目的:评估新型炎症指标中性粒细胞/白蛋白比值(NPAR)对维持性血液透析(MHD)患者蛋白质能量消耗(PEW)之间的关系。方法:回顾性分析2021年06月至2021年12月在新疆医科大学第一附属医院血液净化中心规律随访的MHD患者的一般资料、实验室指...目的:评估新型炎症指标中性粒细胞/白蛋白比值(NPAR)对维持性血液透析(MHD)患者蛋白质能量消耗(PEW)之间的关系。方法:回顾性分析2021年06月至2021年12月在新疆医科大学第一附属医院血液净化中心规律随访的MHD患者的一般资料、实验室指标、完善营养不良炎症评分(MIS)诊断PEW。根据NPAR的3分位间距将研究对象分为3组,比较组间各指标的差异,采用Logistic回归分析NPAR与PEW发病的关系,利用ROC曲线评估NPAR对MHD患者PEW的预测价值。结果:共纳入资料完整的研究对象140例,按NPAR三分位分组(Q1、Q2、Q3),通过Logistic回归分析,在校正年龄、性别、握力、BMI后,NPAR与MHD患者PEW发病风险仍有关,Q3组PEW发病风险为Q1组患者的3.212 (95% CI 1.074~9.612, P P 0.05)。结论:NPAR与MHD患者PEW的发生有关,对MHD患者PEW发病有预测价值。展开更多
[Objectives]To explore the relationship between neutrophil percentage to albumin ratio(NPAR),monocyte to high density lipoprotein ratio(MHR),fasting blood glucose(GLU)and CAD+T2DM and its diagnostic value.[Methods]A t...[Objectives]To explore the relationship between neutrophil percentage to albumin ratio(NPAR),monocyte to high density lipoprotein ratio(MHR),fasting blood glucose(GLU)and CAD+T2DM and its diagnostic value.[Methods]A total of 3937 patients who underwent coronary angiography in the Affiliated Hospital of Chengde Medical University from January 2016 to December 2018 were collected.The patients with Gensini score>0 and diabetes were selected as the experimental group(CAD+T2DM,n=756),and the patients with Gensini score=0 and without diabetes were taken as the control group(n=388),with a total of 1144 cases.The patient's medical record number,sex,age,contact number,biochemical test results,cardiac color ultrasound,coronary artery imaging and other data were recorded.NPAR,MHR,and GLU were calculated.A binary Logistic regression model was established combined with the receiver operating characteristic(ROC)curve.The predictive value of single index and joint test for CAD+T2DM was analyzed.[Results]The serum levels of NPAR,MHR and GLU in CAD+T2DM were significantly higher than those in the control group.Binary Logistic regression analysis showed that serum NPAR,MHR and GLU were risk factors for CAD+T2DM(P<0.05).The final prediction model is P=1/[1+e-(-3.722+0.014×NPAR+0.51×MHR+0.461×GLU)].ROC curve showed that the area under the curve of serum NPAR,MHR and GLU was 0.739,0.628 and 0.852,respectively,and the prediction probability of combined detection was 0.882,which was significantly higher than that of single index.[Conclusions]There was a close correlation between serum NPAR,MHR,GLU and CAD+T2DM in patients with coronary heart disease.The combined application of these indexes can significantly improve the predictive value of CAD+T2DM.展开更多
[Objectives]This study was conducted to explore the relationship between neutrophil percentage-to-albumin ratio(NPAR)and coronary heart disease complicated with diabetes.[Methods]A total of 603 patients with coronary ...[Objectives]This study was conducted to explore the relationship between neutrophil percentage-to-albumin ratio(NPAR)and coronary heart disease complicated with diabetes.[Methods]A total of 603 patients with coronary heart disease who underwent coronary angiography in Pingquan County Hospital from January,2023 to December,2023 and met the inclusion criteria were included as the research object.All the patients were divided into a coronary heart disease complicated with diabetes group(CAD+T2DM group)(n=298 cases)and a control group(CAD group)(n=305 cases),according to patients medical history,heart color ultrasound and biochemical test results.The clinical data,biochemical test results and coronary artery imaging data of patients were recorded,and the Gensini score was calculated.The neutrophil percentage(NEUT%)and albumin count were determined to calculate NPAR.[Results]The NPAR value of the coronary heart disease complicated with diabetes mellitus group was(1.6±0.42),which was significantly higher than that of the control group(1.47±0.49),and the difference was statistically significant(P<0.05).The area under the ROC curve was 0.619(95%CI:0.591-0.675,P<0.05),and the prediction of coronary heart disease complicated with diabetes using NPAR showed a Youden index of 0.31,a sensitivity of 60.4%,a specificity of 40.3%,and a best cut-off score of 1.4506.[Conclusions]The neutrophil percentage-to-albumin ratio(NPAR)is closely related to coronary heart disease complicated with diabetes mellitus,and NPAR has clinical application value in the diagnosis of coronary heart disease complicated with diabetes mellitus.展开更多
在当前医疗领域,精准医疗的兴起激励研究人员积极探索更为准确和便捷的肿瘤预后评估方法。中性粒细胞百分比与白蛋白比值(neutrophil percentage to albumin ratio,NPAR)作为一种新兴的生物标志物,以其便捷性、经济性和易于获取的特点,...在当前医疗领域,精准医疗的兴起激励研究人员积极探索更为准确和便捷的肿瘤预后评估方法。中性粒细胞百分比与白蛋白比值(neutrophil percentage to albumin ratio,NPAR)作为一种新兴的生物标志物,以其便捷性、经济性和易于获取的特点,在多种肿瘤的预后评估中展现出广泛的潜力和重要价值。本综述旨在深入分析NPAR在其他疾病及肿瘤预后评估中的具体应用及其影响因素。通过采用回顾性分析的方法,从多个视角系统性地评估NPAR在患者预后评估中的有效性和可靠性。通过这一分析,不仅提高了对NPAR在结直肠癌预后评估的准确性和可靠性,也通过NPAR分层可优化化疗方案选择,从而进一步推动精准医疗的发展,力求提高结直肠癌患者的治疗效果与生活质量。展开更多
文摘目的:评估新型炎症指标中性粒细胞/白蛋白比值(NPAR)对维持性血液透析(MHD)患者蛋白质能量消耗(PEW)之间的关系。方法:回顾性分析2021年06月至2021年12月在新疆医科大学第一附属医院血液净化中心规律随访的MHD患者的一般资料、实验室指标、完善营养不良炎症评分(MIS)诊断PEW。根据NPAR的3分位间距将研究对象分为3组,比较组间各指标的差异,采用Logistic回归分析NPAR与PEW发病的关系,利用ROC曲线评估NPAR对MHD患者PEW的预测价值。结果:共纳入资料完整的研究对象140例,按NPAR三分位分组(Q1、Q2、Q3),通过Logistic回归分析,在校正年龄、性别、握力、BMI后,NPAR与MHD患者PEW发病风险仍有关,Q3组PEW发病风险为Q1组患者的3.212 (95% CI 1.074~9.612, P P 0.05)。结论:NPAR与MHD患者PEW的发生有关,对MHD患者PEW发病有预测价值。
基金Key Medical Science Research Project of Hebei Health and Family Planning Commission(20181153).
文摘[Objectives]To explore the relationship between neutrophil percentage to albumin ratio(NPAR),monocyte to high density lipoprotein ratio(MHR),fasting blood glucose(GLU)and CAD+T2DM and its diagnostic value.[Methods]A total of 3937 patients who underwent coronary angiography in the Affiliated Hospital of Chengde Medical University from January 2016 to December 2018 were collected.The patients with Gensini score>0 and diabetes were selected as the experimental group(CAD+T2DM,n=756),and the patients with Gensini score=0 and without diabetes were taken as the control group(n=388),with a total of 1144 cases.The patient's medical record number,sex,age,contact number,biochemical test results,cardiac color ultrasound,coronary artery imaging and other data were recorded.NPAR,MHR,and GLU were calculated.A binary Logistic regression model was established combined with the receiver operating characteristic(ROC)curve.The predictive value of single index and joint test for CAD+T2DM was analyzed.[Results]The serum levels of NPAR,MHR and GLU in CAD+T2DM were significantly higher than those in the control group.Binary Logistic regression analysis showed that serum NPAR,MHR and GLU were risk factors for CAD+T2DM(P<0.05).The final prediction model is P=1/[1+e-(-3.722+0.014×NPAR+0.51×MHR+0.461×GLU)].ROC curve showed that the area under the curve of serum NPAR,MHR and GLU was 0.739,0.628 and 0.852,respectively,and the prediction probability of combined detection was 0.882,which was significantly higher than that of single index.[Conclusions]There was a close correlation between serum NPAR,MHR,GLU and CAD+T2DM in patients with coronary heart disease.The combined application of these indexes can significantly improve the predictive value of CAD+T2DM.
基金Supported by Self-financing Project of Chengde Science and Technology Program in 2023(202303A079).
文摘[Objectives]This study was conducted to explore the relationship between neutrophil percentage-to-albumin ratio(NPAR)and coronary heart disease complicated with diabetes.[Methods]A total of 603 patients with coronary heart disease who underwent coronary angiography in Pingquan County Hospital from January,2023 to December,2023 and met the inclusion criteria were included as the research object.All the patients were divided into a coronary heart disease complicated with diabetes group(CAD+T2DM group)(n=298 cases)and a control group(CAD group)(n=305 cases),according to patients medical history,heart color ultrasound and biochemical test results.The clinical data,biochemical test results and coronary artery imaging data of patients were recorded,and the Gensini score was calculated.The neutrophil percentage(NEUT%)and albumin count were determined to calculate NPAR.[Results]The NPAR value of the coronary heart disease complicated with diabetes mellitus group was(1.6±0.42),which was significantly higher than that of the control group(1.47±0.49),and the difference was statistically significant(P<0.05).The area under the ROC curve was 0.619(95%CI:0.591-0.675,P<0.05),and the prediction of coronary heart disease complicated with diabetes using NPAR showed a Youden index of 0.31,a sensitivity of 60.4%,a specificity of 40.3%,and a best cut-off score of 1.4506.[Conclusions]The neutrophil percentage-to-albumin ratio(NPAR)is closely related to coronary heart disease complicated with diabetes mellitus,and NPAR has clinical application value in the diagnosis of coronary heart disease complicated with diabetes mellitus.
文摘在当前医疗领域,精准医疗的兴起激励研究人员积极探索更为准确和便捷的肿瘤预后评估方法。中性粒细胞百分比与白蛋白比值(neutrophil percentage to albumin ratio,NPAR)作为一种新兴的生物标志物,以其便捷性、经济性和易于获取的特点,在多种肿瘤的预后评估中展现出广泛的潜力和重要价值。本综述旨在深入分析NPAR在其他疾病及肿瘤预后评估中的具体应用及其影响因素。通过采用回顾性分析的方法,从多个视角系统性地评估NPAR在患者预后评估中的有效性和可靠性。通过这一分析,不仅提高了对NPAR在结直肠癌预后评估的准确性和可靠性,也通过NPAR分层可优化化疗方案选择,从而进一步推动精准医疗的发展,力求提高结直肠癌患者的治疗效果与生活质量。
