Species from Moraceae family stand out in popular medicine and phytotherapy, have been for example used as expectorants, bronchodilators, anthelmintics and treatment of skin diseases, such as vitiligo, due to the pres...Species from Moraceae family stand out in popular medicine and phytotherapy, have been for example used as expectorants, bronchodilators, anthelmintics and treatment of skin diseases, such as vitiligo, due to the presence of compounds with proven biological activity, as the coumarins. Coumarins are lactones with 1,2-benzopyrone basic structure, and are widely distributed in the plant kingdom, both in free form, and in glycosylated form. This work reports a literature review, describing the data of 13C NMR from 53 coumarins isolated from the family Moraceae, and data comparison between genera who presented photochemical studies, in order to contribute to the chemotaxonomy of this family.展开更多
The magnetic resonance spectroscopy(MRS)results are greatly influenced by reconstruction of the spectrum and quantitative analysis.Because of this requirement a number of programs dedicated to MRS data analysis were d...The magnetic resonance spectroscopy(MRS)results are greatly influenced by reconstruction of the spectrum and quantitative analysis.Because of this requirement a number of programs dedicated to MRS data analysis were developed.The selection and use of appropriate software is crucial not only in clinical procedures,but also while carrying out scientific research.The choice of the software to suit the user's needs should be based on the analysis of the functionality of the program.It is particularly important from the user's viewpoint to identify what data can be loaded and processed in the program.The specific programs allow the user different degree of control over analysis parameters.Moreover,the programs for MRS data analysis differ in terms of the applied signal processing algorithms.The aim of this work,therefore,is to review available packages designed for MRS data analysis,taking into account their capabilities and limitations.展开更多
Aristolochic acids(AAs)are an important group of secondary metabolites in the genus Aristolochia.The presence of aristolochic acids infers the potency of many Aristolochia herbs used forages in traditional medicine of...Aristolochic acids(AAs)are an important group of secondary metabolites in the genus Aristolochia.The presence of aristolochic acids infers the potency of many Aristolochia herbs used forages in traditional medicine of China,Europe,Central America,India,and some other countries.Although being moderately cytotoxic,intake of AAs is asso-ciated with serious health problems,such as nephrotoxicity and carcinogenicity.Analyzing AAs in Aristolochia herbs is crucial for regulating their efficacy and toxicity because phytochemistry works have shown the occurrence of AAs in almost all Aristolochia herbs studied.Using two-dimensional parameters,chemical shifts and coupling constants,NMR spectroscopy is a modern,accurate,and reliable method in the analysis of secondary metabolites.Compar-ing experimental spectroscopic data with those of known and related compounds helps simplify the structural identification of secondary metabolites.The compilation of an NMR database of AAs from scattered sources would also be useful in NMR-based metabolomics.The present review provides updated information on sources and NMR spectroscopic data of 54 aristolochic acid derivatives,including AAs and their methyl esters,denitroaristolochic acids and their derivatives,and sesqui-and diterpene esters of AAs.The report also covers the newest development of ana-lytical and preparative methods used in separation,identification,and quantification of AAs in Aristolochia herbal samples.展开更多
核磁共振(Nuclear Magnetic Resonance,NMR)是材料学、生物学、化学等多个领域中一项重要的检测手段,在分子组成、结构解析和动力学等方面发挥了重要作用。但NMR检测存在信噪比低、谱峰易重叠等问题使得数据处理困难,而深度学习(Deep Le...核磁共振(Nuclear Magnetic Resonance,NMR)是材料学、生物学、化学等多个领域中一项重要的检测手段,在分子组成、结构解析和动力学等方面发挥了重要作用。但NMR检测存在信噪比低、谱峰易重叠等问题使得数据处理困难,而深度学习(Deep Learning,DL)具有其独特优势,可以从原始数据中提取主要特征自主学习,并且可以很好地处理复杂的函数关系。近年来,DL在NMR信号处理上取得了一些突破,本综述既介绍了NMR的基本原理以及应用,更强调了DL和NMR结合所带来的优势,对NMR技术的未来发展起了重要的推动作用。展开更多
文摘Species from Moraceae family stand out in popular medicine and phytotherapy, have been for example used as expectorants, bronchodilators, anthelmintics and treatment of skin diseases, such as vitiligo, due to the presence of compounds with proven biological activity, as the coumarins. Coumarins are lactones with 1,2-benzopyrone basic structure, and are widely distributed in the plant kingdom, both in free form, and in glycosylated form. This work reports a literature review, describing the data of 13C NMR from 53 coumarins isolated from the family Moraceae, and data comparison between genera who presented photochemical studies, in order to contribute to the chemotaxonomy of this family.
文摘The magnetic resonance spectroscopy(MRS)results are greatly influenced by reconstruction of the spectrum and quantitative analysis.Because of this requirement a number of programs dedicated to MRS data analysis were developed.The selection and use of appropriate software is crucial not only in clinical procedures,but also while carrying out scientific research.The choice of the software to suit the user's needs should be based on the analysis of the functionality of the program.It is particularly important from the user's viewpoint to identify what data can be loaded and processed in the program.The specific programs allow the user different degree of control over analysis parameters.Moreover,the programs for MRS data analysis differ in terms of the applied signal processing algorithms.The aim of this work,therefore,is to review available packages designed for MRS data analysis,taking into account their capabilities and limitations.
基金funded by Vietnam National Foundation for Science and Technology Development(NAFOSTED)under Grant Number 104.01-2021.09
文摘Aristolochic acids(AAs)are an important group of secondary metabolites in the genus Aristolochia.The presence of aristolochic acids infers the potency of many Aristolochia herbs used forages in traditional medicine of China,Europe,Central America,India,and some other countries.Although being moderately cytotoxic,intake of AAs is asso-ciated with serious health problems,such as nephrotoxicity and carcinogenicity.Analyzing AAs in Aristolochia herbs is crucial for regulating their efficacy and toxicity because phytochemistry works have shown the occurrence of AAs in almost all Aristolochia herbs studied.Using two-dimensional parameters,chemical shifts and coupling constants,NMR spectroscopy is a modern,accurate,and reliable method in the analysis of secondary metabolites.Compar-ing experimental spectroscopic data with those of known and related compounds helps simplify the structural identification of secondary metabolites.The compilation of an NMR database of AAs from scattered sources would also be useful in NMR-based metabolomics.The present review provides updated information on sources and NMR spectroscopic data of 54 aristolochic acid derivatives,including AAs and their methyl esters,denitroaristolochic acids and their derivatives,and sesqui-and diterpene esters of AAs.The report also covers the newest development of ana-lytical and preparative methods used in separation,identification,and quantification of AAs in Aristolochia herbal samples.
文摘核磁共振(Nuclear Magnetic Resonance,NMR)是材料学、生物学、化学等多个领域中一项重要的检测手段,在分子组成、结构解析和动力学等方面发挥了重要作用。但NMR检测存在信噪比低、谱峰易重叠等问题使得数据处理困难,而深度学习(Deep Learning,DL)具有其独特优势,可以从原始数据中提取主要特征自主学习,并且可以很好地处理复杂的函数关系。近年来,DL在NMR信号处理上取得了一些突破,本综述既介绍了NMR的基本原理以及应用,更强调了DL和NMR结合所带来的优势,对NMR技术的未来发展起了重要的推动作用。
