目的:探讨基于年龄、体质指数、进食情况、体重减少情况的营养风险评估工具(Assessment of Nutritional Risk based on BodyMass Index,Intake and Weight loss,AIWW)和营养风险筛查2002(NRS2002)用于胃癌住院病人营养风险筛查的效果,...目的:探讨基于年龄、体质指数、进食情况、体重减少情况的营养风险评估工具(Assessment of Nutritional Risk based on BodyMass Index,Intake and Weight loss,AIWW)和营养风险筛查2002(NRS2002)用于胃癌住院病人营养风险筛查的效果,分析其在胃癌病人中的适用性。方法:采用便利抽样法,选取2023年10月—2024年4月在广西某三级甲等肿瘤医院胃及腹部肿瘤病区就诊的376例胃癌病人,于病人入院后24 h内用AIWW和NRS2002进行营养筛查,以改良版病人主观整体评估(MPG-SGA)评估结果为营养不良的诊断标准,计算AIWW和NRS2002的灵敏度、特异度、阳性预测值和阴性预测值、阳性似然比和阴性似然比、Kappa值以及受试者特征(ROC)曲线和曲线下面积。结果:共纳入376例胃癌病人,以MPG-SGA为诊断标准,254例(67.6%)病人出现营养不良;使用AIWW、NRS2002诊断胃癌病人营养不良风险分别为67.0%、34.8%。AIWW、NRS2002诊断营养不良的灵敏度分别为0.98,0.51,特异度分别为0.97,0.98;AIWW和NRS2002与MPG-SGA的Kappa一致性结果分别为0.928,0.389;ROC曲线下面积分别为0.982,0.788。结论:AIWW、NRS2002均能为胃癌病人营养不良风险筛查提供依据,且两种工具的一致性较好。诊断效能评价中,AIWW灵敏度较高,与MPG-SGA的一致性较好,且条目简单易于评估。因此,建议使用AIWW于胃癌病人的营养筛查。展开更多
The surface-enhanced Raman scattering(SERS) optical fiber probes were successfully prepared by self-assembling on polyelectrolyte multilayers. Gold nanorods(Au NRs) were used as SERS enhancement material to give excel...The surface-enhanced Raman scattering(SERS) optical fiber probes were successfully prepared by self-assembling on polyelectrolyte multilayers. Gold nanorods(Au NRs) were used as SERS enhancement material to give excellent biological affinity and stability to the SERS optical fiber probes. Au NRs were synthesized by seed growth method. The synergistic effect between AgNO_(3) and surfactant was investigated, and the highest yield was found when AgNO_(3) was 500 uL. Meanwhile, different SERS optical fiber probes were obtained by selecting silane coupling agent, polyelectrolyte multilayer and graphene oxide(GO) to treat quartz fiber. It was found that the SERS optical fiber probes obtained by the self-assembled on polyelectrolyte multilayers method performed better than those by other methods. In addition, Mapping was combined with finite element simulation to analyze the electromagnetic field distribution at the fiber end face.The electromagnetic field distribution of Au NRs was investigated, the difference of electromagnetic field intensity around the Au NRs with different arrangements was compared, the strongest signal was obtained when the Au NRs were head-to-head. Finally, sensitivity of the optimized SERS optical fiber probes could reach 10^(-9)mol/L, with excellent stability and repeatability.展开更多
目的研究分娩球联合自控式硬膜外分娩镇痛对初产妇NRS评分、产后出血量及新生儿Apgar评分的影响。方法选取2018年3-7月在该院分娩的196例初产妇为研究对象,按照随机数字表法分为对照组和观察组,每组各98例。对照组采用硬膜外自控镇痛,...目的研究分娩球联合自控式硬膜外分娩镇痛对初产妇NRS评分、产后出血量及新生儿Apgar评分的影响。方法选取2018年3-7月在该院分娩的196例初产妇为研究对象,按照随机数字表法分为对照组和观察组,每组各98例。对照组采用硬膜外自控镇痛,观察组在对照组基础上联合分娩球镇痛。比较两组产妇镇痛前、镇痛10 min和30 min后NRS评分,临产时胎方位衔接情况,生产方式,产程,产妇失血量及新生儿出生1 min、5 min Apgar评分。结果观察组产妇镇痛10 min及30 min后的NRS疼痛评分、剖宫产率、产钳助产率、第一产程及总产程均低于对照组,枕前位、枕横位衔接率、自然分娩率及出生后5 min Apgar评分高于对照组,差异均有统计学意义(均P<0.05)。两组产妇镇痛前的NRS评分、分娩过程失血量及新生儿出生1 min Apgar评分比较,差异均无统计学意义(均P>0.05)。结论在自控式硬膜外镇痛的基础上联合分娩球镇痛可有效降低初产妇的NRS评分、提高新生儿Apgar评分,而对出血量无明显影响。展开更多
文摘目的:探讨基于年龄、体质指数、进食情况、体重减少情况的营养风险评估工具(Assessment of Nutritional Risk based on BodyMass Index,Intake and Weight loss,AIWW)和营养风险筛查2002(NRS2002)用于胃癌住院病人营养风险筛查的效果,分析其在胃癌病人中的适用性。方法:采用便利抽样法,选取2023年10月—2024年4月在广西某三级甲等肿瘤医院胃及腹部肿瘤病区就诊的376例胃癌病人,于病人入院后24 h内用AIWW和NRS2002进行营养筛查,以改良版病人主观整体评估(MPG-SGA)评估结果为营养不良的诊断标准,计算AIWW和NRS2002的灵敏度、特异度、阳性预测值和阴性预测值、阳性似然比和阴性似然比、Kappa值以及受试者特征(ROC)曲线和曲线下面积。结果:共纳入376例胃癌病人,以MPG-SGA为诊断标准,254例(67.6%)病人出现营养不良;使用AIWW、NRS2002诊断胃癌病人营养不良风险分别为67.0%、34.8%。AIWW、NRS2002诊断营养不良的灵敏度分别为0.98,0.51,特异度分别为0.97,0.98;AIWW和NRS2002与MPG-SGA的Kappa一致性结果分别为0.928,0.389;ROC曲线下面积分别为0.982,0.788。结论:AIWW、NRS2002均能为胃癌病人营养不良风险筛查提供依据,且两种工具的一致性较好。诊断效能评价中,AIWW灵敏度较高,与MPG-SGA的一致性较好,且条目简单易于评估。因此,建议使用AIWW于胃癌病人的营养筛查。
基金Funded by National Natural Science Foundation of China (Nos.51372179, 51772224)the Open Projects Foundation of Yangtze Optical Fiber and Cable Joint Stock Limited Company (YOFC)(No.SKLD1705)。
文摘The surface-enhanced Raman scattering(SERS) optical fiber probes were successfully prepared by self-assembling on polyelectrolyte multilayers. Gold nanorods(Au NRs) were used as SERS enhancement material to give excellent biological affinity and stability to the SERS optical fiber probes. Au NRs were synthesized by seed growth method. The synergistic effect between AgNO_(3) and surfactant was investigated, and the highest yield was found when AgNO_(3) was 500 uL. Meanwhile, different SERS optical fiber probes were obtained by selecting silane coupling agent, polyelectrolyte multilayer and graphene oxide(GO) to treat quartz fiber. It was found that the SERS optical fiber probes obtained by the self-assembled on polyelectrolyte multilayers method performed better than those by other methods. In addition, Mapping was combined with finite element simulation to analyze the electromagnetic field distribution at the fiber end face.The electromagnetic field distribution of Au NRs was investigated, the difference of electromagnetic field intensity around the Au NRs with different arrangements was compared, the strongest signal was obtained when the Au NRs were head-to-head. Finally, sensitivity of the optimized SERS optical fiber probes could reach 10^(-9)mol/L, with excellent stability and repeatability.
文摘目的研究分娩球联合自控式硬膜外分娩镇痛对初产妇NRS评分、产后出血量及新生儿Apgar评分的影响。方法选取2018年3-7月在该院分娩的196例初产妇为研究对象,按照随机数字表法分为对照组和观察组,每组各98例。对照组采用硬膜外自控镇痛,观察组在对照组基础上联合分娩球镇痛。比较两组产妇镇痛前、镇痛10 min和30 min后NRS评分,临产时胎方位衔接情况,生产方式,产程,产妇失血量及新生儿出生1 min、5 min Apgar评分。结果观察组产妇镇痛10 min及30 min后的NRS疼痛评分、剖宫产率、产钳助产率、第一产程及总产程均低于对照组,枕前位、枕横位衔接率、自然分娩率及出生后5 min Apgar评分高于对照组,差异均有统计学意义(均P<0.05)。两组产妇镇痛前的NRS评分、分娩过程失血量及新生儿出生1 min Apgar评分比较,差异均无统计学意义(均P>0.05)。结论在自控式硬膜外镇痛的基础上联合分娩球镇痛可有效降低初产妇的NRS评分、提高新生儿Apgar评分,而对出血量无明显影响。
