以钛网为基底,采用两步法(阳极氧化和电还原)成功制备了三维黑色TiO_(2)纳米管(3D Black TiO_(2)NTs)光电极。通过扫描电子显微镜(SEM)和X射线衍射(XRD)分别对3D Black TiO_(2)NTs光电极的表面形貌和结构进行了表征。结果表明,Black TiO...以钛网为基底,采用两步法(阳极氧化和电还原)成功制备了三维黑色TiO_(2)纳米管(3D Black TiO_(2)NTs)光电极。通过扫描电子显微镜(SEM)和X射线衍射(XRD)分别对3D Black TiO_(2)NTs光电极的表面形貌和结构进行了表征。结果表明,Black TiO_(2)NTs管径约为130 nm,管壁厚度为10 nm。通过线性伏安扫描(LSV)和电化学交流阻抗(EIS)对光电极的光电催化电化学活性进行了研究。研究发现在TiO_(2)NTs晶格引入Ti^(3+)之后,可以提高光生载流子的产生与分离速度,从而使得光电流密度显著提高。同时,Ti^(3+)自掺杂也有效增强了材料的电荷分离与传输性能,从而大大提高了电极的光电催化活性。将该光电极应用于光电催化降解亚甲基蓝(MB),降解120 min后MB完全降解,总有机碳(TOC)降解率高达86%。研究表明,3D Black TiO_(2)NTs光电极在有机废水处理中具有广阔的应用前景。展开更多
目的:本研究旨在探讨NT联合NIPT、早期唐氏筛查及四维超声检查在胎儿染色体疾病筛查中的临床应用价值,评估不同检测方法单独及联合使用时的检出率和诊断效能,为优化胎儿染色体异常的早期筛查策略提供依据。方法:回顾性分析2018年1月至2...目的:本研究旨在探讨NT联合NIPT、早期唐氏筛查及四维超声检查在胎儿染色体疾病筛查中的临床应用价值,评估不同检测方法单独及联合使用时的检出率和诊断效能,为优化胎儿染色体异常的早期筛查策略提供依据。方法:回顾性分析2018年1月至2024年10月于青海红十字医院行产前诊断的532例孕妇的临床数据,所有病例均行NT、NIPT、早期唐氏筛查、四维超声检查及羊水穿刺。分别计算各检测方法单独及联合筛查的阳性检出率、灵敏度、特异度、阳性预测值、阴性预测值及准确率,同时对多种检测联合方案的诊断效能进行ROC曲线分析。结果:两组孕妇的年龄、孕周、孕前BMI、居住地与文化程度均无统计学差异(P > 0.05)。单独检测中,相比NT、早期唐氏筛查及四维超声检查,NIPT具有较高的阳性检出率、灵敏度、特异度、阳性预测值、阴性预测值、准确率及AUC (P Objective: The aim of this study was to investigate the clinical application value of NT combined with NIPT, early Down’s screening, and four-dimensional ultrasonography in the screening of fetal chromosomal disorders, to assess the detection rate and diagnostic efficacy of different testing methods when used individually and in combination, and to provide a basis for optimising the early screening strategy for fetal chromosomal abnormalities. Methods: Clinical data of 532 pregnant women who underwent prenatal diagnosis in Qinghai Red Cross Hospital from January 2018 to October 2024 were retrospectively analysed, and all cases underwent NT, NIPT, early Down’s syndrome screening, four-dimensional ultrasonography, and amniocentesis. The positive detection rate, sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of each test alone and in combination were calculated, and the diagnostic efficacy of the combination of multiple tests was analysed by ROC curve. Results: There were no statistically significant differences in age, gestational week, pre-pregnancy BMI, place of residence, and education between the two groups (P > 0.05). Among individual tests, compared with NT, early Down’s screening, and 4D ultrasound, NIPT alone had a higher positive detection rate, sensitivity, specificity, positive predictive value, negative predictive value, accuracy, and AUC (P < 0.05). Compared to individual screening, NT combined with early Down syndrome screening, and NT combined with four dimensional ultrasound examination, NT combined with NIPT had higher sensitivity, specificity, positive predictive value, negative predictive value, accuracy, and AUC (P < 0.05). Conclusion: NT combined with NIPT, early Down’s syndrome screening, and four-dimensional ultrasound can significantly improve the detection rate and diagnostic accuracy of individual screening, especially the combined NT + NIPT program has high clinical value in the screening of fetal chromosomal abnormalities, which provides a scientific basis for optimizing the screening strategy for high-risk pregnant women.展开更多
The key technology of open architecture CNC systems kernel device driver,including the interrupt mechanism, I/O subsystem, the structure of device driver and the communication between the driver and the application p...The key technology of open architecture CNC systems kernel device driver,including the interrupt mechanism, I/O subsystem, the structure of device driver and the communication between the driver and the application program, is discussed in the paper and a specific application is given at the end.展开更多
Neurotrophin-3 (NT3) is a growth factor found in many body tissues including the heart, intestines, skin, nervous system and in skeletal muscles including muscle spindles (Murase et al., 1994). NT3 is required for the...Neurotrophin-3 (NT3) is a growth factor found in many body tissues including the heart, intestines, skin, nervous system and in skeletal muscles including muscle spindles (Murase et al., 1994). NT3 is required for the survival, correct connectivity and function of sensory (“proprioceptive”) afferents that innervate muscle spindles;these neurons express receptors for NT3 including tropomyocin receptor kinase C. These proprioceptive afferents are important for normal movement (Boyce and Mendell, 2014) and signals from muscle spindles are important for recovery of limb movement (e.g., after spinal cord lateral hemisection)(Takeoka et al., 2014). The level of NT3 declines in most tissues during postnatal development;its level is low in adult and elderly humans and other mammals (Murase et al., 1994). Elevation of NT3 has been shown to improve outcome in various animal models of neurological disease and injury. For example, many groups have shown that delivery of NT3 directly into the central nervous system promotes recovery after spinal cord injury but this often involved invasive routes or gene therapy (Boyce and Mendell, 2014;Petrosyan et al., 2015;Wang et al., 2018).展开更多
The pattern-specific features are: layered design, multitasking support, a virtual device interface and a unique Communication and Coordination subsystem which controls the dynamic behavior.
文摘以钛网为基底,采用两步法(阳极氧化和电还原)成功制备了三维黑色TiO_(2)纳米管(3D Black TiO_(2)NTs)光电极。通过扫描电子显微镜(SEM)和X射线衍射(XRD)分别对3D Black TiO_(2)NTs光电极的表面形貌和结构进行了表征。结果表明,Black TiO_(2)NTs管径约为130 nm,管壁厚度为10 nm。通过线性伏安扫描(LSV)和电化学交流阻抗(EIS)对光电极的光电催化电化学活性进行了研究。研究发现在TiO_(2)NTs晶格引入Ti^(3+)之后,可以提高光生载流子的产生与分离速度,从而使得光电流密度显著提高。同时,Ti^(3+)自掺杂也有效增强了材料的电荷分离与传输性能,从而大大提高了电极的光电催化活性。将该光电极应用于光电催化降解亚甲基蓝(MB),降解120 min后MB完全降解,总有机碳(TOC)降解率高达86%。研究表明,3D Black TiO_(2)NTs光电极在有机废水处理中具有广阔的应用前景。
文摘目的:本研究旨在探讨NT联合NIPT、早期唐氏筛查及四维超声检查在胎儿染色体疾病筛查中的临床应用价值,评估不同检测方法单独及联合使用时的检出率和诊断效能,为优化胎儿染色体异常的早期筛查策略提供依据。方法:回顾性分析2018年1月至2024年10月于青海红十字医院行产前诊断的532例孕妇的临床数据,所有病例均行NT、NIPT、早期唐氏筛查、四维超声检查及羊水穿刺。分别计算各检测方法单独及联合筛查的阳性检出率、灵敏度、特异度、阳性预测值、阴性预测值及准确率,同时对多种检测联合方案的诊断效能进行ROC曲线分析。结果:两组孕妇的年龄、孕周、孕前BMI、居住地与文化程度均无统计学差异(P > 0.05)。单独检测中,相比NT、早期唐氏筛查及四维超声检查,NIPT具有较高的阳性检出率、灵敏度、特异度、阳性预测值、阴性预测值、准确率及AUC (P Objective: The aim of this study was to investigate the clinical application value of NT combined with NIPT, early Down’s screening, and four-dimensional ultrasonography in the screening of fetal chromosomal disorders, to assess the detection rate and diagnostic efficacy of different testing methods when used individually and in combination, and to provide a basis for optimising the early screening strategy for fetal chromosomal abnormalities. Methods: Clinical data of 532 pregnant women who underwent prenatal diagnosis in Qinghai Red Cross Hospital from January 2018 to October 2024 were retrospectively analysed, and all cases underwent NT, NIPT, early Down’s syndrome screening, four-dimensional ultrasonography, and amniocentesis. The positive detection rate, sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of each test alone and in combination were calculated, and the diagnostic efficacy of the combination of multiple tests was analysed by ROC curve. Results: There were no statistically significant differences in age, gestational week, pre-pregnancy BMI, place of residence, and education between the two groups (P > 0.05). Among individual tests, compared with NT, early Down’s screening, and 4D ultrasound, NIPT alone had a higher positive detection rate, sensitivity, specificity, positive predictive value, negative predictive value, accuracy, and AUC (P < 0.05). Compared to individual screening, NT combined with early Down syndrome screening, and NT combined with four dimensional ultrasound examination, NT combined with NIPT had higher sensitivity, specificity, positive predictive value, negative predictive value, accuracy, and AUC (P < 0.05). Conclusion: NT combined with NIPT, early Down’s syndrome screening, and four-dimensional ultrasound can significantly improve the detection rate and diagnostic accuracy of individual screening, especially the combined NT + NIPT program has high clinical value in the screening of fetal chromosomal abnormalities, which provides a scientific basis for optimizing the screening strategy for high-risk pregnant women.
文摘The key technology of open architecture CNC systems kernel device driver,including the interrupt mechanism, I/O subsystem, the structure of device driver and the communication between the driver and the application program, is discussed in the paper and a specific application is given at the end.
基金funded by the Brain Research Trust,the Rosetrees Trust and the International Spinal Research Trusta grant from the European Research Council under the European Union’s Seventh Framework Programme(FP/2007-2013)+5 种基金ERC Grant Agreement n.309731by a Research Councils UK Academic Fellowshipby the Medical Research Council(MRC)and the British Pharmacological Society(BPS)’s Integrative Pharmacology Fundsupported by the Dowager Countess Eleanor Peel Trusta Capacity Building Award in Integrative Mammalian Biology funded by the Biotechnology and Biological Sciences Research Council,BPSHigher Education Funding Council for England,Knowledge Transfer Partnerships,MRC and Scottish Funding Council
文摘Neurotrophin-3 (NT3) is a growth factor found in many body tissues including the heart, intestines, skin, nervous system and in skeletal muscles including muscle spindles (Murase et al., 1994). NT3 is required for the survival, correct connectivity and function of sensory (“proprioceptive”) afferents that innervate muscle spindles;these neurons express receptors for NT3 including tropomyocin receptor kinase C. These proprioceptive afferents are important for normal movement (Boyce and Mendell, 2014) and signals from muscle spindles are important for recovery of limb movement (e.g., after spinal cord lateral hemisection)(Takeoka et al., 2014). The level of NT3 declines in most tissues during postnatal development;its level is low in adult and elderly humans and other mammals (Murase et al., 1994). Elevation of NT3 has been shown to improve outcome in various animal models of neurological disease and injury. For example, many groups have shown that delivery of NT3 directly into the central nervous system promotes recovery after spinal cord injury but this often involved invasive routes or gene therapy (Boyce and Mendell, 2014;Petrosyan et al., 2015;Wang et al., 2018).
文摘The pattern-specific features are: layered design, multitasking support, a virtual device interface and a unique Communication and Coordination subsystem which controls the dynamic behavior.
