚果中吡噻菌胺残留检测的要求。
文摘This review explores multi-directional functionally graded(MDFG)nanostructures,focusing on their material characteristics,modeling approaches,and mechanical behavior.It starts by classifying different types of functionally graded(FG)materials such as conventional,axial,bi-directional,and tri-directional,and the material distribution models like power-law,exponential,trigonometric,polynomial functions,etc.It also discusses the application of advanced size-dependent theories like Eringen’s nonlocal elasticity,nonlocal strain gradient,modified couple stress,and consistent couple stress theories,which are essential to predict the behavior of structures at small scales.The review covers the mechanical analysis of MDFG nanostructures in nanobeams,nanopipes,nanoplates,and nanoshells and their dynamic and static responses under different loading conditions.The effect of multi-directional material gradation on stiffness,stability and vibration is discussed.Moreover,the review highlights the need for more advanced analytical,semi-analytical,and numerical methods to solve the complex vibration problems ofMDFG nanostructures.It is evident that the continued development of these methods is crucial for the design,optimization,and real-world application of MDFG nanostructures in advanced engineering fields like aerospace,biomedicine,and micro/nanoelectromechanical systems(MEMS/NEMS).This study is a reference for researchers and engineers working in the domain of MDFG nanostructures.
文摘Nanoferrites of the CoMn_(x)Fe_(2-x)O_(4) series(x=0.00,0.05,0.10,0.15,0.20)were synthesized in this study using the sol-gel auto-combustion approach.The lattice constants were computed within the range of 8.312-8.406Å,while crystallite sizes were estimated to range between 55.20 and 31.40 nm using the Scherrer method.The different functional groups were found to correlate with various ab-sorption bands using Fourier transform infrared(FTIR)spectroscopy.Five active modes were identified by Raman spectroscopy,reveal-ing vibration modes of O2-ions at tetrahedral and octahedral locations.The ferromagnetic hysteresis loop was observed in all the synthes-ized samples,which can be explained by Neel’s model.The results showed that AC conductivity decreased with increasing Mn^(2+)content at the Fe^(2+)site,while the dielectric constant and dielectric loss increased with increasing frequency.Furthermore,the saturation magnetiz-ation(Ms),remnant magnetization(M_(r)),and coercivity(H_(c))all showed declining trends with the increase in Mn^(2+)doping.Finally,the CoMn_(0.20)Fe_(1.8)O_(4) samples showed Ms and M_(r) values ranging from 73.12 to 66.84 emu/g and from 37.77 to 51.89 emu/g,respectively,while Hc values ranged from 1939 to 1312 Oe,after which coercivity increased.Thus,the CoMn_(0.20)Fe_(1.8)O_(4) sample can be considered a prom-ising candidate for magnetic applications.
基金supported by the Foundation of Health Care for Cadres of Sichuan Provincial Health Commission(Grant No.2023-224).
文摘Low-cost and biodegradable photothermal wound dressings with remarkable therapeutic effects are highly desirable for next-generation wound healing.Herein,we report an efficient photothermal wound dressing mat made of tellurium nanosheet(TeNS)-loaded electrospun polycaprolactone/gelatin(PCL/GEL)nanofibers.The TeNS-loaded PCL/GEL nanofibrous architectures showed antibacterial efficacy against Escherichia coli and Staphylococcus aureus of 87.68%and 94.57%,respectively.Under near-infrared+(NIR)light illumination,they can facilitate cell proliferation as revealed by in vitro scratch assay.The results from in vivo skin wounds combined with tissue staining experiments further showed that the TeNS-loaded dressing could substantially promote wound healing under photothermal conditions.Using immunohistochemical analysis,we found that the TeNS-loaded PCL/GEL nanofibers NIR group have a high expression of specific antigens in epidermal growth factor(EGF)(P<0.001)and endothelial cell adhesion molecule-31(CD31,P<0.05),verifying that the nanofibrous mat can stimulate EGF generation and microvessel proliferation.Furthermore,the PCL/GEL/TeNIR group has the lowest expression in endothelial cell adhesion molecule-68(CD68,P<0.001),suggesting that the nanofibrous mats have a high anti-inflammatory efficiency.Our work sheds light on the development of novel nonanti-inflammatory wound dressings via photothermal sterilization and the promotion of cell growth using two-dimensional(2D)nanosheets.
