Objective The aim of this study was to investigate the relationship between peripheral plasma stem cell factor (SCF)/c-kit levels and the types of dipper and non-dipper hypertension in hypertensive patients.Methods Th...Objective The aim of this study was to investigate the relationship between peripheral plasma stem cell factor (SCF)/c-kit levels and the types of dipper and non-dipper hypertension in hypertensive patients.Methods This cross-sectional study included newly diagnosed hypertensive patients who underwent 24-hour ambulatory blood pressure monitor (ABPM) between January 2009 and 2012 in Jiangning city. Patients were divided into the dipper group and the non-dipper group according to ABPM measurements. The levels of SCF and its receptor c-kit, tumor necrosis factor-α (TNF-α) and interleukin 6 (IL-6) in peripheral blood were measured via enzyme-linked immunosorbent assays. The serum levels of glucose and lipid were examined as well. The levels of SCF/c-kit were compared between the dippers and the non-dippers; and their correlation with 24-hour mean systolic blood pressure (MSBP), 24-hour mean diastolic blood pressure (MDBP), TNF-αand IL-6 were investigated using linear regression analyses statistically.Results A total of 247 patients with newly diagnosed hypertension were recruited into the study, including 116 non-dippers and 131 dippers. The levels of peripheral plasma SCF were higher in non-dipper group (907.1±52.7 ng/L vs. 778.7±44.6 ng/L; t=2.837, P<0.01), and the levels of c-kit were higher in non-dipper group too (13.2±1.7 μg/L vs 9.57±1.4 μg/L; t=2.831, P<0.01). Linear regression analysis revealed that SCF/ckit levels were significantly positively correlated with MSBP, MDBP, plasma TNF-α, and IL-6 levels (all P<0.01).Conclusions Peripheral plasma SCF/c-kit levels are higher in patients with non-dipper hypertension than those with dipper one, and significantly correlate with 24-hour MSBP, 24-hour MDBP, serum TNF-α and IL-6 levels.展开更多
目的分析原发性高血压患者动态动脉硬化指数(AASI)的相关影响因素,研究AASI对靶器官的损害作用及其临床意义。方法行24 h动态血压(ABPM)监测并计算AASI的原发性高血压患者330例,依据AASI结果分为低AASI组(n=167)及高AASI组(n=163),记录...目的分析原发性高血压患者动态动脉硬化指数(AASI)的相关影响因素,研究AASI对靶器官的损害作用及其临床意义。方法行24 h动态血压(ABPM)监测并计算AASI的原发性高血压患者330例,依据AASI结果分为低AASI组(n=167)及高AASI组(n=163),记录2组患者的一般临床资料、动态血压相关指标、冠状动脉造影结果、左室质量指数(LVMI),估算肾小球滤过率(eGFR)及踝臂指数(ABI)。结果高AASI组的年龄(岁:64.91±9.70vs 59.12±10.00)、合并糖尿病比例(33.8%vs 14.8%)、非杓型血压比例(65.6%vs 43.7%)、24 h脉压(mmHg:65.27±11.31 vs 56.06±10.51)、24 h舒张压标准差(mmHg:9.64±2.47 vs 8.31±2.31)、冠状动脉病变支数(1.8±1.1 vs 1.3±1.1)、LVMI(g/m2:125.74±29.65 vs 107.69±23.23)、外周血管病变(27.3%vs 16.4%)高于低AASI组;高AASI组eGFR水平小于低AASI组[mL/(min·1.73 m2):85.31±20.31 vs 99.67±17.76]。相关分析显示AASI与冠脉病变数(r=0.235)、LVMI(r=0.168)、外周血管病变(r=0.167)呈正相关,与eGFR(r=-0.187)呈负相关;多元线性回归分析显示年龄、糖尿病、PP、DB-PSD、非杓型血压是AASI的影响因素。结论 AASI受年龄、糖尿病、24 h脉压、血压变异性及血压杓型的影响,其升高和原发性高血压患者出现心、肾及外周血管疾病有关,检测AASI有助于临床医生评估高血压患者并发症的发生和发展。展开更多
目的探讨高血压病患者血糖水平与血压变异性之间的关系。方法回顾性分析2015年5月—2016年10月在我院心血管内科住院的高血压病患者125例,根据患者是否合并糖尿病,分为高血压合并糖尿病组(59例)和高血压未合并糖尿病组(66例),对2组血压...目的探讨高血压病患者血糖水平与血压变异性之间的关系。方法回顾性分析2015年5月—2016年10月在我院心血管内科住院的高血压病患者125例,根据患者是否合并糖尿病,分为高血压合并糖尿病组(59例)和高血压未合并糖尿病组(66例),对2组血压水平、血压变异性及与血糖水平之间的关系进行分析。结果 (1)高血压合并糖尿病组高脂血症史,低密度脂蛋白胆固醇水平低于高血压未合并糖尿病组,糖化血红蛋白(HbA1c)、24 h舒张压变异系数(24 h DBPCV)、白天收缩压变异系数(dSBPCV)和白天舒张压变异系数(dDBPCV)高于高血压未合并糖尿病组(P<0.05)。(2)对高血压病是否合并糖尿病与血压变异性各指标之间的Spearman相关分析显示,高血压病合并糖尿病与24 h DBPCV、dSBPCV和dDBPCV呈正相关。(3)HbA1c诊断高血压病患者非杓型血压的ROC曲线显示,HbA1c的cut-off值为5.85%,曲线下面积为0.692(P<0.05),敏感度为71.1%,特异度为63.7%。结论高血压伴血糖升高患者血压变异性增加,HbA1c水平对高血压病患者非杓型血压诊断有着潜在的临床价值。展开更多
文摘Objective The aim of this study was to investigate the relationship between peripheral plasma stem cell factor (SCF)/c-kit levels and the types of dipper and non-dipper hypertension in hypertensive patients.Methods This cross-sectional study included newly diagnosed hypertensive patients who underwent 24-hour ambulatory blood pressure monitor (ABPM) between January 2009 and 2012 in Jiangning city. Patients were divided into the dipper group and the non-dipper group according to ABPM measurements. The levels of SCF and its receptor c-kit, tumor necrosis factor-α (TNF-α) and interleukin 6 (IL-6) in peripheral blood were measured via enzyme-linked immunosorbent assays. The serum levels of glucose and lipid were examined as well. The levels of SCF/c-kit were compared between the dippers and the non-dippers; and their correlation with 24-hour mean systolic blood pressure (MSBP), 24-hour mean diastolic blood pressure (MDBP), TNF-αand IL-6 were investigated using linear regression analyses statistically.Results A total of 247 patients with newly diagnosed hypertension were recruited into the study, including 116 non-dippers and 131 dippers. The levels of peripheral plasma SCF were higher in non-dipper group (907.1±52.7 ng/L vs. 778.7±44.6 ng/L; t=2.837, P<0.01), and the levels of c-kit were higher in non-dipper group too (13.2±1.7 μg/L vs 9.57±1.4 μg/L; t=2.831, P<0.01). Linear regression analysis revealed that SCF/ckit levels were significantly positively correlated with MSBP, MDBP, plasma TNF-α, and IL-6 levels (all P<0.01).Conclusions Peripheral plasma SCF/c-kit levels are higher in patients with non-dipper hypertension than those with dipper one, and significantly correlate with 24-hour MSBP, 24-hour MDBP, serum TNF-α and IL-6 levels.
文摘目的分析原发性高血压患者动态动脉硬化指数(AASI)的相关影响因素,研究AASI对靶器官的损害作用及其临床意义。方法行24 h动态血压(ABPM)监测并计算AASI的原发性高血压患者330例,依据AASI结果分为低AASI组(n=167)及高AASI组(n=163),记录2组患者的一般临床资料、动态血压相关指标、冠状动脉造影结果、左室质量指数(LVMI),估算肾小球滤过率(eGFR)及踝臂指数(ABI)。结果高AASI组的年龄(岁:64.91±9.70vs 59.12±10.00)、合并糖尿病比例(33.8%vs 14.8%)、非杓型血压比例(65.6%vs 43.7%)、24 h脉压(mmHg:65.27±11.31 vs 56.06±10.51)、24 h舒张压标准差(mmHg:9.64±2.47 vs 8.31±2.31)、冠状动脉病变支数(1.8±1.1 vs 1.3±1.1)、LVMI(g/m2:125.74±29.65 vs 107.69±23.23)、外周血管病变(27.3%vs 16.4%)高于低AASI组;高AASI组eGFR水平小于低AASI组[mL/(min·1.73 m2):85.31±20.31 vs 99.67±17.76]。相关分析显示AASI与冠脉病变数(r=0.235)、LVMI(r=0.168)、外周血管病变(r=0.167)呈正相关,与eGFR(r=-0.187)呈负相关;多元线性回归分析显示年龄、糖尿病、PP、DB-PSD、非杓型血压是AASI的影响因素。结论 AASI受年龄、糖尿病、24 h脉压、血压变异性及血压杓型的影响,其升高和原发性高血压患者出现心、肾及外周血管疾病有关,检测AASI有助于临床医生评估高血压患者并发症的发生和发展。
文摘目的探讨高血压病患者血糖水平与血压变异性之间的关系。方法回顾性分析2015年5月—2016年10月在我院心血管内科住院的高血压病患者125例,根据患者是否合并糖尿病,分为高血压合并糖尿病组(59例)和高血压未合并糖尿病组(66例),对2组血压水平、血压变异性及与血糖水平之间的关系进行分析。结果 (1)高血压合并糖尿病组高脂血症史,低密度脂蛋白胆固醇水平低于高血压未合并糖尿病组,糖化血红蛋白(HbA1c)、24 h舒张压变异系数(24 h DBPCV)、白天收缩压变异系数(dSBPCV)和白天舒张压变异系数(dDBPCV)高于高血压未合并糖尿病组(P<0.05)。(2)对高血压病是否合并糖尿病与血压变异性各指标之间的Spearman相关分析显示,高血压病合并糖尿病与24 h DBPCV、dSBPCV和dDBPCV呈正相关。(3)HbA1c诊断高血压病患者非杓型血压的ROC曲线显示,HbA1c的cut-off值为5.85%,曲线下面积为0.692(P<0.05),敏感度为71.1%,特异度为63.7%。结论高血压伴血糖升高患者血压变异性增加,HbA1c水平对高血压病患者非杓型血压诊断有着潜在的临床价值。
