Previous studies have found associations between color discrimination deficits and cognitive impairments besides aging.However,investigations into the microstructural pathology of brain white matter(WM)associated with...Previous studies have found associations between color discrimination deficits and cognitive impairments besides aging.However,investigations into the microstructural pathology of brain white matter(WM)associated with these deficits remain limited.This study aimed to examine the microstructural characteristics of WM in the non-demented population with abnormal color discrimination,utilizing Neurite Orientation Dispersion and Density Imaging(NODDI),and to explore their correlations with cognitive functions and cognition-related plasma biomarkers.The tract-based spatial statistic analysis revealed significant differences in specific brain regions between the abnormal color discrimination group and the healthy controls,characterized by increased isotropic volume fraction and decreased neurite density index and orientation dispersion index.Further analysis of region-of-interest parameters revealed that the isotropic volume fraction in the bilateral anterior thalamic radiation,superior longitudinal fasciculus,cingulum,and forceps minor was significantly correlated with poorer performance on neuropsychological assessments and to varying degrees various cognition-related plasma biomarkers.These findings provide neuroimaging evidence that WM microstructural abnormalities in non-demented individuals with abnormal color discrimination are associated with cognitive dysfunction,potentially serving as early markers for cognitive decline.展开更多
Multiple sclerosis is a neurodegenerative and inflammatory disease, a hallmark of which is demyelinating lesions in the white matter. We hypothesized that alterations in white matter microstructures can be non-invasiv...Multiple sclerosis is a neurodegenerative and inflammatory disease, a hallmark of which is demyelinating lesions in the white matter. We hypothesized that alterations in white matter microstructures can be non-invasively characterized by advanced diffusion magnetic resonance imaging. Seven diffusion metrics were extracted from hybrid diffusion imaging acquisitions via classic diffusion tensor imaging, neurite orientation dispersion and density imaging, and q-space imaging. We investigated the sensitivity of the diffusion metrics in 36 sets of regions of interest in the brain white matter of six female patients(age 52.8 ± 4.3 years) with multiple sclerosis. Each region of interest set included a conventional T2-defined lesion, a matched perilesion area, and normal-appearing white matter. Six patients with multiple sclerosis(n = 5) or clinically isolated syndrome(n = 1) at a mild to moderate disability level were recruited. The patients exhibited microstructural alterations from normal-appearing white matter transitioning to perilesion areas and lesions, consistent with decreased tissue restriction, decreased axonal density, and increased classic diffusion tensor imaging diffusivity. The findings suggest that diffusion compartment modeling and q-spa ce analysis appeared to be sensitive for detecting subtle microstructural alterations between perilesion areas and normal-appearing white matter.展开更多
基金supported by the Joint Funds for Innovation of Science and Technology,Fujian Province(2021Y9037)a National Clinical Key Special Subject of China(21281003).
文摘Previous studies have found associations between color discrimination deficits and cognitive impairments besides aging.However,investigations into the microstructural pathology of brain white matter(WM)associated with these deficits remain limited.This study aimed to examine the microstructural characteristics of WM in the non-demented population with abnormal color discrimination,utilizing Neurite Orientation Dispersion and Density Imaging(NODDI),and to explore their correlations with cognitive functions and cognition-related plasma biomarkers.The tract-based spatial statistic analysis revealed significant differences in specific brain regions between the abnormal color discrimination group and the healthy controls,characterized by increased isotropic volume fraction and decreased neurite density index and orientation dispersion index.Further analysis of region-of-interest parameters revealed that the isotropic volume fraction in the bilateral anterior thalamic radiation,superior longitudinal fasciculus,cingulum,and forceps minor was significantly correlated with poorer performance on neuropsychological assessments and to varying degrees various cognition-related plasma biomarkers.These findings provide neuroimaging evidence that WM microstructural abnormalities in non-demented individuals with abnormal color discrimination are associated with cognitive dysfunction,potentially serving as early markers for cognitive decline.
基金supported by Indiana University-Purdue University Indianapolis Imaging Technology Development Program(IUPUI ITDP)National Institutes of Health(NIH)grant R21 NS075791,and R01 AG053993
文摘Multiple sclerosis is a neurodegenerative and inflammatory disease, a hallmark of which is demyelinating lesions in the white matter. We hypothesized that alterations in white matter microstructures can be non-invasively characterized by advanced diffusion magnetic resonance imaging. Seven diffusion metrics were extracted from hybrid diffusion imaging acquisitions via classic diffusion tensor imaging, neurite orientation dispersion and density imaging, and q-space imaging. We investigated the sensitivity of the diffusion metrics in 36 sets of regions of interest in the brain white matter of six female patients(age 52.8 ± 4.3 years) with multiple sclerosis. Each region of interest set included a conventional T2-defined lesion, a matched perilesion area, and normal-appearing white matter. Six patients with multiple sclerosis(n = 5) or clinically isolated syndrome(n = 1) at a mild to moderate disability level were recruited. The patients exhibited microstructural alterations from normal-appearing white matter transitioning to perilesion areas and lesions, consistent with decreased tissue restriction, decreased axonal density, and increased classic diffusion tensor imaging diffusivity. The findings suggest that diffusion compartment modeling and q-spa ce analysis appeared to be sensitive for detecting subtle microstructural alterations between perilesion areas and normal-appearing white matter.
