OBJECTIVE: To investigate whether the Tandistribution and anti-tumor Ⅱef A could improve the ficacy of Pegylated Liposomal Doxorubicin(PLD) via normalizing the structure and function of vasculature in Hepa1-6 hepatom...OBJECTIVE: To investigate whether the Tandistribution and anti-tumor Ⅱef A could improve the ficacy of Pegylated Liposomal Doxorubicin(PLD) via normalizing the structure and function of vasculature in Hepa1-6 hepatoma mice model.METHODS: Hepa1-6 hepatoma-bearing mice were treated with TanⅡA for 14 d. Distribution and anti-tumor efficacy of PLD, and the structure and function of the tumor vasculature were evaluated using various techniques.RESULTS: TanⅡ A significantly reduced the micro-vessel density(MVD). After Tan vascular walls were betteⅡr s A treatment,the tumor tructured, as the increased coverage of the pericytes and the promoted contact of the basement membrane and endothelial cell. Functional tests showed that tumor hypoxia was improved and the exudation amount of Evans blue in the parenchyma of the tumor decreased. In addition, mice treated with TanA had greater PLD penetration distance intratumoⅡrally. Furthermore, combined therapy of Tanibited tumor growth.ⅡA and PLD significantly inhCONCLUSION: This study suggests that Tanasculature andⅡ h A helps normalizing the tumor vas therapeutic potential in increasing the distribution of chemotherapy drug in the tumor.展开更多
During calcining the aluminum hydroxide according to the Bayer process in a rotary kiln,the process of incomplete conversion to alpha alumina by soft calcination leads to a special intermediate alumina product contain...During calcining the aluminum hydroxide according to the Bayer process in a rotary kiln,the process of incomplete conversion to alpha alumina by soft calcination leads to a special intermediate alumina product containing microcrystalline of primary crystal alpha alumina particles less than 0.4μm,and other alumina phases with finer microcrystalline of less than 0.2μm particles.This special alumina powder has similar properties to silica fume or clay,such as high surface area and reactivity,fast wetting,low water demand and high stick-ability.It can partially or completely replace silica fume and clay in dry gunning mixes.It works towards improving the high temperature resistance of the gunning material matrix as well as the corrosion resistance and service life of the gunning materials.The application results show that:the ladle cementfree alumina-magnesia dry gunning mix with this special alumina sub-micro powder,compared with traditional dry gunning materials,has lower rebound loss(<10%),better adhesion rate,higher corrosion resistance and peeling resistance;and it can replace the veneering casting repair to achieve the similar performance.A further improvement goal is to replace the initial casting linings,thus this concept will give a new revolution to the monolithic steel ladles.展开更多
And Then There Were None is one of Agatha Christie's representative detective novel.Since detective novel is different from general literary work,the translation of it is necessary to find some translation skills....And Then There Were None is one of Agatha Christie's representative detective novel.Since detective novel is different from general literary work,the translation of it is necessary to find some translation skills.It analyzes the vivid effect of Newmark's semantic and communicative translations on the De's Chinese version of And Then There Were None which causes the literary fla-vor to the detective novel.De's version accurately expresses Agatha's literary accomplishment even if it is the detective novel which always pays attention to the logical and calm detection and the intelligence race with the reader.It uses Newmark's theory to explore,and has found that the semantic translation in the application of the key clue and the application of the communicative translation on the creation of the characters and the special description of the environment.In conclusion,with different applica-tions in the novel,the semantic and communicative translations have their unique effects on the literary vision.Semantic transla-tion is reflected in the novel's clues and psychological interrogations.Communicative translation is mainly reflected in the charac-terization of the characters and the description of the environment,providing the guidance for the translation of detective novels.展开更多
Natural products and their derivatives repre- sent a rich source for the discovery and development of new cancer therapeutic drugs. Bioactive components derived from natural sources including marine compounds have bee...Natural products and their derivatives repre- sent a rich source for the discovery and development of new cancer therapeutic drugs. Bioactive components derived from natural sources including marine compounds have been shown to be effective agents in the clinic or in preclinical settings. In the present review, we present a story of discovery, synthesis and evaluation of three synthetic tricyclic pyrroloquinone （TPQ） alkaloid analogs as cancer therapeutic agents. Chemical synthesis of these compounds （BA-TPQ, TBA-TPQ, and TCBA-TPQ） has been accomplished and the mechanisms of action （MOA） and structure-activity relationships （SAR） have been investigated. In the past, the complexity of chemical synthesis and the lack of well-defined MOA have dampened the enthusiasm for the development of some makaluvamines. Recent discovery of novel molecular targets for these alkaloids （unrelated to inhibition of Topoisomerase II） warrant further consideration as clinical candidates in the future. In addition to the establishment of novel synthetic approaches and demonstration of in vitro and in vivo anticancer activities, we have successfully demonstrated that these makaluvamines attack several key molecular targets, including the MDM2-p53 pathway, providing ample opportunities of modulating the compound structure based on SAR and the use of such compounds in combination therapy in the future.展开更多
蓝牙+超宽带(Ultra Wide Band,UWB)混合定位系统结合低功耗广域覆盖特性和高精度时空解算能力,为智能物流提供高效精准的位置信息支撑。分析智能物流定位系统的现状和需求,研究蓝牙+UWB混合定位系统关键技术,提出基于粒子滤波和深度学...蓝牙+超宽带(Ultra Wide Band,UWB)混合定位系统结合低功耗广域覆盖特性和高精度时空解算能力,为智能物流提供高效精准的位置信息支撑。分析智能物流定位系统的现状和需求,研究蓝牙+UWB混合定位系统关键技术,提出基于粒子滤波和深度学习优化的混合定位算法,构建高精度终端节点布置方案,并设计非视距路径(None Line of Sight,NLOS)误差补偿策略,旨在提升智能仓储与物流调度的精确度、响应速度及系统稳定性,实现高效、安全、低能耗的智能物流管理。展开更多
基金Supported by National Natural Science Foundation of China(CN):Vascular Normalization by Huoxuehuayu medicine Induces decrease of the Interstitial Fluid and Improves Drug Penetration in Tumors(No.81202784)
文摘OBJECTIVE: To investigate whether the Tandistribution and anti-tumor Ⅱef A could improve the ficacy of Pegylated Liposomal Doxorubicin(PLD) via normalizing the structure and function of vasculature in Hepa1-6 hepatoma mice model.METHODS: Hepa1-6 hepatoma-bearing mice were treated with TanⅡA for 14 d. Distribution and anti-tumor efficacy of PLD, and the structure and function of the tumor vasculature were evaluated using various techniques.RESULTS: TanⅡ A significantly reduced the micro-vessel density(MVD). After Tan vascular walls were betteⅡr s A treatment,the tumor tructured, as the increased coverage of the pericytes and the promoted contact of the basement membrane and endothelial cell. Functional tests showed that tumor hypoxia was improved and the exudation amount of Evans blue in the parenchyma of the tumor decreased. In addition, mice treated with TanA had greater PLD penetration distance intratumoⅡrally. Furthermore, combined therapy of Tanibited tumor growth.ⅡA and PLD significantly inhCONCLUSION: This study suggests that Tanasculature andⅡ h A helps normalizing the tumor vas therapeutic potential in increasing the distribution of chemotherapy drug in the tumor.
文摘During calcining the aluminum hydroxide according to the Bayer process in a rotary kiln,the process of incomplete conversion to alpha alumina by soft calcination leads to a special intermediate alumina product containing microcrystalline of primary crystal alpha alumina particles less than 0.4μm,and other alumina phases with finer microcrystalline of less than 0.2μm particles.This special alumina powder has similar properties to silica fume or clay,such as high surface area and reactivity,fast wetting,low water demand and high stick-ability.It can partially or completely replace silica fume and clay in dry gunning mixes.It works towards improving the high temperature resistance of the gunning material matrix as well as the corrosion resistance and service life of the gunning materials.The application results show that:the ladle cementfree alumina-magnesia dry gunning mix with this special alumina sub-micro powder,compared with traditional dry gunning materials,has lower rebound loss(<10%),better adhesion rate,higher corrosion resistance and peeling resistance;and it can replace the veneering casting repair to achieve the similar performance.A further improvement goal is to replace the initial casting linings,thus this concept will give a new revolution to the monolithic steel ladles.
文摘And Then There Were None is one of Agatha Christie's representative detective novel.Since detective novel is different from general literary work,the translation of it is necessary to find some translation skills.It analyzes the vivid effect of Newmark's semantic and communicative translations on the De's Chinese version of And Then There Were None which causes the literary fla-vor to the detective novel.De's version accurately expresses Agatha's literary accomplishment even if it is the detective novel which always pays attention to the logical and calm detection and the intelligence race with the reader.It uses Newmark's theory to explore,and has found that the semantic translation in the application of the key clue and the application of the communicative translation on the creation of the characters and the special description of the environment.In conclusion,with different applica-tions in the novel,the semantic and communicative translations have their unique effects on the literary vision.Semantic transla-tion is reflected in the novel's clues and psychological interrogations.Communicative translation is mainly reflected in the charac-terization of the characters and the description of the environment,providing the guidance for the translation of detective novels.
文摘Natural products and their derivatives repre- sent a rich source for the discovery and development of new cancer therapeutic drugs. Bioactive components derived from natural sources including marine compounds have been shown to be effective agents in the clinic or in preclinical settings. In the present review, we present a story of discovery, synthesis and evaluation of three synthetic tricyclic pyrroloquinone （TPQ） alkaloid analogs as cancer therapeutic agents. Chemical synthesis of these compounds （BA-TPQ, TBA-TPQ, and TCBA-TPQ） has been accomplished and the mechanisms of action （MOA） and structure-activity relationships （SAR） have been investigated. In the past, the complexity of chemical synthesis and the lack of well-defined MOA have dampened the enthusiasm for the development of some makaluvamines. Recent discovery of novel molecular targets for these alkaloids （unrelated to inhibition of Topoisomerase II） warrant further consideration as clinical candidates in the future. In addition to the establishment of novel synthetic approaches and demonstration of in vitro and in vivo anticancer activities, we have successfully demonstrated that these makaluvamines attack several key molecular targets, including the MDM2-p53 pathway, providing ample opportunities of modulating the compound structure based on SAR and the use of such compounds in combination therapy in the future.
文摘蓝牙+超宽带(Ultra Wide Band,UWB)混合定位系统结合低功耗广域覆盖特性和高精度时空解算能力,为智能物流提供高效精准的位置信息支撑。分析智能物流定位系统的现状和需求,研究蓝牙+UWB混合定位系统关键技术,提出基于粒子滤波和深度学习优化的混合定位算法,构建高精度终端节点布置方案,并设计非视距路径(None Line of Sight,NLOS)误差补偿策略,旨在提升智能仓储与物流调度的精确度、响应速度及系统稳定性,实现高效、安全、低能耗的智能物流管理。
