In comparison with the 660 nm light-triggered type Ⅱ photosensitizers(PSs)for high oxygen consumption,type Ⅰ photo-sensitizers that could be triggered by 808 nm near-infrared(NIR)light to achieve effective electron ...In comparison with the 660 nm light-triggered type Ⅱ photosensitizers(PSs)for high oxygen consumption,type Ⅰ photo-sensitizers that could be triggered by 808 nm near-infrared(NIR)light to achieve effective electron transfer show great application potential in anoxic microenvironments for photodynamic therapy(PDT)due to their lower oxygen dependence.However,developing type Ⅰ PSs still remains a challenge due to the low energy of NIR light and preferred utilization of type Ⅱ rather than type Ⅰ process of PSs under the matched energy levels.Herein,co-assembly of 5,10,15,20-tetrakis-(4-aminophenyl)-porphyrin(TAPP)with N-carbobenzyloxy-L-leucine(Cbz-Leu)affords a supramolecular nano-PS(TAPP@Cbz-Leu).TAPP@Cbz-Leu significantly produces superoxide anions(O_(2)^(·−))when triggered by NIR light(808 nm).The noncovalent tight binding between TAPP and Cbz-Leu was revealed to induce an increase in the photoinduced electron transfer from Cbz-Leu to the triplet TAPP,generating TAPP^(·−)and promoting the formation of O_(2)^(·−).Furthermore,TAPP@Cbz-Leu possess excellent photothermal property under NIR light(808 nm)irradiation.In vivo studies disclose the good antibacterial effect of TAPP@Cbz-Leu on MRSA-infected animal wound models and can effectively promote wound healing.The present result seems to represent the first example of converting type Ⅱ PS into the type Ⅰ PS by means of a simple co-assembly strategy.展开更多
The acidic tumor microenvironment is triggered by glycolysis in hypoxic condition, which can motivate the pHresponsive system to build certain triggers for efficiently tumor-targeted phototherapy. Additionally, the me...The acidic tumor microenvironment is triggered by glycolysis in hypoxic condition, which can motivate the pHresponsive system to build certain triggers for efficiently tumor-targeted phototherapy. Additionally, the metalated porphyrin structures are widely studied in biomedical applications due to the favorable properties of high singlet oxygen quantum yield as well as strong fluorescence imaging ability. Herein, a pH-responsive zinc(II) metalated porphyrin(P-4) was designed and synthesized for amplifying cancer photodynamic/photothermal therapy with excellent fluorescence quantum yield(67.4%), superb singlet oxygen quantum yield(84.3%) and desired photothermal conversion efficiency(30.0%). In vitro, the self-assembled P-4 nanoparticles can specifically target to lysosome subcellular site and realize protonated process of dibutaneaminophenyl(DBAP) groups with high photo toxicity. Under single 660 nm laser illumination, the tumor can be ablated completely with no side effects in vivo. This work demonstrates that the p H-responsive P-4 nanoparticles provide a new avenue for highly efficient cancer combination therapy.展开更多
Due to the widespread of adulteration of lipid in food and feed industry,the quality and safety of lipid are of public concern gradually.Firstly,the current article presents theory and mechanism of species identificat...Due to the widespread of adulteration of lipid in food and feed industry,the quality and safety of lipid are of public concern gradually.Firstly,the current article presents theory and mechanism of species identification of lipid by spectroscopic technique.Potential of near-infrared reflectance spectroscopy(NIR),Fourier transform infrared spectroscopy(FT-IR),and Fourier transform Raman spectroscopy(FT-Raman)applied to species identification of lipid were summarized.In addition,the relationship between lipid and spectroscopy as well as the recent advances of species identification of lipid were discussed.Research showed that FT-IR and FT-Raman spectroscopies possessed more efficient potential for species identification of lipid.Finally,prospects for future lipid detection and relative practical application,and combination of spectroscopy and other technique were further discussed.展开更多
基金supported by the Central Guidance on Local Science and Technology Development Fund of Guangxi Zhuang Autonomous Region(Gui Ke ZY22096010)Guangxi Natural Science Foundation(2023GXNSFAA026181)+4 种基金National Natural Science Foundation of China(22261132512,22468032)BAGUI Youth Outstanding Talent Program of Guangxi Zhuang Autonomous Region of ChinaBAGUI Scholar Program of Guangxi Zhuang Autonomous Region of ChinaEngineering Research Center of Nano-BiomaterialsUniversity of Guangxi。
文摘In comparison with the 660 nm light-triggered type Ⅱ photosensitizers(PSs)for high oxygen consumption,type Ⅰ photo-sensitizers that could be triggered by 808 nm near-infrared(NIR)light to achieve effective electron transfer show great application potential in anoxic microenvironments for photodynamic therapy(PDT)due to their lower oxygen dependence.However,developing type Ⅰ PSs still remains a challenge due to the low energy of NIR light and preferred utilization of type Ⅱ rather than type Ⅰ process of PSs under the matched energy levels.Herein,co-assembly of 5,10,15,20-tetrakis-(4-aminophenyl)-porphyrin(TAPP)with N-carbobenzyloxy-L-leucine(Cbz-Leu)affords a supramolecular nano-PS(TAPP@Cbz-Leu).TAPP@Cbz-Leu significantly produces superoxide anions(O_(2)^(·−))when triggered by NIR light(808 nm).The noncovalent tight binding between TAPP and Cbz-Leu was revealed to induce an increase in the photoinduced electron transfer from Cbz-Leu to the triplet TAPP,generating TAPP^(·−)and promoting the formation of O_(2)^(·−).Furthermore,TAPP@Cbz-Leu possess excellent photothermal property under NIR light(808 nm)irradiation.In vivo studies disclose the good antibacterial effect of TAPP@Cbz-Leu on MRSA-infected animal wound models and can effectively promote wound healing.The present result seems to represent the first example of converting type Ⅱ PS into the type Ⅰ PS by means of a simple co-assembly strategy.
基金supported by the National Natural Science Foundation of China(61525402,61775095 and 21704043)Jiangsu Provincial Key Research and Development Plan(BE2017741)+1 种基金Six Talent Peak Innovation Team in Jiangsu Province(TD-SWYY-009)the Natural Science Foundation of Jiangsu Province(BK20170990and 17KJB150020)
文摘The acidic tumor microenvironment is triggered by glycolysis in hypoxic condition, which can motivate the pHresponsive system to build certain triggers for efficiently tumor-targeted phototherapy. Additionally, the metalated porphyrin structures are widely studied in biomedical applications due to the favorable properties of high singlet oxygen quantum yield as well as strong fluorescence imaging ability. Herein, a pH-responsive zinc(II) metalated porphyrin(P-4) was designed and synthesized for amplifying cancer photodynamic/photothermal therapy with excellent fluorescence quantum yield(67.4%), superb singlet oxygen quantum yield(84.3%) and desired photothermal conversion efficiency(30.0%). In vitro, the self-assembled P-4 nanoparticles can specifically target to lysosome subcellular site and realize protonated process of dibutaneaminophenyl(DBAP) groups with high photo toxicity. Under single 660 nm laser illumination, the tumor can be ablated completely with no side effects in vivo. This work demonstrates that the p H-responsive P-4 nanoparticles provide a new avenue for highly efficient cancer combination therapy.
基金supported by the National Natural Science Foundation of China(21472047,21772041,21702062)the Program for Professor of Special Appointment(Eastern Scholar,GZ2016006)at Shanghai Institutions of Higher Learning,Shanghai Pujiang Program(17PJ1401700)the Fundamental Research Funds for the Central Universities(WK1616004,222201717003,222201714013)
文摘Porphyrins are a class of heterocyclic macrocycles,containing four pyrrolic subunits interconnected at theα-positions with four methine（=CH-）groups.
基金International S&T Cooperation Program of China(2015DFG32170)National Key Scientific Instrument and Equipment Development Project(2014YQ47037705)China Agricultural University‘DaBeiNong Education Fund’.
文摘Due to the widespread of adulteration of lipid in food and feed industry,the quality and safety of lipid are of public concern gradually.Firstly,the current article presents theory and mechanism of species identification of lipid by spectroscopic technique.Potential of near-infrared reflectance spectroscopy(NIR),Fourier transform infrared spectroscopy(FT-IR),and Fourier transform Raman spectroscopy(FT-Raman)applied to species identification of lipid were summarized.In addition,the relationship between lipid and spectroscopy as well as the recent advances of species identification of lipid were discussed.Research showed that FT-IR and FT-Raman spectroscopies possessed more efficient potential for species identification of lipid.Finally,prospects for future lipid detection and relative practical application,and combination of spectroscopy and other technique were further discussed.
