AIM:To systematically evaluate the association between nailfold capillaroscopic findings and diabetic retinopathy(DR)and compare findings in diabetic patients with and without DR.METHODS:PubMed,Web of Science,and Emba...AIM:To systematically evaluate the association between nailfold capillaroscopic findings and diabetic retinopathy(DR)and compare findings in diabetic patients with and without DR.METHODS:PubMed,Web of Science,and Embase databases were searched from inception to February 2024.The quality of the included studies was evaluated using a National Institutes of Health(NIH)Quality Assessment tool for Observational Cohort and Cross Sectional Studies.Metaanalysis was conducted to compare the findings of nailfold capillaroscopy between diabetic patients with or without DR.Subgroup analysis was employed to investigate the source of heterogeneity.RESULTS:Totally 12 studies with 1349 diabetic patients were included,of which 628 had DR.The overall quality of included studies was acceptable.Patients with DR had increased arteriolar diameters[mean difference(MD):2.68,95%confidence interval(CI):0.64-4.72]and a higher risk of developing nailfold capillaroscopic abnormalities,including bushy capillaries[odds ratio(OR):2.82,95%CI:1.65-4.80],neoformation(OR:4.61,95%CI:3.15-6.76),megacapillaries(OR:8.37,95%CI:5.07-13.80),tortuosity(OR:7.29,95%CI:2.76-19.22),microhemorrhages(OR:6.16,95%CI:2.48-15.26),meandering capillaries(OR:4.68,95%CI:1.05-20.80)and avascular areas(OR:7.92,95%CI:2.68-23.38).The presence of tortuous capillary was more common in DR in India than in Turkey,while avascular area in the nailfolds was linked to DR only in India(OR:11.28,95%CI:3.91-32.60).Among the nailfold capillaroscopic abnormalities,tortuosity,microhemorrhage,and meandering capillary showed no significant correlation with the severity of DR,except for avascular area(P=0.04).CONCLUSION:There are significant associations between nailfold capillaroscopic findings and the presence of DR,supporting its potential as a non-invasive technique for monitoring microvascular changes in diabetic patients.However,further research is needed to validate its utility as an early screening tool for microvascular complications in diabetes.展开更多
Nail changes following upper extremity transplantation(UET)cannot be overlooked as they possess diagnostic and prognostic relevance in allotransplantation of upper limbs.This comprehensive review explores nail and nai...Nail changes following upper extremity transplantation(UET)cannot be overlooked as they possess diagnostic and prognostic relevance in allotransplantation of upper limbs.This comprehensive review explores nail and nail bed related changes encountered in UET recipients in the literature.The differential diagnosis of nail abnormalities in UET includes a wide range of systemic,local and iatrogenic conditions other than immune responses to the allograft.It requires interdisciplinary evaluation by primary transplant surgeons,pathologists,dermatologists and immunologists.The possible underlying mechanisms of nail pathology in UET and the management are discussed.It also underscores the importance of onychodystrophy and need for timely intervention and to improve outcomes in UET recipients.展开更多
From 1985 to 1987 Nailfold microcirculation was detected in 60 cases of HFRS for 164 times, and were comprehen- sively evaluated. The results showed that the changes of the capillary loop form were the main feature in...From 1985 to 1987 Nailfold microcirculation was detected in 60 cases of HFRS for 164 times, and were comprehen- sively evaluated. The results showed that the changes of the capillary loop form were the main feature in febrile phase, ∑(A×B) was 3. 15. The capillary loop form, fluidity and the condition around the loops all changed obviously in hypotensive phase ∑(A×B)was 5. 49. The capillary loop form and the condition around the loops also changed obviously ,∑ (A×B) was 4. 73. The fluidity of blood, however, was improved. ,The microcirculation in most of the patients in diuresis phase had recorded, except severe and fatal cases, ∑(A×B) was 3. 83. Analysing ∑(A×B), we considered that there were striking differences among mild, moderate and severe cases (P<0. 05). There was no striking differences between severe and fatal cases(P>0. 05). Nailfold microcirculation can reflect the human body microcirculation function in a certain de- gree. The clinical significances detecting it are: (1) It may be regarded as a reference item for early diagnosis and for determing a degree when the patients are admitted, (2)It may be a supervise measure in hypotensive phase, (3)It may be a reference item for supervising DIC and for anticoagulant treatment. (4) The dynamic changes of nailfold microcirculation may be a reference item for conjecturing prognosis, The quantitative analysis of nailfold microcirculation by∑ (A× B) can reflect 15 items for the changes of human body microcirculation. It can provide the reliable information for guiding the treat -ment arid conjecturing prognosis in HFRS,展开更多
基金Supported by University-Industry Collaborative Education Program of the Ministry of Education(No.231104794161945,No.230700562265543)Engineering Research Center of Integration and Application of Digital Learning Technology,Ministry of Education(No.1311016)+2 种基金Supply and Demand Job Matching and Student Development Program of Ministry of Education(No.2024011802142)Jiangsu Students’Platform for Innovation and Entrepreneurship Training Program(No.202410304127Y)the Science and Technology Project of Nantong City(No.MS2023050).
文摘AIM:To systematically evaluate the association between nailfold capillaroscopic findings and diabetic retinopathy(DR)and compare findings in diabetic patients with and without DR.METHODS:PubMed,Web of Science,and Embase databases were searched from inception to February 2024.The quality of the included studies was evaluated using a National Institutes of Health(NIH)Quality Assessment tool for Observational Cohort and Cross Sectional Studies.Metaanalysis was conducted to compare the findings of nailfold capillaroscopy between diabetic patients with or without DR.Subgroup analysis was employed to investigate the source of heterogeneity.RESULTS:Totally 12 studies with 1349 diabetic patients were included,of which 628 had DR.The overall quality of included studies was acceptable.Patients with DR had increased arteriolar diameters[mean difference(MD):2.68,95%confidence interval(CI):0.64-4.72]and a higher risk of developing nailfold capillaroscopic abnormalities,including bushy capillaries[odds ratio(OR):2.82,95%CI:1.65-4.80],neoformation(OR:4.61,95%CI:3.15-6.76),megacapillaries(OR:8.37,95%CI:5.07-13.80),tortuosity(OR:7.29,95%CI:2.76-19.22),microhemorrhages(OR:6.16,95%CI:2.48-15.26),meandering capillaries(OR:4.68,95%CI:1.05-20.80)and avascular areas(OR:7.92,95%CI:2.68-23.38).The presence of tortuous capillary was more common in DR in India than in Turkey,while avascular area in the nailfolds was linked to DR only in India(OR:11.28,95%CI:3.91-32.60).Among the nailfold capillaroscopic abnormalities,tortuosity,microhemorrhage,and meandering capillary showed no significant correlation with the severity of DR,except for avascular area(P=0.04).CONCLUSION:There are significant associations between nailfold capillaroscopic findings and the presence of DR,supporting its potential as a non-invasive technique for monitoring microvascular changes in diabetic patients.However,further research is needed to validate its utility as an early screening tool for microvascular complications in diabetes.
文摘Nail changes following upper extremity transplantation(UET)cannot be overlooked as they possess diagnostic and prognostic relevance in allotransplantation of upper limbs.This comprehensive review explores nail and nail bed related changes encountered in UET recipients in the literature.The differential diagnosis of nail abnormalities in UET includes a wide range of systemic,local and iatrogenic conditions other than immune responses to the allograft.It requires interdisciplinary evaluation by primary transplant surgeons,pathologists,dermatologists and immunologists.The possible underlying mechanisms of nail pathology in UET and the management are discussed.It also underscores the importance of onychodystrophy and need for timely intervention and to improve outcomes in UET recipients.
文摘From 1985 to 1987 Nailfold microcirculation was detected in 60 cases of HFRS for 164 times, and were comprehen- sively evaluated. The results showed that the changes of the capillary loop form were the main feature in febrile phase, ∑(A×B) was 3. 15. The capillary loop form, fluidity and the condition around the loops all changed obviously in hypotensive phase ∑(A×B)was 5. 49. The capillary loop form and the condition around the loops also changed obviously ,∑ (A×B) was 4. 73. The fluidity of blood, however, was improved. ,The microcirculation in most of the patients in diuresis phase had recorded, except severe and fatal cases, ∑(A×B) was 3. 83. Analysing ∑(A×B), we considered that there were striking differences among mild, moderate and severe cases (P<0. 05). There was no striking differences between severe and fatal cases(P>0. 05). Nailfold microcirculation can reflect the human body microcirculation function in a certain de- gree. The clinical significances detecting it are: (1) It may be regarded as a reference item for early diagnosis and for determing a degree when the patients are admitted, (2)It may be a supervise measure in hypotensive phase, (3)It may be a reference item for supervising DIC and for anticoagulant treatment. (4) The dynamic changes of nailfold microcirculation may be a reference item for conjecturing prognosis, The quantitative analysis of nailfold microcirculation by∑ (A× B) can reflect 15 items for the changes of human body microcirculation. It can provide the reliable information for guiding the treat -ment arid conjecturing prognosis in HFRS,
